L J Layfield

Summary

Affiliation: ARUP Institute for Clinical and Experimental Pathology
Country: USA

Publications

  1. ncbi Fine-needle aspiration in the diagnosis of head and neck lesions: a review and discussion of problems in differential diagnosis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 35:798-805. 2007
  2. doi HER2/neu gene amplification heterogeneity: the significance of cells with a 3:1 HER2/CEP17 ratio
    Lester J Layfield
    Department of Pathology, University of Utah, USA
    Appl Immunohistochem Mol Morphol 20:543-9. 2012
  3. doi Clinician compliance with laboratory regulations requiring submission of relevant clinical data: A one year retrospective analysis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, United States
    Pathol Res Pract 208:668-71. 2012
  4. doi Inflammatory myxohyaline tumor of distal extremities: cytologic findings in a lesion simulating a high-grade myxoid sarcoma
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 40:993-6. 2012
  5. ncbi Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance
    Benjamin L Witt
    University of Utah School of Medicine and the RUP Laboratories, Salt Lake City, UT, 84112, USA
    Arch Pathol Lab Med 136:1259-61. 2012
  6. doi Diagnosis of gastrointestinal stromal tumors from minute specimens: cytomorphology, immunohistochemistry, and molecular diagnostic findings
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diagn Cytopathol 40:484-90. 2012
  7. doi Metastatic disease to the pancreas documented by endoscopic ultrasound guided fine-needle aspiration: a seven-year experience
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84112, USA
    Diagn Cytopathol 40:228-33. 2012
  8. ncbi Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, and ARUP Laboratories, Inc, Salt Lake City, Utah 84132, USA
    J Surg Oncol 83:227-31. 2003
  9. ncbi Fine-needle aspiration cytology of intraductal papillary-mucinous tumors: a retrospective analysis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 32:16-20. 2005
  10. doi Giant-cell containing neoplasms of the pancreas: an aspiration cytology study
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 36:238-44. 2008

Collaborators

Detail Information

Publications71

  1. ncbi Fine-needle aspiration in the diagnosis of head and neck lesions: a review and discussion of problems in differential diagnosis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 35:798-805. 2007
    ..Each site undergoing FNA within the head and neck is associated with a set of differential diagnoses and diagnostic challenges which will be discussed...
  2. doi HER2/neu gene amplification heterogeneity: the significance of cells with a 3:1 HER2/CEP17 ratio
    Lester J Layfield
    Department of Pathology, University of Utah, USA
    Appl Immunohistochem Mol Morphol 20:543-9. 2012
    ..Moreover, 3:1 HER2/CEP17 ratio cells are a poor predictor for the presence of additional amplified cells in a sample...
  3. doi Clinician compliance with laboratory regulations requiring submission of relevant clinical data: A one year retrospective analysis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, UT, United States
    Pathol Res Pract 208:668-71. 2012
    ..Anecdotal evidence indicates that clinician compliance with requests for clinical history is variable...
  4. doi Inflammatory myxohyaline tumor of distal extremities: cytologic findings in a lesion simulating a high-grade myxoid sarcoma
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 40:993-6. 2012
    ..Careful attention to the myxoid background, prominence of inflammatory cells, nature of the pleomorphic cells, and location of the lesion should favor the diagnosis of IMTDE...
  5. ncbi Negative loop electrosurgical cone biopsy finding following a biopsy diagnosis of high-grade squamous intraepithelial lesion: frequency and clinical significance
    Benjamin L Witt
    University of Utah School of Medicine and the RUP Laboratories, Salt Lake City, UT, 84112, USA
    Arch Pathol Lab Med 136:1259-61. 2012
    ..Most LEEPs will confirm the HSIL biopsy diagnosis but a number of them will not. Such negative findings suggest the possibility of an incorrect biopsy diagnosis, removal of the lesion by biopsy, or insufficient LEEP sampling...
  6. doi Diagnosis of gastrointestinal stromal tumors from minute specimens: cytomorphology, immunohistochemistry, and molecular diagnostic findings
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Diagn Cytopathol 40:484-90. 2012
    ..This review outlines a practical approach to the cytologic diagnosis of GISTs and their molecular workup on small specimens obtained by FNA or core biopsy...
