Karen L Sweazea
Affiliation: Arizona State University
Sweazea K, Lekic M, Walker B. Comparison of mechanisms involved in impaired vascular reactivity between high sucrose and high fat diets in rats. Nutr Metab (Lond). 2010;7:48 pubmed publisher
..Oxidative stress diminishes vasodilatory responsiveness in HSD and HFD rats through ROS-mediated scavenging of NO and decreased smooth muscle sensitivity to NO. Inflammation also plays a significant role in the impaired vasodilation. ..
Sweazea K, Simperova A, Juan T, Gadau A, Brant S, Deviche P, et al
. Pathophysiological responses to a schistosome infection in a wild population of mourning doves (Zenaida macroura). Zoology (Jena). 2015;118:386-93 pubmed publisher
..These findings suggest that schistosome infections have pathological effects in doves, but the lack of mature worms suggests that infected birds in this sampling may not have been suitable hosts for parasite maturation. ..
Simperova A, Al Nakkash L, Faust J, Sweazea K. Genistein supplementation prevents weight gain but promotes oxidative stress and inflammation in the vasculature of female obese ob/ob mice. Nutr Res. 2016;36:789-97 pubmed publisher
..028). In summary, although genistein prevents weight gain, it promotes vascular oxidative stress and inflammation in obese ovarian-intact female mice. ..
Jarrett C, Ahmed Z, Faust J, Sweazea K. High glucose impairs acetylcholine-mediated vasodilation in isolated arteries from Mourning doves (Z. macroura). Comp Biochem Physiol A Mol Integr Physiol. 2016;201:141-145 pubmed publisher
..05). Therefore, isolated arteries from doves do not have endogenous mechanisms to prevent impaired vasodilation resulting from high glucose-mediated increases in oxidative stress. ..
Zuck J, Borges C, Braun E, Sweazea K. Chicken albumin exhibits natural resistance to glycation. Comp Biochem Physiol B Biochem Mol Biol. 2017;203:108-114 pubmed publisher
..Further research is needed to characterize this inherent difference in an effort to elucidate mechanisms by which avian plasma protein is glycated to a lesser degree than that of mammals (humans). ..
Sweazea K, Braun E. Reciprocal inhibition of in vitro substrate movement into avian skeletal muscle. Zoology (Jena). 2013;116:85-9 pubmed publisher
..As studies in mammals have shown that FFAs may impair glucose uptake pathways, it is suspected that high FFA uptake by avian skeletal muscle may induce their notably lower glucose transport. ..
Sweazea K, Braun E, Sparr R. Novel role of insulin in the regulation of glucose excretion by mourning doves (Zenaida macroura). Zoology (Jena). 2017;122:58-62 pubmed publisher
..These data demonstrate a significant role for insulin in modulating GFR in mourning doves, which may in part explain the lower PGlu measured following insulin administration. ..
Sweazea K, Walker B. High fat feeding impairs endothelin-1 mediated vasoconstriction through increased iNOS-derived nitric oxide. Horm Metab Res. 2011;43:470-6 pubmed publisher
..Therefore, oxidative stress and iNOS are involved in the attenuation of endothelin-1 mediated vasoconstriction observed in isolated mesenteric arteries from high fat fed rats. ..
Ingram T, Zuck J, Borges C, Redig P, Sweazea K. Variations in native protein glycation and plasma antioxidants in several birds of prey. Comp Biochem Physiol B Biochem Mol Biol. 2017;210:18-28 pubmed publisher
..005). The high concentrations of antioxidants in these birds of prey relative to other birds likely helps protect from complications that may otherwise arise from having high glucose and protein glycation. ..