Jing Xu

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. doi request reprint Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects
    Jing Xu
    Amgen Inc, MS 29 1 A, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Am J Physiol Endocrinol Metab 297:E1105-14. 2009
  2. pmc Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    Jing Xu
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California, USA
    Diabetes 58:250-9. 2009
  3. doi request reprint A novel approach to improve the function of FGF21
    Richard Smith
    Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA
    BioDrugs 27:159-66. 2013
  4. doi request reprint Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
    Clarence Hale
    Department of Metabolic Disorders, Amgen Inc, MS 29 1 A, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:69-80. 2012
  5. doi request reprint Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling
    Junming Yie
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Chem Biol Drug Des 79:398-410. 2012
  6. doi request reprint Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
    Xiaofan Li
    Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA
    FEBS Lett 583:3230-4. 2009
  7. pmc FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
    Murielle M Veniant
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 7:e40164. 2012
  8. doi request reprint Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    Murielle M Veniant
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:4192-203. 2012
  9. doi request reprint FGF21 N- and C-termini play different roles in receptor interaction and activation
    Junming Yie
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
    FEBS Lett 583:19-24. 2009
  10. pmc Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
    Randy Hecht
    Department of Protein Sciences, Amgen Inc, Thousand Oaks, CA, USA
    PLoS ONE 7:e49345. 2012

Collaborators

Detail Information

Publications15

  1. doi request reprint Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects
    Jing Xu
    Amgen Inc, MS 29 1 A, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Am J Physiol Endocrinol Metab 297:E1105-14. 2009
    ..We conclude that the acute glucose-lowering and insulin-sensitizing effects of FGF21 are potentially associated with its metabolic actions in liver and adipose tissues...
  2. pmc Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    Jing Xu
    Department of Metabolic Disorders, Amgen, Thousand Oaks, California, USA
    Diabetes 58:250-9. 2009
    ..The aims of the current study are to evaluate the role of FGF21 in energy metabolism and to provide mechanistic insights into its glucose and lipid-lowering effects in a high-fat diet-induced obesity (DIO) model...
  3. doi request reprint A novel approach to improve the function of FGF21
    Richard Smith
    Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA
    BioDrugs 27:159-66. 2013
    ..Here, we describe a novel approach to modify and improve the function of FGF21 by altering its C-terminal βKlotho interaction domain...
  4. doi request reprint Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance
    Clarence Hale
    Department of Metabolic Disorders, Amgen Inc, MS 29 1 A, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:69-80. 2012
    ..We conclude that overt FGF21 resistance was not evident in the disease models, and increased hepatic FGF21 expression as a result of local metabolic changes is likely a major cause of elevated circulating FGF21 levels...
  5. doi request reprint Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling
    Junming Yie
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Chem Biol Drug Des 79:398-410. 2012
    ..Taken together, our data suggest that the D1/linker region regulates both the FGF21/FGFR1c and FGFR1c/β-Klotho interaction, and a direct interaction of FGF21 with FGFR1c may be an important step in receptor-mediated FGF21 signaling...
  6. doi request reprint Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice
    Xiaofan Li
    Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA
    FEBS Lett 583:3230-4. 2009
    ..These results demonstrate the potential importance of adipocyte lipolysis to the observed acute improvements in plasma parameters...
  7. pmc FGF21 promotes metabolic homeostasis via white adipose and leptin in mice
    Murielle M Veniant
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 7:e40164. 2012
    ..Together these data suggest that adipose tissue is required for the triglyceride and glucose, but not the cholesterol lowering efficacy of FGF21, and that leptin and FGF21 exert additive anti-diabetic effects in Tg mice...
  8. doi request reprint Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys
    Murielle M Veniant
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Endocrinology 153:4192-203. 2012
    ..In conclusion, in more than one species, Fc-FGF21(RG) chronically administered once a week showed similar or greater efficacy than hrFGF21 administered daily...
  9. doi request reprint FGF21 N- and C-termini play different roles in receptor interaction and activation
    Junming Yie
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA 91320, USA
    FEBS Lett 583:19-24. 2009
    ..These data demonstrate that the C-terminus of FGF21 is critical for binding to beta-Klotho and the N-terminus is critical for fibroblast growth factor receptor (FGFR) activation...
  10. pmc Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes
    Randy Hecht
    Department of Protein Sciences, Amgen Inc, Thousand Oaks, CA, USA
    PLoS ONE 7:e49345. 2012
    ..In summary, we engineered a potent and efficacious long-acting FGF21 analog with a favorable pharmaceutical property for potential clinical development...
  11. doi request reprint Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation
    Jing Xu
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, United States
    Bioconjug Chem 24:915-25. 2013
    ....
  12. doi request reprint An acyl-ghrelin-specific neutralizing antibody inhibits the acute ghrelin-mediated orexigenic effects in mice
    Shu Chen Lu
    Department of Metabolic Disorders, Amgen Inc, One Amgen Center Dr, Thousand Oaks, CA 91320, USA
    Mol Pharmacol 75:901-7. 2009
    ..The lack of long-term effects on body weight control by 33A suggests that compensatory mechanisms may contribute to the regulation of energy balance...
  13. doi request reprint Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities
    Todd Hager
    PKDM, Amgen Inc, Thousand Oaks, California 91320, United States
    Anal Chem 85:2731-8. 2013
    ..In this work, the power of the approach is elucidated by application to the optimization of a promising drug candidate, FGF21...
  14. ncbi request reprint Co-receptor requirements for fibroblast growth factor-19 signaling
    Xinle Wu
    Amgen Inc, South San Francisco, California 94080, USA
    J Biol Chem 282:29069-72. 2007
    ..These results suggest that a functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with either alphaKlotho or betaKlotho...
  15. pmc BicaudalD actively regulates microtubule motor activity in lipid droplet transport
    Kristoffer S Larsen
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, California, USA
    PLoS ONE 3:e3763. 2008
    ..Nonetheless, it is widely believed that BicD may act to tether dynein to cargos. Here we use a combination of biophysical and biochemical studies to investigate BicD's role in lipid droplet transport during Drosophila embryogenesis...