  7. doi Metastatic disease to the pancreas documented by endoscopic ultrasound guided fine-needle aspiration: a seven-year experience
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84112, USA
    Diagn Cytopathol 40:228-33. 2012
    ..The metastatic deposits could be detected in the pancreas as many as 10 years following the original diagnosis and resection of the renal cell carcinoma...
  8. ncbi Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, and ARUP Laboratories, Inc, Salt Lake City, Utah 84132, USA
    J Surg Oncol 83:227-31. 2003
    ..Possible mechanisms for over expression of EGFR include gene amplification, transcriptional upregulation, or decreased degredation of the EGFR protein...
  9. ncbi Fine-needle aspiration cytology of intraductal papillary-mucinous tumors: a retrospective analysis
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 32:16-20. 2005
    ..Cytomorphological examination, when coupled with EUS features, is accurate for the diagnosis of these lesions but often it underdiagnoses the grade of the neoplasm...
  10. doi Giant-cell containing neoplasms of the pancreas: an aspiration cytology study
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    Diagn Cytopathol 36:238-44. 2008
    ..The difference in the appearance of the giant-cells aids in distinction of the two neoplasms. When in pure form, the two neoplasms may follow different clinical courses...
  11. doi Post-thyroid FNA testing and treatment options: a synopsis of the National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference
    Lester J Layfield
    Department of Pathology, University of Utah Hospital and Clinics, Salt Lake City, Utah 84112, USA
    Diagn Cytopathol 36:442-8. 2008
    ..Options for surgical intervention are given for the diagnostic categories of "atypical/borderline," "follicular neoplasm," "suspicious for malignancy" and "malignant" (http://thyroidfna.cancer.gov/pages/info/agenda/)...
  12. ncbi Primary sclerosing cholangitis as a cause of false positive bile duct brushing cytology: report of two cases
    Lester J Layfield
    Department of Pathology, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 32:119-24. 2005
    ..We report two patients with PSC in whom bile duct brush cytologies were falsely positive for carcinoma...
  13. ncbi Assessment of NMYC amplification: a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, and ARUP Laboratories, Salt Lake City, Utah, USA
    Anal Quant Cytol Histol 27:5-14. 2005
    ....
  14. ncbi Cost efficiency analysis for fine-needle aspiration in the workup of parotid and submandibular gland nodules
    Lester J Layfield
    ARUP Laboratories, Department of Pathology, University of Utah School of Medicine, 50 N Medical Drive, Salt Lake City, UT 84132, USA
    Diagn Cytopathol 34:734-8. 2006
    ..00 (33% savings over surgical management alone). Based on these data, FNA appears to be cost effective in addition to supplying preoperative diagnoses helpful in counseling, operative planning, and allaying patient anxiety...
  15. ncbi In situ and invasive components of mammary adenocarcinoma: comparison of Her-2/neu status
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132, USA
    Anal Quant Cytol Histol 29:239-43. 2007
    ..To compare the relationship between Her-2/neu in the invasive and in situ components of carcinoma...
  16. ncbi HPV DNA testing in the triage of atypical squamous cells of undetermined significance (ASCUS): cost comparison of two methods
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, 84132, USA
    Diagn Cytopathol 33:138-43. 2005
    ..INFORM HPV appears to be 16% more expensive than HCII but has the advantage of sending 41% fewer women to colposcopy...
  17. ncbi Statistical analysis of cytologic features useful in separation of metastatic urothelial carcinoma from other metastatic epithelial malignancies
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 29:334-8. 2003
    ..While CCs were useful in the identification of UC, CCs occurred in a significant number of SCCs, limiting their diagnostic value as a single variable...
  18. ncbi Cytologic distinction of goiterous nodules from morphologically normal thyroid: analyses of cytomorphologic features
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Cancer 99:217-22. 2003
    ..The authors investigated a set of criteria to determine whether any were useful for separating goiterous nodules from normal thyroid tissue...
  19. doi Fine-needle aspiration of primary osseous lesions: A cost effectiveness study
    Lester J Layfield
    Department of Pathology, University of Utah Medical Center, Salt Lake City, UT 84112, USA
    Diagn Cytopathol 38:239-43. 2010
    ..FNA investigation of the 165 bone lesions cost 575,932 (average of 3,490 per patient). Surgical biopsy alone would have cost 5,760 per patient. FNA resulted in a cost savings of 2,215 per patient...
