Jasmohan S Bajaj

Summary

Country: USA

Publications

  1. ncbi request reprint Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective
    Jasmohan S Bajaj
    Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Am J Gastroenterol 105:106-13. 2010
  2. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
  3. doi request reprint Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
  4. doi request reprint The effect of fatigue on driving skills in patients with hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 104:898-905. 2009
  5. ncbi request reprint Management options for minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23221, USA
    Expert Rev Gastroenterol Hepatol 2:785-90. 2008
  6. ncbi request reprint Patients with minimal hepatic encephalopathy have poor insight into their driving skills
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 6:1135-9; quiz 1065. 2008
  7. doi request reprint Inhibitory control test for the diagnosis of minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia, USA
    Gastroenterology 135:1591-1600.e1. 2008
  8. pmc Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis
    Vishwadeep Ahluwalia
    Radiology, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    J Hepatol 59:467-73. 2013
  9. pmc Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
    PLoS ONE 8:e60042. 2013
  10. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Clostridium difficile is associated with poor outcomes in patients with cirrhosis: A national and tertiary center perspective
    Jasmohan S Bajaj
    Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Am J Gastroenterol 105:106-13. 2010
    ..The aim was to define the effect of CDAD on outcomes and identify risk factors for its development in cirrhosis...
  2. pmc Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23221, USA
    Hepatology 50:1175-83. 2009
    ..03) but MHESPT did not. MHEICT (Odds ratio: 4.51) and prior year crash/violation (Odds ratio: 2.96) were significantly associated with future crash/violation occurrence...
  3. doi request reprint Association of proton pump inhibitor therapy with spontaneous bacterial peritonitis in cirrhotic patients with ascites
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, McGuire VA Medical Center, Virginia Commonwealth University, Richmond, Virginia 23221, USA
    Am J Gastroenterol 104:1130-4. 2009
    ..The aim of this study was to determine whether PPI use in cirrhotics with ascites is associated with SBP...
  4. doi request reprint The effect of fatigue on driving skills in patients with hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 104:898-905. 2009
    ..Hepatic encephalopathy, both overt (OHE) and minimal (MHE), is associated with poor quality of life and fatigue. The aim of this study was to define the effect of fatigue on driving skills in MHE and OHE patients...
  5. ncbi request reprint Management options for minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23221, USA
    Expert Rev Gastroenterol Hepatol 2:785-90. 2008
    ..Therapy can improve the quality of life in MHE patients but the natural history, specific diagnostic strategies and treatment options are still being investigated...
  6. ncbi request reprint Patients with minimal hepatic encephalopathy have poor insight into their driving skills
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA
    Clin Gastroenterol Hepatol 6:1135-9; quiz 1065. 2008
    ..DBS consists of a total score (maximum, 104) and an attention-related driving skills section (maximum, 40). DBS was used to compare self-assessment with observer-assessment of driving skills in cirrhotic patients tested for MHE...
  7. doi request reprint Inhibitory control test for the diagnosis of minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia, USA
    Gastroenterology 135:1591-1600.e1. 2008
    ..We studied the reliability and validity of ICT for MHE diagnosis...
  8. pmc Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis
    Vishwadeep Ahluwalia
    Radiology, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    J Hepatol 59:467-73. 2013
    ..We aimed at studying the effect of hyponatremia on cognition, HRQOL, and brain MR spectroscopy (MRS) independent of HE...
  9. pmc Modulation of the metabiome by rifaximin in patients with cirrhosis and minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia, United States of America
    PLoS ONE 8:e60042. 2013
    ..Aim To perform a systems biology analysis of the microbiome, metabolome and cognitive change after rifaximin in MHE...
  10. pmc Asymmetric dimethylarginine is strongly associated with cognitive dysfunction and brain MR spectroscopic abnormalities in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Hepatol 58:38-44. 2013
    ..We aimed at evaluating the association of ADMA with cognition and brain MR spectroscopy (MRS) in cirrhosis...
  11. doi request reprint A longitudinal systems biology analysis of lactulose withdrawal in hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, 23249, USA
    Metab Brain Dis 27:205-15. 2012
    ..HE recurrence post-lactulose withdrawal can be predicted by baseline cognitive performance and is accompanied by disrupted choline metabolism...
  12. pmc Driving simulation can improve insight into impaired driving skills in cirrhosis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Dig Dis Sci 57:554-60. 2012
    ..Minimal hepatic encephalopathy (MHE) is associated with poor driving skills and insight. Increasing insight may improve receptiveness for therapy or driving restrictions...
