Research Topics
Species | Y ManSummaryAffiliation: Armed Forces Institute of Pathology Country: USA Publications
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Publications
A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markersRoy R Zhang
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
Breast Cancer Res 5:R151-6. 2003..CONCLUSIONS: A subset of morphologically identifiable ME cells lack the expression of nine corresponding immunophenotypic markers, suggesting that ME cells might also be subject to different normal and pathological alterations...
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesisF Moinfar
Armed Forces Institute of Pathology, Department of Gynecologic and Breast Pathology, Washington, DC 20306, USA
Cancer Res 60:2562-6. 2000..We conclude that the mammary stroma may play a key role in inducing neoplastic transformation of epithelial cells, recapitulating its role in normal mammary duct development...
Leukocyte-mediated cell dissemination and metastasis: findings from multiple types of human tumorsYan Gao Man
Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306, USA
J Cell Biochem 112:1154-67. 2011..If confirmed, our hypothesis and technical approach may significantly facilitate early detection and intervention of tumor invasion and metastasis...- Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: A potential mechanism for basal cell layer disruptions and tumor invasionYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
Cancer Detect Prev 29:161-9. 2005..These findings suggest that focal basal cell layer disruptions and leukocyte infiltration are correlated events, representing a potential trigger factor for prostate tumor invasion... - A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasionYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
Cancer Detect Prev 29:323-31. 2005..The purpose of this study was to further elucidate the immunohistochemical and morphological profiles of these ER NCC... - A subset of prostate basal cells lacks the expression of corresponding phenotypic markersYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC 20306 6000, USA
Pathol Res Pract 202:651-62. 2006..These findings suggest that basal cells might be targets of a variety of pathological alterations, which could significantly impact biological presentations of associated tumor cells... - A subset of cell clusters with malignant features in morphologically normal-appearing and hyperplastic tissuesYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, NW, Washington, DC 20306 6000, USA
Cancer Detect Prev 30:239-47. 2006..The development of human breast cancer may be a multistep process, sequentially undergoing normal, hyperplastic, in situ, invasive, and metastatic stages... - Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasionYan Gao Man
Gynecologic and Breast Research Laboratory, Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, United States
Med Hypotheses 69:1340-57. 2007.... - Focal degeneration of basal cells and the resultant auto-immunoreactions: a novel mechanism for prostate tumor progression and invasionYan Gao Man
American Registry of Pathology and Armed Forces Institute of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
Med Hypotheses 70:387-408. 2008..More importantly, our hypothesis might be applicable, and significantly impact the detection, treatment, and prevention of other epithelium-derived tumors... - Bad seeds produce bad crops: a single stage-process of prostate tumor invasionYan Gao Man
American Registry of Pathology and Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
Int J Biol Sci 4:246-58. 2008..These pathways may contribute to early onset of prostate cancer at young ages, and to clinically more aggressive prostate tumors... - BP1, a putative signature marker for inflammatory breast cancer and tumor aggressivenessYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA
Cancer Biomark 5:9-17. 2009..Our findings suggest that BP1 may possess properties of onco-proteins that promote tumor progression, invasion, and metastasis, representing a putative signature marker for IBC and tumor aggressiveness... - Aberrant leukocyte infiltration: a direct trigger for breast tumor invasion and metastasisYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
Int J Biol Sci 6:129-32. 2010..Our findings suggest a novel pathway for tumor cell dissemination from primary sites and journey to new sites... - cDNA expression profiling reveals elevated gene expression in cell clusters overlying focally disrupted myoepithelial cell layers: implications for breast tumor invasionYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
Breast Cancer Res Treat 89:199-208. 2005..This study attempted to assess whether these cells also had a different expression profile on tumor progression related genes... - Direct and repeat uses of tissue sections as templates for liquid-phase polymerase chain reaction amplification: applications and implicationsYan Gao Man
Department of Gynecology and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington 20306 6000, USA
Appl Immunohistochem Mol Morphol 12:266-70. 2004..In addition, the strip could be used for immunohistochemical or other molecular assays after PCR amplifications. Further studies with the same protocol on strips containing chromosomal spreads generated similar results... - Morphologically similar epithelial and stromal cells in primary bilateral breast tumors display different genetic profiles: implications for treatmentYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
Appl Immunohistochem Mol Morphol 12:305-14. 2004.... - The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesisYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