  20. doi Thyroid fine needle aspiration cytology: a review of the National Cancer Institute state of the science symposium
    L J Layfield
    Surgical Pathology, University of Utah School of Medicine, University of Utah Hospital and Clinics, Salt Lake City, UT, USA
    Cytopathology 21:75-85. 2010
    ..Herein we review the presentations given at that conference...
  21. doi Cytopathology of the pancreas: neoplastic and nonneoplastic entities
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Ann Diagn Pathol 14:140-51. 2010
    ..Recently, a number of in situ lesions have been identified, complicating the cytologic diagnosis of pancreatic neoplasia. These noninvasive lesions include pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasm...
  22. doi Implications of the proposed thyroid fine-needle aspiration category of "follicular lesion of undetermined significance": A five-year multi-institutional analysis
    Lester J Layfield
    Department of Pathology, University of Utah, Salt Lake City, USA
    Diagn Cytopathol 37:710-4. 2009
    ..3%) undergoing resection. Use of FLUS varied substantially among pathologists and institutions. FLUS category requires more rigorously defined morphologic criteria for it to become a useful guide in clinical management...
  23. doi Thyroid aspiration cytology: current status
    Lester J Layfield
    University of Utah School of Medicine, University of Utah Hospital and Clinics, Salt Lake City, UT, USA
    CA Cancer J Clin 59:99-110. 2009
    ..The aim of the current article was to discuss indications for FNA, diagnostic terminology, and post-FNA options, issues that are important to physicians who are managing patients with thyroid nodules...
  24. doi Cytologic diagnosis of osseous lesions: a review with emphasis on the diagnosis of primary neoplasms of bone
    Lester J Layfield
    ARUP Laboratories, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Diagn Cytopathol 37:299-310. 2009
    ..Cytomorphologic features of the more common primary neoplasms of bone will be summarized along with recommendations for the utilization of immunohistochemistry and molecular diagnostics in the work-up of primary neoplasms of bone...
  25. ncbi Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues
    Lester J Layfield
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 28:264-71. 2003
    ..There appear to be sufficient cytomorphologic features present within the FNA smears and cell block material to allow cytologic separation of the more common myxoid and mucinous neoplasms involving the sacral and parasacral tissues...
  26. doi Monoplex LightCycler polymerase chain reaction quantitation of the HER2 gene for quality assurance of HER2/neu testing by immunohistochemistry and fluorescence in situ hybridization
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Appl Immunohistochem Mol Morphol 16:562-7. 2008
    ..A random sample of IHC 2+ cases are routinely tested by PCR. We found this practice useful for resolving discrepancies in HER2 testing...
  27. ncbi Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic factors
    Lester J Layfield
    Department of Pathology, University of Utah Hospital and Clinics, Salt Lake City, Utah 84132, USA
    Appl Immunohistochem Mol Morphol 14:91-6. 2006
    ..p53 expression was also determined by immunohistochemistry and correlated with the other variables and survival...
  28. ncbi Evaluation of Her-2/neu gene status in osteosarcoma by fluorescence in situ hybridization and multiplex and monoplex polymerase chain reactions
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Arch Pathol Lab Med 130:691-8. 2006
    ..Previous reports suggest that the human epidermal growth factor 2 (HER-2/neu) receptor may be overexpressed in osteosarcoma...
  29. ncbi Detection of epidermal growth factor receptor and human epidermal growth factor receptor 2 activating mutations in lung adenocarcinoma by high-resolution melting amplicon analysis: correlation with gene copy number, protein expression, and hormone recepto
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Hum Pathol 37:755-63. 2006
    ..Estrogen and progesterone receptor expression was not strong in any of the cases and did not correlate with the presence of EGFR or HER2 mutations...
  30. ncbi Role of HPV DNA testing in predicting cervical intraepithelial lesions: comparison of HC HPV and ISH HPV
    M Nasar Qureshi
    Department of Pathology, Bayonne Medical Center, Bayonne, New Jersey, USA
    Diagn Cytopathol 29:149-55. 2003
    ....
  31. ncbi Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications
    L J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84101, USA
    Diagn Cytopathol 25:38-42. 2001
    ..In this study, we report our findings in a series of nine cases where cytology disclosed atypical squamous epithelium in the aspirates derived from pancreatic lesions...
  32. ncbi Detection of EGFR- and HER2-activating mutations in squamous cell carcinoma involving the head and neck
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84108, USA
    Mod Pathol 19:634-40. 2006
    ..HRMAA could serve as a screening method to easily and rapidly identify these patients...
