M Miettinen

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. ncbi Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Eur J Cancer 38:S39-51. 2002
  2. ncbi Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 438:1-12. 2001
  3. doi Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1624-32. 2009
  4. ncbi Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Pol J Pathol 54:3-24. 2003
  5. ncbi Gastrointestinal stromal tumors in the appendix: a clinicopathologic and immunohistochemical study of four cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:1433-7. 2001
  6. ncbi Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:1121-33. 2001
  7. ncbi A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cancer 112:645-9. 2008
  8. doi DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, NW, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1401-8. 2009
  9. ncbi Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 26:301-11. 2002
  10. ncbi Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Patholgy, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:625-41. 2003

Detail Information

Publications101 found, 100 shown here

  1. ncbi Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Eur J Cancer 38:S39-51. 2002
    ..Functional analysis of the different c-kit mutations and their impact on the response to tyrosine kinase inhibitors are under intense investigation...
  2. ncbi Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 438:1-12. 2001
    ..Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs...
  3. doi Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1624-32. 2009
    ..Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms...
  4. ncbi Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Pol J Pathol 54:3-24. 2003
    ..Majority of these mutations are in-frame-deletions and missense mutations clustering in the 5'-end of juxtamembrane domain (exon 11). A rare mutation, an Ala502-Tyr503 duplication in exon 9, is specific for intestinal GISTs...
  5. ncbi Gastrointestinal stromal tumors in the appendix: a clinicopathologic and immunohistochemical study of four cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:1433-7. 2001
    ..This report documents the rare occurrence of CD117-positive GISTs as primary appendiceal tumors...
  6. ncbi Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:1121-33. 2001
    ..Intramural LMs are exceptional, and true LMSs are rare, and similar to colonic ones, often present as intraluminal polypoid masses that appear to have a better prognosis than GISTs with similar mitotic rates...
  7. ncbi A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cancer 112:645-9. 2008
    ..These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant. In the current study, the authors examined long-term follow-up data of 1892 GIST patients from the U.S...
  8. doi DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, NW, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1401-8. 2009
    ..DOG1 should be added into the diagnostic panel evaluating GI and other abdominal tumors, but limitations in its sensitivity and specificity should be recognized...
  9. ncbi Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 26:301-11. 2002
    ..These tumors are phenotypically similar to peripheral glomus tumors and differ from epithelioid GISTs...
  10. ncbi Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Patholgy, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:625-41. 2003
    ..The great majority of duodenal mesenchymal tumors are GISTs, which have a spectrum from small indolent tumors to overt sarcomas. LMs and LMSs are rare...
  11. doi Gastrointestinal stromal tumors presenting as omental masses--a clinicopathologic analysis of 95 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Building 54, Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1267-75. 2009
    ..KIT positive Cajal cells were not found in normal omental tissues failing to support the presence of these ancestral cells for GIST in the omentum...
  12. doi True smooth muscle tumors of the small intestine: a clinicopathologic, immunhistochemical, and molecular genetic study of 25 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:430-6. 2009
    ..The number of LMS cases is too small for stratification for risk assessment. True SMTs of small intestine should be separated from GISTs because of different pathogenesis and treatment...
  13. ncbi Gastrointestinal stromal tumors: pathology and prognosis at different sites
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:70-83. 2006
    ..Immunohistochemical demonstration of KIT, CD34, or protein kinase theta positivity helps to properly identify these tumors...
  14. doi ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma
    Markku Miettinen
    Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 35:432-41. 2011
    ..Among epithelial tumors, ERG shows a great promise as a marker to identify prostatic carcinoma in both primary and metastatic settings...
  15. ncbi Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arch Pathol Lab Med 130:1466-78. 2006
    ..They are believed to originate from interstitial cells of Cajal or related stem cells...
  16. ncbi KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Appl Immunohistochem Mol Morphol 13:205-20. 2005
    ....
  17. ncbi Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Bldg 54, Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:1373-81. 2005
    ..Their pathogenesis may differ from that of adult GISTs because no KIT or PDGFRA mutations were found; connection with Carney triad seems infrequent despite demographic and histologic similarities...
