Y Man

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. pmc Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness
    Zheli Xu
    Department of Thyroid and Breast Surgery, China Japan Union Hospital, Jilin University, Changchun, Jilin, China
    Int J Biol Sci 5:82-96. 2009
  2. pmc Correlated alterations in prostate basal cell layer and basement membrane
    Aijun Liu
    Department of Pathology, Chinese PLA General Hospital, Beijing, China
    Int J Biol Sci 5:276-85. 2009
  3. pmc Aberrant c-erbB2 expression in cell clusters overlying focally disrupted breast myoepithelial cell layers: a trigger or sign for emergence of more aggressive cell clones?
    Xichen Zhang
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China
    Int J Biol Sci 4:259-69. 2008
  4. pmc Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression
    Yi Hsuan Hsiao
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Int J Biol Sci 6:428-42. 2010
  5. pmc Breast cancer heterogeneity: mechanisms, proofs, and implications
    Yi Hsuan Hsiao
    1 Institute of Medicine, Chung Shan Medical University, Taiwan
    J Cancer 1:6-13. 2010
  6. pmc Tumor cell budding from focally disrupted tumor capsules: a common pathway for all breast cancer subtype derived invasion?
    Yan Gao Man
    Gynecologic and Breast Research Laboratory, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA, and Jilin University, China
    J Cancer 1:32-7. 2010
  7. pmc A seemingly most effective target for early detection and intervention of prostate tumor invasion
    Yan Gao Man
    Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA, and Jilin University, China
    J Cancer 1:63-9. 2010
  8. pmc Dual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of ovarian tumors: a preliminary study of 20 cases
    Yi Hsuan Hsiao
    1 Institute of Medicine, Chung Shan Medical University, Taiwan
    J Cancer 1:93-7. 2010
  9. pmc A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers
    Roy R Zhang
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Breast Cancer Res 5:R151-6. 2003
  10. ncbi Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis
    F Moinfar
    Armed Forces Institute of Pathology, Department of Gynecologic and Breast Pathology, Washington, DC 20306, USA
    Cancer Res 60:2562-6. 2000