Exp Cell Res 301:103-18. 2004.... - An antigen unmasking protocol that satisfies both immunohistochemistry and subsequent PCR amplificationYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, and American Registry of Pathology, Washington 20306 6000, USA
Pathol Res Pract 199:815-25. 2003..Compared to the routine method on untreated tissues, our method consistently produced a comparable quality and quantity of PCR products. Our protocol, however, takes a longer time to yield results... - Multiple use of slab gels in sequencing apparatus for separation of polymerase chain reaction productsY G Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, American Registry of Pathology, Washington, DC 20306 6000, USA
Electrophoresis 22:1915-9. 2001..The combination of a 6% native gel and a lower (45 degrees C) electrophoresis temperature permits multiple uses of a given gel with consistent results, consequently reducing the electrophoresis time and reagent costs... - An improved method for DNA extraction from paraffin sectionsY G Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
Pathol Res Pract 197:635-42. 2001..With these strategies, we have been able to consistently obtain comparable quality and quantity of DNA extracts which yielded uniform PCR products regardless of variations in tissue embedding and processing... - Allelic losses at 3p and 11p are detected in both epithelial and stromal components of cervical small-cell neuroendocrine carcinomaY Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306 6000, USA
Appl Immunohistochem Mol Morphol 9:340-5. 2001..The five losses in stromal cells were in four cases that showed no loss in epithelial cells with same markers, suggesting that stromal cells might play initiative roles in tumor development... - Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasionYan Gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA
Breast Cancer Res 5:R231-41. 2003..This is in contrast to the adjacent cells within the same duct, which were strongly immunoreactive for the ER. The current study attempts to confirm and expand previous observations on a larger scale... - Mammary ducts with and without focal myoepithelial cell layer disruptions show a different frequency of white blood cell infiltration and growth pattern: implications for tumor progression and invasionMorvarid Yousefi
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306-6000, USA
Appl Immunohistochem Mol Morphol 13:30-7. 2005..The significantly different frequency of WBC infiltration and clusters of multiple proliferating cells in ducts with and without ME disruptions suggests that WBCs might play important roles in ME disruption and tumor invasion... - Androgen and estrogen receptor mRNA status in apocrine carcinomasGary L Bratthauer
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Patholology, Washington, DC 20306 6000, USA
Diagn Mol Pathol 11:113-8. 2002..Therefore, the immunohistochemical absence of the estrogen receptor in apocrine cells cannot be explained by an abnormal message at these common sites and should be sought beyond these points... - Correlation of p63 immunoreactivity with tumor grade in meningiomasElisabeth J Rushing
Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Int J Surg Pathol 16:38-42. 2008..Our results indicate a good correlation exists between histological grade and p63 protein expression, suggesting that p63 expression might be correlated with the clinical outcome... - Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasionYan-gao Man
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, USA
Breast Cancer Res Treat 90:241-7. 2005..CONCLUSION: These findings suggest that BP1 is an important upstream factor in an oncogenic pathway, and that expression of BP1 may reliably reflect or directly contribute to tumor progression and/or invasion... - Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasiasGary L Bratthauer
Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA
Hum Pathol 33:620-7. 2002..This group needs further evaluation for better understanding of its significance, pattern of progression, and behavior... - Immune reconstitution inflammatory syndrome of the brain: case illustrations of a challenging entityElisabeth J Rushing
Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, District of Columbia 20306 6000, USA
J Neuropathol Exp Neurol 67:819-27. 2008..In this study, the degree of CD8+ inflammation was more pronounced in the single fatal example, and mast cells were not identified in the infiltrates. Although nonspecific, imaging findings may offer clues to early diagnosis... - High expression of a cytokeratin-associated protein in many cancersKristi A Egland
South Dakota Health Research Foundation Signal Transduction Institute, University of South Dakota School of Medicine and Sioux Valley Hospitals and Health System, Sioux Falls, SD 57105, USA
Proc Natl Acad Sci U S A 103:5929-34. 2006..We name the protein CAPC, cytokeratin-associated protein in cancer... - Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasionYun Ge Zhao
Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
Cancer Res 64:590-8. 2004..Higher levels of MMP-26 mRNA were also detected in DCIS cells by in situ hybridization... - Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxiaMercedes Garayoa
Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Am J Respir Cell Mol Biol 28:80-5. 2003..Further investigations are warranted to evaluate the relevance of modulation of hnRNP A2/B1 in hypoxic environments relative to its previously reported utility as a marker of early lung carcinogenesis... - Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesisRui Hong Wang
Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Mol Cell 32:11-20. 2008..These findings suggest that resveratrol treatment serves as an excellent strategy for targeted therapy for BRCA1-associated breast cancer...