  18. ncbi Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Bldg 54 Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:90-6. 2006
    ..None of the 16 tumors from 15 patients had a KIT exon 9, 11, 13, or 17 or PDGFRA exon 12 or 18 mutation as is typically seen in sporadic GISTs, indicating that GISTs in NF1 patients have a different pathogenesis than sporadic GISTs...
  19. ncbi Evaluation of biological potential of smooth muscle tumours
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Bldg 54, Rm G090, Washington, DC 20306 6000, USA
    Histopathology 48:97-105. 2006
    ..This review summarizes the current knowledge, guidelines, prognostic data and controversies for the classification of SMTs of soft tissue and most visceral sites...
  20. doi Ossifying fibromyxoid tumor of soft parts--a clinicopathologic and immunohistochemical study of 104 cases with long-term follow-up and a critical review of the literature
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 32:996-1005. 2008
    ..When OFT is strictly defined by the criteria noted above, there is potential for local recurrence, but there seems to be little or no risk for metastasis...
  21. ncbi Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: an immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:150-8. 2003
    ....
  22. ncbi Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:477-89. 2006
    ..There were no PDGFRA exon 12 or 8 mutations. Systematic data on prognosis of small intestinal GISTs of various size and mitotic activity categories can be helpful in management and surveillance of patients with these tumors...
  23. ncbi Reticulohistiocytoma (solitary epithelioid histiocytoma): a clinicopathologic and immunohistochemical study of 44 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:521-8. 2006
    ..It needs to be distinguished from Rosai-Dorfman disease, juvenile xanthogranuloma, a variety of granulomatous conditions, and some malignant neoplasms, including histiocytic sarcoma, melanoma, and epithelioid sarcoma...
  24. ncbi A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults ("gastroblastoma"): a series of 3 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1370-7. 2009
    ..5, 5, and 14 years. Because these tumors have some resemblance to blastomas of other organs, we propose the term "gastroblastoma" for this distinctive, at least low-grade malignant epitheliomesenchymal tumor of the stomach...
  25. ncbi Mesenchymal tumors of muscularis mucosae of colon and rectum are benign leiomyomas that should be separated from gastrointestinal stromal tumors--a clinicopathologic and immunohistochemical study of eighty-eight cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Mod Pathol 14:950-6. 2001
    ..Snare polypectomy is an adequate treatment, but ensuring the complete removal and follow-up are necessary precautions for tumors with any atypia or mitotic activity...
  26. ncbi Gastrointestinal stromal tumours
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Ann Chir Gynaecol 87:278-81. 1998
    ....
  27. ncbi Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:205-11. 2001
    ..Microphthalmia transcription factor may be a valuable addition to the marker panel used in diagnosing melanoma, in combination with S100, TYR, and the other markers, but it is not present in cases of desmoplastic melanomas...
  28. ncbi Calretinin and other mesothelioma markers in synovial sarcoma: analysis of antigenic similarities and differences with malignant mesothelioma
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306-6000, USA
    Am J Surg Pathol 25:610-7. 2001
    ..Global expression of K7 and K19 in mesotheliomas versus focal expression in monophasic and poorly differentiated SSs, and differential patterns of K14 expression may also be helpful...
  29. ncbi Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation
    M Debiec-Rychter
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Cancer Genet Cytogenet 128:24-30. 2001
    ..These observations may reflect the different pathways leading to malignant transformation of GISTs...
  30. ncbi Keratin 1 expression in endothelia and mesenchymal tumors: an immunohistochemical analysis of normal and neoplastic tissues
    F Remotti
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Hum Pathol 32:873-9. 2001
    ..The unexpected K1 immunoreactivity in nonvascular soft tissue tumors, such as synovial sarcoma, epithelioid sarcoma, and schwannomas, requires further study...
  31. ncbi Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:478-83. 2002
    ..Genetic markers, including DNA-copy number changes, telomerase activity, and KIT mutation status, may be useful in more accurately identifying tumors with malignant potential...
  32. ncbi Superficial acral fibromyxoma: a clinicopathologic and immunohistochemical analysis of 37 cases of a distinctive soft tissue tumor with a predilection for the fingers and toes
    J F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Hum Pathol 32:704-14. 2001
    ....
