D Nieman

Summary

Affiliation: Appalachian State University
Country: USA

Publications

  1. ncbi request reprint Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Brain Behav Immun 20:578-84. 2006
  2. ncbi request reprint Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race
    D C Nieman
    Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Sports Med Phys Fitness 46:158-62. 2006
  3. ncbi request reprint Chia seed does not promote weight loss or alter disease risk factors in overweight adults
    David C Nieman
    Department of Health, Leisure, and Exercise Science Appalachian State University, Boone, NC 28608, USA
    Nutr Res 29:414-8. 2009
  4. ncbi request reprint Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling
    David C Nieman
    Appalachian State University, Human Performance Lab, North Carolina Research Campus, Kannapolis, North Carolina
    Am J Physiol Regul Integr Comp Physiol 307:R68-74. 2014
  5. ncbi request reprint Immune and inflammation responses to a 3-day period of intensified running versus cycling
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC, USA Electronic address
    Brain Behav Immun 39:180-5. 2014
  6. doi request reprint A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial
    David C Nieman
    Appalachian State University, Human Performance Lab, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA
    Nutr J 12:154. 2013
  7. pmc Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
    Nutrients 6:63-75. 2014
  8. pmc Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
    PLoS ONE 8:e72215. 2013
  9. doi request reprint Validity of COSMED's quark CPET mixing chamber system in evaluating energy metabolism during aerobic exercise in healthy male adults
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 21:136-45. 2013
  10. doi request reprint Gender difference in the acute influence of a 2-hour run on arterial stiffness in trained runners
    David Nieman
    Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 21:66-77. 2013

Collaborators

Detail Information

Publications89

  1. ncbi request reprint Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Brain Behav Immun 20:578-84. 2006
    ..163). In conclusion, ibuprofen use compared to nonuse by athletes competing in a 160-km race did not alter muscle damage or soreness, and was related to elevated indicators of endotoxemia and inflammation...
  2. ncbi request reprint Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race
    D C Nieman
    Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Sports Med Phys Fitness 46:158-62. 2006
    ..5+/-0.7 y) who had qualified to run the 160-km 2003 Western States Endurance Run...
  3. ncbi request reprint Chia seed does not promote weight loss or alter disease risk factors in overweight adults
    David C Nieman
    Department of Health, Leisure, and Exercise Science Appalachian State University, Boone, NC 28608, USA
    Nutr Res 29:414-8. 2009
    ..In conclusion, ingestion of 50 g/d CS vs P for 12 weeks by overweight/obese men and women had no influence on body mass or composition, or various disease risk factor measures...
  4. ncbi request reprint Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling
    David C Nieman
    Appalachian State University, Human Performance Lab, North Carolina Research Campus, Kannapolis, North Carolina
    Am J Physiol Regul Integr Comp Physiol 307:R68-74. 2014
    ..These data support the use of 13-HODE + 9-HODE as an oxidative stress biomarker in acute exercise investigations. ..
  5. ncbi request reprint Immune and inflammation responses to a 3-day period of intensified running versus cycling
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC, USA Electronic address
    Brain Behav Immun 39:180-5. 2014
    ....
  6. doi request reprint A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial
    David C Nieman
    Appalachian State University, Human Performance Lab, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA
    Nutr J 12:154. 2013
    ....
  7. pmc Vitamin D2 supplementation amplifies eccentric exercise-induced muscle damage in NASCAR pit crew athletes
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
    Nutrients 6:63-75. 2014
    ..In summary, 6-weeks vitD2 (3800 IU/day) significantly increased 25(OH)D2 and decreased 25(OH)D3, had no effect on muscle function tests, and amplified muscle damage markers in NASCAR pit crew athletes following eccentric exercise...
  8. pmc Influence of a polyphenol-enriched protein powder on exercise-induced inflammation and oxidative stress in athletes: a randomized trial using a metabolomics approach
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
    PLoS ONE 8:e72215. 2013
    ..Polyphenol supplementation was tested as a countermeasure to inflammation and oxidative stress induced by 3-d intensified training...