  13. pmc Rifaximin improves driving simulator performance in a randomized trial of patients with minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 140:478-487.e1. 2011
    ..We evaluated whether performance on a driving simulator improves in patients with MHE after treatment with rifaximin...
  14. pmc Cognitive performance as a predictor of hepatic encephalopathy in pretransplant patients with cirrhosis receiving psychoactive medications: a prospective study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University McGuire VA Medical Center, Richmond, VA 23249, USA
    Liver Transpl 18:1179-87. 2012
    ..In conclusion, cognitive tests (particularly the ICT) remain valid predictors of HE in the face of psychiatric diseases and medications. SSRI use is associated with better cognitive performance and a reduced likelihood of developing HE...
  15. ncbi request reprint Colonic inflammation and secondary bile acids in alcoholic cirrhosis
    Genta Kakiyama
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire Veterans Affairs Medical Center, Richmond, Virginia
    Am J Physiol Gastrointest Liver Physiol 306:G929-37. 2014
    ..This increase in secondary BAs is associated with a significant increase in expression of inflammatory cytokines in colonic mucosa but not ileal mucosa, which may contribute to alcohol-induced gut barrier injury. ..
  16. pmc Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 55:1164-71. 2012
    ..Net program savings over 5 years ranged from $1.7 to 3.6 million depending on the strategy. Rifaximin therapy was not cost-saving at current prices but would become so at a monthly cost of <$353...
  17. pmc The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Am J Gastroenterol 106:1646-53. 2011
    ..The aim was to study the emotional and socioeconomic burden of cirrhosis and HE on patients and informal caregivers...
  18. pmc The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, USA
    Hepatology 58:1122-32. 2013
    ..App result patterns were similar between the centers. Test-retest reliability in controls and those without previous OHE was good; a learning effect on Ontime in patients with cirrhosis without previous OHE was noted...
  19. pmc Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, 23249, USA
    Am J Physiol Gastrointest Liver Physiol 303:G675-85. 2012
    ....
  20. pmc Persistence of cognitive impairment after resolution of overt hepatic encephalopathy
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Gastroenterology 138:2332-40. 2010
    ..In patients with cirrhosis, hepatic encephalopathy (HE) has acute but reversible as well as chronic components. We investigated the extent of residual cognitive impairment following clinical resolution of overt HE (OHE)...
  21. ncbi request reprint Diagnosis of covert hepatic encephalopathy without specialized tests
    Eiman Nabi
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia
    Clin Gastroenterol Hepatol 12:1384-1389.e2. 2014
    ..We performed a longitudinal study to determine whether demographic data and responses to a validated QOL questionnaire, the Sickness Impact Profile (SIP), can identify patients with CHE...
  22. pmc Second infections independently increase mortality in hospitalized patients with cirrhosis: the North American consortium for the study of end-stage liver disease (NACSELD) experience
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    Hepatology 56:2328-35. 2012
    ..The model for mortality included admission MELD (odds ratio [OR]: 1.12), heart rate (OR: 1.03) albumin (OR: 0.5), and second infection (OR: 4.42) as significant variables...
  23. pmc Linkage of gut microbiome with cognition in hepatic encephalopathy
    Jasmohan S Bajaj
    Div of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth Univ and McGuire VA Medical Ctr, 1201, Broad Rock Blvd, Richmond, VA 23249, USA
    Am J Physiol Gastrointest Liver Physiol 302:G168-75. 2012
    ..Specific bacterial families (Alcaligeneceae, Porphyromonadaceae, Enterobacteriaceae) are strongly associated with cognition and inflammation in HE...
  24. pmc Altered profile of human gut microbiome is associated with cirrhosis and its complications
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA, United States Electronic address
    J Hepatol 60:940-7. 2014
    ..We aimed to study changes in the microbiome over cirrhosis severity, its stability over time and its longitudinal alterations with decompensation...
  25. pmc Modulation of the fecal bile acid profile by gut microbiota in cirrhosis
    Genta Kakiyama
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, United States
    J Hepatol 58:949-55. 2013
    ..We aimed at studying the linkage between fecal BAs and gut microbiota in cirrhosis since this could help understand cirrhosis progression...
  26. pmc A simple and accurate HPLC method for fecal bile acid profile in healthy and cirrhotic subjects: validation by GC-MS and LC-MS
    Genta Kakiyama
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249
    J Lipid Res 55:978-90. 2014
    ..Bile acid concentrations were significantly lower in patients with advanced cirrhosis, suggesting impaired bile acid synthesis...