Collaborators

Detail Information

Publications39

  1. pmc Aberrant p63 and WT-1 expression in myoepithelial cells of pregnancy-associated breast cancer: implications for tumor aggressiveness and invasiveness
    Zheli Xu
    Department of Thyroid and Breast Surgery, China Japan Union Hospital, Jilin University, Changchun, Jilin, China
    Int J Biol Sci 5:82-96. 2009
    ..To our best knowledge, our main finings have not been previously reported. Our findings suggest that the functional status of myoepithelial cells may be significantly associated with tumor aggressiveness and invasiveness...
  2. pmc Correlated alterations in prostate basal cell layer and basement membrane
    Aijun Liu
    Department of Pathology, Chinese PLA General Hospital, Beijing, China
    Int J Biol Sci 5:276-85. 2009
    ..Thus, further elucidation of the specific molecules and mechanism associated with these events may lead to the development of a more effective alternative for repeat biopsy to monitor tumor progression and invasion...
  3. pmc Aberrant c-erbB2 expression in cell clusters overlying focally disrupted breast myoepithelial cell layers: a trigger or sign for emergence of more aggressive cell clones?
    Xichen Zhang
    College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin, China
    Int J Biol Sci 4:259-69. 2008
    ..Our findings suggest that cell clusters overlying FMCLD may represent the precursors of pending invasive lesions, and that aberrant c-erbB2 expression may trigger or signify the emergence of biologically more aggressive cell clones...
  4. pmc Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression
    Yi Hsuan Hsiao
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Int J Biol Sci 6:428-42. 2010
    ..These findings suggest that aberrant sub-cellular localization of p63 expression in normal or hyperplastic appearing epithelial cells may significant contribute to increased invasiveness and aggressiveness of these cells...
  5. pmc Breast cancer heterogeneity: mechanisms, proofs, and implications
    Yi Hsuan Hsiao
    1 Institute of Medicine, Chung Shan Medical University, Taiwan
    J Cancer 1:6-13. 2010
    ....
  6. pmc Tumor cell budding from focally disrupted tumor capsules: a common pathway for all breast cancer subtype derived invasion?
    Yan Gao Man
    Gynecologic and Breast Research Laboratory, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA, and Jilin University, China
    J Cancer 1:32-7. 2010
    ..The potential mechanisms and clinical implications of our observations are discussed...
  7. pmc A seemingly most effective target for early detection and intervention of prostate tumor invasion
    Yan Gao Man
    Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC, USA, and Jilin University, China
    J Cancer 1:63-9. 2010
    ..The rationale, supporting data, and clinical applications of the hypothesis are discussed...
  8. pmc Dual use of a single Wilms' tumor 1 immunohistochemistry in evaluation of ovarian tumors: a preliminary study of 20 cases
    Yi Hsuan Hsiao
    1 Institute of Medicine, Chung Shan Medical University, Taiwan
    J Cancer 1:93-7. 2010
    ..Our findings also suggest that as WT-1 is expressed in both tumor and endothelial cells, the development of therapeutic agents to target WT-1 may provide an effective treatment option for ovarian cancer...
  9. pmc A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers
    Roy R Zhang
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Breast Cancer Res 5:R151-6. 2003
    ..However, some morphologically distinct ME cells fail to stain for SMA. This study intended to assess whether these SMA-negative cells also lack the expression of other ME cell markers...
  10. ncbi Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis
    F Moinfar
    Armed Forces Institute of Pathology, Department of Gynecologic and Breast Pathology, Washington, DC 20306, USA
    Cancer Res 60:2562-6. 2000
    ..We conclude that the mammary stroma may play a key role in inducing neoplastic transformation of epithelial cells, recapitulating its role in normal mammary duct development...
  11. ncbi A subset of cell clusters with malignant features in morphologically normal-appearing and hyperplastic tissues
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, NW, Washington, DC 20306 6000, USA
    Cancer Detect Prev 30:239-47. 2006
    ..The development of human breast cancer may be a multistep process, sequentially undergoing normal, hyperplastic, in situ, invasive, and metastatic stages...
  12. ncbi A subset of prostate basal cells lacks the expression of corresponding phenotypic markers
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington DC 20306 6000, USA
    Pathol Res Pract 202:651-62. 2006
    ..These findings suggest that basal cells might be targets of a variety of pathological alterations, which could significantly impact biological presentations of associated tumor cells...
  13. ncbi Focal degeneration of aged or injured myoepithelial cells and the resultant auto-immunoreactions are trigger factors for breast tumor invasion
    Yan Gao Man
    Gynecologic and Breast Research Laboratory, Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, United States
    Med Hypotheses 69:1340-57. 2007
    ....
  14. ncbi Focal degeneration of basal cells and the resultant auto-immunoreactions: a novel mechanism for prostate tumor progression and invasion
    Yan Gao Man
    American Registry of Pathology and Armed Forces Institute of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
    Med Hypotheses 70:387-408. 2008
    ..More importantly, our hypothesis might be applicable, and significantly impact the detection, treatment, and prevention of other epithelium-derived tumors...
  15. pmc Bad seeds produce bad crops: a single stage-process of prostate tumor invasion
    Yan Gao Man
    American Registry of Pathology and Armed Forces Institute of Pathology, Washington DC 20306 6000, USA
    Int J Biol Sci 4:246-58. 2008
    ..These pathways may contribute to early onset of prostate cancer at young ages, and to clinically more aggressive prostate tumors...
  16. ncbi BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA
    Cancer Biomark 5:9-17. 2009
    ..Our findings suggest that BP1 may possess properties of onco-proteins that promote tumor progression, invasion, and metastasis, representing a putative signature marker for IBC and tumor aggressiveness...
  17. pmc Aberrant leukocyte infiltration: a direct trigger for breast tumor invasion and metastasis
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Int J Biol Sci 6:129-32. 2010
    ..Our findings suggest a novel pathway for tumor cell dissemination from primary sites and journey to new sites...
  18. doi Leukocyte-mediated cell dissemination and metastasis: findings from multiple types of human tumors
    Yan Gao Man
    Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306, USA
    J Cell Biochem 112:1154-67. 2011
    ..If confirmed, our hypothesis and technical approach may significantly facilitate early detection and intervention of tumor invasion and metastasis...
  19. ncbi A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
    Cancer Detect Prev 29:323-31. 2005
    ..The purpose of this study was to further elucidate the immunohistochemical and morphological profiles of these ER NCC...
  20. ncbi An antigen unmasking protocol that satisfies both immunohistochemistry and subsequent PCR amplification
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, and American Registry of Pathology, Washington 20306 6000, USA
    Pathol Res Pract 199:815-25. 2003