  9. doi request reprint Validity of COSMED's quark CPET mixing chamber system in evaluating energy metabolism during aerobic exercise in healthy male adults
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 21:136-45. 2013
    ..This validation study indicates that the CPET mixing chamber system provides valid metabolic measurements that compare closely with the Douglas bag system during aerobic exercise...
  10. doi request reprint Gender difference in the acute influence of a 2-hour run on arterial stiffness in trained runners
    David Nieman
    Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 21:66-77. 2013
    ..These data support a notable gender difference in arterial stiffness following a 2-h bout of running...
  11. doi request reprint Influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach
    David C Nieman
    Human Performance Lab, North Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA
    Plant Foods Hum Nutr 67:415-21. 2012
    ....
  12. doi request reprint Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC, USA
    J Altern Complement Med 18:700-8. 2012
    ..OBJECTIVE/SETTING: This study assessed the effectiveness of milled and whole chia seed in altering disease risk factors in overweight, postmenopausal women using a metabolomics approach...
  13. pmc Bananas as an energy source during exercise: a metabolomics approach
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, North Carolina, United States of America
    PLoS ONE 7:e37479. 2012
    ..Aside from higher dopamine in BAN, shifts in metabolites following BAN and CHO 75-km cycling time trials indicated a similar pattern of heightened production of glutathione and utilization of fuel substrates in several pathways...
  14. doi request reprint Variance in the acute inflammatory response to prolonged cycling is linked to exercise intensity
    David C Nieman
    Human Performance Laboratory, Appalachian State University, Kannapolis, North Carolina 28081, USA
    J Interferon Cytokine Res 32:12-7. 2012
    ..51, P=0.004, and r=0.46, P=0.011, respectively). In summary, variance in exercise-induced inflammation and innate immunity in male cyclists in response to 2 h of endurance exercise is best explained by exercise intensity...
  15. ncbi request reprint Muscle cytokine mRNA changes after 2.5 h of cycling: influence of carbohydrate
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 37:1283-90. 2005
    ..To study the effect of carbohydrate compared to placebo ingestion on plasma cytokines and muscle cytokine mRNA following 2.5 h of intensive cycling in 15 trained cyclists...
  16. ncbi request reprint Nutritional strategies to counter stress to the immune system in athletes, with special reference to football
    David C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Sports Sci 24:763-72. 2006
    ..Animal research indicates that other nutritional components such as beta-glucan, quercetin, and curcumin warrant human investigations to determine if they are effective countermeasures to exercise-induced immune dysfunction...
  17. ncbi request reprint Validation of Cosmed's FitMate in measuring oxygen consumption and estimating resting metabolic rate
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 14:89-96. 2006
    ..579, r = 0.97, mean +/- SD absolute difference 5.81 +/- 80.70 kcal/day). These data indicate that the FitMate is a reliable and valid system for measuring oxygen consumption and RMR in adults...
  18. ncbi request reprint Influence of carbohydrate on immune function following 2 h cycling
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 14:225-37. 2006
    ....
  19. ncbi request reprint Immune changes: 2 h of continuous vs. intermittent cycling
    D Nieman
    Department of HLES, Appalachian State University, Boone, NC, USA
    Int J Sports Med 28:625-30. 2007
    ..In conclusion, immune changes induced by 2 h of intense and prolonged exercise paralleled those measured when athletes rested 3 min every 10 min of exercise...
  20. ncbi request reprint Marathon training and immune function
    David C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Sports Med 37:412-5. 2007
    ..Other countermeasures, such as glutamine, antioxidant supplements and ibuprofen, have had disappointing results and thus the search for companion agents to carbohydrate continues...
  21. ncbi request reprint Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA
    David C Nieman
    Department of Health, Leisure, and Exercise Science, PO Box 32071, Appalachian State Univ, Boone, NC 28608, USA
    J Appl Physiol (1985) 103:1728-35. 2007
    ..Quercetin did not, however, influence any of the muscle measures, including NF-kappaB content, cytokine mRNA, or COX-2 mRNA expression across a 3-day intensified exercise period...
  22. ncbi request reprint Quercetin reduces illness but not immune perturbations after intensive exercise
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 39:1561-9. 2007
    ..To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections (URTI) and exercise-induced changes in immune function...
