Research Topics
Species | Zachary D GoodmanSummaryAffiliation: Armed Forces Institute of Pathology Country: USA Publications
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Detail Information
Publications
Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysisZachary D Goodman
Armed Forces Institute of Pathology, Division of Hepatic Pathology, Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
Hepatology 45:886-94. 2007..CONCLUSION: In advanced chronic hepatitis C, fibrosis increases at a rapid pace that can only be detected by morphometry. This technique can be used in future therapeutic trials of agents to inhibit fibrosis progression...- Drug hepatotoxicityZachary D Goodman
Division of Hepatic Pathology and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Room 3107, 14th Street and Alaska Avenue, NW, Washington, DC 20306, USA
Clin Liver Dis 6:381-97. 2002.... 
Pathology of chronic hepatitis C in children: liver biopsy findings in the Peds-C TrialZachary D Goodman
Armed Forces Institute of Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
Hepatology 47:836-43. 2008....- Grading and staging systems for inflammation and fibrosis in chronic liver diseasesZachary D Goodman
Armed Forces Institute of Pathology, Department of Hepatic and Gastrointestinal Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
J Hepatol 47:598-607. 2007.... - Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinomaHala M Abdul-Al
Division of Hepatic Pathology and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Hum Pathol 39:209-12. 2008..Pathologists should be aware of this phenomenon and exercise caution in interpreting biopsies or other specimens of suspected hepatocellular carcinoma when active necroinflammatory disease is present... - Fibrosis progression in chronic hepatitis C: morphometric image analysis in the HALT-C trialZachary D Goodman
Armed Forces Institute of Pathology, Division of Hepatic Pathology and Veterans Administration Special Reference Laboratory for Pathology, Washington, DC, USA
Hepatology 50:1738-49. 2009..CONCLUSION: Morphometry demonstrated complex, nonlinear changes in fibrosis over time in this heterogeneous cohort of patients with interferon-refractory chronic hepatitis C... - Calcifying nested stromal-epithelial tumors of the liver: a clinicopathologic, immunohistochemical, and molecular genetic study of 9 cases with a long-term follow-upHala R Makhlouf
Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, 6825 16th Street, N W, Building 54, Washington, DC 20306 6000, USA
Am J Surg Pathol 33:976-83. 2009..On the basis of currently available information, this tumor is best considered a low-grade malignancy... - Fibrolamellar hepatocellular carcinoma: an immunohistochemical comparison with conventional hepatocellular carcinomaHala M Abdul-Al
Armed Forces Institute of Pathology, Washington, DC, USA
Int J Surg Pathol 18:313-8. 2010..All tumors had CD34-positive sinusoids. This study shows that FLCs and HCCs differ in the expression of GPC3, CK7, and CK19 and that there is a lack of difference as regards survivin and CD34... - More severe parenchymal injury in chronic hepatitis C acquired by recent injection drug useMatthew M Yeh
Department of Pathology, George Washington University School of Medicine, Washington, DC, and the Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA
J Clin Gastroenterol 39:722-7. 2005..The availability of material from a cohort of patients who had liver biopsy for IDU-related hepatitis C in the 1970s enabled us to compare the histology with that of current patients... - Globular hepatic amyloid: an early stage in the pathway of amyloid formation: a study of 20 new casesHala R Makhlouf
Division of Hepatic Pathology, Department of Hepatic and Gastrointestinal Pathology, and the Veterans Administration Special Reference Laboratory for Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA
Am J Surg Pathol 31:1615-21. 2007.... - Expression of estrogen and progesterone receptors and inhibin-alpha in hepatobiliary cystadenoma: an immunohistochemical studyHala M Abdul-Al
Division of Hepatic Pathology, Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Virchows Arch 450:691-7. 2007..The expression of ER, PR, and inhibin-alpha in the ovarian-like stroma supports the likely hormonal dependence of this tumor and probably explains its almost exclusive occurrence in women... - Diagnosis of focal nodular hyperplasia of the liver by needle biopsyHala R Makhlouf
Division of Hepatic Pathology, Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Hum Pathol 36:1210-6. 2005.... - Neoplasms of the liverZachary D Goodman
Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
Mod Pathol 20:S49-60. 2007..Cholangiocarcinoma resembles adenocarcinomas arising in other tissues, so a definitive diagnosis relies on the exclusion of an extrahepatic primary and distinction from benign biliary lesions... - Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcomaWael I Al-Daraji
