Philip Hedrick

Summary

Affiliation: Arizona State University
Country: USA

Publications

  1. pmc Conservation genetics and evolution in an endangered species: research in Sonoran topminnows
    Philip W Hedrick
    School of Life Sciences, Arizona State University Tempe, AZ, USA
    Evol Appl 5:806-19. 2012
  2. doi request reprint Estimation of male gene flow from measures of nuclear and female genetic differentiation
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    J Hered 104:713-7. 2013
  3. doi request reprint Coat colour in mouse populations selected for weight gain: support for hitchhiking, not pleiotropy
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Genet Res (Camb) 95:4-13. 2013
  4. doi request reprint Genetic evaluation of captive populations of endangered species and merging of populations: Gila topminnows as an example
    Philip W Hedrick
    School of Life Sciences, Arizona State University Tempe, AZ 85287, USA
    J Hered 103:651-60. 2012
  5. pmc Resistance to malaria in humans: the impact of strong, recent selection
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Malar J 11:349. 2012
  6. ncbi request reprint What is the evidence for heterozygote advantage selection?
    Philip W Hedrick
    Arizona State University, Tempe, AZ 85287, USA
    Trends Ecol Evol 27:698-704. 2012
  7. doi request reprint Sex determination: genetic models for oysters
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    J Hered 101:602-11. 2010
  8. ncbi request reprint Genetic sex determination and extinction
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Trends Ecol Evol 21:55-7. 2006
  9. ncbi request reprint "Ground truth" for selection on CCR5-Delta32
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Trends Genet 22:293-6. 2006
  10. ncbi request reprint A standardized genetic differentiation measure
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe 85287 4501, USA
    Evolution 59:1633-8. 2005