  23. pmc Ingestion of micronutrient fortified breakfast cereal has no influence on immune function in healthy children: a randomized controlled trial
    David C Nieman
    Human Performance Lab, North Carolina Research Campus, Kannapolis, NC 28081, USA
    Nutr J 10:36. 2011
    ..This study investigated the influence of 2-months ingestion of an "immune" nutrient fortified breakfast cereal on immune function and upper respiratory tract infection (URTI) in healthy children during the winter season...
  24. doi request reprint Upper respiratory tract infection is reduced in physically fit and active adults
    David C Nieman
    Human Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA
    Br J Sports Med 45:987-92. 2011
    ..The purpose of this study was to monitor URTI symptoms and severity in a heterogeneous group of community adults and contrast across tertiles of physical activity and fitness levels while adjusting for potential confounders...
  25. ncbi request reprint Quercetin's influence on exercise performance and muscle mitochondrial biogenesis
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 42:338-45. 2010
    ..2 +/- 0.4 yr, VO2max = 46.3 +/- 1.2 mL x kg(-1) x min(-1))...
  26. ncbi request reprint Effects of quercetin and EGCG on mitochondrial biogenesis and immunity
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 41:1467-75. 2009
    ....
  27. doi request reprint Beta-glucan, immune function, and upper respiratory tract infections in athletes
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 40:1463-71. 2008
    ....
  28. doi request reprint Immunonutrition support for athletes
    David C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Nutr Rev 66:310-20. 2008
    ..Results from these studies indicate that immunonutrition supplements have the potential to lessen the magnitude of exercise-induced perturbations in immune function and to reduce the risk of upper respiratory tract infections...
  29. doi request reprint Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run
    David C Nieman
    Department of Biology, Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, North Carolina 28608, USA
    J Interferon Cytokine Res 27:1003-11. 2007
    ....
  30. ncbi request reprint Muscle damage is linked to cytokine changes following a 160-km race
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Brain Behav Immun 19:398-403. 2005
    ..NSAID users did not experience a reduction in muscle damage or DOMS, but did have higher post-race plasma levels in five of seven cytokines...
  31. ncbi request reprint Vitamin E and immunity after the Kona Triathlon World Championship
    David C Nieman
    Department of Health and Exercise Science, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 36:1328-35. 2004
    ..To measure the influence of vitamin E ingestion on oxidative stress and immune changes in response to the Triathlon World Championship in Kona, Hawaii...
  32. ncbi request reprint Immune and oxidative changes during and following the Western States Endurance Run
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, USA
    Int J Sports Med 24:541-7. 2003
    ..About one in four ultramarathoners reported URTI during the two-week period post-race, and a low sIgA secretion rate mid-race best predicted URTI occurrence...
  33. ncbi request reprint Is infection risk linked to exercise workload?
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 32:S406-11. 2000
    ..No consistent relationship between nutritional interventions, exercise immunology, and alteration in URTI risk has yet been established...
  34. ncbi request reprint Influence of vitamin C supplementation on cytokine changes following an ultramarathon
    D C Nieman
    Departments of Health and Exercise Science and Biology, Appalachian State University, Boone, NC 28608, USA
    J Interferon Cytokine Res 20:1029-35. 2000
    ..These increases were attenuated in runners ingesting 1500 mg but not 500 mg vitamin C supplements for 1 week prior to the race and on race day...
  35. ncbi request reprint Cytokine changes after a marathon race
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    J Appl Physiol (1985) 91:109-14. 2001
    ..Carbohydrate ingestion, however, had a major effect in attenuating increases in cortisol and two anti-inflammatory cytokines, IL-10 and IL-1ra...
  36. ncbi request reprint Current perspective on exercise immunology
    David C Nieman
    Department of Health and Exercise Science, PO Box 32071, 111 River Street, Holmes Convocation Center, Appalachian State University, Boone, NC 28608, USA
    Curr Sports Med Rep 2:239-42. 2003
    ....
  37. ncbi request reprint A new handheld device for measuring resting metabolic rate and oxygen consumption
    David C Nieman
    Human Performance Laboratory, Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Am Diet Assoc 103:588-92. 2003
    ..The purpose of this study was to test a new handheld device, the BodyGem (HealtheTech Inc., Golden, CO), that measures resting metabolic rate (RMR)...
