GEORGE PETTIT

Summary

Affiliation: Arizona State University
Country: USA

Publications

  1. request reprint
    Pettit G, Numata A, Iwamoto C, Usami Y, Yamada T, Ohishi H, et al. Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea. J Nat Prod. 2006;69:323-7 pubmed
    ..Structures for these new cancer cell growth inhibitors were established by spectroscopic techniques that included HRMS and 2D NMR...
  2. request reprint
    Pettit G, Melody N, Herald D, Knight J, Chapuis J. Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine. J Nat Prod. 2007;70:417-22 pubmed
    ..Biological evaluation of 10b(S)-epipancratistatin (3a) provided evidence that antineoplastic activity was reduced by a factor of 10 when the B/C trans juncture was replaced with a B/C cis ring juncture. ..
  3. request reprint
    Pettit G, Tan R. Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp. J Nat Prod. 2005;68:60-3 pubmed
    ..The chirality of each amino acid unit was determined to be S using chiral HPLC methods. Phakellistatin 14 showed cancer cell growth inhibitory activity (ED(50) 5 microg/mL) against the murine lymphocytic leukemia P388 cell line. ..
  4. request reprint
    Pettit G, Xu J, Doubek D, Chapuis J, Schmidt J. Antineoplastic Agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia. J Nat Prod. 2004;67:1252-5 pubmed
    ..0 x 10(-7)% yield). The structures were determined on the basis of analyses of high-resolution mass spectra and high-field NMR data. All the relative stereochemistry for the chiral centers was designated by utilizing NMR techniques. ..
  5. Pettit G, Quistorf P, Fry J, Herald D, Hamel E, Chapuis J. Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2. J Nat Prod. 2009;72:876-83 pubmed publisher
    ..In contrast to the cancer cell growth inhibitory activity exhibited by combretastatin D-2, relatively minor structural modifications (41, 42) caused elimination of those properties. ..
  6. Pettit G, Knight J, Herald D, Pettit R, Hogan F, Mukku V, et al. Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris. J Nat Prod. 2009;72:366-71 pubmed publisher
    ..The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation. ..
  7. Pettit G, Rosenberg H, Dixon R, Knight J, Hamel E, Chapuis J, et al. Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. J Nat Prod. 2012;75:385-93 pubmed publisher
    ..Parallel biological investigations of tubulin interaction, antiangiogenesis, and antimicrobial effects were also conducted. ..
  8. Pettit G, Tang Y, Knight J. Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus. J Nat Prod. 2005;68:974-8 pubmed
    ..All four turbostatins exhibited significant (GI50 0.15-2.6 microg/mL) cancer cell growth inhibition against the murine P388 lymphocytic leukemia and a panel of human cancer cell lines. ..
  9. request reprint
    Pettit G, Meng Y, Stevenson C, Doubek D, Knight J, Cichacz Z, et al. Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1). J Nat Prod. 2003;66:259-62 pubmed
    ..The new flavonolignan 1 designated palstatin proved to be a methoxy structural modification of 5'-methoxyhydnocarpin-D (2). Flavones 1-4 inhibited growth of the pathogenic bacteria Enterococcus faecalis and/or Neisseria gonorrhoeae. ..

More Information

Publications20

  1. Pettit G, Melody N, Thornhill A, Knight J, Groy T, Herald C. Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. J Nat Prod. 2009;72:1637-42 pubmed publisher
    ..Deprotection of the Z-silyl ether 13 gave E-stilstatin 3 (3a) as the exclusive product. The structure and stereochemistry of 3a was confirmed by X-ray crystal structure determination. ..
  2. Pettit G, Tan R, Cichacz Z. Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta. J Nat Prod. 2005;68:1253-5 pubmed
    ..17 microg/mL, GI50 1.8-8.9 x 10(-1) microg/mL) and proved to be the most inhibitory of the series...
  3. Pettit G, Tang Y, Zhang Q, Bourne G, Arm C, Leet J, et al. Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel . J Nat Prod. 2013;76:420-4 pubmed publisher
    ..All of the isolated compounds were found to be moderate inhibitors of cancer cell growth. Axistatins 1-3 (1-3), formamide 4, and agelasine F (6) also exhibited antimicrobial activity...
  4. Pettit G, Tan R, Bao G, Melody N, Doubek D, Gao S, et al. Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies. J Nat Prod. 2012;75:771-3 pubmed publisher
    ..2-0.69 ?g/mL) some 100× less than that found for pancratistatin (1a) and narciclasine (2), thereby revealing an important configurational requirement in 1a for strong cancer cell growth inhibition...
  5. Pettit G, Ducki S, Eastham S, Melody N. Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine (1a). J Nat Prod. 2009;72:1279-82 pubmed publisher
  6. Pettit G, Meng Y, Herald D, Knight J, Day J. Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. J Nat Prod. 2005;68:1256-8 pubmed
    ..magna that does not appear to utilize amaryllis family plants were discussed...
  7. request reprint
    Pettit G, Zhang Q, Pinilla V, Hoffmann H, Knight J, Doubek D, et al. Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii. J Nat Prod. 2005;68:729-33 pubmed
    ..Except for 1, all were found to cause inhibition of cancer cell growth. In addition, most of the saponins exhibited antimicrobial activity, particularly against the pathogenic fungi Candida albicans and Cryptococcus neoformans...
  8. request reprint
    Pettit G, Tan R, Northen J, Herald D, Chapuis J, Pettit R. Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis. J Nat Prod. 2004;67:1476-82 pubmed
    ..Against a panel of six human cancer cell lines, this series of diterpenes exhibited inhibition over the range GI(50) 0.75-2.0 microg/mL, and all inhibited the growth of Gram-positive bacteria and fungi...
  9. Pettit G, Mukku V, Cragg G, Herald D, Knight J, Herald C, et al. Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents. J Nat Prod. 2008;71:130-3 pubmed publisher
    ..Two other antineoplastic constituents proved to be the known acetogenin uvaribonin (2) and chalcone 3. Constituents 1-3 were all found to show significant cancer cell growth inhibitory activity against a panel of human cancer cell lines...
  10. request reprint
    Pettit G, Zhang Q, Pinilla V, Herald D, Doubek D, Duke J. Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala. J Nat Prod. 2004;67:983-5 pubmed
    ..The structures were assigned on the basis of analyses of HRMS combined with 1D and 2D NMR data. The structure of portentol (5) was confirmed by an X-ray crystal structure determination...
  11. request reprint
    Pettit G, Meng Y, Herald D, Graham K, Pettit R, Doubek D. Isolation and structure of ruprechstyril from Ruprechtia tangarana. J Nat Prod. 2003;66:1065-9 pubmed
    ..The structures and absolute stereochemistry of five of the other compounds were also established by X-ray crystal structure determination...