  33. doi A gastrointestinal stromal tumor of the stomach morphologically resembling a neurofibroma: demonstration of a novel platelet-derived growth factor receptor alpha exon 18 mutation
    Ting Liu
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Hum Pathol 39:1849-53. 2008
    ....
  34. ncbi Molecular diagnostic testing as an adjunct to morphologic evaluation of pancreatic ductal system brushings: potential augmentation for diagnostic sensitivity
    Carlynn Willmore-Payne
    Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Diagn Cytopathol 35:218-24. 2007
    ..Only 8% of specimens from adenocarcinomas had p53 mutations and only 33% of cases had K-ras mutations. Mutational analysis did not appear to improve the cytologic detection of adenocarcinoma by bile duct brushings...
  35. ncbi Effects of fixative and fixation protocols on assessment of Her-2/neu oncogene amplification status by fluorescence in situ hybridization
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, 50 N Medical Drive, Salt Lake City, UT 84132, USA
    Appl Immunohistochem Mol Morphol 15:84-7. 2007
    ..O-Fix did not seem to compromise staining quality in 3 paired specimens tested...
  36. ncbi Relationship between EGFR overexpression and gene amplification status in central nervous system gliomas
    Sheryl R Tripp
    Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, LLC, Salt Lake City, Utah 84108, USA
    Anal Quant Cytol Histol 27:71-8. 2005
    ..To correlate epidermal growth factor receptor (EGFR) protein overexpression, as assessed by immunohistochemistry, with EGFR gene amplification determined by fluorescence in situ hybridization in a series of gliomas...
  37. ncbi Detection of c-kit exons 11- and 17-activating mutations in testicular seminomas by high-resolution melting amplicon analysis
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Mod Pathol 19:1164-9. 2006
    ..This could benefit patients whose tumors are refractory to standard therapeutic protocols...
  38. ncbi Correlation of HER2 gene amplification with immunohistochemistry in breast cancer as determined by a novel monoplex polymerase chain reaction assay
    Carlynn Willmore
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    Appl Immunohistochem Mol Morphol 13:333-41. 2005
    ..The authors conclude that 3+ IHC membrane staining correctly identifies neoplasms showing HER2 gene amplification. Monoplex HER2 PCR may offer significant advantages over both IHC and FISH for HER2 testing in breast cancer...
  39. doi Follicular variant of papillary carcinoma: reproducibility of histologic diagnosis and utility of HBME-1 immunohistochemistry and BRAF mutational analysis as diagnostic adjuncts
    Michelle Wallander
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Appl Immunohistochem Mol Morphol 18:231-5. 2010
    ..More recently, BRAF and HBME-1 (Human Bone Marrow Endothelial Cell-1) have been suggested as markers for FVPTC...
  40. doi Tyrosine kinase activating mutations in human malignancies: implications for diagnostic pathology
    Joseph A Holden
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Exp Mol Pathol 85:68-75. 2008
    ..This may have important predictive and prognostic implications...
  41. pmc The use of EGFR exon 19 and 21 unlabeled DNA probes to screen for activating mutations in non-small cell lung cancer
    Carlynn Willmore-Payne
    Associated Regional and University Pathologists Institute for Clinical and Experimental Patholog y, Salt Lake City, UT 84108, USA
    J Biomol Tech 19:217-24. 2008
    ..This allows for easy identification of activating mutations even in homozygous or amplified states and is useful in the screening of NSCLC for the common EGFR activating mutations...
  42. ncbi Epithelial-myoepithelial cell carcinoma of the parotid gland: a case report and comparison of cytologic features with other stromal, epithelial, and myoepithelial cell containing lesions of the salivary glands
    T Wax
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Diagn Cytopathol 14:298-304. 1996
    ....
  43. ncbi Significance of lymphoglandular bodies in bone marrow aspiration smears
    R C Stern
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Diagn Cytopathol 24:240-3. 2001
    ..001 and P = 0.01, respectively). While lymphoglandular bodies can be seen in a variety of malignant hematopoietic and nonhematopoietic disorders, they are found in significantly greater numbers in B-cell malignancies...
