Christopher J Borgert

Summary

Affiliation: Applied Pharmacology and Toxicology
Country: USA

Publications

  1. ncbi request reprint Synergism, antagonism, or additivity of dietary supplements: application of theory to case studies
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Thromb Res 117:123-32; discussion 145-51. 2005
  2. ncbi request reprint Potency matters: thresholds govern endocrine activity
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, C E H T, University of Florida, Department of Physiological Sciences, 2250 NW 24th Ave, Gainesville, FL 32605, United States Electronic address
    Regul Toxicol Pharmacol 67:83-8. 2013
  3. doi request reprint The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments
    C J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 62:313-28. 2012
  4. ncbi request reprint Understanding human biomonitoring
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 43:215-8. 2005
  5. ncbi request reprint Predicting interactions from mechanistic information: can omic data validate theories?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 223:114-20. 2007
  6. ncbi request reprint Conflict of interest or contravention of science?
    Christopher J Borgert
    President and Principal Scientist, Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 48:4-5. 2007
  7. doi request reprint Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 59:397-411. 2011
  8. ncbi request reprint EPA's new guidance for assessing cancer risks from early life exposures: genotoxic mode of action and implications for human health-based standards
    Christopher J Borgert
    Applied Pharmocology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 42:245-8. 2005
  9. ncbi request reprint Can mode of action predict mixture toxicity for risk assessment?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 201:85-96. 2004
  10. ncbi request reprint Interactive effects of p,p'-dichlorodiphenyldichloroethylene and methoxychlor on hormone synthesis in largemouth bass ovarian cultures
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 23:1947-56. 2004

Detail Information

Publications22

  1. ncbi request reprint Synergism, antagonism, or additivity of dietary supplements: application of theory to case studies
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Thromb Res 117:123-32; discussion 145-51. 2005
  2. ncbi request reprint Potency matters: thresholds govern endocrine activity
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, C E H T, University of Florida, Department of Physiological Sciences, 2250 NW 24th Ave, Gainesville, FL 32605, United States Electronic address
    Regul Toxicol Pharmacol 67:83-8. 2013
    ....
  3. doi request reprint The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments
    C J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 62:313-28. 2012
    ..The proposed approach recommends application of independent action for phthalates and other chemicals with potential anti-androgenic properties at current human exposure levels...
  4. ncbi request reprint Understanding human biomonitoring
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 43:215-8. 2005
  5. ncbi request reprint Predicting interactions from mechanistic information: can omic data validate theories?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 223:114-20. 2007
    ....
  6. ncbi request reprint Conflict of interest or contravention of science?
    Christopher J Borgert
    President and Principal Scientist, Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 48:4-5. 2007
    ..This short commentary is a modest payment on that ink deficit...
  7. doi request reprint Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 59:397-411. 2011
    ....
  8. ncbi request reprint EPA's new guidance for assessing cancer risks from early life exposures: genotoxic mode of action and implications for human health-based standards
    Christopher J Borgert
    Applied Pharmocology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 42:245-8. 2005
  9. ncbi request reprint Can mode of action predict mixture toxicity for risk assessment?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 201:85-96. 2004
    ..A detailed characterization of pharmacodynamics, pharmacokinetics, and slope of dose response curves may be necessary to evaluate whether the toxicity of a mixture can be predicted by the mode of action of its component chemicals...
  10. ncbi request reprint Interactive effects of p,p'-dichlorodiphenyldichloroethylene and methoxychlor on hormone synthesis in largemouth bass ovarian cultures
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 23:1947-56. 2004
    ..These results imply that methoxychlor and DDE inhibit testosterone production by different mechanisms in bass ovaries...
  11. pmc A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Alachua, Florida, USA
    Environ Health Perspect 111:1020-36. 2003
    ..However, clinical and epidemiologic data for infant nutrition sources may provide insights about risks of such substances in human milk and infant formulas...
  12. doi request reprint Hypothesis-driven weight of evidence framework for evaluating data within the US EPA's Endocrine Disruptor Screening Program
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 61:185-91. 2011
    ..Overall WoE scores should be derived based on response and relevance weightings and a WoE narrative developed to clearly describe the final determinations...
  13. ncbi request reprint Influence of seasonality and exposure on the accumulation and reproductive effects of p,p'-dichlorodiphenyldichloroethane and dieldrin in largemouth bass
    Kevin G Johnson
    Department of Fisheries and Aquatic Sciences, University of Florida College of Agricultural and Life Sciences, Gainesville, Florida 32653, USA
    Environ Toxicol Chem 26:927-34. 2007
    ....
  14. ncbi request reprint Topical dose delivery in the reptilian egg treatment model
    Jennifer K Muller
    Applied Pharmacology and Toxicology, Inc, 2250 Northwest 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 26:914-9. 2007
    ..Given the current status of the data, topical treatment of reptilian eggs cannot be considered to be a valid means of establishing causal relationships between chemical treatment and biological outcome...
  15. doi request reprint Relevance weighting of tier 1 endocrine screening endpoints by rank order
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, Florida
    Birth Defects Res B Dev Reprod Toxicol 101:90-113. 2014
    ....
  16. ncbi request reprint Absorption of p,p'-dichlorodiphenyldichloroethylene and dieldrin in largemouth bass from a 60-d slow-release pellet and detection using a novel enzyme-linked immunosorbent assay method for blood plasma
    Jennifer K Muller
    Applied Pharmacology and Toxicology, 2250 NW 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 24:1979-83. 2005
    ..We measured blood and tissue levels by gas chromatography/mass spectrometry and by a novel ELISA method, and present a critical comparison of the results...
  17. ncbi request reprint Dose verification after topical treatment of alligator (Alligator mississippiensis) eggs
    Jennifer K Muller
    Applied Pharmacology and Toxicology Inc, 2250 Northwest 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 26:908-13. 2007
    ..These results are consistent with previous reports in the literature, casting doubt on whether a reproducible internal dose can be achieved in reptilian eggs by topical treatment...
  18. ncbi request reprint Improving the scientific foundation for mixtures joint toxicity and risk assessment: contributions from the SOT mixtures project--introduction
    Ann M Mason
    Chlorine Chemistry Division of the American Chemistry Council, Arlington, Virginia, USA
    Toxicol Appl Pharmacol 223:99-103. 2007
    ..This paper summarizes the activities of the SOT Mixtures Program and serves as the introductory paper to a series of articles in this issue, which hope to inspire innovative research and challenge the status quo...
  19. ncbi request reprint Human milk surveillance and research of environmental chemicals: concepts for consideration in interpreting and presenting study results
    Judy S LaKind
    LaKind Associates LLC, Catonsville, Maryland 21228, USA
    J Toxicol Environ Health A 65:1909-28. 2002
    ..g., expectant mothers, physicians, midwives, nurses, and lactation consultants) can appropriately interpret the research data...
  20. ncbi request reprint Conclusions, research needs, and recommendations of the expert panel: technical workshop on human milk surveillance and research for environmental chemicals in the United States
    Cheston M Berlin
    Milton S Hershey Medical Center, Department of Pediatrics, Pennsylvania State University College of Medicine, USA
    J Toxicol Environ Health A 65:1929-35. 2002
  21. ncbi request reprint Report of an ISRTP workshop: progress and barriers to incorporating alternative toxicological methods in the U.S
    Richard A Becker
    American Chemistry Council, Arlington, VA, USA
    Regul Toxicol Pharmacol 46:18-22. 2006
    ....
  22. ncbi request reprint Conflict of interest: kill the messenger or follow the data?
    Christopher J Borgert
    Environ Sci Technol 41:665. 2007