Jerzy Lasota

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. pmc Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Washington, DC 20306 6000, USA
    J Mol Diagn 9:89-94. 2007
  2. doi request reprint Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Histopathology 53:245-66. 2008
  3. ncbi request reprint Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 87:1029-41. 2007
  4. ncbi request reprint Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
  5. ncbi request reprint GISTs with PDGFRA exon 14 mutations represent subset of clinically favorable gastric tumors with epithelioid morphology
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 86:94-100. 2006
  6. ncbi request reprint A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue NW, Washington, DC 20306 6000, USA
    Lab Invest 84:874-83. 2004
  7. doi request reprint Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 21:476-84. 2008
  8. doi request reprint Genetics for the diagnosis and treatment of mesenchymal tumors
    Jerzy Lasota
    Department of Soft Tissue and Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Musculoskelet Radiol 11:215-30. 2007
  9. doi request reprint KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 39:1728-36. 2008
  10. ncbi request reprint KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:91-102. 2006

Detail Information

Publications60

  1. pmc Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th St NW, Bldg 54, Washington, DC 20306 6000, USA
    J Mol Diagn 9:89-94. 2007
    ..Use of the PCR assay amplifying the specific region affected by duplications and yielding 129 bp in wild-type KIT can substantially improve the detection of these mutations in formalin-fixed, paraffin-embedded GISTs...
  2. doi request reprint Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Histopathology 53:245-66. 2008
    ..GISTs with secondary mutations in exon 13 and 14 are sensitive to sunitinib, another tyrosine kinase inhibitor. KIT and PDGFRA genotyping is important for GIST diagnosis and assessment of sensitivity to tyrosine kinase inhibitors...
  3. ncbi request reprint Presence of homozygous KIT exon 11 mutations is strongly associated with malignant clinical behavior in gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 87:1029-41. 2007
    ..4 months. Based on these findings, we conclude that presence of homozygous KIT exon 11 mutations is associated with malignant course of disease and should be considered an adverse prognostic marker in GISTs...
  4. ncbi request reprint Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 85:237-47. 2005
    ..An isolated LOH at D22S425 was equally found in both benign and malignant tumors. These observations may suggest that LOHs on chromosome 22q in GISTs play a role in early stages of tumor formation as well as in late tumor progression...
  5. ncbi request reprint GISTs with PDGFRA exon 14 mutations represent subset of clinically favorable gastric tumors with epithelioid morphology
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Lab Invest 86:94-100. 2006
    ..In four cases with moderate or high malignant potential GISTs, a long-term follow-up (average 235.5 months) showed favorable course of disease...
  6. ncbi request reprint A great majority of GISTs with PDGFRA mutations represent gastric tumors of low or no malignant potential
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Avenue NW, Washington, DC 20306 6000, USA
    Lab Invest 84:874-83. 2004
    ..Based on long-term follow-up (average 135 months), a majority (83.5%) of GISTs with PDGFRA mutations followed a benign course...
  7. doi request reprint Clinicopathologic profile of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: a multicenter study on 54 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 21:476-84. 2008
    ..The latter is also true for all KIT exon 17 mutant GISTs...
  8. doi request reprint Genetics for the diagnosis and treatment of mesenchymal tumors
    Jerzy Lasota
    Department of Soft Tissue and Orthopedic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Musculoskelet Radiol 11:215-30. 2007
    ..Cytogenetic and molecular genetic alterations identified in various mesenchymal tumors are often valuable for diagnosis, prognosis, and treatment strategies...
  9. doi request reprint KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 39:1728-36. 2008
    ..Moreover, KIT codon 558 insertions might indicate an increased risk of malignant behavior for gastric gastrointestinal stromal tumors...
  10. ncbi request reprint KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:91-102. 2006
    ..Mutation genotyping is a tool in GIST diagnosis and in assessment of sensitivity to kinase inhibitors. This is a US government work. There are no restrictions on its use...