  33. ncbi Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas
    E Paal
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Am J Surg Pathol 25:1355-63. 2001
    ..Most of these tumors resemble uterine leiomyomas by histology and positive hormone receptors, and they seem to have a good long-term prognosis with a small potential for local recurrence...
  34. ncbi Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    Markku Miettinen
    Departments of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:52-68. 2005
    ..The above results may be helpful for setting the criteria for adjuvant treatment such as Gleevec...
  35. doi Synovial sarcoma of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 10 cases
    Hala R Makhlouf
    Department of Hepatic, Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 32:275-81. 2008
    ..Synovial sarcoma rarely occurs as a gastric primary tumor. It has a variable prognosis depending on tumor size and differentiation, and should be considered in the differential diagnosis of KIT-negative gastric spindle cell neoplasms...
  36. ncbi KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 34:1306-12. 2003
    ..GISTs carrying 1530ins6 occur exclusively in the intestinal location, and a great majority of these tumors follow a malignant course...
  37. ncbi Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 11:626-33. 1998
    ..This assay can be used as an adjunct test for diagnostically difficult cases or in retrospective studies to refine the diagnosis of synovial sarcoma in archival material...
  38. ncbi KIT expression in angiosarcomas and fetal endothelial cells: lack of mutations of exon 11 and exon 17 of C-kit
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 13:536-41. 2000
    ..e., reversion of the tumor cell phenotype to that of fetal endothelial cells that may show KIT expression)...
  39. ncbi KIT-positive gastrointestinal stromal tumor in a 22-year-old male chimpanzee (Pan troglodites)
    G A Saturday
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, 14th and Alaska Avenue, Northwest, Building 54, Room G117, Washington, DC 20306 6000, USA
    Vet Pathol 42:362-5. 2005
    ..More cases of nonhuman primate GISTs should be analyzed to discover the clinicopathologic spectrum of GISTs in these species...
  40. ncbi Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases
    D Frost
    Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 40:42-54. 2003
    ..Twenty-eight (97%) were positive for smooth muscle actin and 18 (62%) for desmin but none for CD117 and S-100. Both GISTs and true LMs occur in the GI tract of dogs. Both tumors have distinctive pathologic features...
  41. ncbi CD45 (leukocyte common antigen) immunoreactivity in metastatic undifferentiated and neuroendocrine carcinoma: a potential diagnostic pitfall
    M A Nandedkar
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 11:1204-10. 1998
    ..It is best avoided by employing a panel of leukocyte and epithelial antigens and by use of electron microscopy, if possible...
  42. ncbi Spindle cell tumor of urinary bladder serosa with phenotypic and genotypic features of gastrointestinal stromal tumor
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arch Pathol Lab Med 124:894-7. 2000
    ..This case illustrates that tumors phenotypically and genotypically similar to GISTs may present in sites other than the tubular gastrointestinal tract...
  43. ncbi Splenic angiosarcoma: a clinicopathologic and immunophenotypic study of 28 cases
    T S Neuhauser
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Mod Pathol 13:978-87. 2000
    ..The majority of splenic angiosarcomas coexpress histiocytic and endothelial markers by immunohistochemical analysis, which suggest that some tumors may originate from splenic lining cells...
  44. doi Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Histopathology 53:245-66. 2008
    ..GISTs with secondary mutations in exon 13 and 14 are sensitive to sunitinib, another tyrosine kinase inhibitor. KIT and PDGFRA genotyping is important for GIST diagnosis and assessment of sensitivity to tyrosine kinase inhibitors...
  45. pmc The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Ave, Washington, DC 20306 6000, USA
    Am J Pathol 158:1223-9. 2001
    ..The coexistence of NF2 gene mutations and LOH at the NF2 locus indicates that the NF2 tumor suppressor gene is altered in PNTs by the two-hit mechanism...
  46. ncbi Differentiating lymphoblastic lymphoma and Ewing's sarcoma: lymphocyte markers and gene rearrangement
    M Ozdemirli
    Department of Pathology, Georgetown University Medical Center, 3900 Reservoir Road N.W, Washington, DC 20007, USA
    Mod Pathol 14:1175-82. 2001
    ..Additional analysis using CD79a, CD43, TdT, and PCR should be performed to avoid misdiagnosis. True ES is negative for lymphoid markers including CD79a, CD43, and TdT, as well as for IgH-R and Tgamma-R...