Collaborators

Detail Information

Publications52

  1. pmc Conservation genetics and evolution in an endangered species: research in Sonoran topminnows
    Philip W Hedrick
    School of Life Sciences, Arizona State University Tempe, AZ, USA
    Evol Appl 5:806-19. 2012
    ....
  2. doi request reprint Estimation of male gene flow from measures of nuclear and female genetic differentiation
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    J Hered 104:713-7. 2013
    ..are given and revised values for those species are calculated. The effect of unequal male and female effective population sizes, nonequilibrium conditions, and approximations of differentiation formulas are briefly discussed. ..
  3. doi request reprint Coat colour in mouse populations selected for weight gain: support for hitchhiking, not pleiotropy
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Genet Res (Camb) 95:4-13. 2013
    ..Fourth, the changes at both loci in a short-term selection experiment for low weight gain were in the opposite direction than the changes in the contemporaneous related population selected for high weight gain...
  4. doi request reprint Genetic evaluation of captive populations of endangered species and merging of populations: Gila topminnows as an example
    Philip W Hedrick
    School of Life Sciences, Arizona State University Tempe, AZ 85287, USA
    J Hered 103:651-60. 2012
    ..Based on population-specific markers and a quantitative evaluation of ancestry using a likelihood approach, it appears that ancestry from each of the source populations was retained in both populations...
  5. pmc Resistance to malaria in humans: the impact of strong, recent selection
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Malar J 11:349. 2012
    ..Population genetics can be used to determine the amount and pattern of selection in the past and predict selection in the future for other malaria resistance variants as they are discovered...
  6. ncbi request reprint What is the evidence for heterozygote advantage selection?
    Philip W Hedrick
    Arizona State University, Tempe, AZ 85287, USA
    Trends Ecol Evol 27:698-704. 2012
    ..This is not to say that some heterozygote advantage loci do not have important adaptive functions, but that their role in overall evolutionary change might be more of an unusual phenomenon than a major player in adaptation...
  7. doi request reprint Sex determination: genetic models for oysters
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    J Hered 101:602-11. 2010
    ..Although the mechanism of sex determination may ultimately prove more complex, simple genetic mechanisms can account for the broad features of sexual maturation in oyster families and the stability of sex ratios in populations...
  8. ncbi request reprint Genetic sex determination and extinction
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Trends Ecol Evol 21:55-7. 2006
    ....
  9. ncbi request reprint "Ground truth" for selection on CCR5-Delta32
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Trends Genet 22:293-6. 2006
    ..Interestingly, the extent of heterozygosity, differentiation across populations and linkage disequilibrium in the CCR5 region is not dissimilar to other human genomic regions, challenging claims of recent positive selection...
  10. ncbi request reprint A standardized genetic differentiation measure
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe 85287 4501, USA
    Evolution 59:1633-8. 2005
    ....
  11. ncbi request reprint Large variance in reproductive success and the Ne/N ratio
    Philip Hedrick
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Evolution 59:1596-9. 2005
    ..This finding appears robust when there is a large proportion of families with exactly two progeny or when there is random variation in progeny numbers among these families...
  12. ncbi request reprint Estimation of relative fitnesses from relative risk data and the predicted future of haemoglobin alleles S and C
    P Hedrick
    School of Life Sciences, Arizona State University, Tempe, AR 85287, USA
    J Evol Biol 17:221-4. 2004
    ..Overall, it generally appears that allele C will quickly replace the S allele in malarial environments. Explicit population genetic predictions suggest that this replacement may occur within the next 50 generations in Burkina Faso...
  13. ncbi request reprint Sex: differences in mutation, recombination, selection, gene flow, and genetic drift
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Evolution 61:2750-71. 2007
    ..The evolutionary explanations for sex-specific differences for each factor are multifaceted and, in addition, explanations may include chance, nonadaptive differences, or mechanistic, nonevolutionary factors...
  14. doi request reprint Captive breeding and the reintroduction of Mexican and red wolves
    P W Hedrick
    School of Life Sciences, Arizona State University, Tempe, Arizona 85281 4501, USA
    Mol Ecol 17:344-50. 2008
    ..However, population reintroductions of both Mexican and red wolves appear to have reached numbers well below the generally recommended number for recovery and there is no current effort to re-establish other populations...
  15. doi request reprint Conservation genetics and North American bison (Bison bison)
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    J Hered 100:411-20. 2009
    ..Here I review and evaluate this situation and provide recommendations for the reduction of cattle ancestry, avoidance of inbreeding depression, and maintenance of genetic variation in the conservation herds of bison...
  16. doi request reprint Cattle ancestry in bison: explanations for higher mtDNA than autosomal ancestry
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Mol Ecol 19:3328-35. 2010
    ..Further examination of the cattle genome in bison may shed light on whether these markers, or their associated regions, are indeed neutral...