  11. pmc The neurofibromatosis type 2 gene is mutated in perineurial cell tumors: a molecular genetic study of eight cases
    J Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 14th Street and Alaska Ave, Washington, DC 20306 6000, USA
    Am J Pathol 158:1223-9. 2001
    ..The coexistence of NF2 gene mutations and LOH at the NF2 locus indicates that the NF2 tumor suppressor gene is altered in PNTs by the two-hit mechanism...
  12. doi request reprint Gain-of-function PDGFRA mutations, earlier reported in gastrointestinal stromal tumors, are common in small intestinal inflammatory fibroid polyps. A study of 60 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 22:1049-56. 2009
    ..We also suggest that these polyps may develop from earlier described PDGFRA-positive mesenchymal cells distributed along the villus membrane after oncogenic PDGFRA activation...
  13. ncbi request reprint Evaluation of NF2 and NF1 tumor suppressor genes in distinctive gastrointestinal nerve sheath tumors traditionally diagnosed as benign schwannomas: s study of 20 cases
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 600, USA
    Lab Invest 83:1361-71. 2003
    ..However, lack of NF2 alterations strongly supports the hypothesis that GI schwannomas represent a morphologically and genetically distinct group of peripheral nerve sheath tumors that are different from conventional schwannomas...
  14. ncbi request reprint Gastrointestinal stromal tumors with internal tandem duplications in 3' end of KIT juxtamembrane domain occur predominantly in stomach and generally seem to have a favorable course
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 16:1257-64. 2003
    ..This suggests that presence of these IDTs may define a clinicopathologically favorable subset of GISTs. The consequence of these mutations to KIT signaling should be investigated...
  15. ncbi request reprint KIT exon 11 deletion-inversions represent complex mutations in gastrointestinal stromal tumors
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cancer Genet Cytogenet 175:69-72. 2007
    ..5%, based on evaluation of 700 KIT exon 11 mutants. Molecular events leading to formation of deletion-inversions remain elusive and should be studied further...
  16. ncbi request reprint KIT 1530ins6 mutation defines a subset of predominantly malignant gastrointestinal stromal tumors of intestinal origin
    Jerzy Lasota
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 34:1306-12. 2003
    ..GISTs carrying 1530ins6 occur exclusively in the intestinal location, and a great majority of these tumors follow a malignant course...
  17. doi request reprint Gastrointestinal stromal tumors presenting as omental masses--a clinicopathologic analysis of 95 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Building 54, Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1267-75. 2009
    ..KIT positive Cajal cells were not found in normal omental tissues failing to support the presence of these ancestral cells for GIST in the omentum...
  18. doi request reprint DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, NW, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1401-8. 2009
    ..DOG1 should be added into the diagnostic panel evaluating GI and other abdominal tumors, but limitations in its sensitivity and specificity should be recognized...
  19. ncbi request reprint Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the duodenum: a clinicopathologic, immunohistochemical, and molecular genetic study of 167 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Patholgy, Washington, DC 20306 6000, USA
    Am J Surg Pathol 27:625-41. 2003
    ..The great majority of duodenal mesenchymal tumors are GISTs, which have a spectrum from small indolent tumors to overt sarcomas. LMs and LMSs are rare...
  20. ncbi request reprint Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:478-83. 2002
    ..Genetic markers, including DNA-copy number changes, telomerase activity, and KIT mutation status, may be useful in more accurately identifying tumors with malignant potential...
  21. ncbi request reprint Gastrointestinal stromal tumors of the jejunum and ileum: a clinicopathologic, immunohistochemical, and molecular genetic study of 906 cases before imatinib with long-term follow-up
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:477-89. 2006
    ..There were no PDGFRA exon 12 or 8 mutations. Systematic data on prognosis of small intestinal GISTs of various size and mitotic activity categories can be helpful in management and surveillance of patients with these tumors...
  22. ncbi request reprint Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Arch Pathol Lab Med 130:1466-78. 2006
    ..They are believed to originate from interstitial cells of Cajal or related stem cells...