  38. ncbi request reprint Carbohydrate supplementation affects blood granulocyte and monocyte trafficking but not function after 2.5 h or running
    D C Nieman
    Department of Health, Appalachian State University, Boone, NC 28608, USA
    Am J Clin Nutr 66:153-9. 1997
    ..13, P = 0.001) and monocytes (F[14, 112] = 4.78, P = 0.001), but not on blood granulocyte and monocyte phagocytosis or oxidative burst activity after 2.5 h of intensive running...
  39. ncbi request reprint Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run
    D C Nieman
    Department of Health, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, North Carolina 28608, USA
    J Appl Physiol (1985) 94:1917-25. 2003
    ..063). CHO compared with Pla beverage ingestion attenuates the increase in plasma IL-6, IL-10, and IL-1ra and gene expression for IL-6 and IL-8 in athletes running 3 h at 70% Vo(2 max) despite no differences in muscle glycogen content...
  40. ncbi request reprint Change in salivary IgA following a competitive marathon race
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Biology, Appalachian State University, Boone, North Carolina 28608, USA
    Int J Sports Med 23:69-75. 2002
    ..11, p = 0.293). In conclusion, the output of sIgA decreased in runners following a competitive marathon, and this was not influenced by carbohydrate ingestion, age, or gender...
  41. ncbi request reprint Reducing diet and/or exercise training decreases the lipid and lipoprotein risk factors of moderately obese women
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    J Am Coll Nutr 21:344-50. 2002
    ..This study was designed to measure the influence of diet, exercise or both on serum lipids and lipoproteins in obese women...
  42. ncbi request reprint Influence of skinfold sum and peak VO(2) on immune function in children
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Int J Obes Relat Metab Disord 26:822-9. 2002
    ..To measure the relationship of skinfold sum and peak VO(2) power with immune function in children...
  43. ncbi request reprint Exercise immunology: future directions for research related to athletes, nutrition, and the elderly
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sports Med 21:S61-8. 2000
    ....
  44. ncbi request reprint Psychological response to exercise training and/or energy restriction in obese women
    D C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Psychosom Res 48:23-9. 2000
    ..19 to 5.44 MJ or 1200 to 1300 kcal/day) on psychological general well-being (GWB) and profile of mood states (POMS) was studied in obese women (n = 91, age 45.6 +/- 1.1 years, body mass index 33.1 +/- 0.6 kg/m2)...
  45. ncbi request reprint Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    J Appl Physiol (1985) 92:1970-7. 2002
    ..These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and immune changes during or after a competitive ultramarathon race...
  46. ncbi request reprint Immune response to exercise training and/or energy restriction in obese women
    D C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 30:679-86. 1998
    ..6 +/- 1.1 yr, body mass index 33.1 +/- 0.6 kg x m(-2)) randomized to one of four groups: control (C), exercise (E), diet (D), exercise, and diet (ED)...
  47. ncbi request reprint Exercise and resistance to infection
    D C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Can J Physiol Pharmacol 76:573-80. 1998
    ..Some attempts have been made through chemical or nutritional means (e.g., indomethacin, glutamine, vitamin C, and carbohydrate supplementation) to attenuate immune changes following intensive exercise to lower the risk of infection...
  48. ncbi request reprint Exercise and immune function. Recent developments
    D C Nieman
    Department of Health and Exercise Science, Appalachian State University, Boone, North Carolina, USA
    Sports Med 27:73-80. 1999
    ..No convincing data exist that moderate exercise training is linked with improved T helper cell counts in patients with HIV, or enhanced immunity in elderly participants...
  49. ncbi request reprint Immune response to two hours of rowing in elite female rowers
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Int J Sports Med 20:476-81. 1999
    ..Carbohydrate compared to placebo ingestion attenuated the moderate rise in blood neutrophil counts, but had slight or no effects on other immune parameters...
  50. ncbi request reprint Nutrition, exercise, and immune system function
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, USA
    Clin Sports Med 18:537-48. 1999
    ..The clinical significance of these carbohydrate-induced effects on the endocrine and immune systems awaits further research...
