Renu Virmani

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. ncbi Oral everolimus inhibits in-stent neointimal growth
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 106:2379-84. 2002
  2. ncbi Comparative pathology: radiation-induced coronary artery disease in man and animals
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Interv Cardiol 3:163-72. 1998
  3. ncbi Vulnerable plaque: the pathology of unstable coronary lesions
    Renu Virmani
    Dept of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Washington, DC 20306 6000, USA
    J Interv Cardiol 15:439-46. 2002
  4. ncbi Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans
    Renu Virmani
    Catheterization Laboratories, Ospedale San Raffaele and Emo Centro Cuore Columbus, Milan, Italy
    Circulation 106:2649-51. 2002
  5. ncbi Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC, USA
    Circulation 109:701-5. 2004
  6. ncbi Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825, 16th Street NW, Washington, DC 20306 6000, USA
    J Interv Cardiol 16:267-72. 2003
  7. pmc Drug eluting stents: are human and animal studies comparable?
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Heart 89:133-8. 2003
  8. ncbi Drug-eluting stents: are they really safe?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    Am Heart Hosp J 2:85-8. 2004
  9. ncbi Histopathologic alterations after endovascular radiation and antiproliferative stents: similarities and differences
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Herz 27:1-6. 2002
  10. ncbi Pathology of in-stent restenosis
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Curr Opin Lipidol 10:499-506. 1999

Research Grants

Detail Information

Publications92

  1. ncbi Oral everolimus inhibits in-stent neointimal growth
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 106:2379-84. 2002
    ..The present study evaluated whether orally administered everolimus (a macrolide of the same family as sirolimus) inhibits in-stent neointimal growth in rabbit iliac arteries...
  2. ncbi Comparative pathology: radiation-induced coronary artery disease in man and animals
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Interv Cardiol 3:163-72. 1998
    ..Only long-term clinical follow up and careful autopsy studies will determine if endoluminal or intra-arterial radiation is a viable means of reducing restenosis in man...
  3. ncbi Vulnerable plaque: the pathology of unstable coronary lesions
    Renu Virmani
    Dept of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Washington, DC 20306 6000, USA
    J Interv Cardiol 15:439-46. 2002
    ..Newer catheters and other techniques are at various stages of development and will play a significant role in the understanding of plaque progression and the development of symptomatic coronary artery disease...
  4. ncbi Mechanism of late in-stent restenosis after implantation of a paclitaxel derivate-eluting polymer stent system in humans
    Renu Virmani
    Catheterization Laboratories, Ospedale San Raffaele and Emo Centro Cuore Columbus, Milan, Italy
    Circulation 106:2649-51. 2002
    ..This study presents the histological findings of atherectomy specimens from a subset of these patients receiving implants...
  5. ncbi Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC, USA
    Circulation 109:701-5. 2004
    ..The US Food and Drug Administration recently issued a warning of subacute thrombosis and hypersensitivity reactions to sirolimus-eluting stents (Cypher). The cause and incidence of these events have not been determined...
  6. ncbi Pathology of the thin-cap fibroatheroma: a type of vulnerable plaque
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825, 16th Street NW, Washington, DC 20306 6000, USA
    J Interv Cardiol 16:267-72. 2003
    ..Targeted therapy for the purpose of stabilizing coronary lesions that are prone to rupture is a major future goal of the interventionist...
  7. pmc Drug eluting stents: are human and animal studies comparable?
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Heart 89:133-8. 2003
    ..Continued long term follow up of patients with drug eluting stents for major adverse cardiac events and angiographic restenosis is therefore imperative...
  8. ncbi Drug-eluting stents: are they really safe?
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    Am Heart Hosp J 2:85-8. 2004
    ....
  9. ncbi Histopathologic alterations after endovascular radiation and antiproliferative stents: similarities and differences
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Herz 27:1-6. 2002
    ..Conversely, stainless steel control stents show complete healing with the neointima consisting of smooth muscle cells in a proteoglycan-collagen matrix and near complete luminal surface endothelialization...
  10. ncbi Pathology of in-stent restenosis
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Curr Opin Lipidol 10:499-506. 1999
    ..These pathological findings provide useful targets for therapies aimed at reducing the incidence of in-stent restenosis...