  23. doi request reprint Plexiform fibromyxoma: a distinctive benign gastric antral neoplasm not to be confused with a myxoid GIST
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1624-32. 2009
    ..Plexiform fibromyxoma is a distinctive benign gastric antral neoplasm that should be separated from GIST, nerve sheath tumors, and other fibromyxoid neoplasms...
  24. ncbi request reprint Minute synovial sarcomas of the hands and feet: a clinicopathologic study of 21 tumors less than 1 cm
    Michal Michal
    Sikl s Department of Pathology, Faculty Hospital, Pilsen, Czech Republic, and the Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:721-6. 2006
    ..These tumors should be recognized as part of the spectrum of synovial sarcomas...
  25. ncbi request reprint A distinctive novel epitheliomesenchymal biphasic tumor of the stomach in young adults ("gastroblastoma"): a series of 3 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Building 54, Room G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:1370-7. 2009
    ..5, 5, and 14 years. Because these tumors have some resemblance to blastomas of other organs, we propose the term "gastroblastoma" for this distinctive, at least low-grade malignant epitheliomesenchymal tumor of the stomach...
  26. ncbi request reprint Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up
    Markku Miettinen
    Departments of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:52-68. 2005
    ..The above results may be helpful for setting the criteria for adjuvant treatment such as Gleevec...
  27. ncbi request reprint Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Bldg 54, Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 29:1373-81. 2005
    ..Their pathogenesis may differ from that of adult GISTs because no KIT or PDGFRA mutations were found; connection with Carney triad seems infrequent despite demographic and histologic similarities...
  28. ncbi request reprint A nonrandom association between gastrointestinal stromal tumors and myeloid leukemia
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Cancer 112:645-9. 2008
    ..These tumors most commonly occur in the stomach and small intestine and encompass a clinical spectrum from benign to malignant. In the current study, the authors examined long-term follow-up data of 1892 GIST patients from the U.S...
  29. ncbi request reprint Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, 6825 16th Street NW, Bldg 54 Rm G090, Washington, DC 20306 6000, USA
    Am J Surg Pathol 30:90-6. 2006
    ..None of the 16 tumors from 15 patients had a KIT exon 9, 11, 13, or 17 or PDGFRA exon 12 or 18 mutation as is typically seen in sporadic GISTs, indicating that GISTs in NF1 patients have a different pathogenesis than sporadic GISTs...
  30. pmc Gastric schwannoma: a clinicopathologic study of 51 cases and critical review of the literature
    Lysandra Voltaggio
    George Washington University Hospital, Department of Pathology, Washington, DC 20037, USA
    Hum Pathol 43:650-9. 2012
    ..It should be distinguished from gastrointestinal stromal tumor and other mesenchymal tumors of the gastrointestinal tract, such as the S100 protein-positive gastrointestinal clear cell sarcoma and metastatic melanoma...
  31. ncbi request reprint Gastrointestinal stromal tumors: pathology and prognosis at different sites
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Semin Diagn Pathol 23:70-83. 2006
    ..Immunohistochemical demonstration of KIT, CD34, or protein kinase theta positivity helps to properly identify these tumors...
  32. ncbi request reprint Not all c-kit mutations can be corrected by imatinib
    Jerzy Lasota
    Armed Forces Institute of Pathology, Washington, DC, USA
    Lab Invest 87:317. 2007
  33. doi request reprint True smooth muscle tumors of the small intestine: a clinicopathologic, immunhistochemical, and molecular genetic study of 25 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 33:430-6. 2009
    ..The number of LMS cases is too small for stratification for risk assessment. True SMTs of small intestine should be separated from GISTs because of different pathogenesis and treatment...
  34. ncbi request reprint Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Eur J Cancer 38:S39-51. 2002
    ..Functional analysis of the different c-kit mutations and their impact on the response to tyrosine kinase inhibitors are under intense investigation...
  35. ncbi request reprint Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Pol J Pathol 54:3-24. 2003
    ..Majority of these mutations are in-frame-deletions and missense mutations clustering in the 5'-end of juxtamembrane domain (exon 11). A rare mutation, an Ala502-Tyr503 duplication in exon 9, is specific for intestinal GISTs...