Department of Soft Tissue and Orthopaedic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Am J Surg Pathol 33:826-34. 2009..Primary gallbladder sarcoma (PGBS) is rare, with only 39 documented cases, with the predominant type being leiomyosarcoma... - Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: results of the HALT-C cohortAnna S F Lok
Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48210, USA
Hepatology 42:282-92. 2005..In conclusion, a model based on standard laboratory test results can be used to predict histological cirrhosis with a high degree of accuracy in 50% of patients with CHC... - Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis CRobert J Fontana
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Hepatology 47:789-98. 2008..The stronger correlation of the serum markers with Ishak scores suggests that serum fibrosis markers reflect the pattern of fibrosis more closely than the quantity of hepatic collagen... - Histopathological changes after microwave coagulation therapy for patients with hepatocellular carcinoma: review of 15 explanted liversNoriyo Yamashiki
Division of Hepatology, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
Am J Gastroenterol 98:2052-9. 2003..Pathologists need to be aware that after this form of therapy, portions of the tumor maintain their native morphological features as if the area is fixed, but their cellular activity is destroyed... - Best practices in diagnostic immunohistochemistry: hepatocellular carcinoma versus metastatic neoplasmsSanjay Kakar
Department of Pathology, Veteran Affairs and University of California Medical Center, San Francisco, CA 94121, USA
Arch Pathol Lab Med 131:1648-54. 2007..Because limited tissue is available with fine-needle and core biopsies, appropriate selection of antibodies is imperative... - Peginterferon alfa-2a and ribavirin in patients with chronic hepatitis C who have failed prior treatmentMitchell L Shiffman
Hepatology Section, Virginia Commonwealth University, Richmond, 23298, USA
Gastroenterology 126:1015-23; discussion 947. 2004..This study evaluated the effectiveness of this treatment in patients who were nonresponders to previous interferon-based therapy... - Diabetic hepatosclerosis: diabetic microangiopathy of the liverStephen A Harrison
Liver Center, Department of Medicine, Saint Louis University School of Medicine, St Louis, MO 63110, USA
Arch Pathol Lab Med 130:27-32. 2006..Further studies are needed to precisely characterize diabetic hepatosclerosis and to understand mechanisms of pathogenesis and the clinical significance... - Idiopathic adulthood ductopenia associated with hepatitis C virusAli T Dural
Department of Medicine, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
Dig Dis Sci 47:1625-6. 2002 - Liver biopsy in cirrhotic patientsKenneth E Sherman
University of Cincinnati College of Medicine, Division of Digestive Diseases, Cincinnati, Ohio 45267 0595, USA
Am J Gastroenterol 102:789-93. 2007..No specific safety issues attributable to a particular biopsy method were identified... - Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosisPaul J Pockros
Division of Gastroenterology Hepatology, Scripps Clinic, La Jolla, CA 92037, USA
Hepatology 45:569-78. 2007..Subgroups of patients with elevated ITAC levels and perhaps less advanced disease may be considered for future studies with IFN-gamma1b... - Pathologic assessment of non-alcoholic fatty liver diseaseSilvia Bondini
Center for Liver Diseases at Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA
Clin Liver Dis 11:17-23, vii. 2007..This article reviews some of the studies dealing with the histopathology of NAFLD, with attempts to develop a standardized pathologic scoring system for NASH... - Hepatic iron concentration does not influence response to therapy with interferon plus ribavirin in chronic HCV infectionStephen Pianko
Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA
J Interferon Cytokine Res 22:483-9. 2002..IFN monotherapy nonresponder patients tended to have a higher HIC. With IFN plus ribavirin, the sustained virologic response rate was not affected by the HIC... - Hepatic adenocarcinoma expressing inhibin in a young patient on oral contraceptivesEleni Vrettou
Department of Pathology, Aristotle University Medical School, 540 06 Thessaloniki, Greece
Virchows Arch 446:560-5. 2005..In conclusion, this unique case may represent a rare variant of cholangiocarcinoma expressing inhibin... - Giant cell tumor of the extrahepatic biliary tree: a clinicopathologic study of 4 cases and comparison with anaplastic spindle and giant cell carcinoma with osteoclast-like giant cellsJorge Albores-Saavedra
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Am J Surg Pathol 30:495-500. 2006.... - Hepatic HCV RNA before and after treatment with interferon alone or combined with ribavirinJohn G McHutchison
Division of Gastroenterology Hepatology, Scripps Clinic and Research Foundation, 10666 N Torrey Pines Road N203, La Jolla, CA 92037, USA
Hepatology 35:688-93. 2002..In conclusion, measurement of hepatic HCV RNA before or after therapy reflects changes observed in serum HCV RNA, and correlates inversely with hepatic inflammation and fibrosis, but otherwise has minimal clinical use...