Allen A Thomas

Summary

Affiliation: Array BioPharma
Country: USA

Publications

  1. ncbi Non-charged thiamine analogs as inhibitors of enzyme transketolase
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:509-12. 2008
  2. ncbi Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:2206-10. 2008
  3. ncbi Prodrug thiamine analogs as inhibitors of the enzyme transketolase
    Yvan Le Huerou
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:505-8. 2008

Collaborators

  • Yvan Le Huerou
  • Steven S Gonzales
  • Walter DeWolf
  • Indrani Gunawardana
  • Jason de Meese
  • S Kirk Wright
  • Laura Hayter
  • Steven A Boyd
  • Francis Sullivan
  • Solly Weiler
  • Todd T Romoff
  • Tomas Kaplan
  • Jed Pheneger
  • Jie Lin
  • Christine Lemieux
  • Patrice Lee
  • May Han
  • Gregory Poch

Detail Information

Publications3

  1. ncbi Non-charged thiamine analogs as inhibitors of enzyme transketolase
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:509-12. 2008
    ..The synthesis, SAR, and structure-based rationale for highly potent non-thiazolium TK antagonists are presented...
  2. ncbi Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors
    Allen A Thomas
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:2206-10. 2008
    ..Synthesis and SAR of transketolase inhibitors is described...
  3. ncbi Prodrug thiamine analogs as inhibitors of the enzyme transketolase
    Yvan Le Huerou
    Array BioPharma Inc, 3200 Walnut Street, Boulder, CO 80301, USA
    Bioorg Med Chem Lett 18:505-8. 2008
    ..The synthesis of such prodrugs and their evaluation in rodent models is reported...