G P Vigers

Summary

Affiliation: Array BioPharma
Country: USA

Publications

  1. ncbi request reprint X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1
    G P Vigers
    Department of Inflammation Research, Amgen, Incorporated, Boulder, Colorado 80301, USA
    J Biol Chem 275:36927-33. 2000
  2. ncbi request reprint Multiple active site corrections for docking and virtual screening
    Guy P A Vigers
    Array BioPharma Inc, 3200 Walnut St, Boulder, Colorado 80301, USA
    J Med Chem 47:80-9. 2004
  3. ncbi request reprint Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta
    G P Vigers
    Amgen Inc, Boulder, Colorado 80301, USA
    Nature 386:190-4. 1997
  4. ncbi request reprint X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution
    G P Vigers
    Synergen, Inc, Boulder, Colorado 80301
    J Biol Chem 269:12874-9. 1994

Detail Information

Publications4

  1. ncbi request reprint X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1
    G P Vigers
    Department of Inflammation Research, Amgen, Incorporated, Boulder, Colorado 80301, USA
    J Biol Chem 275:36927-33. 2000
    ..ligand structures. The structure shows an unexpected binding mode for the peptide and may contribute to the design of smaller IL-1R antagonists...
  2. ncbi request reprint Multiple active site corrections for docking and virtual screening
    Guy P A Vigers
    Array BioPharma Inc, 3200 Walnut St, Boulder, Colorado 80301, USA
    J Med Chem 47:80-9. 2004
    ..We have also tested the correction method against an extended set of 63 cocrystals and in a virtual screening experiment. In all cases, MASC significantly improves the results of the docking experiments...
  3. ncbi request reprint Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta
    G P Vigers
    Amgen Inc, Boulder, Colorado 80301, USA
    Nature 386:190-4. 1997
    ..The two receptor-binding regions on IL-1beta identified by site-directed mutagenesis both contact the receptor: one binds to the first two domains of the receptor, while the other binds exclusively to the third domain...
  4. ncbi request reprint X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution
    G P Vigers
    Synergen, Inc, Boulder, Colorado 80301
    J Biol Chem 269:12874-9. 1994
    ..However, there are a number of structural differences between the molecules, including significant differences at the open end of the beta-barrel, which has been identified in IL-1 beta as a receptor binding site...