  47. ncbi Lingual alveolar soft part sarcoma; 14 cases: novel clinical and morphological observations
    J C Fanburg-Smith
    Armed Forces Institute of Pathology, Washington, DC, USA
    Histopathology 45:526-37. 2004
    ..Alveolar soft part sarcoma (ASPS) is a rare sarcoma in the buttocks or thigh of young adults, often with metastases to lung, brain, or bone. This study examines the morphological and clinical features of lingual ASPS...
  48. ncbi KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:91-102. 2006
    ..Mutation genotyping is a tool in GIST diagnosis and in assessment of sensitivity to kinase inhibitors. This is a US government work. There are no restrictions on its use...
  49. doi Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 22:1049-56. 2009
    ..We also suggest that these polyps may develop from earlier described PDGFRA-positive mesenchymal cells distributed along the villus membrane after oncogenic PDGFRA activation...
  50. ncbi Nerve sheath myxoma: a clinicopathologic and immunohistochemical analysis of 57 morphologically distinctive, S-100 protein- and GFAP-positive, myxoid peripheral nerve sheath tumors with a predilection for the extremities and a high local recurrence rate
    John F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:1615-24. 2005
    ..These tumors have a relatively high local recurrence rate when managed by simple local excision. They appear to be unrelated to so-called cellular and mixed-type neurothekeomas...
  51. ncbi GISTs with PDGFRA exon 14 mutations represent subset of clinically favorable gastric tumors with epithelioid morphology
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 86:94-100. 2006
    ..In four cases with moderate or high malignant potential GISTs, a long-term follow-up (average 235.5 months) showed favorable course of disease...
  52. doi Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 21:476-84. 2008
    ..The latter is also true for all KIT exon 17 mutant GISTs...
  53. doi KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 39:1728-36. 2008
    ..Moreover, KIT codon 558 insertions might indicate an increased risk of malignant behavior for gastric gastrointestinal stromal tumors...
  54. ncbi Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 87:1029-41. 2007
    ..4 months. Based on these findings, we conclude that presence of homozygous KIT exon 11 mutations is associated with malignant course of disease and should be considered an adverse prognostic marker in GISTs...
  55. ncbi Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information
    John F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 31:1103-14. 2007
    ..An origin from fibroblastic cells with the ability to differentiate into myofibroblasts and a tendency to recruit histiocytic cells is postulated...
  56. doi From the archives of the AFIP: musculoskeletal fibromatoses: radiologic-pathologic correlation
    Mark D Murphey
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Building 54, Room M 133A, Washington, DC 20306, USA
    Radiographics 29:2143-73. 2009
    ..Recognition that the appearances of the various types of musculoskeletal fibromatoses reflect their pathologic characteristics improves radiologic assessment and helps optimize patient management...
  57. ncbi Minute synovial sarcomas of the hands and feet: a clinicopathologic study of 21 tumors less than 1 cm
    Michal Michal
    Sikl s Department of Pathology, Faculty Hospital, Pilsen, Czech Republic, and the Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:721-6. 2006
    ..These tumors should be recognized as part of the spectrum of synovial sarcomas...
  58. ncbi Pulmonary microcystic fibromyxoma: Report of 3 cases
    Konstantin Shilo
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Am J Surg Pathol 30:1432-5. 2006
    ....
  59. ncbi KIT exon 11 deletion-inversions represent complex mutations in gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cancer Genet Cytogenet 175:69-72. 2007
    ..5%, based on evaluation of 700 KIT exon 11 mutants. Molecular events leading to formation of deletion-inversions remain elusive and should be studied further...
  60. pmc Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Washington, DC 20306 6000, USA
    J Mol Diagn 9:89-94. 2007
    ..Use of the PCR assay amplifying the specific region affected by duplications and yielding 129 bp in wild-type KIT can substantially improve the detection of these mutations in formalin-fixed, paraffin-embedded GISTs...
  61. ncbi Gastrointestinal stromal tumors: differential diagnosis
    Nancy Dow
    Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:111-9. 2006
    ..To comprehensively capture all GISTs, KIT immunostains should be performed on all unclassified epithelioid and mesenchymal tumors of the abdomen. This is a US government work. There are no restrictions on its use...