  44. ncbi c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens
    Carlynn Willmore-Payne
    ARUP Laboratories, Salt Lake City, Utah 84108, USA
    Cancer 105:165-70. 2005
    ..Antigen retrieval may be the cause of this spurious positivity. Recently, the demonstration of KIT and PDGFRA mutations has been shown to be more reliable in establishing the diagnosis of GIST than IHC...
  45. ncbi Cystic lesions of the salivary glands: cytologic features in fine-needle aspiration biopsies
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 27:197-204. 2002
    ..Aspirates of low-grade mucoepidermoid carcinoma may contain no epithelial cells and result in false-negative diagnoses (1 case, 2%)...
  46. ncbi BRAF and c-kit gene copy number in mutation-positive malignant melanoma
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA
    Hum Pathol 37:520-7. 2006
    ..These results have important implications concerning the mechanism of oncogenesis in melanoma as well as in the response of the tumor to anticancer drugs targeting BRAF or c-kit...
  47. ncbi Fibromatosislike metaplastic carcinoma of the breast as a diagnostic pitfall for fine needle aspiration cytology: a case report
    Elke Jarboe
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Acta Cytol 54:712-6. 2010
    ..Rare cells had a "spindle" shape. Nuclear features were low grade. Rare individual cells had retained cytoplasm. Lumpectomy revealed a fibromatosis-like metaplastic carcinoma...
  48. ncbi A comparison of routine and rapid microwave tissue processing in a surgical pathology laboratory. Quality of histologic sections and advantages of microwave processing
    L R Rohr
    Department of Pathology, University of Utah, Salt Lake City, and Associated Regional and University Pathologists (ARUP, Salt Lake City, USA
    Am J Clin Pathol 115:703-8. 2001
    ..Microwave processing considerably shortens the preparation time for permanent histologic sections without a demonstrable decrease in section quality or "readability."..
  49. ncbi Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions?
    Claudia Jones
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 96:83-91. 2002
    ..The authors investigated the ability of FNA to accurately subtype and grade a series of 107 primary sarcomas of the musculoskeletal system...
  50. ncbi Institutional review of outside cytology materials: a retrospective analysis of two institutions' experiences
    Lester J Layfield
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84103, USA
    Diagn Cytopathol 26:45-8. 2002
    ..The 8% major discrepancy rate is slightly higher than that seen in similar studies of surgical pathology material...
  51. ncbi Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis
    Carlynn Willmore
    Department of Pathology, University of Utah, Salt Lake City 84108, USA
    Am J Clin Pathol 122:206-16. 2004
    ..High-resolution melting analysis can be used to scan DNA for potential c-kit-activating mutations and can aid in the diagnosis of GISTs...
  52. doi Histologic, immunohistochemical, and molecular classification of 52 IPMNs of the pancreas
    Barbara Chadwick
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA
    Appl Immunohistochem Mol Morphol 17:31-9. 2009
    ..Prognosis is superior to that of pancreatic invasive ductal carcinoma. IPMNs reveal a variety of epithelial linings expressing different mucin staining patterns and may progress along different oncogenic pathways...
  53. ncbi Immediate on-site interpretation of fine-needle aspiration smears: a cost and compensation analysis
    L J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cancer 93:319-22. 2001
    ..Only when the cytopathologist personally performs the aspirate and immediately interprets it (CPT codes 88172 and 88170) does the Medicare payment adequately compensate for professional services...
  54. ncbi Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature
    E Valencerina Gopez
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah
    Diagn Cytopathol 24:249-52. 2001
    ....
  55. ncbi A comparison of touch imprint cytology and Mohs frozen-section histology in the evaluation of Mohs micrographic surgical margins
    S R Florell
    Departments of Dermatology and Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA
    J Am Acad Dermatol 44:660-4. 2001
    ..Touch imprint cytology (TIC) is commonly used in the diagnosis of tumors and has been applied to margin analysis of breast lumpectomy specimens with good success...
  56. ncbi Histologic and fine-needle aspiration cytologic features of polycystic disease of the parotid glands: case report and review of the literature
    Lester J Layfield
    Department of Pathology, Division of Anatomic Pathology, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Diagn Cytopathol 26:324-8. 2002
    ....
  57. ncbi Fine-needle aspiration cytology of giant cell fibroblastoma: case report and review of the literature
    Lester J Layfield
    Department of Pathology, Division of Anatomic Pathology, University of Utah School of Medicine, and ARUP Laboratories, Inc, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 26:398-403. 2002
    ..Surgical resection of the mass confirmed the diagnosis of giant cell fibroblastoma. We review the characteristic cytologic features of giant cell fibroblastoma and compare them with other soft tissue tumors in the differential diagnosis...
