Gene E Alexander

Summary

Affiliation: Arizona State University
Country: USA

Publications

  1. ncbi request reprint Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies
    Gene E Alexander
    Arizona Alzheimer s Research Center and Department of Psychiatry, Arizona State University, Tempe, 85287 1104, USA
    Am J Psychiatry 159:738-45. 2002
  2. doi request reprint Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque
    Gene E Alexander
    Department of Psychology, Arizona State University, Phoenix, Arizona 85287 1104, USA
    J Neurosci 28:2710-8. 2008
  3. pmc Linking functional and structural brain images with multivariate network analyses: a novel application of the partial least square method
    Kewei Chen
    Banner Alzheimer s Institute and the Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
    Neuroimage 47:602-10. 2009
  4. ncbi request reprint Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates
    Kewei Chen
    Banner Alzheimer Institute, Banner Good Samaritan PET Center, 1111 E McDowell Rd, Phoenix, AZ 85006, USA
    Am J Psychiatry 164:916-21. 2007
  5. ncbi request reprint An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease
    Kewei Chen
    Positron Emission Tomography Center, Banner Good Samaritan Regional Medical Center, 1111 E McDowell Road, Phoenix, AZ 85006, USA
    Neuroimage 22:134-43. 2004
  6. ncbi request reprint Regional network of magnetic resonance imaging gray matter volume in healthy aging
    Gene E Alexander
    Neuroimage Analysis Laboratory, Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neuroreport 17:951-6. 2006
  7. ncbi request reprint Network analysis of single-subject fMRI during a finger opposition task
    Jason F Smith
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Neuroimage 32:325-32. 2006
  8. pmc Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    Eric M Reiman
    Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Proc Natl Acad Sci U S A 101:284-9. 2004
  9. pmc 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
  10. ncbi request reprint Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease
    Harald Hampel
    Dementia Research and Neuroimaging Section, Memory Clinic, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Neurol Sci 194:15-9. 2002