  36. ncbi request reprint Gastrointestinal glomus tumors: a clinicopathologic, immunohistochemical, and molecular genetic study of 32 cases
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 26:301-11. 2002
    ..These tumors are phenotypically similar to peripheral glomus tumors and differ from epithelioid GISTs...
  37. ncbi request reprint CD45 (leukocyte common antigen) immunoreactivity in metastatic undifferentiated and neuroendocrine carcinoma: a potential diagnostic pitfall
    M A Nandedkar
    Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Mod Pathol 11:1204-10. 1998
    ..It is best avoided by employing a panel of leukocyte and epithelial antigens and by use of electron microscopy, if possible...
  38. ncbi request reprint Gastrointestinal stromal tumors and leiomyomas in the dog: a histopathologic, immunohistochemical, and molecular genetic study of 50 cases
    D Frost
    Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Vet Pathol 40:42-54. 2003
    ..Twenty-eight (97%) were positive for smooth muscle actin and 18 (62%) for desmin but none for CD117 and S-100. Both GISTs and true LMs occur in the GI tract of dogs. Both tumors have distinctive pathologic features...
  39. ncbi request reprint Gastrointestinal stromal tumors, intramural leiomyomas, and leiomyosarcomas in the rectum and anus: a clinicopathologic, immunohistochemical, and molecular genetic study of 144 cases
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:1121-33. 2001
    ..Intramural LMs are exceptional, and true LMSs are rare, and similar to colonic ones, often present as intraluminal polypoid masses that appear to have a better prognosis than GISTs with similar mitotic rates...
  40. ncbi request reprint Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 438:1-12. 2001
    ..Angiosarcomas and metastatic melanomas, both of which are often KIT-positive, should not be confused with GISTs...
  41. ncbi request reprint Gastrointestinal stromal tumours
    M Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Ann Chir Gynaecol 87:278-81. 1998
    ....
  42. ncbi request reprint KIT-positive gastrointestinal stromal tumor in a 22-year-old male chimpanzee (Pan troglodites)
    G A Saturday
    Department of Veterinary Pathology, Armed Forces Institute of Pathology, 14th and Alaska Avenue, Northwest, Building 54, Room G117, Washington, DC 20306 6000, USA
    Vet Pathol 42:362-5. 2005
    ..More cases of nonhuman primate GISTs should be analyzed to discover the clinicopathologic spectrum of GISTs in these species...
  43. ncbi request reprint KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
    Markku Miettinen
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Appl Immunohistochem Mol Morphol 13:205-20. 2005
    ....
  44. ncbi request reprint Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation
    M Debiec-Rychter
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Cancer Genet Cytogenet 128:24-30. 2001
    ..These observations may reflect the different pathways leading to malignant transformation of GISTs...
  45. ncbi request reprint Calretinin and other mesothelioma markers in synovial sarcoma: analysis of antigenic similarities and differences with malignant mesothelioma
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306-6000, USA
    Am J Surg Pathol 25:610-7. 2001
    ..Global expression of K7 and K19 in mesotheliomas versus focal expression in monophasic and poorly differentiated SSs, and differential patterns of K14 expression may also be helpful...
  46. pmc Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists
    Jeanny H Wang
    Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    J Cancer 2:90-3. 2011
    ..A classification based on both SDHB expression status and KIT and PDGFRA mutation status characterize GISTs more accurately and allow subdivision of SDHB-positive tumors into different clinico-genetic categories...
  47. ncbi request reprint Microphthalmia transcription factor in the immunohistochemical diagnosis of metastatic melanoma: comparison with four other melanoma markers
    M Miettinen
    Armed Forces Institute of Pathology, Department of Soft Tissue Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 25:205-11. 2001
    ..Microphthalmia transcription factor may be a valuable addition to the marker panel used in diagnosing melanoma, in combination with S100, TYR, and the other markers, but it is not present in cases of desmoplastic melanomas...
  48. ncbi request reprint Diagnosis of gastrointestinal stromal tumors: a consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Int J Surg Pathol 10:81-9. 2002
    ....
