Research Topics
| Praveen BallabhSummaryCountry: USA Publications
Research Grants
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Detail Information
Publications
The blood-brain barrier: an overview: structure, regulation, and clinical implicationsPraveen Ballabh
Department of Pediatrics, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA
Neurobiol Dis 16:1-13. 2004..Finally, this review describes the pathogenesis of increased BBB permeability in hypoxia-ischemia and inflammatory mechanisms involving the BBB in septic encephalopathy, HIV-induced dementia, multiple sclerosis, and Alzheimer disease...
Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cellsAnna Csiszar
Dept of Physiology, New York Medical College, Valhalla, New York 10595, USA
Am J Physiol Heart Circ Physiol 295:H569-77. 2008..The vascular bed-specific endothelial effects of BMP-4 are likely to contribute to its differential pathophysiological role in the systemic and pulmonary circulation...
Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhageParaskevi Georgiadis
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY, USA
Stroke 39:3378-88. 2008..Despite this, there is no standardized animal model of IVH depicting acute brain injuries...- Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroidsP Ballabh
Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, USA
Arch Dis Child Fetal Neonatal Ed 89:F76-83. 2004.... - Intraventricular hemorrhage in premature infants: mechanism of diseasePraveen Ballabh
Department of Pediatrics, Anatomy and Cell Biology, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Pediatr Res 67:1-8. 2010..Hence, the rapid stabilization of the angiogenic vessels and the restoration of normal CBF on the first day of life are potential strategies to prevent IVH in premature infants... - Neonatal outcome of triplet versus twin and singleton pregnancies: a matched case control studyPraveen Ballabh
Division of Neonatology, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
Eur J Obstet Gynecol Reprod Biol 107:28-36. 2003..To determine the neonatal outcome of triplet gestations versus that of singletons and twins matched for gestational age... - Angiogenic inhibition reduces germinal matrix hemorrhagePraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
Nat Med 13:477-85. 2007..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants... - Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matterPraveen Ballabh
Department of Pediatrics, Westchester Medicak Center New York Medical College, Valhalla, 10595, USA
Pediatr Res 58:791-8. 2005.... - Anatomic analysis of blood vessels in germinal matrix, cerebral cortex, and white matter in developing infantsPraveen Ballabh
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Pediatr Res 56:117-24. 2004..of the GM compared with gray and white matter may play a role in GM hemorrhage, whereas a relatively low vascularity of white matter may increase the propensity for the occurrence of periventricular leukomalacia in premature infants.. - Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cellsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 297:H1876-81. 2009.... - Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibitionGovindaiah Vinukonda
Department of Paediatrics, New York Medical College Westchester Medical Centre, Valhalla, NY 10595, USA
Brain 133:2264-80. 2010.... - Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopusNazar Labinskyy
Department of Physiology, New York Medical College, Valhalla, New York, USA
Am J Physiol Heart Circ Physiol 296:H946-56. 2009..leucopus is associated with decreased cellular ROS generation and increased resistance to prooxidant and proinflammatory effects of metabolic stress, which accord with predictions of the oxidative stress hypothesis of aging... - Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1Anna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Mech Ageing Dev 130:518-27. 2009..CR exerts anti-oxidant and anti-inflammatory vascular effects, which are likely mediated by circulating factors, in part, via a SIRT1-dependent pathway... - Effect of prenatal glucocorticoids on cerebral vasculature of the developing brainGovindaiah Vinukonda
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 41:1766-73. 2010..Therefore, we asked whether glucocorticoid treatment would suppress angiogenesis and enhance periendothelial coverage by pericytes and glial fibrillary acidic protein-positive end feet in the germinal matrix microvasculature... - Paucity of pericytes in germinal matrix vasculature of premature infantsAlex Braun
Department of Pathology, New York Medical College, Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 27:12012-24. 2007..Hence, a paucity of pericytes in the GM vasculature may contribute to its propensity to hemorrhage, and a lower expression of TGF-beta1 could be a basis of reduced pericyte density in its vasculature... - Respiratory burst activity in bronchopulmonary dysplasia and changes with dexamethasonePraveen Ballabh
Division of Neonatology, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York, USA
Pediatr Pulmonol 35:392-9. 2003..Greater pulmonary damage in BPD cannot be attributed to reduced burst activity in either neutrophils or monocytes. Dexamethasone treatment was associated with decreased neutrophil respiratory burst activity... - Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasoneHongmin Xu
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci Res 86:1482-500. 2008..Because fibronectin provides structural stability to the blood vessels, its reduced expression in the germinal matrix may contribute to the fragility of germinal matrix vasculature and the propensity to hemorrhage in premature neonates... - Resveratrol induces mitochondrial biogenesis in endothelial cellsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 297:H13-20. 2009..Resveratrol induced mitochondrial biogenesis in the aortas of type 2 diabetic mice, suggesting the potential for new treatment approaches targeting endothelial mitochondria in metabolic diseases... - Oxidative-nitrosative stress in a rabbit pup model of germinal matrix hemorrhage: role of NAD(P)H oxidaseMuhammad T Zia
