Kemin Tan

Summary

Affiliation: Argonne National Laboratory
Country: USA

Publications

  1. pmc The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
    BMC Struct Biol 11:22. 2011
  2. pmc The crystal structure of the heparin-binding reelin-N domain of f-spondin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Biol 381:1213-23. 2008
  3. pmc The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Structure 14:33-42. 2006
  4. pmc The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding
    Kemin Tan
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA
    FASEB J 23:2490-501. 2009
  5. pmc Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 283:3932-41. 2008
  6. pmc Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication
    Kemin Tan
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 159:373-82. 2002
  7. pmc Structure and electrostatic property of cytoplasmic domain of ZntB transporter
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Argonne, Illinois 60439, USA
    Protein Sci 18:2043-52. 2009
  8. pmc Structures of open (R) and close (T) states of prephenate dehydratase (PDT)--implication of allosteric regulation by L-phenylalanine
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Building 202, Room A125 9700, S Cass Avenue, Argonne National Laboratory, Argonne, IL 60439, USA
    J Struct Biol 162:94-107. 2008
  9. pmc Novel α-glucosidase from human gut microbiome: substrate specificities and their switch
    Kemin Tan
    Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA
    FASEB J 24:3939-49. 2010
  10. pmc GH1-family 6-P-β-glucosidases from human microbiome lactic acid bacteria
    Karolina Michalska
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA
    Acta Crystallogr D Biol Crystallogr 69:451-63. 2013

Collaborators

Detail Information

Publications19

  1. pmc The structure of the Ca²+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL 60439, USA
    BMC Struct Biol 11:22. 2011
    ..The FS domain is found in F-spondins, mindins, M-spondin and amphiF-spondin...
  2. pmc The crystal structure of the heparin-binding reelin-N domain of f-spondin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Biol 381:1213-23. 2008
    ..The homophilic asymmetric dimer can potentially offer advantages in binding to ligands such as glycosaminoglycans, which may, in turn, bridge the two reelin-N domains and stabilize the dimer...
  3. pmc The structures of the thrombospondin-1 N-terminal domain and its complex with a synthetic pentameric heparin
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Structure 14:33-42. 2006
    ..The TSPN-1 structure and identified adjacent linker region provide a structural framework for the analysis of the TSPN domain of various molecules, including TSPs, NELLs, many collagens, TSPEAR, and kielin...
  4. pmc The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding
    Kemin Tan
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA
    FASEB J 23:2490-501. 2009
    ..The structure presented here and its unique molecular packing in the crystal identify potential interactive sites for glycosaminoglycans, integrins, and collagens, which are key to cartilage structure and function...
  5. pmc Heparin-induced cis- and trans-dimerization modes of the thrombospondin-1 N-terminal domain
    Kemin Tan
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 283:3932-41. 2008
    ..Dimer formation may also involve TSPN-1 domains from two separate TSP-1 molecules. This association would enable glycosaminoglycans to cluster TSP-1...
  6. pmc Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication
    Kemin Tan
    Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    J Cell Biol 159:373-82. 2002
    ..This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily...
  7. pmc Structure and electrostatic property of cytoplasmic domain of ZntB transporter
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Argonne, Illinois 60439, USA
    Protein Sci 18:2043-52. 2009
    ..The presence of the bound Cl(-) ions increases the stability of cations along the pore suggesting they could be important in enhancing cation transport...
  8. pmc Structures of open (R) and close (T) states of prephenate dehydratase (PDT)--implication of allosteric regulation by L-phenylalanine
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Building 202, Room A125 9700, S Cass Avenue, Argonne National Laboratory, Argonne, IL 60439, USA
    J Struct Biol 162:94-107. 2008
    ..Similarly at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation...
  9. pmc Novel α-glucosidase from human gut microbiome: substrate specificities and their switch
    Kemin Tan
    Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439, USA
    FASEB J 24:3939-49. 2010
    ..The preference can be switched by a single mutation at its active site, suggestive of widespread adaptation to utilization of a variety of polysaccharides by intestinal micro-organisms as energy resources...
  10. pmc GH1-family 6-P-β-glucosidases from human microbiome lactic acid bacteria
    Karolina Michalska
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Argonne, Illinois, USA
    Acta Crystallogr D Biol Crystallogr 69:451-63. 2013
    ..mutans enzyme (E375Q), the structure of a 6'-P-salicin complex has also been determined. The presence of natural ligands enabled the definition of the structural elements that are responsible for substrate recognition during catalysis...
  11. pmc Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family
    Kemin Tan
    Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 21:2076-86. 2002
    ..We discuss the structural basis of virus receptor activities of murine CEACAM1 proteins, binding of Neisseria to human CEACAM1, and other homophilic and heterophilic interactions of CEA family members...
  12. ncbi request reprint CD8alphabeta has two distinct binding modes of interaction with peptide-major histocompatibility complex class I
    Hsiu Ching Chang
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:28090-6. 2006
    ..We propose that CD8alphabeta binds to pMHCI in at least two distinguishable orientations...
  13. ncbi request reprint Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer
    Hsiu Ching Chang
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 23:661-71. 2005
    ..The implications of these findings and additional CD8alpha mutational studies for CD8alphabeta- versus CD8alphaalpha-MHCI binding are discussed...
  14. pmc A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division
    Desirée C Yang
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 85:768-81. 2012
    ..Analogous conformational control mechanisms are likely to be part of a general strategy used to control PG hydrolases present within multienzyme PG-remodelling machines...
  15. pmc The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria
    Kemin Tan
    Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
    J Biol Chem 284:36670-9. 2009
    ..Therefore, MtlR/YggD belongs to a new class of transcription factors in bacteria that may regulate gene expression indirectly as a part of a larger transcriptional complex...
  16. pmc Cleavable C-terminal His-tag vectors for structure determination
    William H Eschenfeldt
    Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Bldg 202 Rm BE111, 9700 South Cass Avenue, Argonne, IL 60439, USA
    J Struct Funct Genomics 11:31-9. 2010
    ..The new vectors allow appending C-terminal His(6)-tag and His(6)- and MBP-tags, and are cleavable with TEV or with both TEV and TVMV proteases...
  17. doi request reprint Structural and functional characterization of solute binding proteins for aromatic compounds derived from lignin: p-Coumaric acid and related aromatic acids
    Kemin Tan
    Biosciences Division, Argonne National Laboratory, Lemont, Illinois, 60439 The Midwest Center for Structural Genomics, Argonne National Laboratory, Lemont, Illinois, 60439 Structural Biology Center, Argonne National Laboratory, Lemont, Illinois, 60439
    Proteins 81:1709-26. 2013
    ..Proteins 2013; 81:1709-1726. © 2013 Wiley Periodicals, Inc. ..
  18. pmc Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design
    Andy Ka Leung Ng
    Department of Biochemistry and Center for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    FASEB J 22:3638-47. 2008
    ..Our study of H5N1 NP provides insight into the oligomerization interface and the RNA-binding groove, which are attractive drug targets, and it identifies the epitopes that might be used for universal vaccine development...
  19. pmc Large-scale evaluation of protein reductive methylation for improving protein crystallization
    Youngchang Kim
    Nat Methods 5:853-4. 2008