    ..Compared to the routine method on untreated tissues, our method consistently produced a comparable quality and quantity of PCR products. Our protocol, however, takes a longer time to yield results...
  21. pmc Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA
    Breast Cancer Res 5:R231-41. 2003
    ..This is in contrast to the adjacent cells within the same duct, which were strongly immunoreactive for the ER. The current study attempts to confirm and expand previous observations on a larger scale...
  22. ncbi Allelic losses at 3p and 11p are detected in both epithelial and stromal components of cervical small-cell neuroendocrine carcinoma
    Y Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306 6000, USA
    Appl Immunohistochem Mol Morphol 9:340-5. 2001
    ..The five losses in stromal cells were in four cases that showed no loss in epithelial cells with same markers, suggesting that stromal cells might play initiative roles in tumor development...
  23. ncbi An improved method for DNA extraction from paraffin sections
    Y G Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Pathol Res Pract 197:635-42. 2001
    ..With these strategies, we have been able to consistently obtain comparable quality and quantity of DNA extracts which yielded uniform PCR products regardless of variations in tissue embedding and processing...
  24. ncbi The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the "protease-centered" hypothesis
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Exp Cell Res 301:103-18. 2004
    ....
  25. ncbi Morphologically similar epithelial and stromal cells in primary bilateral breast tumors display different genetic profiles: implications for treatment
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Appl Immunohistochem Mol Morphol 12:305-14. 2004
    ....
  26. ncbi Multiple use of slab gels in sequencing apparatus for separation of polymerase chain reaction products
    Y G Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, American Registry of Pathology, Washington, DC 20306 6000, USA
    Electrophoresis 22:1915-9. 2001
    ..The combination of a 6% native gel and a lower (45 degrees C) electrophoresis temperature permits multiple uses of a given gel with consistent results, consequently reducing the electrophoresis time and reagent costs...
  27. ncbi Direct and repeat uses of tissue sections as templates for liquid-phase polymerase chain reaction amplification: applications and implications
    Yan Gao Man
    Department of Gynecology and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington 20306 6000, USA
    Appl Immunohistochem Mol Morphol 12:266-70. 2004
    ..In addition, the strip could be used for immunohistochemical or other molecular assays after PCR amplifications. Further studies with the same protocol on strips containing chromosomal spreads generated similar results...
  28. ncbi cDNA expression profiling reveals elevated gene expression in cell clusters overlying focally disrupted myoepithelial cell layers: implications for breast tumor invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street, NW, Washington, DC 20306 6000, USA
    Breast Cancer Res Treat 89:199-208. 2005
    ..This study attempted to assess whether these cells also had a different expression profile on tumor progression related genes...
  29. ncbi Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: A potential mechanism for basal cell layer disruptions and tumor invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    Cancer Detect Prev 29:161-9. 2005
    ..These findings suggest that focal basal cell layer disruptions and leukocyte infiltration are correlated events, representing a potential trigger factor for prostate tumor invasion...
  30. ncbi Mammary ducts with and without focal myoepithelial cell layer disruptions show a different frequency of white blood cell infiltration and growth pattern: implications for tumor progression and invasion
    Morvarid Yousefi
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Appl Immunohistochem Mol Morphol 13:30-7. 2005
    ..The significantly different frequency of WBC infiltration and clusters of multiple proliferating cells in ducts with and without ME disruptions suggests that WBCs might play important roles in ME disruption and tumor invasion...
  31. ncbi Correlation of p63 immunoreactivity with tumor grade in meningiomas
    Elisabeth J Rushing
    Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Int J Surg Pathol 16:38-42. 2008
    ..Our results indicate a good correlation exists between histological grade and p63 protein expression, suggesting that p63 expression might be correlated with the clinical outcome...
  32. ncbi Androgen and estrogen receptor mRNA status in apocrine carcinomas
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Patholology, Washington, DC 20306 6000, USA
    Diagn Mol Pathol 11:113-8. 2002
    ..Therefore, the immunohistochemical absence of the estrogen receptor in apocrine cells cannot be explained by an abnormal message at these common sites and should be sought beyond these points...
  33. ncbi Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:620-7. 2002
    ..This group needs further evaluation for better understanding of its significance, pattern of progression, and behavior...
  34. ncbi Expression of BP1, a novel homeobox gene, correlates with breast cancer progression and invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, The George Washington University Medical Center, 2300 Eye Street, Washington, DC 20037, USA
    Breast Cancer Res Treat 90:241-7. 2005
    ..This study investigated the immunohistochemical profile of BP1, to determine whether the expression of BP1 protein correlated with breast tumor progression and invasion and whether BP1 was co-localized with erbB2...
  35. ncbi Immune reconstitution inflammatory syndrome of the brain: case illustrations of a challenging entity
    Elisabeth J Rushing
    Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, District of Columbia 20306 6000, USA
    J Neuropathol Exp Neurol 67:819-27. 2008
    ..In this study, the degree of CD8+ inflammation was more pronounced in the single fatal example, and mast cells were not identified in the infiltrates. Although nonspecific, imaging findings may offer clues to early diagnosis...
  36. ncbi Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
    Cancer Res 64:590-8. 2004
    ..Higher levels of MMP-26 mRNA were also detected in DCIS cells by in situ hybridization...
  37. pmc High expression of a cytokeratin-associated protein in many cancers
    Kristi A Egland
    South Dakota Health Research Foundation Signal Transduction Institute, University of South Dakota School of Medicine and Sioux Valley Hospitals and Health System, Sioux Falls, SD 57105, USA
    Proc Natl Acad Sci U S A 103:5929-34. 2006
    ..We name the protein CAPC, cytokeratin-associated protein in cancer...
  38. ncbi Downregulation of hnRNP A2/B1 expression in tumor cells under prolonged hypoxia
    Mercedes Garayoa
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Respir Cell Mol Biol 28:80-5. 2003
    ..Further investigations are warranted to evaluate the relevance of modulation of hnRNP A2/B1 in hypoxic environments relative to its previously reported utility as a marker of early lung carcinogenesis...
  39. pmc Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
    Rui Hong Wang
    Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Mol Cell 32:11-20. 2008
    ..These findings suggest that resveratrol treatment serves as an excellent strategy for targeted therapy for BRCA1-associated breast cancer...