Jeffery K Taubenberger

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. pmc 1918 Influenza: the mother of all pandemics
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    Emerg Infect Dis 12:15-22. 2006
  2. pmc Influenza revisited
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland, USA
    Emerg Infect Dis 12:1-2. 2006
  3. ncbi request reprint Characterization of the 1918 influenza virus polymerase genes
    Jeffery K Taubenberger
    Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
    Nature 437:889-93. 2005
  4. pmc The evolutionary genetics and emergence of avian influenza viruses in wild birds
    Vivien G Dugan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000076. 2008
  5. ncbi request reprint Capturing a killer flu virus
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, MD, USA
    Sci Am 292:48-57. 2005
  6. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
  7. ncbi request reprint Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
    Nat Rev Microbiol 2:909-14. 2004
  8. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  9. pmc Novel origin of the 1918 pandemic influenza virus nucleoprotein gene
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850 3125, USA
    J Virol 78:12462-70. 2004
  10. pmc Characterization of the 1918 "Spanish" influenza virus matrix gene segment
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:10717-23. 2002

Collaborators

Detail Information

Publications53

  1. pmc 1918 Influenza: the mother of all pandemics
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    Emerg Infect Dis 12:15-22. 2006
    ..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis...
  2. pmc Influenza revisited
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, Maryland, USA
    Emerg Infect Dis 12:1-2. 2006
  3. ncbi request reprint Characterization of the 1918 influenza virus polymerase genes
    Jeffery K Taubenberger
    Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
    Nature 437:889-93. 2005
    ..The sequence changes identified here may be important in the adaptation of influenza viruses to humans...
  4. pmc The evolutionary genetics and emergence of avian influenza viruses in wild birds
    Vivien G Dugan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 4:e1000076. 2008
    ....
  5. ncbi request reprint Capturing a killer flu virus
    Jeffery K Taubenberger
    Armed Forces Institute of Pathology, Rockville, MD, USA
    Sci Am 292:48-57. 2005
  6. ncbi request reprint Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
    Elodie Ghedin
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
    Nature 437:1162-6. 2005
    ..All data from this project are being deposited, without delay, in public archives...
  7. ncbi request reprint Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Boulevard, Building 101, Rockville, Maryland 20850, USA
    Nat Rev Microbiol 2:909-14. 2004
    ..Determining whether a pandemic influenza virus can emerge by different mechanisms will affect the scope and focus of surveillance and prevention efforts...
  8. pmc 1918 influenza pandemic caused by highly conserved viruses with two receptor-binding variants
    Ann H Reid
    Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Building 101, Rockville, MD 20850 3125, USA
    Emerg Infect Dis 9:1249-53. 2003
  9. pmc Novel origin of the 1918 pandemic influenza virus nucleoprotein gene
    Ann H Reid
    Armed Forces Institute of Pathology, Department of Molecular Pathology, 1413 Research Blvd, Building 101, Rockville, MD 20850 3125, USA
    J Virol 78:12462-70. 2004
    ....
  10. pmc Characterization of the 1918 "Spanish" influenza virus matrix gene segment
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:10717-23. 2002
    ....
  11. pmc The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase
    Brett W Jagger
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 1:. 2010
    ....
  12. pmc 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birds
    Thomas G Fanning
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
    J Virol 76:7860-2. 2002
    ....
  13. pmc Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice
    Li Qi
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:9211-20. 2012
    ..While the mechanisms of influenza virus host switch, and particularly mammalian host adaptation are still only partly understood, these data suggest that the 1918 virus, whatever its origin, is very similar to avian influenza virus...
  14. ncbi request reprint The origin of the 1918 pandemic influenza virus: a continuing enigma
    Ann H Reid
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Blvd, Building 101, Room 1057, Rockville, MD 20850 3125, USA
    J Gen Virol 84:2285-92. 2003
    ..Determining whether pandemic influenza virus strains can emerge via different pathways will affect the scope and focus of surveillance and prevention efforts...
  15. ncbi request reprint Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore
    Teri J Franks
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Wshington, DC 20306, USA
    Hum Pathol 34:743-8. 2003
    ..Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD...
  16. pmc Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses
    John C Kash
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    MBio 2:. 2011