  49. ncbi request reprint Diagnosis of gastrointestinal stromal tumors: A consensus approach
    Christopher D M Fletcher
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston MA 02115, USA
    Hum Pathol 33:459-65. 2002
    ....
  50. ncbi request reprint Complex genetic alterations in gastrointestinal stromal tumors with autonomic nerve differentiation
    Maria Debiec-Rychter
    Center for Human Genetics, Katholieke Universiteit Leuven, Belgium
    Mod Pathol 15:692-8. 2002
    ..These findings suggest that accumulated genetic changes contribute to the pathogenesis of GANTs and that 22q13 loss may be a characteristic feature of these tumors...
  51. ncbi request reprint Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: a tissue microarray study
    Regine Schneider-Stock
    Department of Pathology, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Clin Cancer Res 11:638-45. 2005
    ..P16 loss is a common molecular abnormality in GISTs and might be used in routine diagnosis to identify patients with high-risk tumors...
  52. ncbi request reprint A new familial GIST identified
    Jerzy Lasota
    Am J Surg Pathol 30:1342. 2006
  53. ncbi request reprint Gastrointestinal stromal tumors. A multicenter experience
    Katarzyna Urbanczyk
    Department of Clinical and Experimental Pathomorphology, Collegium Medicum, Jagiellonian University, Krakow
    Pol J Pathol 56:51-61. 2005
    ....
  54. ncbi request reprint Benign epithelioid peripheral nerve sheath tumors of the soft tissues: clinicopathologic spectrum of 33 cases
    William B Laskin
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Am J Surg Pathol 29:39-51. 2005
    ..Accurate subclassification of some of these lesions is difficult based on currently available techniques...
  55. ncbi request reprint Occurrence of other malignancies in patients with gastrointestinal stromal tumors
    Abbas Agaimy
    Institute of Pathology, Nuremberg Clinic Center, Nuremberg, Germany
    Semin Diagn Pathol 23:120-9. 2006
    ..The potential nonrandom association and causal relationship between GIST and other neoplasms remain to be investigated...
  56. ncbi request reprint High prognostic value of p16INK4 alterations in gastrointestinal stromal tumors
    Regine Schneider-Stock
    Department of Pathology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    J Clin Oncol 21:1688-97. 2003
    ..To determine the prognostic relevance of p16INK4 alterations in GISTs, we investigated a larger group of GISTs and correlated the genetic findings with clinicopathological factors and patient survival...
  57. pmc Apparent KIT Ser(715) deletion in GIST mRNA is not detectable in genomic DNA and represents a previously known splice variant of KIT transcript
    Jerzy Lasota
    Am J Pathol 161:739-41. 2002
  58. ncbi request reprint Mutations in gastrointestinal stromal tumors--a population-based study from Northern Norway
    Sonja E Steigen
    Department of Pathology, University Hospital of Northern Norway, Tromsø, Norway
    APMIS 115:289-98. 2007
    ..KIT and PDGFRA wild type was found in 15% of cases. Analysis of KIT and PDGFRA mutations is of significance for treatment with tyrosine kinase inhibitors, and may also have value when assessing the biological potential of GIST...
  59. ncbi request reprint Array comparative genomic hybridization analysis of chromosomal imbalances and their target genes in gastrointestinal stromal tumors
    Reetta Assämäki
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Genes Chromosomes Cancer 46:564-76. 2007
    ..Array CGH proved to be an effective tool for the identification of chromosome regions involved in the development and progression of GISTs...
  60. ncbi request reprint A unique occurrence of a cerebral atypical teratoid/rhabdoid tumor in an infant and a spinal canal primitive neuroectodermal tumor in her father
    Ewa Izycka-Swieszewska
    Department of Pathology, Medical University of Gdansk, Poland
    J Neurooncol 61:219-25. 2003
    ..Thus, our findings emphasize the genetic differences between the two specimens and suggest that the occurrence of these two aggressive tumors of CNS in one family could be coincidental...