  11. ncbi Drug-eluting stents: caution and concerns for long-term outcome
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Coron Artery Dis 15:313-8. 2004
    ..This incidence promotes a cautionary view and perhaps supports the use of DES only in high-risk patients...
  12. ncbi Plaque rupture and plaque erosion
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Thromb Haemost 82:1-3. 1999
    ..The mechanisms of plaque erosion are unclear, and there are no consistent risk factors, although patients are often smokers...
  13. ncbi Sudden cardiac death
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cardiovasc Pathol 10:211-8. 2001
    ....
  14. ncbi Pathology of radiation-induced coronary artery disease in human and pig
    R Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cardiovasc Radiat Med 1:98-101. 1999
    ..The purpose of the present study was to compare external beam radiation-induced accelerated coronary atherosclerosis in humans with that seen in the pig coronary arteries following radioactive stent placement...
  15. ncbi Extracellular matrix changes in stented human coronary arteries
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 110:940-7. 2004
    ..The composition of the in-stent ECM has not been well characterized in humans...
  16. ncbi Optimal dosing and duration of oral everolimus to inhibit in-stent neointimal growth in rabbit iliac arteries
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Cardiovasc Revasc Med 7:179-84. 2006
    ..Everolimus is an orally active derivative of sirolimus. Oral administration of rapamycin is efficacious in the reduction of neointima formation and clinical restenosis; however, its optimal dose and duration have not been determined...
  17. ncbi Radiation-induced atherosclerotic plaque progression in a hypercholesterolemic rabbit: a prospective vulnerable plaque model?
    Rajbabu Pakala
    Cardiovascular Research Institute, Washington Hospital Center, 110 Irving Street, NW, Suite 4B 1, Washington, DC 20010, USA
    Cardiovasc Radiat Med 4:146-51. 2003
    ..Currently, there is no standard animal model of vulnerable plaque; therefore, the purpose of this study is to develop a pathophysiologically relevant vulnerable plaque model...
  18. ncbi In vivo comparison of a polymer-free Biolimus A9-eluting stent with a biodegradable polymer-based Biolimus A9 eluting stent and a bare metal stent in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Catheter Cardiovasc Interv 80:429-36. 2012
    ....
  19. doi Effects of exogenous peripheral-blood-derived endothelial progenitor cells or unfractionated bone-marrow-derived cells on neointimal formation and inflammation in cholesterol-fed, balloon-denuded, and radiated iliac arteries of inbred rabbits
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
    Cardiovasc Revasc Med 10:110-6. 2009
    ....
  20. ncbi Peroxisome proliferator-activated receptor gamma ligand pioglitazone alters neointimal composition in a balloon-denuded and radiated hypercholesterolemic rabbit
    Rajbabu Pakala
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC, USA
    J Cardiovasc Pharmacol 48:299-305. 2006
    ..47 vs. 4.82 +/- 0.93, P < 0.05 and 3.24 +/- 0.71 vs. 4.29 +/- 0.74, P < 0.05, respectively). Pioglitazone reduced neointimal area and modified its composition in a balloon-denuded and radiated hypercholesterolemic rabbit model...
  21. ncbi Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arterioscler Thromb Vasc Biol 24:1266-71. 2004
    ..Coronary atherosclerotic plaque composition of diabetic subjects and localization of receptor for advanced glycation end products (RAGE) and its ligands have not been extensively studied...
  22. doi Effect of clopidogrel on neointimal formation and inflammation in balloon-denuded and radiated hypercholesterolemic rabbit iliac arteries
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    J Interv Cardiol 21:122-8. 2008
    ..The aim of this study is to find out by modulating inflammation if clopidogrel can affect neointima formation in balloon-denuded iliac arteries of hypercholesterolemic rabbits...
  23. ncbi Efficacy and safety of pimecrolimus-eluting stents in porcine coronary arteries
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Cardiovasc Revasc Med 8:259-74. 2007
    ..We aimed to evaluate an effective dosage and safety profile of pimecrolimus as an anti-inflammatory drug for drug-eluting stents...
