JEFFERY TAUBENBERGER

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  2. ncbi request reprint Diagnosis of influenza virus: coming to grips with the molecular era
    J K Taubenberger
    Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD 20850 3125, USA
    Mol Diagn 6:291-305. 2001
  3. pmc Molecular genetic evidence of a novel morbillivirus in a long-finned pilot whale (Globicephalus melas)
    J K Taubenberger
    Armed Forces Institute of Pathology, Washington, D C, USA
    Emerg Infect Dis 6:42-5. 2000
  4. pmc Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virus
    J K Taubenberger
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Room 1057D, Building 101, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
    Philos Trans R Soc Lond B Biol Sci 356:1829-39. 2001
  5. ncbi request reprint Postmortem diagnosis of morbillivirus infection in bottlenose dolphins (Tursiops truncatus) in the Atlantic and Gulf of Mexico epizootics by polymerase chain reaction-based assay
    A Krafft
    Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, D C 20306, USA
    J Wildl Dis 31:410-5. 1995
  6. ncbi request reprint Morbilliviral epizootic in bottlenose dolphins of the Gulf of Mexico
    T P Lipscomb
    Armed Forces Institute of Pathology, Department of Veterinary Pathology, Washington, DC 20306, USA
    J Vet Diagn Invest 8:283-90. 1996
  7. pmc Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification
    A E Krafft
    Department of Molecular Pathology, Armed Forces Institute of Pathology, 1413 Research Blvd, Rockville, MD 20850 3125, USA
    J Clin Microbiol 43:1768-75. 2005
  8. ncbi request reprint Morbilliviral dermatitis in seals
    T P Lipscomb
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 38:724-6. 2001
  9. ncbi request reprint Cutaneous follicle center lymphoma: a clinicopathologic study of 19 cases
    N S Aguilera
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Mod Pathol 14:828-35. 2001
  10. ncbi request reprint The 1918 Spanish influenza: integrating history and biology
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue N W, DC 20306 6000, USA
    Microbes Infect 3:81-7. 2001

Research Grants

  1. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2002
  2. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2003
  3. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2004
  4. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2005
  5. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2006

