G L Bratthauer

Summary

Affiliation: Armed Forces Institute of Pathology
Country: USA

Publications

  1. ncbi request reprint Cells with minimal expression of the JAK/STAT pathway related proteins STAT5a and the prolactin receptor: evidence of an alternate prolactin receptor isoform in breast disease
    G L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Protein Pept Lett 17:104-8. 2010
  2. ncbi request reprint Cytokeratin immunoreactivity in lobular intraepithelial neoplasia
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Histochem Cytochem 51:1527-31. 2003
  3. ncbi request reprint STAT 5a expression in various lesions of the breast
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 448:165-71. 2006
  4. ncbi request reprint Androgen and estrogen receptor mRNA status in apocrine carcinomas
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Patholology, Washington, DC 20306 6000, USA
    Diagn Mol Pathol 11:113-8. 2002
  5. ncbi request reprint Lobular intraepithelial neoplasia: previously unexplored aspects assessed in 775 cases and their clinical implications
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 440:134-8. 2002
  6. ncbi request reprint Antibodies targeting p63 react specifically in the cytoplasm of breast epithelial cells exhibiting secretory differentiation
    G L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington DC 20306, USA
    Histopathology 47:611-6. 2005
  7. ncbi request reprint Assessment of lesions coexisting with various grades of ductal intraepithelial neoplasia of the breast
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 444:340-4. 2004
  8. ncbi request reprint Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis
    F Moinfar
    Armed Forces Institute of Pathology, Department of Gynecologic and Breast Pathology, Washington, DC 20306, USA
    Cancer Res 60:2562-6. 2000
  9. ncbi request reprint Multiple use of slab gels in sequencing apparatus for separation of polymerase chain reaction products
    Y G Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, American Registry of Pathology, Washington, DC 20306 6000, USA
    Electrophoresis 22:1915-9. 2001
  10. ncbi request reprint Allelic losses at 3p and 11p are detected in both epithelial and stromal components of cervical small-cell neuroendocrine carcinoma
    Y Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306 6000, USA
    Appl Immunohistochem Mol Morphol 9:340-5. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Cells with minimal expression of the JAK/STAT pathway related proteins STAT5a and the prolactin receptor: evidence of an alternate prolactin receptor isoform in breast disease
    G L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Protein Pept Lett 17:104-8. 2010
    ..The intermediate isoform was essentially only detected in these lesions. In some breast lesions PRLR isoforms may be involved in JAK/STAT pathway disturbances...
  2. ncbi request reprint Cytokeratin immunoreactivity in lobular intraepithelial neoplasia
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    J Histochem Cytochem 51:1527-31. 2003
    ....
  3. ncbi request reprint STAT 5a expression in various lesions of the breast
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 448:165-71. 2006
    ..The absence of STAT 5a in the abnormal breast epithelial cells may indicate a defect contributory to the abnormal state...
  4. ncbi request reprint Androgen and estrogen receptor mRNA status in apocrine carcinomas
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Patholology, Washington, DC 20306 6000, USA
    Diagn Mol Pathol 11:113-8. 2002
    ..Therefore, the immunohistochemical absence of the estrogen receptor in apocrine cells cannot be explained by an abnormal message at these common sites and should be sought beyond these points...
  5. ncbi request reprint Lobular intraepithelial neoplasia: previously unexplored aspects assessed in 775 cases and their clinical implications
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 440:134-8. 2002
    ..It is also possible that the neoplastic cells may reflect or retain stem cell characteristics with plasticity and the capacity to attain or progress into either a ductal or lobular invasive phenotype...
  6. ncbi request reprint Antibodies targeting p63 react specifically in the cytoplasm of breast epithelial cells exhibiting secretory differentiation
    G L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington DC 20306, USA
    Histopathology 47:611-6. 2005
    ..While examining myoepithelial cells for p63 a very strong cytoplasmic reaction product was noted in secretory cells. The aim was to determine whether this reaction is specific for p63 and indicative of all breast secretory cells...
  7. ncbi request reprint Assessment of lesions coexisting with various grades of ductal intraepithelial neoplasia of the breast
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Virchows Arch 444:340-4. 2004
    ....
  8. ncbi request reprint Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis
    F Moinfar
    Armed Forces Institute of Pathology, Department of Gynecologic and Breast Pathology, Washington, DC 20306, USA
    Cancer Res 60:2562-6. 2000
    ..We conclude that the mammary stroma may play a key role in inducing neoplastic transformation of epithelial cells, recapitulating its role in normal mammary duct development...
  9. ncbi request reprint Multiple use of slab gels in sequencing apparatus for separation of polymerase chain reaction products
    Y G Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, American Registry of Pathology, Washington, DC 20306 6000, USA
    Electrophoresis 22:1915-9. 2001
    ..The combination of a 6% native gel and a lower (45 degrees C) electrophoresis temperature permits multiple uses of a given gel with consistent results, consequently reducing the electrophoresis time and reagent costs...
  10. ncbi request reprint Allelic losses at 3p and 11p are detected in both epithelial and stromal components of cervical small-cell neuroendocrine carcinoma
    Y Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, District of Columbia 20306 6000, USA
    Appl Immunohistochem Mol Morphol 9:340-5. 2001