  24. ncbi Transepicardial autologous bone marrow-derived mononuclear cell therapy in a porcine model of chronically infarcted myocardium
    Ron Waksman
    Washington Hospital Center, Suite 4B 1, 110 Irving Street, NW, Washington, DC 20010, USA
    Cardiovasc Radiat Med 5:125-31. 2004
    ..We evaluated the effect of bone marrow-derived mononuclear cell (BMMNC) transplantation on collateral vessel development and myocardial function in a porcine model of chronically infarcted heart...
  25. ncbi The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Curr Opin Lipidol 15:575-82. 2004
    ..This review discusses the putative role of extracellular matrix molecules, in particular proteoglycans/hyaluronan, in the development of acute coronary thrombosis associated with erosion...
  26. ncbi Intraplaque hemorrhage and progression of coronary atheroma
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    N Engl J Med 349:2316-25. 2003
    ..Intraplaque hemorrhage is common in advanced coronary atherosclerotic lesions. The relation between hemorrhage and the vulnerability of plaque to disruption may involve the accumulation of free cholesterol from erythrocyte membranes...
  27. ncbi Pathological mechanisms of fatal late coronary stent thrombosis in humans
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 108:1701-6. 2003
    ..Coronary stent deployment is associated with a low incidence of acute thrombosis. However, late stent thrombosis (LST) has likely been underrecognized clinically, and pathological descriptions are lacking...
  28. ncbi Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arterioscler Thromb Vasc Biol 22:1642-8. 2002
    ..The importance of the extracellular matrix molecules versican, biglycan, decorin, and hyaluronan in plaque instability has not been recognized...
  29. ncbi Superficial pseudoaneurysms: clinicopathologic aspects and involvement of extracellular matrix proteoglycans
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Mod Pathol 17:482-8. 2004
    ..The immunohistochemical studies confirm that versican is upregulated in areas of tensile stress. In addition, the presence of endothelial expression of decorin supports the concept of decorin's involvement in angiogenesis...
  30. ncbi Pathology of the unstable plaque
    Renu Virmani
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Prog Cardiovasc Dis 44:349-56. 2002
    ..The influence of risk factors for coronary artery disease on culprit lesion morphology is also discussed. Finally, the value of coronary calcification, as a predictor of unstable plaques in the clinical setting, is explored...
  31. doi PhotoPoint photodynamic therapy promotes stabilization of atherosclerotic plaques and inhibits plaque progression
    Ron Waksman
    Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    J Am Coll Cardiol 52:1024-32. 2008
    ..The purpose of this study was to determine how photodynamic therapy (PDT) promotes stabilization and reduction of regional atherosclerosis...
  32. ncbi Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:2019-23. 2002
    ..Elevations in serum C-reactive protein measured by high-sensitivity assay (hs-CRP) have been associated with unstable coronary syndromes. There have been no autopsy studies correlating hs-CRP to fatal coronary artery disease...
  33. ncbi Time course of stent endothelialization after intravascular radiation therapy in rabbit iliac arteries
    Edouard Cheneau
    Cardiovascular Research Institute, Washington Hospital Center, 110 Irving St, NW, Suite 4B 1, Washington, DC 20010, USA
    Circulation 107:2153-8. 2003
    ..Late total occlusion after vascular brachytherapy (VBT) continues to be a serious complication. Delayed reendothelialization was suggested as a pivotal cause, but the time course for complete healing is unknown...
  34. ncbi Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cardiovasc Pathol 14:150-5. 2005
    ..TTP may result in myocardial hemorrhages and rapid death. We compared rapidly fatal TTP with heart involvement and DIC cases to determine if the differential diagnosis of TTP and DIC could be aided by immunohistochemical techniques...
  35. ncbi Morphological predictors of arterial remodeling in coronary atherosclerosis
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Circulation 105:297-303. 2002
    ..Although arterial remodeling in atherosclerotic arteries affects luminal patency, the role of plaque components has not been systematically studied...
  36. ncbi Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel
    Frank D Kolodgie
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Circulation 106:1195-8. 2002
    ..The present study tested the efficacy of a novel systemic delivery nanoparticle PXL for reducing in-stent restenosis...
  37. ncbi Characterization of intimal changes in coronary artery specimens with MR microscopy
    Breno S Pessanha
    Department of Cardiovascular Pathology and Magnetic Resonance Microscopy Facility, Armed Forces Institute of Pathology, Washington, DC, USA
    Radiology 241:107-15. 2006
    ..To determine if magnetic resonance (MR) microscopy can yield images sufficient for discriminating early progressive atherosclerotic lesions from nonprogressive atherosclerotic lesions in human coronary arteries...
