Research Topics
Species | Kewei ChenSummaryAffiliation: Arizona State University Country: USA Publications
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Detail Information
Publications
A variant of logistic transfer function in Infomax and a postprocessing procedure for independent component analysis applied to fMRI dataXia Wu
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 10088, PR China
Magn Reson Imaging 25:703-11. 2007..The effectiveness of both approaches on separating components and functional localization was evaluated with simulated and real fMRI data...- Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy ratesKewei Chen
Banner Alzheimer Institute, Banner Good Samaritan PET Center, 1111 E McDowell Rd, Phoenix, AZ 85006, USA
Am J Psychiatry 164:916-21. 2007..The authors previously found accelerated whole brain atrophy rates in patients with probable Alzheimer's disease by computing changes in brain volume from sequential magnetic resonance images (MRIs)... 
Linking functional and structural brain images with multivariate network analyses: a novel application of the partial least square methodKewei Chen
Banner Alzheimer s Institute and the Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
Neuroimage 47:602-10. 2009....- An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's diseaseKewei Chen
Positron Emission Tomography Center, Banner Good Samaritan Regional Medical Center, 1111 E McDowell Road, Phoenix, AZ 85006, USA
Neuroimage 22:134-43. 2004..8 x 10(-4)]). The IPCA could be used in tracking the progression of AD, evaluating the disease-modifying effects of putative treatments, and investigating the course of other normal and pathological changes in brain morphology... - Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal agingEric M Reiman
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, 901 East Willetta Street, Phoenix, AZ 85006, USA
Neuroimage 49:169-76. 2010..We propose using PET in proof-of-concept randomized controlled trials to rapidly evaluate the effects of midlife cholesterol-lowering treatments on the brain changes associated with normal aging and AD... - Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squaresKewei Chen
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA
Neuroimage 60:2316-22. 2012..7 × 10(-4)). Our findings support the possibility of using the MMPLS to analyze complementary datasets from the same person in the presymptomatic detection and tracking of AD... - Less activation in the left dorsolateral prefrontal cortex in the reanalysis of the response to a meal in obese than in lean women and its association with successful weight lossDuc Son Nt Le
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85016, USA
Am J Clin Nutr 86:573-9. 2007.... - Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 alleleJessica B S Langbaum
Banner Alzheimer s Institute, 901 E Willetta St, Phoenix, AZ 85006, USA
Arch Neurol 67:462-8. 2010.... - Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolismEric M Reiman
Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
Proc Natl Acad Sci U S A 102:8299-302. 2005..This study raises the possibility of using PET as a quantitative presymptomatic endophenotype to help evaluate the individual and aggregate effects of putative genetic and nongenetic modifiers of AD risk... - Twelve-month metabolic declines in probable Alzheimer's disease and amnestic mild cognitive impairment assessed using an empirically pre-defined statistical region-of-interest: findings from the Alzheimer's Disease Neuroimaging InitiativeKewei Chen
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA
Neuroimage 51:654-64. 2010..05, roughly one-tenth the number of the patients needed to study MCI patients using clinical endpoints. Our findings support the use of FDG PET, brain-mapping algorithms and empirically pre-defined sROIs in RCTs of AD-slowing treatments... - Characterizing Alzheimer's disease using a hypometabolic convergence indexKewei Chen
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA
Neuroimage 56:52-60. 2011..More generally, our conversion index strategy could be applied to a range of imaging modalities and voxel-based image-analysis algorithms... - Reanalysis of the obesity-related attenuation in the left dorsolateral prefrontal cortex response to a satiating meal using gyral regions-of-interestDuc Son Nguyen Trung Le
Obesity and Diabetes Clinical Research Section, NIDDK NIH, DHHS, Phoenix, Arizona 85016, USA
J Am Coll Nutr 28:667-73. 2009..In this study, we sought to determine which gyri in the LDLPFC best distinguished the neuronal responses to a meal using a different statistical approach... - Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's diseaseEric M Reiman
Banner Alzheimer s Institute and the Positron Emission Tomography Center, Good Samaritan Regional Medical Center, Phoenix, AZ 85006, USA
Proc Natl Acad Sci U S A 106:6820-5. 2009.... - Blood pressure is associated with higher brain amyloid burden and lower glucose metabolism in healthy late middle-age personsJessica B S Langbaum
Banner Alzheimer s Institute, Phoenix, AZ 85006, USA
Neurobiol Aging 33:827.e11-9. 2012..These preliminary findings provide additional evidence that higher BP, likely a reflection of arterial stiffness, during late midlife may be associated with increased risk of presymptomatic AD... - Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individualsJason J Corneveaux
Neurogenomics Division, The Translational Genomics Research Institute Gen, 445 N Fifth Street, Phoenix, AZ 85004, USA