  62. ncbi Keratin expression in schwannoma; a study of 115 retroperitoneal and 22 peripheral schwannomas
    Julie C Fanburg-Smith
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 19:115-21. 2006
    ..However, focal expression of K1 and K7 cannot be ruled out. Keratin-positive schwannomas should not be confused with other keratin-positive tumors, such as sarcomatoid carcinoma, mesothelioma, and synovial sarcoma...
  63. ncbi Palmar-plantar fibromatosis in children and preadolescents: a clinicopathologic study of 56 cases with newly recognized demographics and extended follow-up information
    John F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Am J Surg Pathol 29:1095-105. 2005
    ..Thirty-two of 38 patients (84.2%) with clinical follow-up, ranging from 4 months to 33 years (mean, 14 years 9 months; median, 16 years 1 month), had one (n = 16) or more (n = 16) local recurrence of their fibromatosis...
  64. ncbi From the archives of the AFIP: abdominal neoplasms in patients with neurofibromatosis type 1: radiologic-pathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Alaska and Fern Sts NW, Washington, DC 20306 6000, USA
    Radiographics 25:455-80. 2005
    ..Interpreting abdominal imaging studies in patients with NF1 can be challenging because of the wide spectrum and diverse nature of tumors that occur in this disease...
  65. ncbi Epithelioid hemangioma of the penis: a clinicopathologic and immunohistochemical analysis of 19 cases, with special reference to exuberant examples often confused with epithelioid hemangioendothelioma and epithelioid angiosarcoma
    John F Fetsch
    Department of Soft Tissue, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 28:523-33. 2004
    ..Optimal management appears to be complete local excision with periodic follow-up visits to monitor for local recurrence...
  66. ncbi Leiomyosarcoma of the penis: a clinicopathologic study of 14 cases with review of the literature and discussion of the differential diagnosis
    John F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
    Am J Surg Pathol 28:115-25. 2004
    ..Superficial leiomyosarcomas of the penis are optimally managed by wide local excision whenever this is technically feasible. Tumors with a deep-seated component may require more aggressive intervention to ensure complete removal...
  67. ncbi Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 16:1257-64. 2003
    ..This suggests that presence of these IDTs may define a clinicopathologically favorable subset of GISTs. The consequence of these mutations to KIT signaling should be investigated...
  68. ncbi Cytokeratin immunoreactivity in lobular intraepithelial neoplasia
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Histochem Cytochem 51:1527-31. 2003
    ....
  69. ncbi Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 600, USA
    Lab Invest 83:1361-71. 2003
    ..However, lack of NF2 alterations strongly supports the hypothesis that GI schwannomas represent a morphologically and genetically distinct group of peripheral nerve sheath tumors that are different from conventional schwannomas...
  70. ncbi Anorectal gastrointestinal stromal tumors: CT and MR imaging features with clinical and pathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St, N W, Washington, DC 20306 6000, USA
    AJR Am J Roentgenol 180:1607-12. 2003
    ..The purpose of this study was to describe the imaging features of anorectal gastrointestinal stromal tumors with clinical and pathologic correlation...
  71. ncbi Gastrointestinal stromal tumors: radiologic features with pathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Washington, DC 20306 6000, USA
    Radiographics 23:283-304, 456; quiz 532. 2003
    ..Although the radiologic features of GISTs are often distinct from those of epithelial tumors, criteria to separate GISTs radiologically from other nonepithelial tumors have not yet been fully developed...
  72. ncbi Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases
    Lester D R Thompson
    Department of Endocrine and Otorhinolaryngic Head and Neck Pathology, Armed Forces Institute of Pathology, Building 54, 6825 16th Street NW, Washington, DC 20306 6000, U S A
    Am J Surg Pathol 26:153-70. 2002
    ..Recurrences developed in 85 (45%) patients. Overall, T1 glottic tumors managed by complete surgical eradication had the best outcome (mean follow-up, 7.8 years)...
  73. ncbi A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue NW, Washington, DC 20306 6000, USA
    Lab Invest 84:874-83. 2004
    ..Based on long-term follow-up (average 135 months), a majority (83.5%) of GISTs with PDGFRA mutations followed a benign course...
