Gwendolyn A McMillin

Summary

Affiliation: ARUP Institute for Clinical and Experimental Pathology
Country: USA

Publications

  1. ncbi request reprint Flow cytometric assay for genotyping cytochrome p450 2C9 and 2C19: comparison with a microelectronic DNA array
    Jerry W Pickering
    Associated Regional and University Pathologists, Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Am J Pharmacogenomics 4:199-207. 2004
  2. doi request reprint Analytical performance of a new liquid chromatography/tandem mass spectrometric method for determination of everolimus concentrations in whole blood
    Gwendolyn A McMillin
    Department of Pathology, University of Utah, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Ther Drug Monit 34:222-6. 2012
  3. doi request reprint Patterns of free (unconjugated) buprenorphine, norbuprenorphine, and their glucuronides in urine using liquid chromatography-tandem mass spectrometry
    Gwendolyn A McMillin
    ARUP Laboratories, Inc, Salt Lake City, UT 84108, USA
    J Anal Toxicol 36:81-7. 2012
  4. doi request reprint Gene-based warfarin dosing compared with standard of care practices in an orthopedic surgery population: a prospective, parallel cohort study
    Gwendolyn A McMillin
    University of Utah Health Sciences, Department of Internal Medicine, Salt Lake City, Utah, USA
    Ther Drug Monit 32:338-45. 2010
  5. ncbi request reprint Evaluation of a new ELISA kit for the detection of benzodiazepines in meconium
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108 1221, USA
    J Anal Toxicol 33:177-81. 2009
  6. doi request reprint Evaluation of the NexScreen and DrugCheck Waive RT urine drug detection cups
    Chia Ni Lin
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    J Anal Toxicol 37:30-6. 2013
  7. doi request reprint Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA
    J Anal Toxicol 36:472-6. 2012
  8. doi request reprint Performance characteristics of the ARK diagnostics gabapentin immunoassay
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, UT, USA
    Ther Drug Monit 33:398-401. 2011
  9. doi request reprint Rapid screening for 67 drugs and metabolites in serum or plasma by accurate-mass LC-TOF-MS
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    J Anal Toxicol 36:477-86. 2012
  10. ncbi request reprint Simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS-MS
    Rebecka Coles
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 31:1-14. 2007

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Flow cytometric assay for genotyping cytochrome p450 2C9 and 2C19: comparison with a microelectronic DNA array
    Jerry W Pickering
    Associated Regional and University Pathologists, Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Am J Pharmacogenomics 4:199-207. 2004
    ..To correlate the dose required for therapeutic drug efficacy with genotype, accurate and reliable methods for detecting single nucleotide polymorphisms (SNPs) of CYP2C9 and CYP2C19 are required...
  2. doi request reprint Analytical performance of a new liquid chromatography/tandem mass spectrometric method for determination of everolimus concentrations in whole blood
    Gwendolyn A McMillin
    Department of Pathology, University of Utah, ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Ther Drug Monit 34:222-6. 2012
    ..96x - 1.12 (r = 0.99), n = 20, 2.5-44.7 ng/mL. Method B comparison: y = 0.96x + 0.49 (r = 0.99), n = 44, 2.1-85.6 ng/mL. We conclude that this method could support TDM of everolimus for a wide range of clinical indications...
  3. doi request reprint Patterns of free (unconjugated) buprenorphine, norbuprenorphine, and their glucuronides in urine using liquid chromatography-tandem mass spectrometry
    Gwendolyn A McMillin
    ARUP Laboratories, Inc, Salt Lake City, UT 84108, USA
    J Anal Toxicol 36:81-7. 2012
    ..Concentrations of buprenorphine > 100 ng/mL (particularly with low metabolite concentrations) are suspect of urine adulteration with medication (4% in the database) that can be checked in most cases by concurrent analysis for naloxone...
  4. doi request reprint Gene-based warfarin dosing compared with standard of care practices in an orthopedic surgery population: a prospective, parallel cohort study
    Gwendolyn A McMillin
    University of Utah Health Sciences, Department of Internal Medicine, Salt Lake City, Utah, USA
    Ther Drug Monit 32:338-45. 2010
    ..Findings suggest alternative strategies for dosing based on the presence or absence of genetic variants is needed...