Hum Mol Genet 19:3295-301. 2010.... - Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriersWinnie S Liang
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
Neuroimage 54:1896-902. 2011..It also supports the use of brain-imaging endophenotypes to help assess possible modifiers of AD risk... - Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)Jessica B S Langbaum
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA
Neuroimage 45:1107-16. 2009.... - Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementiaEric M Reiman
Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
Proc Natl Acad Sci U S A 101:284-9. 2004..Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia... - Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regionsEric M Reiman
Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
Neuroimage 40:1214-21. 2008..The results support the role of cholesterol-related genes in the predisposition to AD and support the value of neuroimaging in the presymptomatic assessment of putative modifiers of AD risk... - Tasting a liquid meal after a prolonged fast is associated with preferential activation of the left hemisphereAngelo Del Parigi
Obesity, Diabetes and Energy Metabolism Unit, Clinical Diabetes and Nutrition Section, NIDDK-NIH, 4212 North 16th Street, Phoenix, AZ 85016, USA
Neuroreport 13:1141-5. 2002..This raises the possibility that the physiological context in which perception takes place (i.e. extreme vs moderate vs no hunger) may importantly affect the brain representation of chemosensory stimuli... - Less activation of the left dorsolateral prefrontal cortex in response to a meal: a feature of obesityDuc Son N T Le
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85016, USA
Am J Clin Nutr 84:725-31. 2006..The subjects received a meal proportional to their body size; therefore, the meal volume was different for each person... - Evidence for an association between KIBRA and late-onset Alzheimer's diseaseJason J Corneveaux
Translational Genomics Research Institute TGen, Neurogenomics Division, Phoenix, AZ 85004, USA
Neurobiol Aging 31:901-9. 2010..034; OR=1.29) and in a combined analysis of 1026 additional living and expired subjects (P=0.039; OR=1.26). Our findings suggest that KIBRA is associated with both individual variation in normal episodic memory and predisposition to AD... - Sensory experience of food and obesity: a positron emission tomography study of the brain regions affected by tasting a liquid meal after a prolonged fastAngelo DelParigi
Clinical Diabetes and Nutrition Section, NIDDK NIH, DHHS, Phoenix, AZ 85016, USA
Neuroimage 24:436-43. 2005..These results provide a new perspective on the understanding of the neuroanatomical correlates of abnormal eating behavior and their relationship with obesity in humans... 
Postprandial plasma PYY concentrations are associated with increased regional gray matter volume and rCBF declines in caudate nuclei--a combined MRI and H2(15)O PET studyChristopher M Weise
Obesity and Diabetes Clinical Research Section, NIDDK NIH, DHHS, Phoenix, AZ 85016, USA
Neuroimage 60:592-600. 2012..Thus, PYY may act centrally to modulate eating behavior via striatal networks...- Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatmentsEric M Reiman
Banner Alzheimer s Institute, Phoenix, AZ 85006, USA
J Alzheimers Dis 26:321-9. 2011.... - Neuroimaging and obesity: mapping the brain responses to hunger and satiation in humans using positron emission tomographyAngelo Del Parigi
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
Ann N Y Acad Sci 967:389-97. 2002..PET studies might help to unravel the neuropathophysiology underlying human obesity... - Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional studyAdam S Fleisher
Banner Alzheimer s Institute, Phoenix, AZ, USA
Lancet Neurol 11:1057-65. 2012..We sought to characterise the age-related accumulation of Aβ deposition in presenilin 1 (PSEN1) E280A mutation carriers across the spectrum of preclinical disease... - Resting-state BOLD networks versus task-associated functional MRI for distinguishing Alzheimer's disease risk groupsAdam S Fleisher
Banner Alzheimer s Institute, Phoenix, AZ 85006, USA
Neuroimage 47:1678-90. 2009.... - Are we addicted to food?Angelo Del Parigi
Clinical Diabetes and Nutrition Section, National Institutes of Health, Phoenix, Arizona 85016, USA
Obes Res 11:493-5. 2003 - Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer diseaseAdam S Fleisher
Banner Alzheimer s Institute, 901 E Willetta St, Phoenix, AZ 85006, USA
Arch Neurol 68:1404-11. 2011.... - Brain abnormalities in human obesity: a voxel-based morphometric studyNicola Pannacciulli
Obesity and Diabetes Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ 85016, USA
Neuroimage 31:1419-25. 2006..These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity... - Gray matter network associated with risk for Alzheimer's disease in young to middle-aged adultsGene E Alexander
Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
Neurobiol Aging 33:2723-32. 2012.... - Regional network of magnetic resonance imaging gray matter volume in healthy agingGene E Alexander
Neuroimage Analysis Laboratory, Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
Neuroreport 17:951-6. 2006..Scaled Subprofile Model network analysis may aid in the detection and tracking of brain aging and in the evaluation of putative antiaging therapies... - FDG-PET parametric imaging by total variation minimizationHongbin Guo
Arizona State University, Department of Mathematics and Statistics, 1711 S Rural Rd, Tempe, AZ 85287 1804, USA