    ..This study reveals that the extent of lung damage during viral infection influences the severity of secondary bacterial infections and may help explain some differences in mortality during influenza pandemics...
  17. pmc The 1918 influenza pandemic: lessons for 2009 and the future
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Crit Care Med 38:e10-20. 2010
    ..Thus, we must remain vigilant and use the knowledge we have gained from 1918 and other influenza pandemics to direct targeted research and pandemic influenza preparedness planning, emphasizing prevention, containment, and treatment...
  18. pmc Detection of SYT-SSX fusion transcripts in archival synovial sarcomas by real-time reverse transcriptase-polymerase chain reaction
    Karen E Bijwaard
    Division of Molecular Pathology, the Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Washington, DC, USA
    J Mol Diagn 4:59-64. 2002
    ..All 13 non-synovial sarcomas tested were negative for SYT-SSX1 and SYT-SSX2 fusion transcripts. This method is a relatively simple and rapid procedure for the detection of the t(X;18)(p11.2;q11.2)...
  19. pmc Age- and sex-specific mortality associated with the 1918-1919 influenza pandemic in Kentucky
    Cecile Viboud
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 207:721-9. 2013
    ..Here we characterize pandemic-related mortality by single year of age in a unique statewide Kentucky data set and explore breakpoints in the age curves...
  20. pmc Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness
    David M Morens
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 198:962-70. 2008
    ..Despite the availability of published data on 4 pandemics that have occurred over the past 120 years, there is little modern information on the causes of death associated with influenza pandemics...
  21. pmc The origin and virulence of the 1918 "Spanish" influenza virus
    Jeffery K Taubenberger
    Department of Molecular Pathology Armed Forces Institute of Pathology Rockville, Maryland, USA
    Proc Am Philos Soc 150:86-112. 2006
    ..This information should help elucidate how pandemic influenza virus strains emerge and what genetic features contribute to virulence in humans...
  22. pmc Fatal 1918 pneumonia case complicated by erythrocyte sickling
    Zong Mei Sheng
    National Institutes of Health, Bethesda, Maryland, USA
    Emerg Infect Dis 16:2000-1. 2010
    ..The inheritance pattern of sickle cell anemia was determined in 1949; in 1957, Ingram identified the single amino acid change in hemoglobin S (4)...
  23. pmc The relationship between encephalitis lethargica and influenza: a critical analysis
    Sherman McCall
    Department of Clinical Pathology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Neurovirol 14:177-85. 2008
    ..Almost 100 years after the EL epidemic, its etiology remains enigmatic, raising the possibility of a recurrence of EL in a future influenza pandemic...
  24. ncbi request reprint Fixed and frozen flu: the 1918 influenza and lessons for the future
    Jeffery K Taubenberger
    Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
    Avian Dis 47:789-91. 2003
  25. doi request reprint Characterization of the Noncoding Regions of the 1918 Influenza A H1N1 Virus
    Ruixue Wang
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 88:1815-8. 2014
    ..No growth differences between the NCR variant 1918 influenza viruses were noted. ..
  26. pmc Molecular basis for broad neuraminidase immunity: conserved epitopes in seasonal and pandemic H1N1 as well as H5N1 influenza viruses
    Hongquan Wan
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA
    J Virol 87:9290-300. 2013
    ....
  27. ncbi request reprint Serial analysis of gene expression in murine fetal thymocyte cell lines
    Feng qi Zhao
    Molecular Pathology Division, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
    Int Immunol 14:1383-95. 2002
    ..These genes, and others identified by this analysis, are likely to play important roles in the development of T cells...
  28. ncbi request reprint Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus
    James Stevens
    Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 312:404-10. 2006
    ....
  29. ncbi request reprint Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Science 310:77-80. 2005
    ..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
  30. ncbi request reprint Heading off an influenza pandemic
    Edward C Holmes
    Science 309:989. 2005
  31. pmc Whole-genome analysis of human influenza A virus reveals multiple persistent lineages and reassortment among recent H3N2 viruses
    Edward C Holmes
    Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    PLoS Biol 3:e300. 2005
    ....
  32. pmc Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus
    John C Kash
    Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 78:9499-511. 2004
    ..These studies document clear differences in gene expression profiles that were correlated with pulmonary disease pathology induced by virulent and attenuated influenza virus infections...
  33. pmc The next influenza pandemic: can it be predicted?
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 2520, USA
    JAMA 297:2025-7. 2007
  34. pmc Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 101:3166-71. 2004
    ..These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus...
  35. ncbi request reprint Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 303:1866-70. 2004
    ....