  5. ncbi request reprint Evaluation of a new ELISA kit for the detection of benzodiazepines in meconium
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108 1221, USA
    J Anal Toxicol 33:177-81. 2009
    ..The new kit using clonazepam as the calibrator provided the most sensitive assay for detection of the 11 benzodiazepines and metabolites reported here...
  6. doi request reprint Evaluation of the NexScreen and DrugCheck Waive RT urine drug detection cups
    Chia Ni Lin
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    J Anal Toxicol 37:30-6. 2013
    ..Overall, the NexScreen cup demonstrated better sensitivity than claimed, whereas the sensitivity of the DrugCheck Waive RT cup did not meet claims...
  7. doi request reprint Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA
    J Anal Toxicol 36:472-6. 2012
    ..0708x + 1.6521, r(2) = 0.9822. This UPLC-MS-MS method is suitable for the quantification of benzodiazepines and hypnotics in serum and plasma, and offers fast, reliable and sensitive results...
  8. doi request reprint Performance characteristics of the ARK diagnostics gabapentin immunoassay
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, UT, USA
    Ther Drug Monit 33:398-401. 2011
    ..Here, we evaluated the immunoassay on a random access instrument...
  9. doi request reprint Rapid screening for 67 drugs and metabolites in serum or plasma by accurate-mass LC-TOF-MS
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    J Anal Toxicol 36:477-86. 2012
    ..The most frequent was 6-acetylmorphine in the absence of morphine. The LC-TOF-MS targeted screening method presented represents a sensitive and specific technology for drug screening of serum or plasma...
  10. ncbi request reprint Simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, oxycodone, and 6-acetylmorphine in urine, serum, plasma, whole blood, and meconium by LC-MS-MS
    Rebecka Coles
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 31:1-14. 2007
    ..Although 6-AM is infrequent in meconium, it provides a definitive proof of illegal heroin abuse by the pregnant mother. This method has been routinely used in our laboratory over the last 6 months on more than 1500 patient specimens...
  11. ncbi request reprint Confirmation of cannabinoids in meconium using two-dimensional gas chromatography with mass spectrometry detection
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Inc, 500 Chipeta Way, Salt Lake City, UT 84108 1221, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:59-64. 2007
    ..The 2D GC-MS method improved chromatography which significantly reduced interferences and carryover when compared to the previous GC-MS method...
  12. ncbi request reprint Drugs of abuse detection in meconium: a comparison between ELISA and biochip microarray
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA
    J Anal Toxicol 35:40-5. 2011
    ..Agreement of the Randox assay was greater than 90% when compared to the ELISA assay for all drug classes except cannabinoids (88%). Specificity of the biochip assay was slightly better for amphetamines and cocaine...
  13. ncbi request reprint Comparison of drugs of abuse detection in meconium by EMIT II and ELISA
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108 1221, USA
    J Anal Toxicol 33:148-54. 2009
    ..EMIT II appears to be more sensitive for the detection of barbiturates and benzodiazepines. The ELISA method reduced turnaround time by 50% compared to the EMIT II method...
  14. ncbi request reprint Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV
    JoEtta Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Inc, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    J Anal Toxicol 30:27-30. 2006
    ..The assay should be attractive to clinical laboratories because the run time for quantification of both drugs is approximately 5 min per sample, and no interferences are currently known...
  15. doi request reprint LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT, USA
    Methods Mol Biol 603:89-105. 2010
    ..The serum and plasma specimens are quantified using the urine calibrators but employing plasma-based controls. Oxazepam glucuronide is used as a hydrolysis control...
  16. ncbi request reprint Evaluation of the integrated E-Z split key(®) cup II for rapid detection of twelve drug classes in urine
    Dina N Greene
    University of Utah Health Sciences Center, Department of Pathology, Salt Lake City, UT 84108, USA
    J Anal Toxicol 35:46-53. 2011
    ..One false-negative result for barbiturates was observed, but was resolved. Overall, the cups demonstrated excellent sensitivity, specificity, and diagnostic efficiency for all drugs represented...