Collaborators

Detail Information

Publications66

  1. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  2. ncbi request reprint Diagnosis of influenza virus: coming to grips with the molecular era
    J K Taubenberger
    Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD 20850 3125, USA
    Mol Diagn 6:291-305. 2001
    ..RT-PCR for influenza also can be performed from tissue biopsy specimens for both retrospective diagnosis and research...
  3. pmc Molecular genetic evidence of a novel morbillivirus in a long-finned pilot whale (Globicephalus melas)
    J K Taubenberger
    Armed Forces Institute of Pathology, Washington, D C, USA
    Emerg Infect Dis 6:42-5. 2000
    ..Novel sequences most closely related to, but distinct from, those of dolphin and porpoise morbilliviruses suggest that this virus may represent a third member of the cetacean morbillivirus group...
  4. pmc Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virus
    J K Taubenberger
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Room 1057D, Building 101, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
    Philos Trans R Soc Lond B Biol Sci 356:1829-39. 2001
    ..This information should help to elucidate how pandemic influenza strains emerge and what genetic features contribute to their virulence...
  5. ncbi request reprint Postmortem diagnosis of morbillivirus infection in bottlenose dolphins (Tursiops truncatus) in the Atlantic and Gulf of Mexico epizootics by polymerase chain reaction-based assay
    A Krafft
    Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, D C 20306, USA
    J Wildl Dis 31:410-5. 1995
    ..Application of this method to autolyzed post-mortem tissues allows diagnoses of morbillivirus infection to be made in specimens which cannot be evaluated by histologic and immunocytochemical techniques...
  6. ncbi request reprint Morbilliviral epizootic in bottlenose dolphins of the Gulf of Mexico
    T P Lipscomb
    Armed Forces Institute of Pathology, Department of Veterinary Pathology, Washington, DC 20306, USA
    J Vet Diagn Invest 8:283-90. 1996
    ..Concomitant pulmonary aspergillosis was diagnosed histologically in 4 dolphins. This is the 5th reported morbilliviral epizootic of aquatic mammals and the 2nd involving bottlenose dolphins in the United States...
  7. pmc Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identification
    A E Krafft
    Department of Molecular Pathology, Armed Forces Institute of Pathology, 1413 Research Blvd, Rockville, MD 20850 3125, USA
    J Clin Microbiol 43:1768-75. 2005
    ..Lower specificities of the real-time assays corresponded to the increased detection of PCR-positive but culture-negative specimens. Influenza virus RNA was detected as well or better after 6 months of storage in ethanol...
  8. ncbi request reprint Morbilliviral dermatitis in seals
    T P Lipscomb
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 38:724-6. 2001
    ..This is the first report of morbilliviral dermatitis in marine mammals...
  9. ncbi request reprint Cutaneous follicle center lymphoma: a clinicopathologic study of 19 cases
    N S Aguilera
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Mod Pathol 14:828-35. 2001
    ..Follow-up showed no evidence of disease in 14/17 patients (4 to 137 mos). 3/17 patients are alive with disease (17 to 100 mo), and no patients died of disease...
  10. ncbi request reprint The 1918 Spanish influenza: integrating history and biology
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue N W, DC 20306 6000, USA
    Microbes Infect 3:81-7. 2001
    ..In 1918 an influenza pandemic killed 40 million people. It is now possible to study the genetic features of the 1918 virus. Such analyses will try to answer questions about the origin and the unusual virulence of this pandemic virus...
  11. ncbi request reprint Quantitative real-time reverse transcription-PCR assay for cyclin D1 expression: utility in the diagnosis of mantle cell lymphoma
    K E Bijwaard
    Department of Cellular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306 6000, USA
    Clin Chem 47:195-201. 2001
    ..Quantification of cyclin D1 expression can distinguish MCL from other lymphomas...
  12. ncbi request reprint Common metastatic carcinoma of California sea lions (Zalophus californianus): evidence of genital origin and association with novel gammaherpesvirus
    T P Lipscomb
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 37:609-17. 2000
    ..These findings support the genital origin of the sea lion carcinoma and implicate a novel gammaherpesvirus as a possible cause...
  13. ncbi request reprint Initial genetic characterization of the 1918 "Spanish" influenza virus
    J K Taubenberger
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Science 275:1793-6. 1997
    ..The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup...
  14. ncbi request reprint Histologic, immunohistochemical, and polymerase chain reaction studies of bottlenose dolphins from the 1987-1988 United States Atlantic coast epizootic
    F Y Schulman
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 34:288-95. 1997
    ..Histologic, immunohistochemical, and PCR results provide strong evidence that morbillivirus infection was the primary cause of the 1987-1988 bottlenose dolphin epizootic...
  15. pmc Loss of heterozygosity on chromosome 11p15 during histological progression in microdissected ductal carcinoma of the breast
    J H Lichy
    Molecular Pathology Division, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Pathol 153:271-8. 1998
    ..We conclude that 11p15 LOH usually occurs early in breast cancer development but less frequently does not develop until the infiltrating or metastatic stages of tumor progression...
  16. pmc Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin gene
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Proc Natl Acad Sci U S A 96:1651-6. 1999
    ..Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918...
  17. ncbi request reprint Genetic heterogeneity in ductal carcinoma of the breast
    J H Lichy
    Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 80:291-301. 2000
    ..The results indicate that the different tumor components observed microscopically in breast cancer specimens often represent genetically divergent clones...
  18. pmc Characterization of the 1918 "Spanish" influenza virus neuraminidase gene
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Proc Natl Acad Sci U S A 97:6785-90. 2000
    ..Phylogenetically, the 1918 neuraminidase gene appears to be intermediate between mammals and birds, suggesting that it was introduced into mammals just before the 1918 pandemic...
  19. ncbi request reprint Influenza A virus neuraminidase: regions of the protein potentially involved in virus-host interactions
    T G Fanning
    Division of Molecular Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306 6000, USA
    Virology 276:417-23. 2000
    ..Many PIRs are coincident with antigenic or glycosylation sites. Other PIRs may represent additional antigenic sites or may be involved in other aspects of virus-host biology...
  20. ncbi request reprint Relationship of pre-1918 avian influenza HA and NP sequences to subsequent avian influenza strains
    A H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Room 1057D, Rockville, MD 20850 3125, USA
    Avian Dis 47:921-5. 2003
    ..The 1917 avian NP sequences are also closely related to modern avian sequences and distinct from the mammalian clade in which the 1918 NP sequence is found...
  21. ncbi request reprint Influenza RNA not detected in archival brain tissues from acute encephalitis lethargica cases or in postencephalitic Parkinson cases
    S McCall
    FDepartment of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
    J Neuropathol Exp Neurol 60:696-704. 2001
    ..Thus, it is unlikely that the 1918 influenza virus was neurotropic and directly responsible for the outbreak of EL...
  22. ncbi request reprint Experimenting on the past: the enigma of von Economo's encephalitis lethargica
    A H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
    J Neuropathol Exp Neurol 60:663-70. 2001
    ..Similarly, tissue samples from EL victims can now be examined for evidence of infection by the 1918 influenza virus...
  23. ncbi request reprint Heading off an influenza pandemic
    Edward C Holmes
    Science 309:989. 2005
  24. ncbi request reprint Characterization of the 1918 influenza virus polymerase genes
    Jeffery K Taubenberger
    Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
    Nature 437:889-93. 2005