  38. ncbi Morphological predictors of restenosis after coronary stenting in humans
    Andrew Farb
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:2974-80. 2002
    ..Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis...
  39. ncbi Increased serum homocysteine and sudden death resulting from coronary atherosclerosis with fibrous plaques
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Arterioscler Thromb Vasc Biol 22:1936-41. 2002
    ..Modest elevations of total homocysteine have been associated with increased risk for coronary atherosclerosis but correlation between elevated homocysteine and plaque morphology has not been described in humans...
  40. ncbi A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases
    Aloke V Finn
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 0004 USA
    J Vasc Res 39:414-25. 2002
    ..In summary, vascular healing following carotid artery stenting in the rat parallels that of larger animals; however, it is accelerated relative to humans...
  41. ncbi Traditional risk factors and the incidence of sudden coronary death with and without coronary thrombosis in blacks
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Circulation 105:419-24. 2002
    ..Blacks have a high rate of sudden coronary death (SCD). We determined the rate of SCD in men and women 30 to 69 years of age in a 6-year period recorded at a state Medical Examiner's Office...
  42. ncbi Atherosclerotic plaque morphology and coronary thrombi
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Nucl Cardiol 9:95-103. 2002
  43. doi Postmortem confirmation of Lyme carditis with polymerase chain reaction
    Fabio Tavora
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Cardiovasc Pathol 17:103-7. 2008
    ..Cardiac involvement in Lyme disease is uncommon and typically manifests clinically by conduction disturbances. Postmortem identification of Borrelia burgdorferi has never been reported in a case of Lyme carditis...
  44. ncbi Role of SCN5A Y1102 polymorphism in sudden cardiac death in blacks
    Allen Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Circulation 112:798-802. 2005
    ..It has been linked to lethal arrhythmias in black families with ventricular tachycardia. The prevalence of the Y1102 polymorphism in a series of sudden death in blacks is unknown...
  45. ncbi Targeting of apoptotic macrophages and experimental atheroma with radiolabeled annexin V: a technique with potential for noninvasive imaging of vulnerable plaque
    Frank D Kolodgie
    Armed Forces Institute of Pathology, Washington, DC, USA
    Circulation 108:3134-9. 2003
    ..Because annexin V has a high affinity for exposed phosphatidylserine on apoptotic cells, radiolabeled annexin V may be used for noninvasive detection of apoptosis in atherosclerotic lesions...
  46. ncbi Left ventricular noncompaction: a pathological study of 14 cases
    Allen Burke
    Department of Cardiovasular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Hum Pathol 36:403-11. 2005
    ..A clear-cut morphological distinction between "isolated" and "secondary" LVNC was not apparent. The pathologist should be aware of the entity because the diagnosis is often first established at autopsy...
  47. ncbi Multiple spontaneous coronary artery dissections in association with anomalous origin of right coronary and intramural coronary artery dysplasia
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
    Cardiovasc Pathol 13:173-5. 2004
    ..The coincidence of multiple spontaneous coronary dissections, coronary arterial dysplasia, and anomalous origin of the right coronary artery is unique...
  48. ncbi 34th Bethesda Conference: Task force #2--What is the pathologic basis for new atherosclerosis imaging techniques?
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Building 54, Room 2005, 14th Street and Alaska Avenue NW, Washington, DC 20306 0001, USA
    J Am Coll Cardiol 41:1874-86. 2003
  49. doi Beta radiation for renal nerve denervation: initial feasibility and safety
    Ron Waksman
    Interventional Cardiology, Medstar Washington Hospital Center, Washington, DC, USA
    EuroIntervention 9:738-44. 2013
    ..The purpose of the present study was to assess the safety and feasibility of renal artery brachytherapy for sympathetic renal denervation...
  50. ncbi Adult cellular rhabdomyoma of the heart: a report of 3 cases
    Allen P Burke
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Hum Pathol 33:1092-7. 2002
    ..Although surgical excision was possible in all patients, long-term follow-up will be required to determine the true biologic behavior of these neoplasms...