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer's Disease Treatment Studies
    Gene E Alexander
    Arizona Alzheimer s Research Center and Department of Psychiatry, Arizona State University, Tempe, 85287 1104, USA
    Am J Psychiatry 159:738-45. 2002
    ....
  2. doi request reprint Age-related regional network of magnetic resonance imaging gray matter in the rhesus macaque
    Gene E Alexander
    Department of Psychology, Arizona State University, Phoenix, Arizona 85287 1104, USA
    J Neurosci 28:2710-8. 2008
    ....
  3. pmc Linking functional and structural brain images with multivariate network analyses: a novel application of the partial least square method
    Kewei Chen
    Banner Alzheimer s Institute and the Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
    Neuroimage 47:602-10. 2009
    ....
  4. ncbi request reprint Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates
    Kewei Chen
    Banner Alzheimer Institute, Banner Good Samaritan PET Center, 1111 E McDowell Rd, Phoenix, AZ 85006, USA
    Am J Psychiatry 164:916-21. 2007
    ..The authors previously found accelerated whole brain atrophy rates in patients with probable Alzheimer's disease by computing changes in brain volume from sequential magnetic resonance images (MRIs)...
  5. ncbi request reprint An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease
    Kewei Chen
    Positron Emission Tomography Center, Banner Good Samaritan Regional Medical Center, 1111 E McDowell Road, Phoenix, AZ 85006, USA
    Neuroimage 22:134-43. 2004
    ..8 x 10(-4)]). The IPCA could be used in tracking the progression of AD, evaluating the disease-modifying effects of putative treatments, and investigating the course of other normal and pathological changes in brain morphology...
  6. ncbi request reprint Regional network of magnetic resonance imaging gray matter volume in healthy aging
    Gene E Alexander
    Neuroimage Analysis Laboratory, Department of Psychology, Arizona State University, Tempe, AZ 85287 1104, USA
    Neuroreport 17:951-6. 2006
    ..Scaled Subprofile Model network analysis may aid in the detection and tracking of brain aging and in the evaluation of putative antiaging therapies...
  7. ncbi request reprint Network analysis of single-subject fMRI during a finger opposition task
    Jason F Smith
    Department of Psychology, Arizona State University, Tempe, AZ 85287, USA
    Neuroimage 32:325-32. 2006
    ....
  8. pmc Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    Eric M Reiman
    Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Proc Natl Acad Sci U S A 101:284-9. 2004
    ..Carriers of a common Alzheimer's susceptibility gene have functional brain abnormalities in young adulthood, several decades before the possible onset of dementia...
  9. pmc 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
    ..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials...
  10. ncbi request reprint Age transformation of combined hippocampus and amygdala volume improves diagnostic accuracy in Alzheimer's disease
    Harald Hampel
    Dementia Research and Neuroimaging Section, Memory Clinic, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
    J Neurol Sci 194:15-9. 2002
    ..We propose an adjustment for this age effect to increase the diagnostic accuracy of hippocampal volumes in AD...
  11. pmc Cholesterol-related genetic risk scores are associated with hypometabolism in Alzheimer's-affected brain regions
    Eric M Reiman
    Banner Alzheimer s Institute and Banner Good Samaritan PET Center, Phoenix, AZ 85006, USA
    Neuroimage 40:1214-21. 2008
    ..The results support the role of cholesterol-related genes in the predisposition to AD and support the value of neuroimaging in the presymptomatic assessment of putative modifiers of AD risk...
  12. pmc Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
    Richard G Boyes
    Dementia Research Centre, Institute of Neurology, Box 16, University College London, Queen Square, London, UK
    Neuroimage 39:1752-62. 2008
    ....
  13. ncbi request reprint Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment
    Richard J Caselli
    Department of Neurology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Arch Neurol 64:1306-11. 2007
    ..These changes could represent presymptomatic disease in some, despite their youth...
  14. pmc GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers
    Eric M Reiman
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Neuron 54:713-20. 2007
    ..Our findings suggest that GAB2 modifies LOAD risk in APOE epsilon4 carriers and influences Alzheimer's neuropathology...
  15. ncbi request reprint Progression of corpus callosum atrophy in Alzheimer disease
    Stefan J Teipel
    and Harald Hampel, MD, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
    Arch Neurol 59:243-8. 2002
    ..Atrophy of the corpus callosum in the absence of primary white matter degeneration reflects loss of intracortical projecting neocortical pyramidal neurons in Alzheimer disease (AD)...
  16. ncbi request reprint Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease
    Jack S Krasuski
    Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD, USA
    Am J Psychiatry 159:74-81. 2002
    ....
  17. ncbi request reprint A preliminary fluorodeoxyglucose positron emission tomography study in healthy adults reporting dream-enactment behavior
    Richard J Caselli
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    Sleep 29:927-33. 2006
    ..To test the hypothesis that healthy adults reporting dream-enactment behavior (DEB+) have reduced cerebral metabolic rate for glucose (CMRgl) in regions preferentially affected in patients with dementia with Lewy bodies (DLB)...
  18. ncbi request reprint A distinctive interaction between chronic anxiety and problem solving in asymptomatic APOE e4 homozygotes
    Richard J Caselli
    Department of Neurology, Mayo Clinic Scottsdale, University of Arizona, AZ, USA
    J Neuropsychiatry Clin Neurosci 16:320-9. 2004
    ..Chronic anxiety adversely affects cognitive skills in all groups, and is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 HMZ...
  19. ncbi request reprint A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes
    Richard J Caselli
    Department of Neurology, Mayo Clinic Scottsdale, University of Arizona, 85259, USA
    Sleep 25:447-53. 2002
    ..To correlate memory measures with a trait measure of chronic daytime somnolence in cognitively normal individuals with different gene doses of the apolipoprotein E (APOE) e4 allele, a common Alzheimer's disease susceptibility gene...
  20. ncbi request reprint Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Dementia and Neuroimaging Section, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Brain 127:811-24. 2004
    ..The most likely substrate of these changes is alterations or loss of allocortical and neocortical neurons due to Alzheimer's disease-type pathology...
  21. pmc Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism
    Eric M Reiman
    Positron Emission Tomography Center, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Proc Natl Acad Sci U S A 102:8299-302. 2005
    ..This study raises the possibility of using PET as a quantitative presymptomatic endophenotype to help evaluate the individual and aggregate effects of putative genetic and nongenetic modifiers of AD risk...
  22. ncbi request reprint Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophy
    Vicente Ibanez
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 63:147-54. 2004
    ..Thus, statistically significant age reductions in regional brain glucose metabolism, corrected for brain atrophy, are not detectable in healthy normotensive men scanned while in the resting state...
  23. doi request reprint Correlating cerebral hypometabolism with future memory decline in subsequent converters to amnestic pre-mild cognitive impairment
    Richard J Caselli
    Department of Neurology, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Arch Neurol 65:1231-6. 2008
    ....
  24. ncbi request reprint Relation of corpus callosum and hippocampal size to age in nondemented adults with Down's syndrome
    Stefan J Teipel
    Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig Macimilian University, Munich, Germany
    Am J Psychiatry 160:1870-8. 2003
    ..This study investigated whether atrophy of the corpus callosum and hippocampus occurs in nondemented subjects with Down's syndrome and compared the degree of age-related atrophy between these structures...
  25. ncbi request reprint Apolipoprotein E and intellectual achievement
    Richard J Caselli
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona 85259, USA
    J Am Geriatr Soc 50:49-54. 2002
    ..To determine whether apolipoprotein E (apo E) genotype influences intellectual achievement in cognitively normal individuals...
  26. pmc Longitudinal stability of MRI for mapping brain change using tensor-based morphometry
    Alex D Leow
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology and Semel Institute of Neuroscience, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:627-40. 2006
    ..No strong evidence favored B0 correction. Although SPGR/FLASH images showed least deviation here, pulse sequence selection for the ADNI project was based on multiple additional image analyses, to be reported elsewhere...
  27. ncbi request reprint Cognitive performance in older women relative to ApoE-epsilon4 genotype and aerobic fitness
    Jennifer L Etnier
    Department of Exercise and Sport Science, University of North Carolina, Greensboro, NC 27402, USA
    Med Sci Sports Exerc 39:199-207. 2007
    ..Apolipoprotein E (ApoE) genotype and aerobic fitness are each associated with cognitive performance in older adults. However, their potentially interactive effects on cognitive performance have not been examined...
  28. pmc Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain
    Winnie S Liang
    Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Physiol Genomics 28:311-22. 2007
    ..These neuronal profiles will provide valuable reference information for future studies of the brain, in normal aging, AD and other neurological and psychiatric disorders...

Research Grants2

  1. Visual Attention/Perception and APOE Risk for AD
    Gene Alexander; Fiscal Year: 2002
    ....
  2. Neuroanatomical Substrates of Aging & Cognitive Decline
    Gene Alexander; Fiscal Year: 2007
    ....