Christopher J Borgert

Summary

Affiliation: Applied Pharmacology and Toxicology
Country: USA

Publications

  1. ncbi request reprint Synergism, antagonism, or additivity of dietary supplements: application of theory to case studies
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Thromb Res 117:123-32; discussion 145-51. 2005
  2. doi request reprint Potency matters: Thresholds govern endocrine activity
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, C E H T, University of Florida, Department of Physiological Sciences, 2250 NW 24th Ave, Gainesville, FL 32605, United States Electronic address
    Regul Toxicol Pharmacol 67:83-8. 2013
  3. doi request reprint The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments
    C J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 62:313-28. 2012
  4. doi request reprint Hypothesis-driven weight of evidence framework for evaluating data within the US EPA's Endocrine Disruptor Screening Program
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 61:185-91. 2011
  5. doi request reprint Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 59:397-411. 2011
  6. ncbi request reprint Conflict of interest or contravention of science?
    Christopher J Borgert
    President and Principal Scientist, Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 48:4-5. 2007
  7. ncbi request reprint Predicting interactions from mechanistic information: can omic data validate theories?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 223:114-20. 2007
  8. ncbi request reprint Understanding human biomonitoring
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 43:215-8. 2005
  9. pmc A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Alachua, Florida, USA
    Environ Health Perspect 111:1020-36. 2003
  10. ncbi request reprint EPA's new guidance for assessing cancer risks from early life exposures: genotoxic mode of action and implications for human health-based standards
    Christopher J Borgert
    Applied Pharmocology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 42:245-8. 2005