  51. ncbi Infectious endocarditis due to Corynebacterium xerosis
    Breno Pessanha
    Department of Cardiovascular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cardiovasc Pathol 12:98-101. 2003
    ..While often considered a blood culture contaminant, serious infections by this organism have been reported. C. xerosis endocarditis is associated with poor outcomes that could be potentially improved by early recognition and treatment...
  52. pmc Pathologic Etiologies of Late and Very Late Stent Thrombosis following First-Generation Drug-Eluting Stent Placement
    Fumiyuki Otsuka
    Department of Cardiovascular Pathology, CVPath Institute Inc, 19 Firstfield Road, Gaithersburg, MD 20878, USA
    Thrombosis 2012:608593. 2012
    ....
  53. ncbi Vascular pathology of drug-eluting stents
    Gaku Nakazawa
    CVPath Institute, Inc, Gaithersburg, MD 20878, USA
    Herz 32:274-80. 2007
    ..Since the time course of complete healing with DES is unknown, the optimal duration of antiplatelet treatment remains to be determined...
  54. ncbi Engineering aspects of stents design and their translation into clinical practice
    Giuseppe Sangiorgi
    Ospedale San Raffaele, Via Olgettina 64, 20132 Milan, Italy
    Ann Ist Super Sanita 43:89-100. 2007
    ....
  55. ncbi Elimination of neoangiogenesis for plaque stabilization: is there a role for local drug therapy?
    Frank D Kolodgie
    CVPath Institute, Gaithersburg, Maryland, USA
    J Am Coll Cardiol 49:2093-101. 2007
    ..A multitargeted approach involving selective local antiangiogenic agents should contribute to prevention of plaque progression and its clinical consequences...
  56. ncbi A novel bioengineered small-caliber vascular graft incorporating heparin and sirolimus: excellent 6-month patency
    Yosuke Ishii
    Washington University School of Medicine, Barnes Jewish Hospital, Division of Cardiothoracic Surgery, St Louis, MO, USA
    J Thorac Cardiovasc Surg 135:1237-45; discussion 1245-6. 2008
    ..The objective of this study was to examine the in vivo biological performance and biomechanical characteristics of this graft...
  57. ncbi Vascular responses to drug eluting stents: importance of delayed healing
    Aloke V Finn
    CVPath Institute, Inc, 19 Firstfield, Road, Gaithersburg, MD 20878, USA
    Arterioscler Thromb Vasc Biol 27:1500-10. 2007
    ..Because the time course of complete healing with DES in man is unknown, the optimal duration of antiplatelet treatment remains to be determined...
  58. ncbi Angiographic and histological assessment of successfully treated late acute stent thrombosis secondary to a sirolimus-eluting stent
    Peter Barlis
    Department of Cardiology, Royal Brompton Hospital, Sydney Street, London, UK
    Eur Heart J 28:1675. 2007
  59. ncbi Effects of oral prednisone after stenting in a rabbit model of established atherosclerosis
    Flavio Ribichini
    Division of Cardiology of the Università di Verona, Ospedale Civile Maggiore, Verona, Italy
    J Am Coll Cardiol 50:176-85. 2007
    ..Natick, Massachusetts) on neointimal inhibition and vessel healing in an atherosclerotic rabbit model...
  60. ncbi Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes
    Sadako Motoyama
    Department of Cardiology, Fujita Health University, Toyoake, Japan
    J Am Coll Cardiol 50:319-26. 2007
    ..To evaluate the feasibility of noninvasive assessment of the characteristics of disrupted atherosclerotic plaques, the authors interrogated the culprit lesions in acute coronary syndromes (ACS) by multislice computed tomography (CT)...
  61. ncbi Frequency and distribution of thin-cap fibroatheroma and ruptured plaques in human coronary arteries: a pathologic study
    Pavan K Cheruvu
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 50:940-9. 2007
    ..Our purpose was to quantify the frequency and distribution of suspected vulnerable lesions, defined as thin-capped fibroatheroma (TCFA) and ruptured plaque, in human coronary artery autopsy specimens...
  62. ncbi The significance of preclinical evaluation of sirolimus-, paclitaxel-, and zotarolimus-eluting stents
    Gaku Nakazawa
    CVPath Institute Inc, Gaithersburg, Maryland 20878, USA
    Am J Cardiol 100:36M-44M. 2007
    ....