  51. ncbi request reprint Physical fitness and vegetarian diets: is there a relation?
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Am J Clin Nutr 70:570S-575S. 1999
    ..Although some concerns have been raised about the nutrient status of vegetarian athletes, a varied and well-planned vegetarian diet is compatible with successful athletic endeavor...
  52. ncbi request reprint Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training
    D C Nieman
    Department of Health, Appalachian State University, Boone, NC 28608, USA
    J Appl Physiol (1985) 96:1292-8. 2004
    ..Pla ingestion did not alter modest increases measured for plasma IL-6, IL-10, IL-1ra, and IL-8, and muscle gene expression for IL-1beta, IL-6, IL-8, and TNF-alpha in strength-trained subjects lifting weights intensively for 2 h...
  53. ncbi request reprint Carbohydrate affects natural killer cell redistribution but not activity after running
    D C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 29:1318-24. 1997
    ..79, P = 0.015], but not natural killer cell activity following 2.5 h of intensive running...
  54. doi request reprint Post-160-km race illness rates and decreases in granulocyte respiratory burst and salivary IgA output are not countered by quercetin ingestion
    D Henson
    Department of Biology, Appalachian State University, Boone, North Carolina 28608, United States
    Int J Sports Med 29:856-63. 2008
    ....
  55. ncbi request reprint n-3 polyunsaturated fatty acids do not alter immune and inflammation measures in endurance athletes
    David C Nieman
    Dept of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 19:536-46. 2009
    ....
  56. ncbi request reprint Effect of NSAID on muscle injury and oxidative stress
    S McAnulty
    Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sports Med 28:909-15. 2007
    ..Based upon these findings, caution should be used when consuming nonsteroidal anti-inflammatory drugs during ultra distance events...
  57. ncbi request reprint Carbohydrate effect: hormone and oxidative changes
    S McAnulty
    Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, United States
    Int J Sports Med 28:921-7. 2007
    ..The decrease in muscle glycogen was not different. During cycling exercise, oxidative stress appears to be heavily influenced by carbohydrate ingestion and increased stress hormones...
  58. ncbi request reprint Influence of carbohydrate, intense exercise, and rest intervals on hormonal and oxidative changes
    Steven R McAnulty
    Dept of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 17:478-90. 2007
    ..This pattern was identical in the C condition (21). Oxidative stress during cycling was unaffected by use of short rest intervals but was diminished by CHO...
  59. ncbi request reprint Influence of carbohydrate and age on lymphocyte function following a marathon
    Dru A Henson
    Department of Biology, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 14:308-22. 2004
    ..This decrease occurred in both younger and older runners and was not influenced by carbohydrate...
  60. ncbi request reprint A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects
    Serena A Heinz
    Department of Biology, Appalachian State University, Boone, NC, USA
    Br J Nutr 104:849-57. 2010
    ....
  61. ncbi request reprint Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon
    Franziska M Palmer
    Department of Health, Leisure and Exercise Science, Appalachian State University, PO Box 32071, Boone, NC 28608, USA
    Eur J Appl Physiol 89:100-7. 2003
    ..50, P=0.006). These data indicate that vitamin C supplementation in carbohydrate-fed runners does not serve as a countermeasure to oxidative and sIgA changes during or following a competitive ultramarathon race...
  62. ncbi request reprint Validation of a new handheld device for measuring resting metabolic rate and oxygen consumption in children
    David C Nieman
    Dept of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Int J Sport Nutr Exerc Metab 15:186-94. 2005
    ..4 mL/min and 124 kcal/d, respectively. In conclusion, these data indicate that the MedGem is a reliable and valid system for measuring oxygen consumption and RMR in children...
  63. doi request reprint Effects of commercially formulated water on the hydration status of dehydrated collegiate wrestlers
    J Scott Valiente
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, USA
    J Strength Cond Res 23:2210-6. 2009
    ....
  64. ncbi request reprint Quercetin supplementation does not alter antioxidant status in humans
    R Andrew Shanely
    North Carolina Research Campus, Appalachian State University, Human Performance Laboratory, Plants for Human Health Building, 600 Laureate Way, Kannapolis, NC 28081, USA
    Free Radic Res 44:224-31. 2010
    ..In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity...