  74. ncbi Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  75. ncbi Abdominal lymphangiomas: imaging features with pathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    AJR Am J Roentgenol 182:1485-91. 2004
  76. ncbi Ectopic hamartomatous thymoma: a clinicopathologic and immunohistochemical analysis of 21 cases with data supporting reclassification as a branchial anlage mixed tumor
    John F Fetsch
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 28:1360-70. 2004
    ..The differential diagnosis includes conventional mixed tumors of skin adnexal or salivary gland origin, synovial sarcoma, a peripheral nerve sheath tumor variant, and cystic teratoma...
  77. ncbi Gastrointestinal stromal tumors in patients with neurofibromatosis: imaging features with clinicopathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, Alaska and Fern Streets, NW, Washington, DC 20306 6000, USA
    AJR Am J Roentgenol 183:1629-36. 2004
    ..The purpose of this study was to evaluate the clinical, pathologic, and imaging features of gastrointestinal stromal tumors that occur in patients with neurofibromatosis...
  78. ncbi Schwannomas in the colon and rectum: a clinicopathologic and immunohistochemical study of 20 cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Am J Surg Pathol 25:846-55. 2001
    ..Colorectal schwannomas behaved in a benign fashion with no evidence of aggressive behavior or connection with neurofibromatosis 1 or 2, based on follow-up information on 18 patients...
  79. ncbi The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases
    M A Furlong
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Am J Surg Pathol 25:809-14. 2001
    ..It is a benign tumor that does not recur with complete excision. Hibernomas should not be confused with atypical lipomas or well-differentiated liposarcoma...
  80. ncbi Low-affinity nerve growth factor receptor (p75) in dermatofibrosarcoma protuberans and other nonneural tumors: a study of 1,150 tumors and fetal and adult normal tissues
    J C Fanburg-Smith
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
    Hum Pathol 32:976-83. 2001
    ..p75 may be useful to distinguish DFSP from benign fibrous histiocytoma...
  81. ncbi Gastrointestinal schwannomas: CT features with clinicopathologic correlation
    Angela D Levy
    Department of Radiologic Pathology, Armed Forces Institute of Pathology, 6825 16th St, NW, Washington, DC 20306 6000, USA
    AJR Am J Roentgenol 184:797-802. 2005
    ..They are homogeneously attenuating, well-defined, mural masses on CT. The lack of low-attenuation hemorrhage, necrosis, and degeneration within the tumor may help distinguish these tumors from gastrointestinal stromal tumors on CT...
  82. ncbi Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic study of 115 cases with a proposed staging system
    Lester D R Thompson
    Department of Endocrine and Otorhinolaryngic Head and Neck Patholgy, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:594-611. 2003
    ..3 years), whereas 40 patients are either alive or had died of unrelated causes (mean 13.9 years). A TNM-type classification separated by anatomic site of involvement and metastatic disease is proposed to predict biologic behavior...
  83. ncbi Mapping of the keratin polypeptides in meningiomas of different types: an immunohistochemical analysis of 463 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:590-8. 2002
    ..Careful histologic analysis is necessary to differentiate anaplastic meningiomas and metastatic carcinomas, which have overlapping patterns of several keratins except K20, which was never present in any type of meningioma...
  84. ncbi Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163
    Jeffrey A Vos
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 18:693-704. 2005
    ..CD163 appears to be a specific histiocytic marker and is important in establishing the diagnosis of HS...
  85. doi Pulmonary artery sarcoma: a histologic and follow-up study with emphasis on a subset of low-grade myofibroblastic sarcomas with a good long-term follow-up
    Fabio Tavora
    Department of Pulmonary and Mediastinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 32:1751-61. 2008
    ..We conclude that survival beyond 3 years is possible for primary pulmonary artery sarcoma, but cure without evidence of disease is currently possible only for the select subtype of intravascular low-grade myofibroblastic sarcoma...
  86. ncbi From morphological to molecular diagnosis of soft tissue tumors
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Adv Exp Med Biol 587:99-113. 2006
    ....