    ..The sequence changes identified here may be important in the adaptation of influenza viruses to humans...
  25. pmc 1918 Influenza: the mother of all pandemics
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    Emerg Infect Dis 12:15-22. 2006
    ..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis...
  26. ncbi request reprint Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    James Stevens
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:404-10. 2006
    ....
  27. pmc Influenza revisited
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland, USA
    Emerg Infect Dis 12:1-2. 2006
  28. ncbi request reprint Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Science 310:77-80. 2005
    ..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
  29. pmc Stochastic processes are key determinants of short-term evolution in influenza a virus
    Martha I Nelson
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 2:e125. 2006
    ..Thus, predicting future patterns of influenza virus evolution for vaccine strain selection is inherently complex and requires intensive surveillance, whole-genome sequencing, and phenotypic analysis...
  30. ncbi request reprint Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCR
    Atif A Ahmed
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Dev Pathol 9:488-95. 2006
    ..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies...
  31. pmc The next influenza pandemic: can it be predicted?
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2520, USA
    JAMA 297:2025-7. 2007
  32. pmc The origin and virulence of the 1918 "Spanish" influenza virus
    Jeffery K Taubenberger
    Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
    Proc Am Philos Soc 150:86-112. 2006
    ..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans...
  33. pmc Discovery and characterization of the 1918 pandemic influenza virus in historical context
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 12:581-91. 2007
    ....
  34. pmc Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird feces
    David L Evers
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Avian Dis 51:965-8. 2007
    ..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers...
  35. pmc Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR method
    Ruixue Wang
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 375:182-9. 2008
    ..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds...
  36. pmc The genomic and epidemiological dynamics of human influenza A virus
    Andrew Rambaut
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Nature 453:615-9. 2008
    ..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions...
  37. pmc Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918
    Martha I Nelson
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 4:e1000012. 2008
    ..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized...
  38. pmc The evolutionary genetics and emergence of avian influenza viruses in wild birds
    Vivien G Dugan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000076. 2008
    ....
  39. pmc Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS Biol 3:e300. 2005
    ....
  40. ncbi request reprint Capturing a killer flu virus
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, MD, USA
    Sci Am 292:48-57. 2005
  41. pmc Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reaction
    Karen E Bijwaard
    Division of Molecular Pathology, the Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
    J Mol Diagn 4:59-64. 2002
    ..All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. This method is a relatively simple and rapid procedure for the detection of the t(X;18)(p11.2;q11.2)...
  42. pmc 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds
    Thomas G Fanning
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:7860-2. 2002
    ....
  43. pmc Characterization of the 1918 "Spanish" influenza virus matrix gene segment
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:10717-23. 2002
    ....
  44. pmc Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 99:13849-54. 2002
    ..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus...
  45. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
    ..All data from this project are being deposited, without delay, in public archives...
  46. ncbi request reprint The origin of the 1918 pandemic influenza virus: a continuing enigma
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850 3125, USA
    J Gen Virol 84:2285-92. 2003
    ..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts...
  47. ncbi request reprint Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore
    Teri J Franks
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
    Hum Pathol 34:743-8. 2003
    ..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD...
  48. ncbi request reprint Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:1866-70. 2004
    ....
  49. pmc Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 101:3166-71. 2004
    ..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus...
  50. pmc Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 78:9499-511. 2004
    ..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections...
  51. ncbi request reprint Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
    Nat Rev Microbiol 2:909-14. 2004
    ..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts...
  52. pmc Influenza and the origins of The Philips Collection, Washington, DC
    David M Morens
    National Institutes of Health, Bethesda, MD, USA
    Emerg Infect Dis 12:78-80. 2006
  53. pmc Pandemic and seasonal influenza: therapeutic challenges
    Matthew J Memoli
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Drug Discov Today 13:590-5. 2008
    ....
  54. pmc The relationship between encephalitis lethargica and influenza: a critical analysis
    Sherman McCall
    Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Neurovirol 14:177-85. 2008
    ..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic...
  55. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  56. ncbi request reprint Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditis
    Paul C McGovern
    Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 21:290-3. 2002
    ..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place...
  57. ncbi request reprint Serial analysis of gene expression in murine fetal thymocyte cell lines
    Feng qi Zhao
    Molecular Pathology Division, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
    Int Immunol 14:1383-95. 2002
    ..These genes, and others identified by this analysis, are likely to play important roles in the development of T cells...
  58. pmc Homologous recombination is very rare or absent in human influenza A virus
    Maciej F Boni
    Resources for the Future, 1616 P St NW, Washington, DC 20036, USA
    J Virol 82:4807-11. 2008
    ..We therefore conclude that, if it occurs at all, homologous recombination plays only a very minor role in the evolution of human influenza A virus...
  59. pmc Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    Gary K Geiss
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:10736-41. 2002
    ....
  60. pmc Novel origin of the 1918 pandemic influenza virus nucleoprotein gene
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850 3125, USA
    J Virol 78:12462-70. 2004
    ....
  61. pmc The pathology of influenza virus infections
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Pathol 3:499-522. 2008
    ....
  62. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  63. ncbi request reprint Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1143-55. 2006
    ..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza...
  64. ncbi request reprint Fixed and frozen flu: the 1918 influenza and lessons for the future
    Jeffery K Taubenberger
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
    Avian Dis 47:789-91. 2003
  65. pmc Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 443:578-81. 2006
    ..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies...
  66. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...

Research Grants5

  1. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2002
    ....
  2. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2003
    ....
  3. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2004
    ....
  4. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2005
    ....
  5. Complete Characterization of the 1918 Influenza Virus
    JEFFERY TAUBENBERGER; Fiscal Year: 2006
    ....