Thomas G Beach

Summary

Affiliation: Banner Good Samaritan Medical Center
Country: USA

Publications

  1. Beach T, Sue L, Walker D, Sabbagh M, Serrano G, Dugger B, et al. Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging. J Alzheimers Dis. 2012;28:869-76 pubmed publisher
    ..Validation of this hypothesis will require autopsy studies of subjects that had amyloid imaging during life. ..
  2. Beach T. Alzheimer's disease and the "Valley Of Death": not enough guidance from human brain tissue?. J Alzheimers Dis. 2013;33 Suppl 1:S219-33 pubmed publisher
    ..To optimize the promise of these new technologies, however, it is critical that brain banks are rejuvenated by enhanced governmental and/or private support. ..
  3. Dugger B, Davis K, Malek Ahmadi M, Hentz J, Sandhu S, Beach T, et al. Neuropathological comparisons of amnestic and nonamnestic mild cognitive impairment. BMC Neurol. 2015;15:146 pubmed publisher
    ..However, these data suggest the possibility for naMCI to have a propensity for increased LBs and aMCI for increased NFTs in select anatomic regions. ..
  4. Beach T, Maarouf C, Brooks R, Shirohi S, Daugs I, Sue L, et al. Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease. BMC Geriatr. 2011;11:3 pubmed publisher
  5. Dumitriu A, Golji J, Labadorf A, Gao B, Beach T, Myers R, et al. Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease. BMC Med Genomics. 2016;9:5 pubmed publisher
    ..Combining multiple genome-wide platforms offers novel insights into the pathological processes responsible for this disease by identifying pathways implicated across methodologies. ..
  6. Gaugler J, Ascher Svanum H, Roth D, Fafowora T, Siderowf A, Beach T. Characteristics of patients misdiagnosed with Alzheimer's disease and their medication use: an analysis of the NACC-UDS database. BMC Geriatr. 2013;13:137 pubmed publisher
    ..Additional research is needed to demonstrate the link between potentially inappropriate treatment and adverse health outcomes in misdiagnosed AD patients. ..
  7. Beach T, Adler C, Lue L, Sue L, Bachalakuri J, Henry Watson J, et al. Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction. Acta Neuropathol. 2009;117:613-34 pubmed publisher
    ..It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases...
  8. Beach T. A Review of Biomarkers for Neurodegenerative Disease: Will They Swing Us Across the Valley?. Neurol Ther. 2017;6:5-13 pubmed publisher
  9. Beach T, Adler C, Sue L, Vedders L, Lue L, White Iii C, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119:689-702 pubmed publisher
    ..Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest. ..

More Information

Publications12

  1. Beach T, Monsell S, Phillips L, Kukull W. Accuracy of the clinical diagnosis of Alzheimer disease at National Institute on Aging Alzheimer Disease Centers, 2005-2010. J Neuropathol Exp Neurol. 2012;71:266-73 pubmed publisher
    ..The misdiagnosis rate should be considered when estimating subject numbers for AD studies, including clinical trials and epidemiologic studies. ..
  2. Beach T, Adler C, Dugger B, Serrano G, Hidalgo J, Henry Watson J, et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol. 2013;72:130-6 pubmed publisher
    ..This would be particularly advantageous for subject selection in early-stage clinical trials for invasive therapies or for verifying other biomarker studies...
  3. Dashtipour K, Tafreshi A, Adler C, Beach T, Chen X, Serrano G, et al. Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) Gene in the Cerebral Cortex of Patients with Sporadic Parkinson's Disease. Brain Sci. 2017;7: pubmed publisher
    ..Hypomethylation of SNCAIP may function to protect against PD. The current results may suggest that the methylation status of SNCAIP could be useful as a marker in PD diagnosis and treatment and warrants further investigation. ..