Jennifer A A Gubbels

Summary

Affiliation: Augustana College
Country: USA

Publications

  1. doi request reprint Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53711, USA
    Cancer Immunol Immunother 60:1789-800. 2011
  2. pmc MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cancer 9:11. 2010
  3. pmc The mucin MUC16 (CA125) binds to NK cells and monocytes from peripheral blood of women with healthy pregnancy and preeclampsia
    Chanel Tyler
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53792, USA
    Am J Reprod Immunol 68:28-37. 2012
  4. pmc Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125)
    Jennifer A Belisle
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53792, USA
    Immunology 122:418-29. 2007
  5. pmc Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin
    David B Engle
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, H4 636, Madison, WI 53792 6188, USA
    Gynecol Oncol 112:631-6. 2009
  6. pmc Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting
    Ilia N Buhtoiarov
    UW Carbone Cancer Center, 4159 MACC Fund UW Childhood Cancer Research Wing, WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
    J Leukoc Biol 89:625-38. 2011
  7. ncbi request reprint The immunomodulating roles of glycoproteins in epithelial ovarian cancer
    Manish S Patankar
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, WI 53792 6188, USA
    Front Biosci (Elite Ed) 4:631-50. 2012
  8. pmc Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, USA
    Mol Cancer 5:50. 2006

Collaborators

Detail Information

Publications8

  1. doi request reprint Ab-IL2 fusion proteins mediate NK cell immune synapse formation by polarizing CD25 to the target cell-effector cell interface
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53711, USA
    Cancer Immunol Immunother 60:1789-800. 2011
    ..These findings demonstrate that the IL-2 component of the IC allows IL2Rs to function not only as receptors for this cytokine but also as facilitators of peritoneal NK cell binding to IC-coated tumor cells...
  2. pmc MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI, USA
    Mol Cancer 9:11. 2010
    ..Our results indicate that MUC16-mediated inhibition of immune synapse formation is an effective mechanism employed by ovarian tumors to evade immune recognition...
  3. pmc The mucin MUC16 (CA125) binds to NK cells and monocytes from peripheral blood of women with healthy pregnancy and preeclampsia
    Chanel Tyler
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53792, USA
    Am J Reprod Immunol 68:28-37. 2012
    ..MUC16 (CA125) released from ovarian tumors binds to NK cells and monocytes via the inhibitory receptor Siglec-9. Here, we investigate whether MUC16 also binds to circulating immune cells during pregnancy and in women with preeclampsia...
  4. pmc Peritoneal natural killer cells from epithelial ovarian cancer patients show an altered phenotype and bind to the tumour marker MUC16 (CA125)
    Jennifer A Belisle
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, WI 53792, USA
    Immunology 122:418-29. 2007
    ..Similar to EOC, MUC16 in early pregnancy also binds to NK cells suggesting shared mechanisms of NK cell suppression in feto-maternal tolerance and immune evasion by ovarian cancers...
  5. pmc Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin
    David B Engle
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, H4 636, Madison, WI 53792 6188, USA
    Gynecol Oncol 112:631-6. 2009
    ..Cytotoxicity assays examining ALCAR's effect on paclitaxel and carboplatin were done by flow cytometry and infrared plate-reader...
  6. pmc Differential internalization of hu14.18-IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting
    Ilia N Buhtoiarov
    UW Carbone Cancer Center, 4159 MACC Fund UW Childhood Cancer Research Wing, WIMR, 1111 Highland Ave, Madison, WI 53705 2275, USA
    J Leukoc Biol 89:625-38. 2011
    ..These studies demonstrate that once IC binds to the tumor, it is present on the tumor surface for a prolonged time, inducing the recruitment of NK cells to the tumor site, followed by tumor cell killing...
  7. ncbi request reprint The immunomodulating roles of glycoproteins in epithelial ovarian cancer
    Manish S Patankar
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, WI 53792 6188, USA
    Front Biosci (Elite Ed) 4:631-50. 2012
    ....
  8. pmc Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    Jennifer A A Gubbels
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Madison, USA
    Mol Cancer 5:50. 2006
    ..Here we have addressed this deficit and provide further evidence supporting the role of the MUC16-mesothelin interaction in facilitating cell-cell binding under conditions that mimic the peritoneal environment...