  17. doi request reprint Simultaneous quantification of levetiracetam and gabapentin in plasma by ultra-pressure liquid chromatography coupled with tandem mass spectrometry detection
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah, USA
    Ther Drug Monit 33:209-13. 2011
    ..Gabapentin is also used extensively to manage neuropathic pain, and for this indication, wherein higher doses are prescribed, plasma concentrations of 15-30 mg/L are typical...
  18. doi request reprint Evaluation of the Abbott ARCHITECT i2000 sirolimus assay and comparison with the Abbott IMx sirolimus assay and an established liquid chromatography-tandem mass spectrometry method
    Kamisha L Johnson-Davis
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah, USA
    Ther Drug Monit 33:453-9. 2011
    ..The purpose of our study was to validate the Abbott ARCHITECT i2000 sirolimus assay...
  19. ncbi request reprint Determination of CYP2D6, CYP2C9 and CYP2C19 genotypes with Tag-It mutation detection assays
    Roberta Melis
    ARUP Institute for Experimental and Clinical Pathology, 500 Chipeta Way, Salt Lake City, UT 84108, USA
    Expert Rev Mol Diagn 6:811-20. 2006
    ..The CYP2D6 assay was somewhat less robust and could be improved by associating the 2850C>T variant with a specific allele, as well as by discriminating the allele affected when gene duplication is detected...
  20. doi request reprint Simultaneous UPLC-MS/MS assay for the detection of the traditional antipsychotics haloperidol, fluphenazine, perphenazine, and thiothixene in serum and plasma
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, UT 84108, United States Electronic address
    Clin Chim Acta 423:32-4. 2013
    ..A rapid and simple procedure for monitoring haloperidol, thiothixene, fluphenazine, and perphenazine is described here...
  21. pmc Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy
    Benjamin D Horne
    Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Utah 84107, USA
    Thromb Haemost 107:232-40. 2012
    ..7 mg/week. In conclusion, a pharmacogenetic warfarin dose-refinement algorithm based on clinical, INR, and genetic factors can explain at least 69.1% of therapeutic warfarin dose variability after about one week of therapy...
  22. doi request reprint Unresolved discrepancies between cannabinoid test results for infant urine
    Vilte E Barakauskas
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Clin Chem 58:1364-7. 2012
    ..This study investigated the rate of unconfirmed positive screen results in infant and noninfant urine samples and evaluated possible reasons for differences...
  23. doi request reprint A comparison of two FDA approved lamotrigine immunoassays with ultra-high performance liquid chromatography tandem mass spectrometry
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, UT 84108, United States
    Clin Chim Acta 412:1879-82. 2011
    ..Chromatographic techniques are currently used for performing most TDM of lamotrigine, but this may change, as automated immunoassays were recently introduced...
  24. doi request reprint An automated method for supporting busulfan therapeutic drug monitoring
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108 1221, USA
    Ther Drug Monit 33:315-20. 2011
    ..TDM of busulfan is not widely available due to the lack of commercially available and rapid methods to determine the area under the plasma concentration curve...
  25. doi request reprint Discordant carbamazepine values between two immunoassays: carbamazepine values determined by ADVIA Centaur correlate better with those determined by LC-MS/MS than PETINIA assay
    Gwendolyn A McMillin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA
    J Clin Lab Anal 25:212-6. 2011
    ..Such discordance may cause confusion in interpreting serum carbamazepine levels...
  26. ncbi request reprint Quantitation of benzodiazepines in urine, serum, plasma, and meconium by LC-MS-MS
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108 1221, USA
    J Anal Toxicol 32:491-8. 2008
    ..Oxazepam glucuronide was evaluated as a hydrolysis control for the urine and meconium specimens...
  27. ncbi request reprint Drug monitoring and toxicology: a procedure for the monitoring of oxcarbazepine metabolite by HPLC-UV
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, Utah 84108, USA
    J Chromatogr Sci 44:45-8. 2006
    ..In comparison to other published methods, this procedure would be of interest to clinical laboratories because it employs a precipitation step for sample preparation, instead of conventional yet time-consuming solid-phase extraction...