    ..The five losses in stromal cells were in four cases that showed no loss in epithelial cells with same markers, suggesting that stromal cells might play initiative roles in tumor development...
  11. ncbi request reprint LINE-1 retrotransposon expression in pediatric germ cell tumors
    G L Bratthauer
    Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000
    Cancer 71:2383-6. 1993
    ..Human LINE-1 (L1Hs) is a retrotransposon that is known to cause insertion mutations. Previous work demonstrated that at least 10% of adult testicular germ cell cancers expressed the L1Hs element...
  12. ncbi request reprint An improved method for DNA extraction from paraffin sections
    Y G Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Pathol Res Pract 197:635-42. 2001
    ..With these strategies, we have been able to consistently obtain comparable quality and quantity of DNA extracts which yielded uniform PCR products regardless of variations in tissue embedding and processing...
  13. doi request reprint The avidin-biotin complex (ABC) method and other avidin-biotin binding methods
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:257-70. 2010
    ..Finally, biotinylated tyramide used in conjunction with peroxidase precipitates even greater amounts of biotin molecules for detection by enzyme-labeled avidin molecules...
  14. doi request reprint Overview of antigen detection through enzymatic activity
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:231-41. 2010
    ..Finally, avidin or biotin can be labeled with enzyme, and used either singly or in complexes, and peroxidase mediated biotin amplification can be used to increase the sensitivity in some procedures...
  15. doi request reprint Processing of tissue specimens
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:93-102. 2010
    ..The sections are then ready to be tested with antibody after an incubation in a normal serum solution blocks any available charged sites...
  16. doi request reprint Processing of tissue culture cells
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:85-92. 2010
    ..The sections are then ready to test with antibody after an incubation in a normal serum solution blocks any available charged sites...
  17. doi request reprint Processing of cytological specimens
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:75-84. 2010
    ..The sections are then ready to test with antibody after an incubation in a normal serum solution blocks any available charged sites...
  18. doi request reprint Preparation of frozen sections for analysis
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Methods Mol Biol 588:67-73. 2010
    ....
  19. pmc Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC, USA
    Breast Cancer Res 5:R231-41. 2003
    ..This is in contrast to the adjacent cells within the same duct, which were strongly immunoreactive for the ER. The current study attempts to confirm and expand previous observations on a larger scale...
  20. ncbi request reprint Tubulolobular carcinoma of the breast: an analysis of 27 cases of a tumor with a hybrid morphology and immunoprofile
    Darren T Wheeler
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Am J Surg Pathol 28:1587-93. 2004
    ..The prognosis of these tumors appears to be excellent, especially in those cases that are unilateral and less than 2 cm in size...
  21. ncbi request reprint STAT 5a expression in the breast is maintained in secretory carcinoma, in contrast to other histologic types
    Brian L Strauss
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 37:586-92. 2006
    ....
  22. ncbi request reprint Combined E-cadherin and high molecular weight cytokeratin immunoprofile differentiates lobular, ductal, and hybrid mammary intraepithelial neoplasias
    Gary L Bratthauer
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
    Hum Pathol 33:620-7. 2002
    ..This group needs further evaluation for better understanding of its significance, pattern of progression, and behavior...
  23. pmc A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers
    Roy R Zhang
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Breast Cancer Res 5:R151-6. 2003
    ..However, some morphologically distinct ME cells fail to stain for SMA. This study intended to assess whether these SMA-negative cells also lack the expression of other ME cell markers...
  24. ncbi request reprint Morphologically similar epithelial and stromal cells in primary bilateral breast tumors display different genetic profiles: implications for treatment
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, Washington, DC 20306 6000, USA
    Appl Immunohistochem Mol Morphol 12:305-14. 2004
    ....
  25. doi request reprint The ductal phenotypic expression of the E-cadherin/catenin complex in tubulolobular carcinoma of the breast: an immunohistochemical and clinicopathologic study
    Gary L Bratthauer
    Mod Pathol 21:1058; author reply 1058-9. 2008
  26. ncbi request reprint Immunohistochemical analysis of sox9 in ovarian Sertoli cell tumors and other tumors in the differential diagnosis
    Chengquan Zhao
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
    Int J Gynecol Pathol 26:1-9. 2007
    ..Understanding the role of Sox9 in the pathogenesis of ovarian Sertoli cell tumor requires further study...
  27. ncbi request reprint The T cell receptor gamma chain alternate reading frame protein (TARP), a prostate-specific protein localized in mitochondria
    Hiroshi Maeda
    Laboratory of Molecular Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 4264, USA
    J Biol Chem 279:24561-8. 2004
    ..These data demonstrate that TARP is the first prostate-specific protein localizing in mitochondria and indicate that TARP, an androgen-regulated protein, may act on mitochondria to carry out its biological functions...
  28. ncbi request reprint Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor
    Chengquan Zhao
    Department of Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:1378-86. 2007
    ..This marker is useful for the distinction of Sertoli cell tumor from endometrioid tumors and carcinoid. The diagnostic utility of WT1 in Sertoli cell tumor is similar to inhibin but better than that of calretinin...