Praveen Ballabh

Summary

Country: USA

Publications

  1. ncbi request reprint The blood-brain barrier: an overview: structure, regulation, and clinical implications
    Praveen Ballabh
    Department of Pediatrics, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
    Neurobiol Dis 16:1-13. 2004
  2. pmc Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 295:H569-77. 2008
  3. doi request reprint Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage
    Paraskevi Georgiadis
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY, USA
    Stroke 39:3378-88. 2008
  4. doi request reprint Pathogenesis and prevention of intraventricular hemorrhage
    Praveen Ballabh
    Department of Pediatrics, Cell Biology and Anatomy, Regional Neonatal Center, New York Medical College, Maria Fareri Children s Hospital, Westchester Medical Center, 100 Woods Road, Valhalla, NY 10595, USA Electronic address
    Clin Perinatol 41:47-67. 2014
  5. pmc Intraventricular hemorrhage in premature infants: mechanism of disease
    Praveen Ballabh
    Department of Pediatrics, Anatomy and Cell Biology, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Pediatr Res 67:1-8. 2010
  6. ncbi request reprint Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
  7. ncbi request reprint Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter
    Praveen Ballabh
    Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
    Pediatr Res 58:791-8. 2005
  8. ncbi request reprint Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Pediatr Res 56:117-24. 2004
  9. pmc Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids
    P Ballabh
    Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Arch Dis Child Fetal Neonatal Ed 89:F76-83. 2004
  10. ncbi request reprint Neonatal outcome of triplet versus twin and singleton pregnancies: a matched case control study
    Praveen Ballabh
    Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Eur J Obstet Gynecol Reprod Biol 107:28-36. 2003

