Research Topics
| Jeffery K TaubenbergerSummaryAffiliation: Armed Forces Institute of Pathology Country: USA Publications
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Detail Information
Publications
1918 Influenza: the mother of all pandemicsJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
Emerg Infect Dis 12:15-22. 2006..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis...
Characterization of the 1918 influenza virus polymerase genesJeffery K Taubenberger
Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
Nature 437:889-93. 2005..The sequence changes identified here may be important in the adaptation of influenza viruses to humans...- Influenza revisitedJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland, USA
Emerg Infect Dis 12:1-2. 2006 - Capturing a killer flu virusJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, MD, USA
Sci Am 292:48-57. 2005 - Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolutionElodie Ghedin
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
Nature 437:1162-6. 2005..All data from this project are being deposited, without delay, in public archives... - The evolutionary genetics and emergence of avian influenza viruses in wild birdsVivien G Dugan
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
PLoS Pathog 4:e1000076. 2008.... - Evidence of an absence: the genetic origins of the 1918 pandemic influenza virusAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
Nat Rev Microbiol 2:909-14. 2004..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts... - 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variantsAnn H Reid
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850-3125, USA
Emerg Infect Dis 9:1249-53. 2003 - Novel origin of the 1918 pandemic influenza virus nucleoprotein geneAnn H Reid
Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850-3125, USA
J Virol 78:12462-70. 2004.... - Characterization of the 1918 "Spanish" influenza virus matrix gene segmentAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:10717-23. 2002.... - The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymeraseBrett W Jagger
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
MBio 1:. 2010.... - 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birdsThomas G Fanning
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:7860-2. 2002.... - Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in miceLi Qi
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:9211-20. 2012..While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus... - Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from SingaporeTeri J Franks
Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
Hum Pathol 34:743-8. 2003..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD... - The origin of the 1918 pandemic influenza virus: a continuing enigmaAnn H Reid
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850-3125, USA
J Gen Virol 84:2285-92. 2003..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts... - Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responsesJohn C Kash
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
MBio 2:. 2011..This study reveals that the extent of lung damage during viral infection influences the severity of secondary bacterial infections and may help explain some differences in mortality during influenza pandemics... - The 1918 influenza pandemic: lessons for 2009 and the futureDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Crit Care Med 38:e10-20. 2010..Thus, we must remain vigilant and use the knowledge we have gained from 1918 and other influenza pandemics to direct targeted research and pandemic influenza preparedness planning, emphasizing prevention, containment, and treatment... - Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reactionKaren E Bijwaard
Division of Molecular Pathology, the Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
J Mol Diagn 4:59-64. 2002..All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. This method is a relatively simple and rapid procedure for the detection of the t(X;18)(p11.2;q11.2)... - Age- and sex-specific mortality associated with the 1918-1919 influenza pandemic in kentuckyCecile Viboud
Fogarty International Center
J Infect Dis 207:721-9. 2013..The atypical age mortality patterns of the 1918-1919 pandemic cannot be explained by military crowding, war-related factors, or prior immunity alone and likely result from a combination of unknown factors... - Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparednessDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 198:962-70. 2008..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics... - The origin and virulence of the 1918 "Spanish" influenza virusJeffery K Taubenberger
Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
Proc Am Philos Soc 150:86-112. 2006..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans... - The relationship between encephalitis lethargica and influenza: a critical analysisSherman McCall
Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
J Neurovirol 14:177-85. 2008..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic... - Fixed and frozen flu: the 1918 influenza and lessons for the futureJeffery K Taubenberger
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850-3125, USA
Avian Dis 47:789-91. 2003 - Fatal 1918 pneumonia case complicated by erythrocyte sicklingZong Mei Sheng
National Institutes of Health, Bethesda, Maryland, USA
Emerg Infect Dis 16:2000-1. 2010..The inheritance pattern of sickle cell anemia was determined in 1949; in 1957, Ingram identified the single amino acid change in hemoglobin S (4)... - Serial analysis of gene expression in murine fetal thymocyte cell linesFeng-Qi Zhao
Molecular Pathology Division, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
Int Immunol 14:1383-95. 2002..These genes, and others identified by this analysis, are likely to play important roles in the development of T cells... - Heading off an influenza pandemicEdward C Holmes
Science 309:989. 2005 - Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 virusesEdward C Holmes
Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
PLoS Biol 3:e300. 2005.... - Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918Martha I Nelson
Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
PLoS Pathog 4:e1000012. 2008..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized... - The genomic and epidemiological dynamics of human influenza A virusAndrew Rambaut
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
Nature 453:615-9. 2008..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions... - Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCRAtif A Ahmed
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Pediatr Dev Pathol 9:488-95. 2006..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies... - Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR methodRuixue Wang
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Virology 375:182-9. 2008..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds... - Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird fecesDavid L Evers
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Avian Dis 51:965-8. 2007..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers... - Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 101:3166-71. 2004..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus... - Discovery and characterization of the 1918 pandemic influenza virus in historical contextJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Antivir Ther 12:581-91. 2007.... - Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus... - The next influenza pandemic: can it be predicted?Jeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2520, USA
JAMA 297:2025-7. 2007 - Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virusJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 303:1866-70. 2004.... - Stochastic processes are key determinants of short-term evolution in influenza a virusMartha I Nelson
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
PLoS Pathog 2:e125. 2006..Thus, predicting future patterns of influenza virus evolution for vaccine strain selection is inherently complex and requires intensive surveillance, whole-genome sequencing, and phenotypic analysis... - Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virusTerrence M Tumpey
Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
Proc Natl Acad Sci U S A 99:13849-54. 2002..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus... - Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virusJames Stevens
Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 312:404-10. 2006.... - Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virusJohn C Kash
Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
J Virol 78:9499-511. 2004..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections... - Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenzaGary K Geiss
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 99:10736-41. 2002.... - Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditisPaul C McGovern
Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
J Heart Lung Transplant 21:290-3. 2002..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place... - Pandemic and seasonal influenza: therapeutic challengesMatthew J Memoli
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Drug Discov Today 13:590-5. 2008.... - Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificitiesJames Stevens
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Mol Biol 355:1143-55. 2006..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza... - The pathology of influenza virus infectionsJeffery K Taubenberger
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Annu Rev Pathol 3:499-522. 2008.... - A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificityLaurel Glaser
Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Virol 79:11533-6. 2005..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor... - Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virusJohn C Kash
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nature 443:578-81. 2006..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies... - Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005.... - Influenza and the origins of The Philips Collection, Washington, DCDavid M Morens
National Institutes of Health, Bethesda, MD, USA
Emerg Infect Dis 12:78-80. 2006 - Homologous recombination is very rare or absent in human influenza A virusMaciej F Boni
Resources for the Future, 1616 P St NW, Washington, DC 20036, USA
J Virol 82:4807-11. 2008..We therefore conclude that, if it occurs at all, homologous recombination plays only a very minor role in the evolution of human influenza A virus...