James F Blake


Affiliation: Array BioPharma
Country: USA


  1. Blake J, Kallan N, Xiao D, Xu R, Bencsik J, Skelton N, et al. Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg Med Chem Lett. 2010;20:5607-12 pubmed publisher
    ..The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts. ..
  2. Blake J, Gaudino J, de Meese J, Mohr P, Chicarelli M, Tian H, et al. Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg Med Chem Lett. 2014;24:2635-9 pubmed publisher
    ..The compounds demonstrate potent and selective inhibition of Erk2 and knockdown of phospho-RSK levels in HepG2 cells and tumor xenografts. ..