  58. ncbi A comparison of immunohistochemical stain quality in conventional and rapid microwave processed tissues
    Lyska L Emerson
    Department of Pathology, University of Utah, Salt Lake City, USA
    Am J Clin Pathol 125:176-83. 2006
    ..The potential need for immunohistochemical analysis is not a contraindication for microwave-assisted rapid tissue processing...
  59. doi Lack of BRAF activating mutations in prostate adenocarcinoma: a study of 93 cases
    Ting Liu
    Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, UT 84112, USA
    Appl Immunohistochem Mol Morphol 17:121-5. 2009
    ..None were found. This suggests that BRAF mutations may not play an important role in the oncogenesis or therapy of prostate adenocarcinoma...
  60. ncbi Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis
    Carlynn Willmore-Payne
    Department of Pathology, University of Utah, Salt Lake City, 84108, USA
    Hum Pathol 36:486-93. 2005
    ....
  61. doi Collecting duct carcinoma arising in association with BK nephropathy post-transplantation in a pediatric patient. A case report with immunohistochemical and in situ hybridization study
    Lyska L Emerson
    Department of Pathology, University of Utah School of Medicine and Associated Regional and University Pathologists ARUP Laboratories, Salt Lake City, UT, USA
    Pediatr Transplant 12:600-5. 2008
    ..The finding of T-Ag protein expression in both intraepithelial and invasive neoplastic tissues in our case raises the possibility of BK virus as a causative agent in oncogenesis...
  62. doi Translocations and amplifications of chromosome 12 in liposarcoma demonstrated by the LSI CHOP breakapart rearrangement probe
    Carlynn Willmore-Payne
    ARUP Laboratories, Salt Lake City, Utah, USA
    Arch Pathol Lab Med 132:952-7. 2008
    ..Amplifications occur within the 12q13-15 region of atypical lipomatous tumors and well-differentiated liposarcomas but not lipomas...
  63. ncbi Adenocarcinoma arising in association with gastric heterotopic pancreas: A case report and review of the literature
    Lyska Emerson
    Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah, USA
    J Surg Oncol 87:53-7. 2004
    ..Adenocarcinoma arising within ectopic pancreas is a rare occurrence with fewer than 30 well-documented cases reported in the world literature to our knowledge...
  64. ncbi Percutaneous image-guided fine-needle aspiration of peritoneal lesions
    Lester J Layfield
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Diagn Cytopathol 28:6-12. 2003
    ..In our series, no acute or chronic postprocedural complications were identified, indicating that FNA in this setting is a safe technique. Accurate cytologic diagnosis was achieved in 74% of cases. The overall insufficiency rate was 26%...
  65. ncbi Interobserver agreement and reproducibility in classification of invasive breast carcinoma: an NCI breast cancer family registry study
    Teri A Longacre
    Department of Pathology, Stanford University, Stanford, CA, USA
    Mod Pathol 19:195-207. 2006
    ....
  66. ncbi A c-kit-negative gastrointestinal stromal tumor with a platelet-derived growth factor receptor alpha mutation
    Jorge C Isaac
    University of Utah, Health Sciences Center, Salt Lake City, Utah
    Appl Immunohistochem Mol Morphol 14:52-6. 2006
    ..This additional molecular study allowed the authors to formulate the precise diagnosis of a c-kit-negative GIST with strong smooth muscle marker expression...
  67. ncbi Initial margin status for invasive ductal carcinoma of the breast and subsequent identification of carcinoma in reexcision specimens
    Silvia Skripenova
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Arch Pathol Lab Med 134:109-14. 2010
    ..Optimal surgical technique requires microscopic margins free of carcinoma by at least 2 mm. Recurrence following lumpectomy is associated with residual carcinoma secondary to inadequate resection...
  68. ncbi Quest for a uniform cyto-diagnostic approach to thyroid aspirates: a consensus proposal
    Zubair Baloch
    Diagn Cytopathol 34:85-6. 2006
  69. ncbi Utility of four-quadrant random sections in mastectomy specimens
    Dilip Gupta
    Magee Woman s Hospital and University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Breast J 9:307-11. 2003
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