Research Topics
| JEFFERY TAUBENBERGERSummaryAffiliation: Armed Forces Institute of Pathology Country: USA Publications
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Publications
Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virusJ K Taubenberger
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Room 1057D, Building 101, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
Philos Trans R Soc Lond B Biol Sci 356:1829-39. 2001..This information should help to elucidate how pandemic influenza strains emerge and what genetic features contribute to their virulence...
Diagnosis of influenza virus: coming to grips with the molecular eraJ K Taubenberger
Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD 20850 3125, USA
Mol Diagn 6:291-305. 2001..RT-PCR for influenza also can be performed from tissue biopsy specimens for both retrospective diagnosis and research...- Molecular genetic evidence of a novel morbillivirus in a long-finned pilot whale (Globicephalus melas)J K Taubenberger
Armed Forces Institute of Pathology, Washington, D C, USA
Emerg Infect Dis 6:42-5. 2000..Novel sequences most closely related to, but distinct from, those of dolphin and porpoise morbilliviruses suggest that this virus may represent a third member of the cetacean morbillivirus group... - Postmortem diagnosis of morbillivirus infection in bottlenose dolphins (Tursiops truncatus) in the Atlantic and Gulf of Mexico epizootics by polymerase chain reaction-based assayA Krafft
Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, D C 20306, USA
J Wildl Dis 31:410-5. 1995..Application of this method to autolyzed post-mortem tissues allows diagnoses of morbillivirus infection to be made in specimens which cannot be evaluated by histologic and immunocytochemical techniques... - Morbilliviral epizootic in bottlenose dolphins of the Gulf of MexicoT P Lipscomb
Armed Forces Institute of Pathology, Department of Veterinary Pathology, Washington, DC 20306, USA
J Vet Diagn Invest 8:283-90. 1996..Concomitant pulmonary aspergillosis was diagnosed histologically in 4 dolphins. This is the 5th reported morbilliviral epizootic of aquatic mammals and the 2nd involving bottlenose dolphins in the United States... - The 1918 Spanish influenza: integrating history and biologyA H Reid
Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue N W, DC 20306 6000, USA
Microbes Infect 3:81-7. 2001..In 1918 an influenza pandemic killed 40 million people. It is now possible to study the genetic features of the 1918 virus. Such analyses will try to answer questions about the origin and the unusual virulence of this pandemic virus... - Cutaneous follicle center lymphoma: a clinicopathologic study of 19 casesN S Aguilera
Department of Hematopathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
Mod Pathol 14:828-35. 2001..Follow-up showed no evidence of disease in 14/17 patients (4 to 137 mos). 3/17 patients are alive with disease (17 to 100 mo), and no patients died of disease... - Morbilliviral dermatitis in sealsT P Lipscomb
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Vet Pathol 38:724-6. 2001..This is the first report of morbilliviral dermatitis in marine mammals... - Evaluation of PCR testing of ethanol-fixed nasal swab specimens as an augmented surveillance strategy for influenza virus and adenovirus identificationA E Krafft
Department of Molecular Pathology, Armed Forces Institute of Pathology, 1413 Research Blvd, Rockville, MD 20850 3125, USA
J Clin Microbiol 43:1768-75. 2005..Lower specificities of the real-time assays corresponded to the increased detection of PCR-positive but culture-negative specimens. Influenza virus RNA was detected as well or better after 6 months of storage in ethanol... - Quantitative real-time reverse transcription-PCR assay for cyclin D1 expression: utility in the diagnosis of mantle cell lymphomaK E Bijwaard
Department of Cellular Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306 6000, USA
Clin Chem 47:195-201. 2001..Quantification of cyclin D1 expression can distinguish MCL from other lymphomas... - Common metastatic carcinoma of California sea lions (Zalophus californianus): evidence of genital origin and association with novel gammaherpesvirusT P Lipscomb
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Vet Pathol 37:609-17. 2000..These findings support the genital origin of the sea lion carcinoma and implicate a novel gammaherpesvirus as a possible cause... - Influenza A virus neuraminidase: regions of the protein potentially involved in virus-host interactionsT G Fanning
Division of Molecular Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306 6000, USA
Virology 276:417-23. 2000..Many PIRs are coincident with antigenic or glycosylation sites. Other PIRs may represent additional antigenic sites or may be involved in other aspects of virus-host biology... - Initial genetic characterization of the 1918 "Spanish" influenza virusJ K Taubenberger
Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
Science 275:1793-6. 1997..The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup... - Histologic, immunohistochemical, and polymerase chain reaction studies of bottlenose dolphins from the 1987-1988 United States Atlantic coast epizooticF Y Schulman
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Vet Pathol 34:288-95. 1997..Histologic, immunohistochemical, and PCR results provide strong evidence that morbillivirus infection was the primary cause of the 1987-1988 bottlenose dolphin epizootic... - Loss of heterozygosity on chromosome 11p15 during histological progression in microdissected ductal carcinoma of the breastJ H Lichy
