Wade S Samowitz
Affiliation: ARUP Institute for Clinical and Experimental Pathology
Samowitz W, Curtin K, Wolff R, Tripp S, Caan B, Slattery M. Microsatellite instability and survival in rectal cancer. Cancer Causes Control. 2009;20:1763-8 pubmed publisher
Samowitz W, Albertsen H, Sweeney C, Herrick J, Caan B, Anderson K, et al
. Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst. 2006;98:1731-8 pubmed
..Previously identified associations between smoking and colon cancer, whether microsatellite unstable or stable, appear to be explained by the association of smoking with CIMP and BRAF mutations. ..
Yantiss R, Samowitz W. Molecular Pathology of Gastrointestinal Cancer. Surg Pathol Clin. 2012;5:821-42 pubmed publisher
Affolter K, Samowitz W, Boynton K, Kelly E. Doxycycline-induced gastrointestinal injury. Hum Pathol. 2017;66:212-215 pubmed publisher
..Confirmation and increased understanding of this drug-specific injury pattern are important for patient management, as cessation appears to result in symptom improvement and healing. ..
Samowitz W, Wolff R, Curtin K, Sweeney C, Ma K, Andersen K, et al
. Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Clin Gastroenterol Hepatol. 2006;4:894-901 pubmed
..In this study, the major effect seen was an enhancement by slower-metabolizing CYP2C9 variants of the chemopreventive activity of ibuprofen against colorectal cancer. ..
Samowitz W, Curtin K, Wolff R, Albertsen H, Sweeney C, Caan B, et al
. The MLH1 -93 G>A promoter polymorphism and genetic and epigenetic alterations in colon cancer. Genes Chromosomes Cancer. 2008;47:835-44 pubmed publisher
Furtado L, Samowitz W. Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm. Virchows Arch. 2017;471:235-242 pubmed publisher
..This review focuses on the current indications and strategies for molecular testing in CRC and discusses the potential changes in CRC testing approach associated with the emerging clinical application of genomic-based technologies. ..