Detail Information

Publications21

  1. ncbi request reprint Synergism, antagonism, or additivity of dietary supplements: application of theory to case studies
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Thromb Res 117:123-32; discussion 145-51. 2005
  2. doi request reprint Potency matters: Thresholds govern endocrine activity
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, C E H T, University of Florida, Department of Physiological Sciences, 2250 NW 24th Ave, Gainesville, FL 32605, United States Electronic address
    Regul Toxicol Pharmacol 67:83-8. 2013
    ....
  3. doi request reprint The human relevant potency threshold: reducing uncertainty by human calibration of cumulative risk assessments
    C J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 62:313-28. 2012
    ..The proposed approach recommends application of independent action for phthalates and other chemicals with potential anti-androgenic properties at current human exposure levels...
  4. doi request reprint Hypothesis-driven weight of evidence framework for evaluating data within the US EPA's Endocrine Disruptor Screening Program
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL, USA
    Regul Toxicol Pharmacol 61:185-91. 2011
    ..Overall WoE scores should be derived based on response and relevance weightings and a WoE narrative developed to clearly describe the final determinations...
  5. doi request reprint Evaluation of EPA's Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 59:397-411. 2011
    ....
  6. ncbi request reprint Conflict of interest or contravention of science?
    Christopher J Borgert
    President and Principal Scientist, Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 48:4-5. 2007
    ..This short commentary is a modest payment on that ink deficit...
  7. ncbi request reprint Predicting interactions from mechanistic information: can omic data validate theories?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, 2250 NW 24th Avenue, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 223:114-20. 2007
    ....
  8. ncbi request reprint Understanding human biomonitoring
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 43:215-8. 2005
  9. pmc A critical review of methods for comparing estrogenic activity of endogenous and exogenous chemicals in human milk and infant formula
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Alachua, Florida, USA
    Environ Health Perspect 111:1020-36. 2003
    ..However, clinical and epidemiologic data for infant nutrition sources may provide insights about risks of such substances in human milk and infant formulas...
  10. ncbi request reprint EPA's new guidance for assessing cancer risks from early life exposures: genotoxic mode of action and implications for human health-based standards
    Christopher J Borgert
    Applied Pharmocology and Toxicology, Inc, Gainesville, FL 32605, USA
    Regul Toxicol Pharmacol 42:245-8. 2005
  11. ncbi request reprint Interactive effects of p,p'-dichlorodiphenyldichloroethylene and methoxychlor on hormone synthesis in largemouth bass ovarian cultures
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 23:1947-56. 2004
    ..These results imply that methoxychlor and DDE inhibit testosterone production by different mechanisms in bass ovaries...
  12. ncbi request reprint Can mode of action predict mixture toxicity for risk assessment?
    Christopher J Borgert
    Applied Pharmacology and Toxicology, Inc, Gainesville, FL 32605, USA
    Toxicol Appl Pharmacol 201:85-96. 2004
    ..A detailed characterization of pharmacodynamics, pharmacokinetics, and slope of dose response curves may be necessary to evaluate whether the toxicity of a mixture can be predicted by the mode of action of its component chemicals...
  13. ncbi request reprint Influence of seasonality and exposure on the accumulation and reproductive effects of p,p'-dichlorodiphenyldichloroethane and dieldrin in largemouth bass
    Kevin G Johnson
    Department of Fisheries and Aquatic Sciences, University of Florida College of Agricultural and Life Sciences, Gainesville, Florida 32653, USA
    Environ Toxicol Chem 26:927-34. 2007
    ....
  14. ncbi request reprint Topical dose delivery in the reptilian egg treatment model
    Jennifer K Muller
    Applied Pharmacology and Toxicology, Inc, 2250 Northwest 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 26:914-9. 2007
    ..Given the current status of the data, topical treatment of reptilian eggs cannot be considered to be a valid means of establishing causal relationships between chemical treatment and biological outcome...
  15. ncbi request reprint Absorption of p,p'-dichlorodiphenyldichloroethylene and dieldrin in largemouth bass from a 60-d slow-release pellet and detection using a novel enzyme-linked immunosorbent assay method for blood plasma
    Jennifer K Muller
    Applied Pharmacology and Toxicology, 2250 NW 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 24:1979-83. 2005
    ..We measured blood and tissue levels by gas chromatography/mass spectrometry and by a novel ELISA method, and present a critical comparison of the results...
  16. ncbi request reprint Dose verification after topical treatment of alligator (Alligator mississippiensis) eggs
    Jennifer K Muller
    Applied Pharmacology and Toxicology Inc, 2250 Northwest 24th Avenue, Gainesville, Florida 32605, USA
    Environ Toxicol Chem 26:908-13. 2007
    ..These results are consistent with previous reports in the literature, casting doubt on whether a reproducible internal dose can be achieved in reptilian eggs by topical treatment...
  17. ncbi request reprint Improving the scientific foundation for mixtures joint toxicity and risk assessment: contributions from the SOT mixtures project--introduction
    Ann M Mason
    Chlorine Chemistry Division of the American Chemistry Council, Arlington, Virginia, USA
    Toxicol Appl Pharmacol 223:99-103. 2007
    ..This paper summarizes the activities of the SOT Mixtures Program and serves as the introductory paper to a series of articles in this issue, which hope to inspire innovative research and challenge the status quo...
  18. ncbi request reprint Conclusions, research needs, and recommendations of the expert panel: technical workshop on human milk surveillance and research for environmental chemicals in the United States
    Cheston M Berlin
    Milton S Hershey Medical Center, Department of Pediatrics, Pennsylvania State University College of Medicine, USA
    J Toxicol Environ Health A 65:1929-35. 2002
  19. ncbi request reprint Human milk surveillance and research of environmental chemicals: concepts for consideration in interpreting and presenting study results
    Judy S LaKind
    LaKind Associates LLC, Catonsville, Maryland 21228, USA
    J Toxicol Environ Health A 65:1909-28. 2002
    ..g., expectant mothers, physicians, midwives, nurses, and lactation consultants) can appropriately interpret the research data...
  20. ncbi request reprint Conflict of interest: kill the messenger or follow the data?
    Christopher J Borgert
    Environ Sci Technol 41:665. 2007
  21. ncbi request reprint Report of an ISRTP workshop: progress and barriers to incorporating alternative toxicological methods in the U.S
    Richard A Becker
    American Chemistry Council, Arlington, VA, USA
    Regul Toxicol Pharmacol 46:18-22. 2006
    ....