  17. pmc Population genetics of malaria resistance in humans
    P W Hedrick
    School of Life Sciences, Arizona State University, Tempe, USA
    Heredity (Edinb) 107:283-304. 2011
    ....
  18. doi request reprint Selection and mutation for α Thalassemia in nonmalarial and malarial environments
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Ann Hum Genet 75:468-74. 2011
    ..Overall, this population genetic examination provides an evolutionary framework for understanding the worldwide frequency of α thalassemia and the deletions that cause it in both nonmalarial and malarial environments...
  19. doi request reprint Rapid decrease in horn size of bighorn sheep: environmental decline, inbreeding depression, or evolutionary response to trophy hunting?
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 95287 4501, USA
    J Hered 102:770-81. 2011
    ....
  20. doi request reprint Population genetics of the white-phased "Spirit" black bear of British Columbia
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Evolution 66:305-13. 2012
    ..Examination of population genetic factors, singly and jointly, provides insight into the establishment and maintenance of this unusual polymorphism...
  21. ncbi request reprint Comment on "Parasite selection for immunogenetic optimality"
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Science 303:957; author reply 957. 2004
  22. ncbi request reprint Canine parvovirus enteritis, canine distemper, and major histocompatibility complex genetic variation in Mexican wolves
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    J Wildl Dis 39:909-13. 2003
    ..Resistance to pathogens is an important aspect of the management and long-term survival of endangered taxa, such as the Mexican wolf...
  23. ncbi request reprint Evaluation of d2, a microsatellite measure of inbreeding and outbreeding, in wolves with a known pedigree
    P Hedrick
    Department of Biology, Arizona State University, Tempe 85287, USA
    Evolution 55:1256-60. 2001
    ..We suggest that the measure be examined theoretically to determine when (and how much) the predictive value of the measure is different from that of heterozygosity for inbreeding or outbreeding levels in a variety of different scenarios...
  24. ncbi request reprint Using microsatellite and MHC variation to identify species, ESUs, and MUs in the endangered Sonoran topminnow
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, AZ 85287, USA
    Mol Ecol 10:1399-412. 2001
    ..In addition, there appeared to have been a duplication of the MHC locus that was present in most of the fish in six of the natural populations of the Gila topminnow...
  25. ncbi request reprint Founder effect in an island population of bighorn sheep
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, AZ 85287, USA
    Mol Ecol 10:851-7. 2001
    ....
  26. ncbi request reprint Major histocompatibility complex (MHC) variation in the endangered Mexican wolf and related canids
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, AZ 95287, U S A
    Heredity (Edinb) 85:617-24. 2000
    ..Examination of the known dog sequences for this locus showed that one of the Mexican wolf alleles was found in dogs and that the allele found in both grey and red wolves is also found in dogs...
  27. doi request reprint Reversing mother's curse revisited
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Evolution 66:612-6. 2012
    ..The implications of these findings are briefly discussed...
  28. ncbi request reprint Major histocompatibility complex variation in the Arabian oryx
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 95287, USA
    Evolution 54:2145-51. 2000
    ..As a result, maintenance of these variants should be considered as a goal in the captive breeding program of the Arabian oryx...
  29. ncbi request reprint Lethals in finite populations
    Philip W Hedrick
    Department of Biology, Arizona State University, Tempe 85287 1501, USA
    Evolution 56:654-7. 2002
    ..This asymmetry may result in a lower standing genetic variation for inbreeding depression than expected from mutation rates and contemporary population size data...
  30. ncbi request reprint Establishing a captive broodstock for the endangered bonytail chub (Gila elegans)
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 85287 1501, USA
    J Hered 91:35-9. 2000
    ..The approach given here could be applied to retain genetic variation in other endangered species in a captive broodstock until they have stable natural populations of adequate size...
  31. ncbi request reprint Pathogen resistance and genetic variation at MHC loci
    Philip W Hedrick
    Department of Biology, Arizona State University, Tempe 85287, USA
    Evolution 56:1902-8. 2002
    ..Overall, resistance conferred by specific alleles to temporally variable pathogens may contribute to the observed polymorphism at MHC genes and other similar host defense loci...
  32. ncbi request reprint Hopi Indians, "cultural" selection, and albinism
    Philip W Hedrick
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Am J Phys Anthropol 121:151-6. 2003
    ....
  33. ncbi request reprint Balancing selection
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Curr Biol 17:R230-1. 2007
  34. pmc Premating, not postmating, barriers drive genetic dynamics in experimental hybrid populations of the endangered Sonoran topminnow
    C R Hurt
    School of Life Sciences, Arizona State University, Tempe, 82587 4501, USA
    Genetics 171:655-62. 2005
    ....
  35. ncbi request reprint Estimation of linkage disequilibrium for loci with multiple alleles: basic approach and an application using data from bighorn sheep
    S T Kalinowski
    Department of Biology, Arizona State University, Tempe, AZ 85287, USA
    Heredity 87:698-708. 2001
    ..Disequilibrium values are calculated and tested for statistical significance. High levels of disequilibrium are found between all pairs of major histocompatibility complex (MHC) loci and between MHC and a linked microsatellite locus...