  87. ncbi High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors
    Regine Schneider-Stock
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    J Clin Oncol 21:1688-97. 2003
    ..To determine the prognostic relevance of p16INK4 alterations in GISTs, we investigated a larger group of GISTs and correlated the genetic findings with clinicopathological factors and patient survival...
  88. ncbi Malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (malignant triton tumor) with balanced t(7;9)(q11.2;p24) and unbalanced translocation der(16)t(1;16)(q23;q13)
    Gopalrao V N Velagaleti
    Department of Pediatrics, The University of Texas Medical Branch, Children s Hospital, Suite 3 350, 301 University Boulevard, Galveston, TX 77555, USA
    Cancer Genet Cytogenet 149:23-7. 2004
    ..This finding may relate to the observed poor prognostic outcome in this type of sarcoma. Also unique to our case is the translocation involving 7q and 9p, both regions may play a role in MPNST...
  89. ncbi Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 28:1-30. 2004
    ..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO...
  90. ncbi Occurrence of other malignancies in patients with gastrointestinal stromal tumors
    Abbas Agaimy
    Institute of Pathology, Nuremberg Clinic Center, Nuremberg, Germany
    Semin Diagn Pathol 23:120-9. 2006
    ..The potential nonrandom association and causal relationship between GIST and other neoplasms remain to be investigated...
  91. ncbi Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases
    William B Laskin
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 29:39-51. 2005
    ..Accurate subclassification of some of these lesions is difficult based on currently available techniques...
  92. ncbi New challenges in the identification of gastrointestinal stromal tumors and other possible KIT-driven tumors
    Markku Miettinen
    Am J Clin Pathol 117:183-5. 2002
  93. ncbi Epithelial-type and neural-type cadherin expression in malignant noncarcinomatous neoplasms with epithelioid features that involve the soft tissues
    William B Laskin
    Department of Pathology, Northwestern University Medical School, Chicago, IL 60611 3053, USA
    Arch Pathol Lab Med 126:425-31. 2002
    ..Consequently, the presence of epithelioid cells in certain malignant noncarcinomatous neoplasms raises speculation that the expression of ECAD and NCAD in these neoplasms may have diagnostic significance...
  94. ncbi Diagnosis of gastrointestinal stromal tumors: a consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Int J Surg Pathol 10:81-9. 2002
    ....
  95. ncbi Primary gastrointestinal stromal tumor of the esophagus in an HIV-positive patient
    Anthony Padula
    Department of Hematophatology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Diagn Pathol 9:49-53. 2005
    ..The occurrence of this tumor in an HIV-positive patient is coincidental, and it resulted in an extremely unusual metastatic site that has not been reported for GISTs...
  96. ncbi Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002
    ....
  97. ncbi Mutations in gastrointestinal stromal tumors--a population-based study from Northern Norway
    Sonja E Steigen
    Department of Pathology, University Hospital of Northern Norway, Tromsø, Norway
    APMIS 115:289-98. 2007
    ..KIT and PDGFRA wild type was found in 15% of cases. Analysis of KIT and PDGFRA mutations is of significance for treatment with tyrosine kinase inhibitors, and may also have value when assessing the biological potential of GIST...
  98. ncbi Patterns of nestin and other intermediate filament expression distinguish between gastrointestinal stromal tumors, leiomyomas and schwannomas
    Maarit Sarlomo-Rikala
    Department of Pathology, Haartman Institute of the University of Helsinki, Finland
    APMIS 110:499-507. 2002
    ..The potential presence of K8 and K18 in GISTs should not lead to the misdiagnosis of carcinoma on biopsy...
  99. ncbi Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: a tissue microarray study
    Regine Schneider-Stock
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Clin Cancer Res 11:638-45. 2005
    ..P16 loss is a common molecular abnormality in GISTs and might be used in routine diagnosis to identify patients with high-risk tumors...
  100. ncbi Epithelioid sarcoma: new insights based on an extended immunohistochemical analysis
    William B Laskin
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    Arch Pathol Lab Med 127:1161-8. 2003
    ..Antibodies to certain keratin subunits and other novel antigens now available to surgical pathologists have not been tested on a large number of cases...
  101. ncbi A new familial GIST identified
    Jerzy Lasota
    Am J Surg Pathol 30:1342. 2006