  28. doi request reprint Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity
    Roberta Melis
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, Utah 84108, USA
    Genet Test Mol Biomarkers 16:1111-4. 2012
    ..The fact HCP5 occurs within a region of copy number variation and the fact LD is incomplete and may vary between ethnicities should be considered when using the HCP5 SNP as a surrogate marker for HLA-B*57:01...
  29. doi request reprint Current challenges in personalizing warfarin therapy
    Gwendolyn A McMillin
    Department of Pathology, University of Utah, ARUP Laboratories, UT, USA
    Expert Rev Clin Pharmacol 4:349-62. 2011
    ..Through further investigative work, allowing these personalized strategies to realize their full potential, warfarin may remain a preferred therapeutic oral anticoagulant for years to come...
  30. doi request reprint Evaluation of a CYP2C19 genotype panel on the GenMark eSensor® platform and the comparison to the Autogenomics Infiniti™ and Luminex CYP2C19 panels
    Christine C Lee
    Department of Pathology, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637 1470, USA
    Clin Chim Acta 412:1133-7. 2011
    ..Predicting patient response through pre-therapeutic genotyping may therefore guide selection of antiplatelet therapy...
  31. pmc An ImmunoChip prototype for simultaneous detection of antiepileptic drugs using an enhanced one-step homogeneous immunoassay
    Xiaoyun Yang
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Anal Biochem 365:222-9. 2007
    ..The ImmunoChip assay platform described in this article may be well suited for therapeutic monitoring of drugs and metabolites at the point-of-care setting...
  32. doi request reprint Quantification of tricyclic antidepressants using UPLC-MS/MS
    Kamisha L Johnson-Davis
    ARUP Laboratories Inc, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Methods Mol Biol 902:175-84. 2012
    ..The sample preparation employs a rapid protein precipitation with 50:50 MeOH:acetonitrile, high speed centrifugation, and injection of 5 μL of supernatant onto the instrument, with a 5 min run-time...
  33. ncbi request reprint Specimen dilution for C2 monitoring with the Abbott TDxFLx cyclosporine monoclonal whole blood assay
    JoEtta M Juenke
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, UT 84108, USA
    Clin Chem 50:1430-3. 2004
  34. doi request reprint Nicotine and metabolites in paired umbilical cord tissue and meconium specimens
    Stephanie J Marin
    ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108 1221, USA
    Ther Drug Monit 33:80-5. 2011
    ..Although different nicotine and metabolite patterns exist in meconium versus umbilical cord tissue, this work indicates that either specimen can be used to detect third-trimester fetal nicotine exposure...
  35. doi request reprint Rapid and specific quantification of ethylene glycol levels: adaptation of a commercial enzymatic assay to automated chemistry analyzers
    JoEtta M Juenke
    ARUP Institute for Clinical and ExperimentalPathology, Salt Lake City, UT, USA
    Am J Clin Pathol 136:318-24. 2011
    ..This modified assay should make it possible for more clinical laboratories to offer ethylene glycol measurements...
  36. ncbi request reprint Simultaneous analysis of the Delta9-THC metabolites 11-nor-9-carboxy-Delta9-THC and 11-hydroxy-Delta9-THC in meconium by GC-MS
    Rebecka Coles
    ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories Inc, Salt Lake City, Utah 84108, USA
    J Anal Toxicol 29:522-7. 2005
    ..5% increase in the positivity rate compared to 9-carboxy-THC alone...
  37. doi request reprint A rapid and fully-automated method for the quantitation of tricyclic antidepressants in serum using turbulent-flow liquid chromatography-tandem mass spectrometry
    Autumn R Breaud
    The Johns Hopkins School of Medicine, Department of Pathology, Clinical Chemistry, Baltimore, MD, USA
    Clin Chim Acta 411:825-32. 2010
    ..We describe a fully-automated turbulent-flow liquid chromatography-tandem mass spectrometry method for the detection of tricyclic antidepressant drugs (amitriptyline, desipramine, imipramine, and nortriptyline) in serum...
  38. doi request reprint Pediatric reference intervals for serum copper and zinc
    Chia Ni Lin
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, 84112, United States
    Clin Chim Acta 413:612-5. 2012
    ..We established age- and gender-specific reference intervals for serum copper and zinc, with a large healthy pediatric population...