  36. doi request reprint Isolation by distance among California sea lion populations in Mexico: redefining management stocks
    M Gonzalez-Suarez
    Arizona State University, Tempe, 85287, USA
    Mol Ecol 18:1088-99. 2009
    ..This revised classification should be considered in future assessment and management of California sea lion populations in Mexican waters...
  37. pmc Major histocompatibility complex variation in the endangered Przewalski's horse
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Genetics 152:1701-10. 1999
    ..Because other organisms have extensive variation at homologous loci, the Przewalski's horse may have quite low variation in this important adaptive region...
  38. ncbi request reprint The impact of supplementation in winter-run chinook salmon on effective population size
    P W Hedrick
    Department of Biology, Arizona State University, Temple 85287, USA
    J Hered 91:112-6. 2000
    ..Rapid genetic analysis of captured spawners and a new rearing facility on the Sacramento River should alleviate these problems and their negative effect on the effective population size in future years...
  39. ncbi request reprint Random mating and selection in families against homozygotes for HLA in south Amerindians
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 85287, USA
    Hereditas 127:51-8. 1997
    ..For three or more alleles, the model has the qualities of a traditional balancing selection model...
  40. ncbi request reprint Is the decline of desert bighorn sheep from infectious disease the result of low MHC variation?
    G A Gutierrez-Espeleta
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Heredity 86:439-50. 2001
    ..To reconcile the species and gene trees for the 104 sequences examined, 95 'deep coalescent' events were necessary, illustrating the importance of balancing selection maintaining variation over speciation events...
  41. pmc HLA and mate selection: no evidence in South Amerindians
    P W Hedrick
    Department of Biology, Arizona State University, Tempe 85287 1501, USA
    Am J Hum Genet 61:505-11. 1997
    ..In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians...
  42. ncbi request reprint Class I MHC polymorphism and evolution in endangered California Chinook and other Pacific salmon
    D Garrigan
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Immunogenetics 53:483-9. 2001
    ....
  43. ncbi request reprint Major histocompatibility complex variation in red wolves: evidence for common ancestry with coyotes and balancing selection
    P W Hedrick
    Department of Biology, Arizona State University, Tempe, AZ 85287, USA
    Mol Ecol 11:1905-13. 2002
    ..Examination of the level and pattern of linkage disequilibria between pairs of sites suggest that the heterozygosity, substitution and frequencies at individual amino acids are not highly dependent upon each other...
  44. ncbi request reprint Gene flow and selection balance in haplodiploid social insects
    J D Parker
    Department of Biology, Arizona State University, Tempe AZ 85287 1501, U S A
    Heredity (Edinb) 85:530-8. 2000
    ..This continent-island model gives results that well describe the system. Issues fundamental to the differences between X-linked and haplodiploid genetic systems and diploid genetic systems are also discussed...
  45. ncbi request reprint MHC variation and tissue transplantation in fish
    T N Cardwell
    Department of Biology, Arizona State University, Tempe, AZ 85287-1501, USA
    J Hered 92:305-8. 2001
    ..This suggests that other loci, presumably other MHC loci, play a significant role in transplantation success in fishes, as they do in mammals...
  46. ncbi request reprint Perspective: detecting adaptive molecular polymorphism: lessons from the MHC
    Daniel Garrigan
    Department of Biology, Arizona State University, Tempe, Arizona 85287 1501, USA
    Evolution 57:1707-22. 2003
    ..Inference of the nature of the selection events that create such signals should be approached with caution. However, a combination of tests on different time scales may overcome such problems...
  47. ncbi request reprint Dynamics of hybridization and introgression in red wolves and coyotes
    Richard J Fredrickson
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4601, USA
    Conserv Biol 20:1272-83. 2006
    ..Our modeling approach may prove generally useful in providing insight into situations involving complex species interactions when data are few...
  48. ncbi request reprint A heterozygote advantage
    Philip W Hedrick
    Science 302:57. 2003
  49. pmc Genetic rescue and inbreeding depression in Mexican wolves
    Richard J Fredrickson
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Proc Biol Sci 274:2365-71. 2007
    ..The low litter and pack sizes observed in the wild population are consistent with this genetic load, but it appears that there is still potential to establish vigorous wild populations...
  50. pmc Virgin birth, genetic variation and inbreeding
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Biol Lett 3:715-6. 2007
  51. ncbi request reprint Initial stages of reproductive isolation in two species of the endangered Sonoran topminnow
    Carla R Hurt
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287, USA
    Evolution 57:2835-41. 2003
    ..Our results illustrate the importance of distinctly defining hybrid classes in studies of reproductive isolation. To our knowledge, this is the first such detailed evolutionary analysis in endangered fish taxa...
  52. pmc Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate
    Gabriel Bedoya
    Laboratorio de Genética Molecular and Departamentos de Historia and Psiquiatria, Universidad de Antioquia, Apartado aereo 1226, Medellin, Colombia
    Proc Natl Acad Sci U S A 103:7234-9. 2006
    ..This scenario is consistent with historical information and with results from population genetics theory...