CHERYL CONRAD

Summary

Affiliation: Arizona State University
Country: USA

Publications

  1. ncbi request reprint Sex differences in spatial and non-spatial Y-maze performance after chronic stress
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neurobiol Learn Mem 79:32-40. 2003
  2. pmc Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore
    Jonathan K Kleen
    Department of Psychology, Arizona State University, Tempe, AZ 85224 1107, USA
    Behav Neurosci 120:842-51. 2006
  3. doi request reprint A critical review of chronic stress effects on spatial learning and memory
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, United States
    Prog Neuropsychopharmacol Biol Psychiatry 34:742-55. 2010
  4. pmc Metyrapone reveals that previous chronic stress differentially impairs hippocampal-dependent memory
    C D Conrad
    Department of Psychology Arizona State University, Tempe, AZ 85287 1 104, USA
    Stress 4:305-18. 2001
  5. pmc Chronic stress and a cyclic regimen of estradiol administration separately facilitate spatial memory: relationship with hippocampal CA1 spine density and dendritic complexity
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Behav Neurosci 126:142-56. 2012
  6. doi request reprint Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ, USA
    Prog Brain Res 182:31-76. 2010
  7. doi request reprint Converging effects of acute stress on spatial and recognition memory in rodents: a review of recent behavioural and pharmacological findings
    Brittany N Cazakoff
    Department of Physiology, Neural Systems and Plasticity Research Group, University of Saskatchewan, Saskatoon, SK, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:733-41. 2010
  8. pmc Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis
    Cheryl D Conrad
    Arizona State University, Department of Psychology, Box 1104, Tempe, AZ 85282, USA
    Rev Neurosci 19:395-411. 2008
  9. pmc Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, Arizona 85287 1104, USA
    J Neurosci 27:8278-85. 2007
  10. pmc What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?
    Cheryl D Conrad
    Deparment of Psychology, Arizona State University, Box 1104, Tempe, 85287 1104, USA
    Behav Cogn Neurosci Rev 5:41-60. 2006