  63. doi Delayed arterial healing and increased late stent thrombosis at culprit sites after drug-eluting stent placement for acute myocardial infarction patients: an autopsy study
    Gaku Nakazawa
    CVPath Institute, Inc, 19 Firstfield Rd, Gaithersburg, MD 20878, USA
    Circulation 118:1138-45. 2008
    ..Using autopsy data, we evaluated the pathological responses of the stented segment in patients treated with DES for AMI and compared with patients with stable angina...
  64. doi Site-specific targeting of nanoparticle prednisolone reduces in-stent restenosis in a rabbit model of established atheroma
    Michael Joner
    Deutsches Herzzentrum Muenchen und Medizinische Klinik, Klinikum rechts der Isar, Muenchen, Germany
    Arterioscler Thromb Vasc Biol 28:1960-6. 2008
    ..This may allow for neointimal suppression via directed targeting to areas of injury at systemic concentrations low enough to avoid adverse side effects known to occur with oral delivery of steroids...
  65. ncbi A placebo controlled, dose-ranging, safety study of allogenic mesenchymal stem cells injected by endomyocardial delivery after an acute myocardial infarction
    Seyed M Hashemi
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Eur Heart J 29:251-9. 2008
    ..Although mesenchymal stem cells (MSCs) show promising signs in reducing myocardial infarct (MI) size, the safety of endomyocardial delivery and the most efficacious dose is unknown...
  66. ncbi Drug-eluting stent pathology--should we still be cautious?
    Gaku Nakazawa
    Nat Clin Pract Cardiovasc Med 5:1. 2008
  67. doi Endothelial cell recovery between comparator polymer-based drug-eluting stents
    Michael Joner
    German Heart Center, Munich, Germany
    J Am Coll Cardiol 52:333-42. 2008
    ..The purpose of this study was to assess trends in endothelial coverage and recovery among leading polymer-based drug-eluting stents (DES)...
  68. ncbi Systemic nanoparticle paclitaxel (nab-paclitaxel) for in-stent restenosis I (SNAPIST-I): a first-in-human safety and dose-finding study
    James Margolis
    Miami International Cardiology Consultants, Miami, Florida, USA
    Clin Cardiol 30:165-70. 2007
    ..Systemic treatment with a novel 130-nm, albumin-bound particle form of paclitaxel (nab-paclitaxel) has been shown to reduce restenosis in animals...
  69. ncbi Pathological correlates of late drug-eluting stent thrombosis: strut coverage as a marker of endothelialization
    Aloke V Finn
    Cardiac Unit, Department of Internal Medicine, Massachusetts General Hospital, Boston, USA
    Circulation 115:2435-41. 2007
    ..Although the clinical predictors of LST have been reported, specific morphological and histological correlates of LST remain unknown...
  70. ncbi Preclinical restenosis models and drug-eluting stents: still important, still much to learn
    Robert S Schwartz
    Minneapolis Heart Institute, Minneapolis, Minnesota 55407, USA
    J Am Coll Cardiol 44:1373-85. 2004
    ..Ongoing research into animal models will reconcile apparent differences with clinical trials and advance our understanding of how to apply animal models to clinical stenting in the era of DESs...
  71. ncbi Actinomycin-eluting stent for coronary revascularization: a randomized feasibility and safety study: the ACTION trial
    Patrick W Serruys
    Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 44:1363-7. 2004
    ..We sought to demonstrate the safety and performance of the actinomycin D-coated Multilink-Tetra stent(Guidant Corp., Santa Clara, California) in the treatment of patients with single de novo native coronary lesions...
  72. ncbi Images in cardiovascular medicine. Vascular healing 4 years after the implantation of sirolimus-eluting stent in humans: a histopathological examination
    J Eduardo Sousa
    Institute Dante Pazzanese of Cardiology, Sao Paulo, Brazil
    Circulation 110:e5-6. 2004
  73. ncbi Initial experience with the novel 6 Fr-compatible system for debulking de novo coronary arterial lesions
    Fumiaki Ikeno
    Stanford University Medical Center, Stanford, California, USA
    Catheter Cardiovasc Interv 62:308-17. 2004
    ..Quantitative angiographic and IVUS analysis indicate that this system can effectively debulk plaque from selected noncalcified atherosclerotic lesions and thus may represent an alternative treatment strategy for coronary artery disease...