Comput Med Imaging Graph 33:295-303. 2009..Brain phantom simulations demonstrate significant improvement in quality of images by the proposed method as compared to Patlak images with post-filtering using Gaussian or median filters... - Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment StudiesGene E Alexander
Arizona Alzheimer s Research Center and Department of Psychiatry, Arizona State University, Tempe, 85287 1104, USA
Am J Psychiatry 159:738-45. 2002.... - Clustering huge data sets for parametric PET imagingHongbin Guo
Department of Mathematics and Statistics, Arizona State University, Tempe, AZ 85287 1804, USA
Biosystems 71:81-92. 2003..The efficiency and superiority of the preclustering scheme combined with thresholding is validated by comparison of the results for clustering both with and without preclustering for FDG-PET brain data of 13 healthy subjects... - Improving tissue segmentation of human brain MRI through preprocessing by the Gegenbauer reconstruction methodRick Archibald
The Center for System Science and Engineering Research, Arizona State University, Tempe, AZ 85287 1804, USA
Neuroimage 20:489-502. 2003.... - An input function estimation method for FDG-PET human brain studiesHongbin Guo
Department of Mathematics and Statistics, Arizona State University, Tempe, AZ 85287 1804, USA
Nucl Med Biol 34:483-92. 2007..A new model of an input function for human [(18)F]-2-Deoxy-2-fluoro-d-glucose fluoro (FDG) positron emission tomography (PET) brain studies with bolus injection is presented... - Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control studyEric M Reiman
Banner Alzheimer s Institute, Phoenix, AZ, USA
Lancet Neurol 11:1048-56. 2012.... - The value of positron emission tomography and proliferation index in predicting progression in low-grade astrocytomas of childhoodMichael C Kruer
Division of Pediatrics, Phoenix Children s Hospital, Phoenix, AZ 85016, USA
J Neurooncol 95:239-45. 2009..The ability to identify a subset of progressive LGAs earlier may suggest the need for second-look neurosurgical procedures or more intensified adjuvant treatment that may ultimately improve outcome and survival... - Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaqueGene E Alexander
Department of Psychology, Arizona State University, Phoenix, Arizona 85287 1104, USA
J Neurosci 28:2710-8. 2008.... - Sex differences in the human brain's response to hunger and satiationAngelo Del Parigi
Clinical Diabetes and Nutrition Section, NIDDK, NIH, Phoenix, AZ 85016, USA
Am J Clin Nutr 75:1017-22. 2002..Recent neuroimaging studies have provided functional maps of the human cerebral areas activated in response to hunger and satiation... - A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reporting dream-enactment behaviorRichard J Caselli
Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
Sleep 29:927-33. 2006..To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgl) in regions preferentially affected in patients with dementia with Lewy bodies (DLB)... - Cerebral asymmetry in children when reading Chinese charactersGui Xue
Institute of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, P.R. China
Brain Res Cogn Brain Res 24:206-14. 2005..e., the fusiform cortex) are discussed in terms of the contribution of the logographic nature of Chinese characters to the asymmetry pattern in the hierarchical visual system... - Association between trait emotional awareness and dorsal anterior cingulate activity during emotion is arousal-dependentKateri McRae
Department of Psychiatry, University of Arizona, Tucson, AZ 85724 5002, USA
Neuroimage 41:648-55. 2008.... - Interpreting scan data acquired from multiple scanners: a study with Alzheimer's diseaseCynthia M Stonnington
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
Neuroimage 39:1180-5. 2008..Similar analyses in other multi-scanner data-sets could be used to justify the pooling of data when needed, such as in studies of rare disorders or in multi-center designs... - Ipsilateral brain deactivation specific to the nondominant hand during simple finger movementsXia Wu
State Key Lab of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, PR China
Neuroreport 19:483-6. 2008..This dominant/nondominant deactivation difference was consistent for all participants, regardless of their handedness. These results suggest asymmetrically functional patterns for the dominant and nondominant motor cortices... - Arithmetic processing in the brain shaped by culturesYiyuan Tang
Institute of Neuroinformatics and Laboratory for Brain and Mind, Dalian University of Technology, Dalian 116023, China
Proc Natl Acad Sci U S A 103:10775-80. 2006.... - Postprandial glucagon-like peptide-1 (GLP-1) response is positively associated with changes in neuronal activity of brain areas implicated in satiety and food intake regulation in humansNicola Pannacciulli
Obesity and Diabetes Clinical Research Section, NIDDK NIH, DHHS, 4212 N 16th St Phoenix, AZ 85016, USA
Neuroimage 35:511-7. 2007..The postprandial GLP-1 response is associated with activation of areas of the human brain previously implicated in satiation and food intake regulation... - Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairmentRichard J Caselli
Department of Neurology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
Arch Neurol 65:1231-6. 2008.... - Brain development in Chinese children and adolescents: a structural MRI studyXiaojuan Guo
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Neuroreport 18:875-80. 2007..White matter showed significant linear increases in internal capsule, arcuate fasciculus, superior and inferior longitudinal fasciculus, and cingulate fasciculus...