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Sex differences in spatial and non-spatial Y-maze performance after chronic stress
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neurobiol Learn Mem 79:32-40. 2003
    ..Overall, these results show important sex differences in response to chronic stress with females exhibiting an ability to recover quickly from deficits in Y-maze performance...
  2. pmc Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore
    Jonathan K Kleen
    Department of Psychology, Arizona State University, Tempe, AZ 85224 1107, USA
    Behav Neurosci 120:842-51. 2006
    ..Chronic restraint produces functional, neuromorphological, and physiological alterations that parallel symptoms of depression in humans...
  3. doi request reprint A critical review of chronic stress effects on spatial learning and memory
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, United States
    Prog Neuropsychopharmacol Biol Psychiatry 34:742-55. 2010
    ..Chronic stress clearly impacts nearly every brain region and thus, how chronic stress alters hippocampal spatial ability likely depends upon the engagement of other brain structures during behavioral training and testing...
  4. pmc Metyrapone reveals that previous chronic stress differentially impairs hippocampal-dependent memory
    C D Conrad
    Department of Psychology Arizona State University, Tempe, AZ 85287 1 104, USA
    Stress 4:305-18. 2001
    ..Moreover,these data suggest that chronic stress impairs hippocampal-dependent processes more robustly than hippocampal-independent processes after metyrapone to reduce corticosterone secretion during aversive training...
  5. pmc Chronic stress and a cyclic regimen of estradiol administration separately facilitate spatial memory: relationship with hippocampal CA1 spine density and dendritic complexity
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Behav Neurosci 126:142-56. 2012
    ....
  6. doi request reprint Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, AZ, USA
    Prog Brain Res 182:31-76. 2010
    ....
  7. doi request reprint Converging effects of acute stress on spatial and recognition memory in rodents: a review of recent behavioural and pharmacological findings
    Brittany N Cazakoff
    Department of Physiology, Neural Systems and Plasticity Research Group, University of Saskatchewan, Saskatoon, SK, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:733-41. 2010
    ..Taken together, these findings have significantly advanced our understanding of the neural mechanisms mediating learning and memory and may stimulate the search for novel therapeutics to treat stress-related psychiatric disorders...
  8. pmc Chronic stress-induced hippocampal vulnerability: the glucocorticoid vulnerability hypothesis
    Cheryl D Conrad
    Arizona State University, Department of Psychology, Box 1104, Tempe, AZ 85282, USA
    Rev Neurosci 19:395-411. 2008
    ..The relevance of these findings is discussed with regard to conditions exhibiting parallels in hippocampal plasticity, including Cushing's disease, major depressive disorder (MDD), and post-traumatic stress disorder (PTSD)...
  9. pmc Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Tempe, Arizona 85287 1104, USA
    J Neurosci 27:8278-85. 2007
    ..These findings have significance for many disorders with elevated glucocorticoids that include depression, schizophrenia, Alzheimer's disease, and Cushing's disease...
  10. pmc What is the functional significance of chronic stress-induced CA3 dendritic retraction within the hippocampus?
    Cheryl D Conrad
    Deparment of Psychology, Arizona State University, Box 1104, Tempe, 85287 1104, USA
    Behav Cogn Neurosci Rev 5:41-60. 2006
    ..These findings are presented in the context of clinical conditions associated with elevated glucocorticoids...
  11. ncbi request reprint Support for a bimodal role for type II adrenal steroid receptors in spatial memory
    C D Conrad
    The Department of Psychology, Arizona State University, Tempe, Arizona 85287 1104, USA
    Neurobiol Learn Mem 72:39-46. 1999
    ..These data suggest that the Type II receptors may be responsible for the inverted U-shaped relationship between spatial memory and corticosterone levels reported by others...
  12. pmc Chronic stress enhances ibotenic acid-induced damage selectively within the hippocampal CA3 region of male, but not female rats
    C D Conrad
    Department of Psychology, Box 1104, Arizona State University, Tempe, AZ 85287 1104, USA
    Neuroscience 125:759-67. 2004
    ..Whether the conditions surrounding CA3 dendritic retraction in females represents vulnerability is less clear and warrants further investigation...
  13. ncbi request reprint Influence of chronic corticosterone and glucocorticoid receptor antagonism in the amygdala on fear conditioning
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, USA
    Neurobiol Learn Mem 81:185-99. 2004
    ....
  14. ncbi request reprint Repeated restraint stress facilitates fear conditioning independently of causing hippocampal CA3 dendritic atrophy
    C D Conrad
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Behav Neurosci 113:902-13. 1999
    ..These data argue that different neural substrates underlie spatial recognition memory and fear conditioning...
  15. ncbi request reprint Acute stress increases neuropeptide Y mRNA within the arcuate nucleus and hilus of the dentate gyrus
    C D Conrad
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Brain Res Mol Brain Res 79:102-9. 2000
    ....
  16. ncbi request reprint Acute stress impairs spatial memory in male but not female rats: influence of estrous cycle
    Cheryl D Conrad
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, USA
    Pharmacol Biochem Behav 78:569-79. 2004
    ..No differences in corticosterone levels were observed at baseline or following 2 h of recovery from restraint. These data show important differences in how sex and estrous cycle influence cognitive functions following acute stress...
  17. pmc Attenuating corticosterone levels on the day of memory assessment prevents chronic stress-induced impairments in spatial memory