  74. ncbi Drug-eluting versus bare metal coronary stents: long-term human pathology. Findings from different coronary arteries in the same patient
    Giulio Guagliumi
    Cardiovascular Department, Ospedali Riuniti, Bergamo, Italy
    Ital Heart J 4:713-20. 2003
    ..Scanning electron microscopy showed > 80% endothelialization of the stent. The 24-month-old RCA bare metal stent showed mild to moderate neointimal growth with > 90% endothelialization...
  75. ncbi Pilot study of oral rapamycin to prevent restenosis in patients undergoing coronary stent therapy: Argentina Single-Center Study (ORAR Trial)
    Alfredo E Rodriguez
    Cardiac Unit, Otamendi Hospital, Buenos Aires, Argentina centroceci sion com
    J Invasive Cardiol 15:581-4. 2003
    ..Higher therapeutic rapamycin blood levels were associated with a lower late loss and a trend toward a lower restenosis rate in de novo lesions...
  76. ncbi The black hole: echolucent tissue observed following intracoronary radiation
    I Patrick Kay
    Thoraxcenter, Rotterdam, The Netherlands
    Int J Cardiovasc Intervent 5:137-42. 2003
    ..The authors describe a new observation noted on intravascular ultrasound: that of intraluminal echolucent tissue, dubbed the 'black hole', noted at six-month follow-up...
  77. ncbi Collagenase plaque digestion for facilitating guide wire crossing in chronic total occlusions
    Bradley H Strauss
    Roy and Ann Foss Interventional Cardiology Research Program, Terrence Donnelly Heart Center, St Michael s Hospital, Toronto, Ontario, Canada
    Circulation 108:1259-62. 2003
    ..Collagen is the predominant component of the atherosclerotic plaque. The objective of this study was to determine the efficacy and toxicity of local delivery of a collagen-degrading enzyme to facilitate guide wire crossing in CTO...
  78. ncbi Images in cardiovascular medicine. Sirolimus-eluting stent implanted in human coronary artery for 16 months: pathological findings
    Giulio Guagliumi
    Cardiovascular Department, Ospedali Riuniti di Bergamo, Bergamo, Italy
    Circulation 107:1340-1. 2003
  79. ncbi Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group
    Robert S Schwartz
    Minnesota Cardiovascular Research Institute and Minneapolis Heart Institute Foundation Minneapolis, 55407, USA
    Circulation 106:1867-73. 2002
  80. ncbi Preclinical evaluation of drug-eluting stents for peripheral applications: recommendations from an expert consensus group
    Robert S Schwartz
    Minneapolis Heart Institute Foundation, Minnesota Cardiovascular Research Institute, 920 E 28th St, Minneapolis, MN 55407, USA
    Circulation 110:2498-505. 2004
  81. ncbi Particle debris from a nanoporous stent coating obscures potential antiproliferative effects of tacrolimus-eluting stents in a porcine model of restenosis
    Marc Kollum
    Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany
    Catheter Cardiovasc Interv 64:85-90. 2005
    ..Alternatively, omission of any coating used as a drug reservoir may eliminate inflammatory particle debris after placement of drug-eluting stents...
  82. ncbi Drug-eluting stent and coronary thrombosis: biological mechanisms and clinical implications
    Thomas F Luscher
    Cardiovascular Center, University of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Circulation 115:1051-8. 2007
    ..The present review focuses on the pathophysiological mechanisms and pathological findings of stent thrombosis in DES...
  83. ncbi Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
    ..This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST)...
  84. ncbi Experimental efficacy of an everolimus eluting cobalt chromium stent
    Andrew J Carter
    Medical Device Research Laboratory, Borgess Medical Center, Kalamazoo, MI 49048, USA
    Catheter Cardiovasc Interv 68:97-103. 2006
    ..Rapamycin and its analogs are now being coated on different stent platforms, using different polymer matrices to prevent restenosis by impairing vascular smooth muscle cell proliferation and neointimal formation...