  65. doi request reprint Effect of n-3 fatty acids and antioxidants on oxidative stress after exercise
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 42:1704-11. 2010
    ....
  66. doi request reprint Effect of an acute bout of whole body vibration exercise on muscle force output and motor neuron excitability
    Jeffrey M McBride
    Neuromuscular Laboratory, Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina, USA
    J Strength Cond Res 24:184-9. 2010
    ..Thus, it is plausible to use WBV as a method for acute increase in muscle force output for athletes immediately before competition...
  67. ncbi request reprint Carbohydrate supplementation and perceived exertion during resistance exercise
    Alan C Utter
    Department of Health, Appalachian State University, Boone, North Carolina 28608, USA
    J Strength Cond Res 19:939-43. 2005
    ..05). Carbohydrate supplementation exerted no attenuating effect on ratings of perceived exertion (RPE) during resistance training...
  68. ncbi request reprint Children's OMNI Scale of Perceived Exertion: walking/running evaluation
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 34:139-44. 2002
    ..The Children's OMNI-walk/run Scale of Perceived Exertion (category range, 0-10) was evaluated using male and female children (6-13 yr of age) during a treadmill graded exercise test...
  69. doi request reprint Quercetin does not affect rating of perceived exertion in athletes during the Western States endurance run
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 17:71-83. 2009
    ..Ratings of perceived exertion (RPE) did not increase in a linear fashion but instead fluctuated nonmonotonically throughout the self-paced endurance running event...
  70. ncbi request reprint Influence of carbohydrate ingestion on oxidative stress and plasma antioxidant potential following a 3 h run
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Free Radic Res 37:835-40. 2003
    ..668). Despite an attenuation in the cortisol response, carbohydrate compared to placebo ingestion does not counter the increase in oxidative stress or modulate plasma antioxidant potential in athletes running 3 h at 70% VO2(max)...
  71. ncbi request reprint Ratings of perceived exertion throughout an ultramarathon during carbohydrate ingestion
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Percept Mot Skills 97:175-84. 2003
    ..Therefore, during competitive self-paced exercise the perceptual responses may be mediated through other neurological and physiological mechanisms...
  72. ncbi request reprint Validation of Omni scale of perceived exertion during prolonged cycling
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 38:780-6. 2006
    ..The present investigation was conducted to validate the OMNI ratings of perceived exertion (RPE) scale during prolonged cycle exercise when subjects were supplemented with either carbohydrate or placebo...
  73. ncbi request reprint Effect of resistance exercise and carbohydrate ingestion on oxidative stress
    Steven R McAnulty
    Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Free Radic Res 39:1219-24. 2005
    ..F(2)-isoprostanes were unaffected by exercise. These results indicate that exhaustive resistance exercise and carbohydrate ingestion have no effect on oxidative stress or plasma antioxidant potential in trained subjects...
  74. ncbi request reprint Evaluation of leg-to-leg BIA in assessing body composition of high-school wrestlers
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 37:1395-400. 2005
    ....
  75. ncbi request reprint Carbohydrate supplementation and perceived exertion during prolonged running
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA
    Med Sci Sports Exerc 36:1036-41. 2004
    ..The purpose of this study was to investigate the relationship between carbohydrate energy substrate and hormonal regulation on the perception of exertion during prolonged running...
  76. ncbi request reprint Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    J Nutr Biochem 16:530-7. 2005
    ..039). This study indicates that prolonged large doses of alpha-tocopherol supplementation did not affect plasma Hcy concentrations and exhibited pro-oxidant characteristics in highly trained athletes during exhaustive exercise...
  77. ncbi request reprint Immune response to a 30-minute walk
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Appalachian State University, P O Box 32071, 111 Rivers Street, Holmes Convocation Center, Boone, NC 28608, USA
    Med Sci Sports Exerc 37:57-62. 2005
    ..To measure several components of immune changes related to walking 30 min with or without an exercise assist device compared with sitting...
  78. ncbi request reprint Validation of the Adult OMNI Scale of perceived exertion for walking/running exercise
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, North Carolina 28608, USA
    Med Sci Sports Exerc 36:1776-80. 2004
    ..Concurrent and construct validity of the OMNI-Walk/Run Scale of Perceived Exertion was examined using young adult women and men (18-36 yr)...