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The blood-brain barrier: an overview: structure, regulation, and clinical implications
    Praveen Ballabh
    Department of Pediatrics, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
    Neurobiol Dis 16:1-13. 2004
    ..Finally, this review describes the pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease...
  2. pmc Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells
    Anna Csiszar
    Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Am J Physiol Heart Circ Physiol 295:H569-77. 2008
    ..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation...
  3. doi request reprint Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage
    Paraskevi Georgiadis
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY, USA
    Stroke 39:3378-88. 2008
    ..Despite this, there is no standardized animal model of IVH depicting acute brain injuries...
  4. doi request reprint Pathogenesis and prevention of intraventricular hemorrhage
    Praveen Ballabh
    Department of Pediatrics, Cell Biology and Anatomy, Regional Neonatal Center, New York Medical College, Maria Fareri Children s Hospital, Westchester Medical Center, 100 Woods Road, Valhalla, NY 10595, USA Electronic address
    Clin Perinatol 41:47-67. 2014
    ..Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH. ..
  5. pmc Intraventricular hemorrhage in premature infants: mechanism of disease
    Praveen Ballabh
    Department of Pediatrics, Anatomy and Cell Biology, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Pediatr Res 67:1-8. 2010
    ..Hence, the rapid stabilization of the angiogenic vessels and the restoration of normal CBF on the first day of life are potential strategies to prevent IVH in premature infants...
  6. ncbi request reprint Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  7. ncbi request reprint Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter
    Praveen Ballabh
    Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
    Pediatr Res 58:791-8. 2005
    ....
  8. ncbi request reprint Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infants
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Pediatr Res 56:117-24. 2004
    ..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants..
  9. pmc Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids
    P Ballabh
    Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
    Arch Dis Child Fetal Neonatal Ed 89:F76-83. 2004
    ....
  10. ncbi request reprint Neonatal outcome of triplet versus twin and singleton pregnancies: a matched case control study
    Praveen Ballabh
    Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Eur J Obstet Gynecol Reprod Biol 107:28-36. 2003
    ..To determine the neonatal outcome of triplet gestations versus that of singletons and twins matched for gestational age...
  11. pmc Intraventricular hemorrhage induces deposition of proteoglycans in premature rabbits, but their in vivo degradation with chondroitinase does not restore myelination, ventricle size and neurological recovery
    Govindaiah Vinukonda
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Exp Neurol 247:630-44. 2013
    ....
  12. pmc Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 297:H1876-81. 2009
    ....
  13. pmc Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Mech Ageing Dev 130:518-27. 2009
    ..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway...
  14. pmc Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition
    Govindaiah Vinukonda
    Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
    Brain 133:2264-80. 2010
    ....
  15. pmc Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus
    Nazar Labinskyy
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H946-56. 2009
    ..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging...
  16. pmc Effect of prenatal glucocorticoids on cerebral vasculature of the developing brain
    Govindaiah Vinukonda
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 41:1766-73. 2010
    ..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature...
  17. doi request reprint Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone
    Hongmin Xu
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci Res 86:1482-500. 2008
    ..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates...
  18. ncbi request reprint Paucity of pericytes in germinal matrix vasculature of premature infants
    Alex Braun
    Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 27:12012-24. 2007
    ..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature...
  19. ncbi request reprint Respiratory burst activity in bronchopulmonary dysplasia and changes with dexamethasone
    Praveen Ballabh
    Division of Neonatology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    Pediatr Pulmonol 35:392-9. 2003
    ..Greater pulmonary damage in BPD cannot be attributed to reduced burst activity in either neutrophils or monocytes. Dexamethasone treatment was associated with decreased neutrophil respiratory burst activity...
  20. pmc Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidase
    Muhammad T Zia
    Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 40:2191-8. 2009
    ....
  21. pmc Resveratrol induces mitochondrial biogenesis in endothelial cells
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 297:H13-20. 2009
    ..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases...
  22. doi request reprint Development of integrins in the vasculature of germinal matrix, cerebral cortex, and white matter of fetuses and premature infants
    Krishna Dummula
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York, USA
    J Neurosci Res 88:1193-204. 2010
    ..We speculate that selective alpha5beta1 integrin inhibition might suppress angiogenesis in the GM and thus prevent brain hemorrhage in premature infants...
  23. ncbi request reprint Lymphocyte subpopulations in bronchopulmonary dysplasia
    Praveen Ballabh
    Division of Newborn Unit, Westchester Medical Center, Valhalla, New York
    Am J Perinatol 20:465-75. 2003
    ..As a whole these data suggest that reduction of CD4(+) T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD...
  24. pmc Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage
    Linnea R Vose
    Departments of Pediatrics, and Cell Biology and Anatomy, Regional Neonatal Center, Maria Fareri Children s Hospital at Westchester Medical Center New York Medical College, Valhalla, New York 10595, Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, Department of Neuroscience, University of Connecticut, Farmington, Connecticut 06269, and Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33146
    J Neurosci 33:17232-46. 2013
    ..Given that TH promotes neurological recovery in IVH, TH treatment might improve the neurodevelopmental outcome of preterm infants with IVH. ..
  25. pmc Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth
    Sabrina Malik
    Department of Pediatrics, Regional Neonatal Center, Maria Fareri Children s Hospital at Westchester Medical Center and New York Medical College, Valhalla, New York 10595, USA
    J Neurosci 33:411-23. 2013
    ....
  26. pmc Consequences of intraventricular hemorrhage in a rabbit pup model
    Caroline O Chua
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
    Stroke 40:3369-77. 2009
    ..We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis...
  27. ncbi request reprint Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infants
    Nadine El-Khoury
    Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
    Pediatr Res 59:673-9. 2006
    ....
  28. ncbi request reprint Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone
    Praveen Ballabh
    Department of Neonatology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Pediatrics 111:461-8. 2003
    ....
  29. pmc Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
    ..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging...
  30. pmc Bone morphogenetic protein inhibition promotes neurological recovery after intraventricular hemorrhage
    Krishna Dummula
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    J Neurosci 31:12068-82. 2011
    ..Hence, BMP inhibition might enhance neurological recovery in premature infants with IVH...
  31. pmc Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infants
    Govindaiah Vinukonda
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York, USA
    J Neurosci Res 90:2173-82. 2012
    ..Importantly, plasma appears to induce greater white matter damage than erythrocytes in IVH,indicating plasma as a source of neurotoxic components...
  32. ncbi request reprint Outcomes of dichorionic triplet pregnancies
    Stephen T Chasen
    Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
    Am J Obstet Gynecol 186:765-7. 2002
    ..The objective of this study was to describe outcomes in a series of dichorionic triplet pregnancies...
  33. ncbi request reprint Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis
    Gary Laborada
    Perinatology Center, New York Presbyterian Hospital, New York, New York 10021, USA
    Am J Perinatol 20:491-501. 2003
    ..In conclusion, a combination of CRP + IL-6 provided additional diagnostic accuracy for differentiation between septic and nonseptic patients during the first 24 hours of suspected sepsis...
  34. ncbi request reprint Pharmacokinetics of betamethasone in twin and singleton pregnancy
    Praveen Ballabh
    Department of Neonatology, New York Presbyterian Hospital Weill Medical College of Cornell University, NY 10021, USA
    Clin Pharmacol Ther 71:39-45. 2002
    ..The aims of the study were to compare the pharmacokinetics of betamethasone in singleton pregnancy with the pharmacokinetics in twin pregnancy and to assess the adrenal suppression produced by betamethasone...
  35. pmc Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants
    Joshua R Buser
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 71:93-109. 2012
    ..We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte-rich lesions...
  36. ncbi request reprint Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Aging Cell 6:783-97. 2007
    ..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging...

Research Grants2

  1. White matter injury in germinal matrix hemorrhage
    Praveen Ballabh; Fiscal Year: 2010
    ..Hence, the proposed study will elucidate the mechanism of white matter injury in IVH and may lead to novel strategies in prevention of cerebral palsy in premature infants. ..
  2. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. ..