  85. ncbi A novel paclitaxel-eluting porous carbon-carbon nanoparticle coated, nonpolymeric cobalt-chromium stent: evaluation in a porcine model
    Balram Bhargava
    All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Catheter Cardiovasc Interv 67:698-702. 2006
    ..We aimed to evaluate the response of porcine coronary arteries to a novel paclitaxel-eluting porous carbon-carbon nanoparticle coated, nonpolymeric cobalt chromium stent...
  86. ncbi First experimental application of bevacizumab-eluting PC coated stent for inhibition of vasa vasorum of atherosclerotic plaque: angiographic results in a rabbit atheromatic model
    Christodoulos Stefanadis
    First Department of Cardiology, Hippokration Hospital, Athens Medical School, Greece
    Hellenic J Cardiol 47:7-10. 2006
    ..We hypothesized that local delivery of bevacizumab by stent would inhibit the development of vasa vasorum at the stented arterial segment in an atheromatic rabbit model...
  87. ncbi Hypersensitivity cases associated with drug-eluting coronary stents: a review of available cases from the Research on Adverse Drug Events and Reports (RADAR) project
    Jonathan R Nebeker
    Veterans Administration Salt Lake City, Salt Lake City, Utah, USA
    J Am Coll Cardiol 47:175-81. 2006
    ..We undertook the review of all available cases of hypersensitivity reactions after placement of a drug-eluting stent (DES) and classified potential causes...
  88. ncbi Histology of in-stent restenosis in a transplanted heart
    Peter N Ruygrok
    Cardiology Department, Green Lane Hospital, Auckland, New Zealand
    J Heart Lung Transplant 23:143-6. 2004
    ..She remains well 1 year after a second heart transplant operation...
  89. ncbi Evaluation of a novel endoluminal vascular occlusion device in a porcine model: early and late follow-up
    Nicholas Kipshidze
    Department of Interventional Cardiac and Vascular Services, Lenox Hill Hospital, New York, New York 10021, USA
    J Endovasc Ther 12:486-94. 2005
    ..To evaluate the efficacy of a new vascular occlusion device (VOD) in a preclinical controlled study versus embolization coils...
  90. ncbi Differential response of delayed healing and persistent inflammation at sites of overlapping sirolimus- or paclitaxel-eluting stents
    Aloke V Finn
    CVPath, International Registry of Pathology, Gaithersburg, MD 20878, USA
    Circulation 112:270-8. 2005
    ..Although effective coverage of challenging coronary lesions has warranted the use of overlapping drug-eluting stents, the histopathological response to stent overlap is unknown...
  91. ncbi Stent-based delivery of ABT-578 via a phosphorylcholine surface coating reduces neointimal formation in the porcine coronary model
    Robin Collingwood
    Medical Device Research Laboratory, Borgess Medical Center, Kalamazoo, Michigan 49024, USA
    Catheter Cardiovasc Interv 65:227-32. 2005
    ..Further study is necessary to determine the dose-response and long-term effects ABT-578-eluting stents in the porcine coronary model...
  92. ncbi Biocompatibility and performance of the Wallstent and the Wallgraft, Jostent, and Hemobahn stent-grafts in a sheep model
    Manfred Cejna
    Department of Radiology, University of Vienna, Austria
    J Vasc Interv Radiol 13:823-30. 2002
    ..Three recently developed stent-grafts and the Wallstent were compared directly in an ovine animal model with regard to performance and biocompatibility...

Research Grants9

  1. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 2001
    ..In addition, analysis of plaque morphology in the animal model proposed in Project 4 will be carried out in project 1. ..
  2. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 1999
    ..In addition, analysis of plaque morphology in the animal model proposed in Project 4 will be carried out in project 1. ..
  3. CHOLESTEROL & PLAQUE RUPTURE--WOMEN AND PLAQUE EROSION
    Renu Virmani; Fiscal Year: 2000
    ..In addition, analysis of plaque morphology in the animal model proposed in Project 4 will be carried out in project 1. ..
  4. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2002
    ..abstract_text> ..
  5. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2003
    ..abstract_text> ..
  6. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2004
    ..abstract_text> ..
  7. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2005
    ..abstract_text> ..
  8. Plaque Progression, Apoptosis and Inflammation
    Renu Virmani; Fiscal Year: 2005
    ..abstract_text> ..