  79. ncbi request reprint Blood leukocyte mRNA expression for IL-10, IL-1Ra, and IL-8, but not IL-6, increases after exercise
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Biology, Family and Consumer Sciences, Fischer Hamilton Nycom Biochemistry Laboratory, Appalachian State University, Boone, NC 28608, USA
    J Interferon Cytokine Res 26:668-74. 2006
    ..mRNA expression was high enough to indicate a substantial contribution of blood leukocytes to plasma levels of IL-8, IL-10, and IL-1Ra during prolonged exercise...
  80. doi request reprint Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Appl Physiol Nutr Metab 33:254-62. 2008
    ....
  81. ncbi request reprint Effect of carbohydrate ingestion on ratings of perceived exertion during a marathon
    Alan C Utter
    Department of Health, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 34:1779-84. 2002
    ..The purpose of this study was to investigate the effects of carbohydrate substrate availability on ratings of perceived exertion (RPE) and hormonal regulation during a competitive marathon...
  82. ncbi request reprint Effect of duration and exogenous carbohydrate on gross efficiency during cycling
    Charles L Dumke
    Human Performance Laboratory, Fisher Hamilton Nycom Laboratory, and Neuromuscular Laboratory, Appalachian State University, Boone, North Carolina 28608, USA
    J Strength Cond Res 21:1214-9. 2007
    ..This suggests that the positive effect of carbohydrate supplementation on endurance performance may be through the maintenance of metabolic efficiency...
  83. ncbi request reprint Ratings of perceived exertion during intermittent and continuous exercise
    Alan C Utter
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Percept Mot Skills 104:1079-87. 2007
    ..120. These data indicate that perception of exertion is similar during prolonged intermittent and continuous exercise when performed at the same relative intensities throughout 90 min. of exercise...
  84. ncbi request reprint Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2
    Steven R McAnulty
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 39:1075-9. 2007
    ..Oxidative stress was examined with use (N = 29) or nonuse (N = 25) of ibuprofen in ultramarathoners after the Western States Endurance Run...
  85. ncbi request reprint Carbohydrate attenuates perceived exertion during intermittent exercise and recovery
    Alan C Utter
    Departments of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Med Sci Sports Exerc 39:880-5. 2007
    ..The purpose of this study was to examine the effect of carbohydrate supplementation on differentiated and undifferentiated ratings of perceived exertion (RPE) during prolonged intermittent exercise and recovery...
  86. pmc Ibuprofen does not affect serum electrolyte concentrations after an ultradistance run
    Charles L Dumke
    Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC 28608, USA
    Br J Sports Med 41:492-6; discussion 496. 2007
    ..To determine the effects of ibuprofen on serum electrolyte concentrations after a 160 km running race...
  87. doi request reprint Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial
    Serena A Heinz
    Department of Biology, Appalachian State University, Boone, NC 28608, USA
    Pharmacol Res 62:237-42. 2010
    ..A reduction in URTI total sick days and severity was noted in middle aged and older subjects ingesting 1000 mg quercetin/day for 12 weeks who rated themselves as physically fit...
  88. ncbi request reprint Validation of Cosmed's FitMate in measuring exercise metabolism
    David C Nieman
    Department of Health, Leisure, and Exercise Science, Human Performance Lab, Appalachian State University, Boone, North Carolina 28608, USA
    Res Sports Med 15:67-75. 2007
    ..23 +/- 0.91 ml.kg-1.min-1 or 14.2 +/- 67.5 ml.min-1. In conclusion, the FitMate metabolic system accurately measures oxygen consumption during graded treadmill exercise when compared with the Douglas bag system in male and female adults...
  89. ncbi request reprint Exercise, nutrition and immune function
    Michael Gleeson
    School of Sport and Exercise Sciences, Loughborough University, Loughborough LE11 3TU, UK
    J Sports Sci 22:115-25. 2004
    ..Convincing evidence that so-called 'immune-boosting' supplements, including high doses of antioxidant vitamins, glutamine, zinc, probiotics and Echinacea, prevent exercise-induced immune impairment is currently lacking...