    Ryan L Wright
    Department of Psychology, Arizona State University, Tempe, 85287, USA
    Eur J Neurosci 24:595-605. 2006
    ..These results have significance for treating cognitive decline in conditions associated with elevated glucocorticoids that include subpopulations in ageing, depression, Cushing's disease and Alzheimer's disease...
  18. ncbi request reprint Peripubertal anxiety profile can predict predisposition to spatial memory impairments following chronic stress
    Rudy Bellani
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, USA
    Behav Brain Res 166:263-70. 2006
    ..These results indicate that peripubertal anxiety and chronic stress interact to influence hippocampal-dependent spatial memory in adulthood...
  19. doi request reprint Chronic stress, cyclic 17β-estradiol, and daily handling influences on fear conditioning in the female rat
    Ann N Hoffman
    Department of Psychology, Arizona State University, Box 1104, Tempe, AZ 85287 1104, USA
    Neurobiol Learn Mem 94:422-33. 2010
    ..Thus, chronic stress impacts amygdala-mediated fear learning in both OVX- and gonadally-intact females as found previously in males, with handling significantly influencing these outcomes...
  20. pmc Acute episodes of predator exposure in conjunction with chronic social instability as an animal model of post-traumatic stress disorder
    Phillip R Zoladz
    Department of Psychology, University of South Florida, Tampa, FL 33620, USA
    Stress 11:259-81. 2008
    ..This work demonstrates the effectiveness of acute inescapable episodes of predator exposure administered in conjunction with daily social instability as an animal model of PTSD...
  21. pmc Chronic stress leaves novelty-seeking behavior intact while impairing spatial recognition memory in the Y-maze
    Ryan L Wright
    Department of Psychology, Arizona State University, Tempe 85287 1104, USA
    Stress 8:151-4. 2005
    ..The results indicate that the deficits in Y-maze performance following chronic stress are not attributed to neophobia, but likely reflect neurochemical and/or neurobiological changes underlying spatial memory ability...
  22. pmc Enriched environment prevents chronic stress-induced spatial learning and memory deficits
    Ryan L Wright
    Department of Psychology, Arizona State University, Box 871104, Tempe, AZ 85287 1104, United States
    Behav Brain Res 187:41-7. 2008
    ..The results showed that EE in adulthood prevented spatial learning and memory impairment in chronically stressed rats, indicating that the context of stress exposure impacts susceptibility to chronic stress-induced cognitive deficits...
  23. pmc Prefrontal cortex lesions and sex differences in fear extinction and perseveration
    Sarah E Baran
    Department of Psychology, Arizona State University, Tempe, Arizona 85287 1104, USA
    Learn Mem 17:267-78. 2010
    ....
  24. pmc Combination of high fat diet and chronic stress retracts hippocampal dendrites
    Sarah E Baran
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neuroreport 16:39-43. 2005
    ..g., cardiovascular) systems demonstrating a synergy between stress and high fat diet, and are relevant toward understanding how diet and stress interact to adversely affect brain and memory processing...
  25. pmc The effects of chronic stress on hippocampal morphology and function: an evaluation of chronic restraint paradigms
    Katie J McLaughlin
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Brain Res 1161:56-64. 2007
    ....
  26. pmc Chronic 17beta-estradiol or cholesterol prevents stress-induced hippocampal CA3 dendritic retraction in ovariectomized female rats: possible correspondence between CA1 spine properties and spatial acquisition
    Katie J McLaughlin
    Department of Psychology, Arizona State University, Tempe, Arizona 85287 1104, USA
    Hippocampus 20:768-86. 2010
    ..These stress- and 17beta-estradiol-induced morphological changes may provide insight into how dendritic complexity and spine properties contribute to spatial ability...
  27. doi request reprint Chronic stress- and sex-specific neuromorphological and functional changes in limbic structures
    Katie J McLaughlin
    Department of Psychology, Loras College, Dubuque, IA 52001, USA
    Mol Neurobiol 40:166-82. 2009
    ....
  28. pmc Chronic stress and sex differences on the recall of fear conditioning and extinction
    Sarah E Baran
    Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, United States
    Neurobiol Learn Mem 91:323-32. 2009
    ....
  29. pmc Assessment of estradiol influence on spatial tasks and hippocampal CA1 spines: evidence that the duration of hormone deprivation after ovariectomy compromises 17beta-estradiol effectiveness in altering CA1 spines
    Katie J McLaughlin
    Department of Psychology, Arizona State University, Tempe, AZ, 85287 1104, USA
    Horm Behav 54:386-95. 2008
    ..Collectively, these findings highlight the complex interactions among estradiol, CA1 spine density/morphology, and task requirements, all of which contribute to behavioral outcomes...
  30. ncbi request reprint Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis
    David M Diamond
    Medical Research Service, VA Hospital, Tampa, Florida 33612, USA
    Hippocampus 16:571-6. 2006
    ..Overall, this work provides evidence of structural plasticity in dendrites of CA1 neurons which may be involved in the consolidation process, and how spinogenesis and memory are modulated by stress...
  31. pmc Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats
    Collin R Park
    Medical Research Service, VA Hospital, Tampa, Florida 33612, USA
    Learn Mem 15:271-80. 2008
    ..These findings may provide insight into commonalities in how traumatic stress affects the brain and memory in men and women...
  32. ncbi request reprint Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Endocrinology 147:1664-74. 2006
    ..These data indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation...

Research Grants6

  1. Significance of Stress-Induced Hippocampal Atrophy
    CHERYL CONRAD; Fiscal Year: 2006
    ..abstract_text> ..