Molecular Pathology Division, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Am J Pathol 153:271-8. 1998..We conclude that 11p15 LOH usually occurs early in breast cancer development but less frequently does not develop until the infiltrating or metastatic stages of tumor progression... - Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin geneA H Reid
Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Proc Natl Acad Sci U S A 96:1651-6. 1999..Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918... - Genetic heterogeneity in ductal carcinoma of the breastJ H Lichy
Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Lab Invest 80:291-301. 2000..The results indicate that the different tumor components observed microscopically in breast cancer specimens often represent genetically divergent clones... - Characterization of the 1918 "Spanish" influenza virus neuraminidase geneA H Reid
Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Proc Natl Acad Sci U S A 97:6785-90. 2000..Phylogenetically, the 1918 neuraminidase gene appears to be intermediate between mammals and birds, suggesting that it was introduced into mammals just before the 1918 pandemic... - Relationship of pre-1918 avian influenza HA and NP sequences to subsequent avian influenza strainsA H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Room 1057D, Rockville, MD 20850-3125, USA
Avian Dis 47:921-5. 2003..The 1917 avian NP sequences are also closely related to modern avian sequences and distinct from the mammalian clade in which the 1918 NP sequence is found... - Influenza RNA not detected in archival brain tissues from acute encephalitis lethargica cases or in postencephalitic Parkinson casesS McCall
FDepartment of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
J Neuropathol Exp Neurol 60:696-704. 2001..Thus, it is unlikely that the 1918 influenza virus was neurotropic and directly responsible for the outbreak of EL... - Experimenting on the past: the enigma of von Economo's encephalitis lethargicaA H Reid
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
J Neuropathol Exp Neurol 60:663-70. 2001..Similarly, tissue samples from EL victims can now be examined for evidence of infection by the 1918 influenza virus... - Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 virusesEdward C Holmes
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
PLoS Biol 3:e300. 2005.... - Heading off an influenza pandemicEdward C Holmes
Science 309:989. 2005 - Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus... - 1918 Influenza: the mother of all pandemicsJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
Emerg Infect Dis 12:15-22. 2006..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis... - Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virusJames Stevens
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 312:404-10. 2006.... - Influenza revisitedJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland, USA
Emerg Infect Dis 12:1-2. 2006 - Characterization of the 1918 influenza virus polymerase genesJeffery K Taubenberger
Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
Nature 437:889-93. 2005..The sequence changes identified here may be important in the adaptation of influenza viruses to humans... - Stochastic processes are key determinants of short-term evolution in influenza a virusMartha I Nelson
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
PLoS Pathog 2:e125. 2006..Thus, predicting future patterns of influenza virus evolution for vaccine strain selection is inherently complex and requires intensive surveillance, whole-genome sequencing, and phenotypic analysis... - Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCRAtif A Ahmed
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Pediatr Dev Pathol 9:488-95. 2006..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies... - The next influenza pandemic: can it be predicted?Jeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2520, USA
JAMA 297:2025-7. 2007 - The origin and virulence of the 1918 "Spanish" influenza virusJeffery K Taubenberger
Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
Proc Am Philos Soc 150:86-112. 2006..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans... - Discovery and characterization of the 1918 pandemic influenza virus in historical contextJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Antivir Ther 12:581-91. 2007.... - Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird fecesDavid L Evers
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Avian Dis 51:965-8. 2007..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers... - Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR methodRuixue Wang
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 375:182-9. 2008..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds... - The genomic and epidemiological dynamics of human influenza A virusAndrew Rambaut
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
Nature 453:615-9. 2008..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions... - Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918Martha I Nelson
Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
PLoS Pathog 4:e1000012. 2008..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized... - The evolutionary genetics and emergence of avian influenza viruses in wild birdsVivien G Dugan
