Rui Xu

Summary

Affiliation: Array BioPharma
Country: USA

Publications

  1. doi Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
    Rui Xu
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:2335-40. 2011
  2. doi Discovery of pyrrolopyrimidine inhibitors of Akt
    James F Blake
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 20:5607-12. 2010
  3. doi Discovery and SAR of spirochromane Akt inhibitors
    Nicholas C Kallan
    Array BioPharma, Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:2410-4. 2011
  4. ncbi Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
    James F Blake
    Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, USA
    J Med Chem 55:8110-27. 2012
  5. doi Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
    Josef R Bencsik
    Array BioPharma Inc, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 20:7037-41. 2010

Detail Information

Publications5

  1. doi Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA
    Rui Xu
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:2335-40. 2011
    ..Representative compounds showed favorable Akt potency while exhibiting up to 1000-fold selectivity against PKA...
  2. doi Discovery of pyrrolopyrimidine inhibitors of Akt
    James F Blake
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 20:5607-12. 2010
    ..The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts...
  3. doi Discovery and SAR of spirochromane Akt inhibitors
    Nicholas C Kallan
    Array BioPharma, Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 21:2410-4. 2011
    ..Attempted replacement of the phenol hinge binder provided compounds with excellent Akt enzyme and cell activities but greatly diminished selectivity over PKA...
  4. ncbi Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors
    James F Blake
    Array BioPharma Inc, 3200 Walnut Street, Boulder, Colorado 80301, USA
    J Med Chem 55:8110-27. 2012
    ..28 is currently being evaluated in human clinical trials for the treatment of cancer...
  5. doi Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
    Josef R Bencsik
    Array BioPharma Inc, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 20:7037-41. 2010
    ..A representative dihydrothieno compound (34) was advanced into a PC3-NCI prostate mouse tumor model in which it demonstrated a dose-dependent reduction in tumor growth and stasis when dosed orally daily at 200 mg/kg...