  36. pmc Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus
    Terrence M Tumpey
    Southeast Poultry Research Laboratory, United States Department of Agriculture, Athens, GA 30605, USA
    Proc Natl Acad Sci U S A 99:13849-54. 2002
    ..These data suggest that current antiviral strategies would be effective in curbing the dangers of a re-emergent 1918 or 1918-like virus...
  37. pmc The genomic and epidemiological dynamics of human influenza A virus
    Andrew Rambaut
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Nature 453:615-9. 2008
    ..These results suggest a sink-source model of viral ecology in which new lineages are seeded from a persistent influenza reservoir, which we hypothesize to be located in the tropics, to sink populations in temperate regions...
  38. pmc Examining the hemagglutinin subtype diversity among wild duck-origin influenza A viruses using ethanol-fixed cloacal swabs and a novel RT-PCR method
    Ruixue Wang
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 375:182-9. 2008
    ..This study further demonstrates the complex ecobiology of avian influenza A viruses in wild birds...
  39. pmc Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918
    Martha I Nelson
    Department of Biology, Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 4:e1000012. 2008
    ..Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized...
  40. pmc Effect of preservative on recoverable RT-PCR amplicon length from influenza A virus in bird feces
    David L Evers
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Avian Dis 51:965-8. 2007
    ..These results suggest that this approach is feasible in the field and that preserved specimens might be better assayed molecularly when preserved in guanidine or commercial buffers...
  41. pmc Discovery and characterization of the 1918 pandemic influenza virus in historical context
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Antivir Ther 12:581-91. 2007
    ....
  42. pmc Stochastic processes are key determinants of short-term evolution in influenza a virus
    Martha I Nelson
    Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS Pathog 2:e125. 2006
    ..Thus, predicting future patterns of influenza virus evolution for vaccine strain selection is inherently complex and requires intensive surveillance, whole-genome sequencing, and phenotypic analysis...
  43. ncbi request reprint Ewing sarcoma family of tumors in unusual sites: confirmation by rt-PCR
    Atif A Ahmed
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Dev Pathol 9:488-95. 2006
    ..Accurate diagnosis of Ewing sarcoma family of tumors is crucial for the management of patients, and when found in such rare locations, diagnosis should be supported by immunohistochemical and/or molecular genetic studies...
  44. ncbi request reprint Successful explantation of a ventricular assist device following fulminant influenza type A-associated myocarditis
    Paul C McGovern
    Division of Infectious Diseases, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 21:290-3. 2002
    ..This case suggests those patients with fulminant viral myocarditis and refractory ventricular arrhythmias may be supported successfully with ventricular assist devices until myocardial recovery takes place...
  45. pmc Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza
    Gary K Geiss
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 99:10736-41. 2002
    ....
  46. ncbi request reprint Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
    James Stevens
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:1143-55. 2006
    ..The glycan array thus provides highly detailed profiles of influenza receptor specificity that can be used to map the evolution of new human pathogenic strains, such as the H5N1 avian influenza...
  47. pmc Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
    John C Kash
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nature 443:578-81. 2006
    ..Moreover, understanding the contribution of host immune responses to virulent influenza virus infections is an important starting point for the identification of prognostic indicators and the development of novel antiviral therapies...
  48. pmc Influenza and the origins of The Philips Collection, Washington, DC
    David M Morens
    National Institutes of Health, Bethesda, MD, USA
    Emerg Infect Dis 12:78-80. 2006
  49. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  50. pmc Pandemic and seasonal influenza: therapeutic challenges
    Matthew J Memoli
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Drug Discov Today 13:590-5. 2008
    ....
  51. pmc A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity
    Laurel Glaser
    Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Virol 79:11533-6. 2005
    ..Mutation of this single amino acid back to the avian consensus resulted in a preference for the avian receptor...
  52. pmc The pathology of influenza virus infections
    Jeffery K Taubenberger
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Annu Rev Pathol 3:499-522. 2008
    ....
  53. pmc Homologous recombination is very rare or absent in human influenza A virus
    Maciej F Boni
    Resources for the Future, 1616 P St NW, Washington, DC 20036, USA
    J Virol 82:4807-11. 2008
    ..We therefore conclude that, if it occurs at all, homologous recombination plays only a very minor role in the evolution of human influenza A virus...