Annemarie Ledeboer

Summary

Affiliation: Avigen Inc
Country: USA

Publications

  1. pmc The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain
    Annemarie Ledeboer
    Department of Preclinical Development, Avigen Inc, Alameda, CA 94502, USA
    Neuron Glia Biol 2:279-91. 2006
  2. ncbi Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
    Annemarie Ledeboer
    Avigen, Inc, Department of Preclinical Development, Alameda, CA 94502, USA
    Expert Opin Investig Drugs 16:935-50. 2007
  3. pmc Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
  4. ncbi Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, 80309 0345, USA
    J Pain 7:757-67. 2006
  5. pmc Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120
    Diana K Schoeniger-Skinner
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 30809 0345, USA
    Brain Behav Immun 21:660-7. 2007
  6. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
  7. pmc Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:131-46. 2007
  8. ncbi Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    Annemarie Ledeboer
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 22:1977-86. 2005
  9. ncbi Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE
    Annemarie Ledeboer
    Department of Medical Pharmacology, Research Institute Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Neuroimmunol 136:94-103. 2003
  10. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007

Detail Information

Publications12

  1. pmc The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain
    Annemarie Ledeboer
    Department of Preclinical Development, Avigen Inc, Alameda, CA 94502, USA
    Neuron Glia Biol 2:279-91. 2006
    ..Overall, the results indicate that AV411 is effective in diverse models of neuropathic pain and support further exploration of its potential as a therapeutic agent for the treatment of neuropathic pain...
  2. ncbi Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
    Annemarie Ledeboer
    Avigen, Inc, Department of Preclinical Development, Alameda, CA 94502, USA
    Expert Opin Investig Drugs 16:935-50. 2007
    ..Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action...
  3. pmc Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Brain Behav Immun 21:686-98. 2007
    ..We propose that targeting the production of proinflammatory cytokines by intrathecal IL-10 gene therapy may be a promising therapeutic strategy for the relief of paclitaxel-induced neuropathic pain...
  4. ncbi Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, 80309 0345, USA
    J Pain 7:757-67. 2006
    ..Taken together, the present data suggest that acidic saline-induced bilateral allodynia is created independently of glial activation...
  5. pmc Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120
    Diana K Schoeniger-Skinner
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 30809 0345, USA
    Brain Behav Immun 21:660-7. 2007
    ..These results would suggest that IL-6 induces pain facilitation, and may do so in part by stimulating the production and release of other pro-inflammatory cytokines...
  6. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
    ..Taken together these data highlight the importance of microglial activation in the development of exaggerated pain states...
  7. pmc Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:131-46. 2007
    ....
  8. ncbi Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    Annemarie Ledeboer
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 22:1977-86. 2005
    ..Together, these results demonstrate that spinal cord NF-kappaB activation is involved, at least in part, in exaggerated pain states...
  9. ncbi Regional and temporal expression patterns of interleukin-10, interleukin-10 receptor and adhesion molecules in the rat spinal cord during chronic relapsing EAE
    Annemarie Ledeboer
    Department of Medical Pharmacology, Research Institute Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Neuroimmunol 136:94-103. 2003
    ..During relapse, IL-10, IL-10R1, ICAM-1, VCAM-1 mRNA levels and neurological scores show positive correlations. We conclude that endogenous IL-10 is not a crucial factor inhibiting adhesion molecule expression in this model...
  10. ncbi A role for G protein-coupled receptor kinase 2 in mechanical allodynia
    Wendy Kleibeuker
    University Medical Center Utrecht, Laboratory of Psychoneuroimmunology, KC03 068 0, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
    Eur J Neurosci 25:1696-704. 2007
    ..We propose cytokine-induced down-regulation of spinal cord neuronal GRK2 expression as a novel mechanism that contributes to increased neuronal signalling in mechanical allodynia...
  11. ncbi Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells
    Annemarie Ledeboer
    Department of Medical Pharmacology, Research Institute Neurosciences Free University, VUMC, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Eur J Neurosci 16:1175-85. 2002
    ..Together the findings support the concept that IL-10, produced by activated microglial and astroglial cells, modulates glia-mediated inflammatory responses through high-affinity IL-10 receptors via paracrine and autocrine interactions...
  12. ncbi Site-specific modulation of LPS-induced fever and interleukin-1 beta expression in rats by interleukin-10
    Annemarie Ledeboer
    Research Institute Neurosciences Free University, Department of Medical Pharmacology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 282:R1762-72. 2002
    ....