  27. doi request reprint Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival
    R Todd Stravitz
    Section of Hepatology, Division of Gastroenterology, Hepatology and Nutrition and the Hume Lee Transplant Center, Virginia Commonwealth University, Richmond, VA, USA
    Liver Int 33:1324-31. 2013
    ..N-Acetylcysteine (NAC) improves transplant-free survival in patients with non-acetaminophen acute liver failure (ALF) when administered in early stages of hepatic encephalopathy. The mechanisms of this benefit are unknown...
  28. pmc Effect of obstructive sleep apnea on the sleep architecture in cirrhosis
    Matthew R Kappus
    Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA 23249, USA
    J Clin Sleep Med 9:247-51. 2013
    ..We aimed to evaluate the additional effect of cirrhosis with and without prior HE on the sleep architecture and perceived sleep disturbances of OSA patients...
  29. doi request reprint Covert hepatic encephalopathy: not as minimal as you might think
    Matthew R Kappus
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia 23249, USA
    Clin Gastroenterol Hepatol 10:1208-19. 2012
    ..Patients with MHE are first managed by excluding other causes of neurocognitive dysfunction. Therapy with gut-specific agents might be effective. We review management strategies and important areas of research for MHE and covert HE...
  30. doi request reprint Advances in the evaluation and management of minimal hepatic encephalopathy
    Jennifer Y Montgomery
    Virginia Commonwealth University, Richmond, VA 23249, USA
    Curr Gastroenterol Rep 13:26-33. 2011
    ..MHE is a real and growing problem that is epidemic in cirrhosis, and increasing awareness of this condition is necessary for adequate management of these patients...
  31. doi request reprint Diet and cognition in chronic liver disease
    Toufic Kachaamy
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia, USA
    Curr Opin Gastroenterol 27:174-9. 2011
    ....
  32. pmc Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures
    Jasmohan S Bajaj
    Department of Medicine, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, VA
    Hepatology 60:250-6. 2014
    ..Independent predictors of poor 30-day survival were I-ACLF, second infections, and admission values of high MELD, low MAP, high white blood count, and low albumin...
  33. pmc Assessment of minimal hepatic encephalopathy (with emphasis on computerized psychometric tests)
    Matthew R Kappus
    Division of Gastroenterology, Hepatology and Nutrition, McGuire VA Medical Center, Virginia Commonwealth University, 1201 Broad Rock Boulevard, Richmond, VA 23249, USA
    Clin Liver Dis 16:43-55. 2012
    ..Neurophysiologic tests also provide useful information. The diagnosis of MHE is an important issue for clinicians and patients alike. Testing strategies depend on the normative data available, patient comfort, and local expertise...
  34. ncbi request reprint Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience
    Jasmohan S Bajaj
    Division of Gastroenterology and Hepatology Division of Allergy and Immunology, Department of Medicine, Digestive Disease Center, Froedtert Memorial Lutheran Hospital, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Am J Gastroenterol 100:1121-5. 2005
    ..EAR precludes azathioprine use in patients with Crohn's disease (CD) and autoimmune hepatitis (AIH). Our aims were to investigate differential rates of EAR to azathioprine in CD compared to AIH in a tertiary referral center population...
  35. ncbi request reprint Bile acids and the gut microbiome
    Jason M Ridlon
    aDepartment of Microbiology and Immunology, Virginia Commonwealth University bMcGuire VA Medical Center cDivision of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA
    Curr Opin Gastroenterol 30:332-8. 2014
    ..Our focus revolves around two key microbial pathways for degrading bile salts, and the impact of bile acid composition in the gut on the gut microbiome and host physiology...
  36. pmc Cognitive dysfunction is associated with poor socioeconomic status in patients with cirrhosis: an international multicenter study
    Jasmohan S Bajaj
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, Richmond, Virginia Electronic address
    Clin Gastroenterol Hepatol 11:1511-6. 2013
    ..We investigated the association between SES and cognition in a multicenter study of cirrhosis...
  37. pmc Antibiotics for the treatment of hepatic encephalopathy
    Kavish R Patidar
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and McGuire VA Medical Center, 1201 Broad Rock Boulevard, Richmond, VA, USA
    Metab Brain Dis 28:307-12. 2013
    ..Antibiotics, especially rifaximin, have a definite role in the management across the spectrum of HE...
  38. doi request reprint Should a radiological diagnosis of hepatocellular carcinoma be routinely confirmed by a biopsy? No
    Douglas M Heuman
    Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Hunter Holmes McGuire Department of Veterans Affairs Medical Center, Richmond, VA 23249, USA
    Eur J Intern Med 23:37-9. 2012
    ..Biopsy for assessment of tumor molecular markers is promising but remains investigational. When diagnosis of HCC is clinically evident by imaging criteria, tumor biopsy should not be required prior to initiating treatment...