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 4:e1000076. 2008.... - Capturing a killer flu virusJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, MD, USA
Sci Am 292:48-57. 2005 - 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variantsAnn H Reid
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850-3125, USA
Emerg Infect Dis 9:1249-53. 2003 - Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from SingaporeTeri J Franks
Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
Hum Pathol 34:743-8. 2003..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD... - The origin of the 1918 pandemic influenza virus: a continuing enigmaAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850-3125, USA
J Gen Virol 84:2285-92. 2003..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts... - Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolutionElodie Ghedin
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
Nature 437:1162-6. 2005..All data from this project are being deposited, without delay, in public archives... - Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 99:13849-54. 2002..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus... - Characterization of the 1918 "Spanish" influenza virus matrix gene segmentAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:10717-23. 2002.... - 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birdsThomas G Fanning
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:7860-2. 2002.... - Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reactionKaren E Bijwaard
Division of Molecular Pathology, the Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
J Mol Diagn 4:59-64. 2002..All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. This method is a relatively simple and rapid procedure for the detection of the t(X;18)(p11.2;q11.2)... - Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virusJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:1866-70. 2004.... - Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 101:3166-71. 2004..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus... - Evidence of an absence: the genetic origins of the 1918 pandemic influenza virusAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
Nat Rev Microbiol 2:909-14. 2004..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts... - Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virusJohn C Kash
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
J Virol 78:9499-511. 2004..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections... - Influenza and the origins of The Philips Collection, Washington, DCDavid M Morens
National Institutes of Health, Bethesda, MD, USA
Emerg Infect Dis 12:78-80. 2006 - A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificityLaurel Glaser
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 79:11533-6. 2005..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor... - Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditisPaul C McGovern
Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
J Heart Lung Transplant 21:290-3. 2002..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place... - Novel origin of the 1918 pandemic influenza virus nucleoprotein geneAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850-3125, USA
J Virol 78:12462-70. 2004.... - The relationship between encephalitis lethargica and influenza: a critical analysisSherman McCall
Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
J Neurovirol 14:177-85. 2008..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic... - Pandemic and seasonal influenza: therapeutic challengesMatthew J Memoli
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Drug Discov Today 13:590-5. 2008.... - Homologous recombination is very rare or absent in human influenza A virusMaciej F Boni
Resources for the Future, 1616 P St NW, Washington, DC 20036, USA
J Virol 82:4807-11. 2008..We therefore conclude that, if it occurs at all, homologous recombination plays only a very minor role in the evolution of human influenza A virus... - Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenzaGary K Geiss
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 99:10736-41. 2002.... - Serial analysis of gene expression in murine fetal thymocyte cell linesFeng-Qi Zhao
Molecular Pathology Division, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
Int Immunol 14:1383-95. 2002..These genes, and others identified by this analysis, are likely to play important roles in the development of T cells... - The pathology of influenza virus infectionsJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Annu Rev Pathol 3:499-522. 2008.... - Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005.... - Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificitiesJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 355:1143-55. 2006..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza... - Fixed and frozen flu: the 1918 influenza and lessons for the futureJeffery K Taubenberger
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850-3125, USA
Avian Dis 47:789-91. 2003 - Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virusJohn C Kash
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nature 443:578-81. 2006..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies... - Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparednessDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 198:962-70. 2008..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
Research Grants
- Complete Characterization of the 1918 Influenza VirusJEFFERY TAUBENBERGER; Fiscal Year: 2006....