Pediatrics, Maria Fareri Children s Hospital at Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:2191-8. 2009.... - Lymphocyte subpopulations in bronchopulmonary dysplasiaPraveen Ballabh
Division of Newborn Unit, Westchester Medical Center, Valhalla, New York
Am J Perinatol 20:465-75. 2003..As a whole these data suggest that reduction of CD4(+) T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD... - Development of integrins in the vasculature of germinal matrix, cerebral cortex, and white matter of fetuses and premature infantsKrishna Dummula
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York, USA
J Neurosci Res 88:1193-204. 2010..We speculate that selective alpha5beta1 integrin inhibition might suppress angiogenesis in the GM and thus prevent brain hemorrhage in premature infants... - Astrocyte end-feet in germinal matrix, cerebral cortex, and white matter in developing infantsNadine El-Khoury
Department of Pediatrics, Westchester Medical Center, New York Medical College, Valhalla, New York 10595, USA
Pediatr Res 59:673-9. 2006.... - Consequences of intraventricular hemorrhage in a rabbit pup modelCaroline O Chua
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY 10595, USA
Stroke 40:3369-77. 2009..We asked whether induction of moderate-to-severe IVH in premature rabbit pups would produce long-term sequelae of cerebral palsy, posthemorrhagic hydrocephalus, reduced myelination, and gliosis... - Bone morphogenetic protein inhibition promotes neurological recovery after intraventricular hemorrhageKrishna Dummula
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
J Neurosci 31:12068-82. 2011..Hence, BMP inhibition might enhance neurological recovery in premature infants with IVH... - Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasonePraveen Ballabh
Department of Neonatology, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA
Pediatrics 111:461-8. 2003..Low levels of sL-selectin and increasing levels of sE-selectin may be risk factors for BPD. The effects of dexamethasone treatment include significant modulation of adhesion molecules... - Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterationsAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2721-35. 2008..The vasoprotective effects of resveratrol will likely contribute to its antiaging action in mammals and may be especially beneficial in pathophysiological conditions associated with accelerated vascular aging... - Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsisGary Laborada
Perinatology Center, New York Presbyterian Hospital, New York, New York 10021, USA
Am J Perinatol 20:491-501. 2003..In conclusion, a combination of CRP + IL-6 provided additional diagnostic accuracy for differentiation between septic and nonseptic patients during the first 24 hours of suspected sepsis... - Outcomes of dichorionic triplet pregnanciesStephen T Chasen
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA
Am J Obstet Gynecol 186:765-7. 2002..01). CONCLUSION: Twin-twin transfusion syndrome or spontaneous loss before viability complicated approximately 30% of dichorionic triplet pregnancies. Lower birth weights were noted in triplets from monochorionic twin pairs... - Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birthSabrina Malik
Departments of Pediatrics and Cell Biology and Anatomy, Regional Neonatal Center, Maria Fareri Children s Hospital at Westchester Medical Center and New York Medical College, Valhalla, New York 10595, Department of Neurological Surgery, University of Washington, Seattle, Washington 98101, and Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030
J Neurosci 33:411-23. 2013.... - Novel organotypic in vitro slice culture model for intraventricular hemorrhage of premature infantsGovindaiah Vinukonda
Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York, USA
J Neurosci Res 90:2173-82. 2012..Importantly, plasma appears to induce greater white matter damage than erythrocytes in IVH,indicating plasma as a source of neurotoxic components... - Pharmacokinetics of betamethasone in twin and singleton pregnancyPraveen Ballabh
Department of Neonatology, New York Presbyterian Hospital-Weill Medical College of Cornell University, NY 10021, USA
Clin Pharmacol Ther 71:39-45. 2002..29 for twins and 0.08 for singletons). CONCLUSION: The shorter half-life of betamethasone in twin pregnancy than in singleton pregnancy may cause the level of betamethasone to be subtherapeutic for lung maturation in twin pregnancy... - Arrested preoligodendrocyte maturation contributes to myelination failure in premature infantsJoshua R Buser
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
Ann Neurol 71:93-109. 2012..We hypothesized that myelination failure associated with diffuse WMI involves an aberrant injury response linked to arrested preoligodendrocyte (preOL) maturation in reactive astrocyte-rich lesions... - Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevityAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Aging Cell 6:783-97. 2007..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging...
Research Grants
- White matter injury in germinal matrix hemorrhagePraveen Ballabh; Fiscal Year: 2010..Hence, the proposed study will elucidate the mechanism of white matter injury in IVH and may lead to novel strategies in prevention of cerebral palsy in premature infants. ..
- Pericytes in Pathogenesis of Germinal-Matrix HemorrhagePraveen Ballabh; Fiscal Year: 2006..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. ..