Claire L Sutherland

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi request reprint ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
    Claire L Sutherland
    Department of Oncology, Amgen Inc, Seattle, WA, 98119, USA
    Blood 108:1313-9. 2006
  2. ncbi request reprint ULBP4 is a novel ligand for human NKG2D
    N Jan Chalupny
    Amgen, 51 University St, Seattle, WA 98101, USA
    Biochem Biophys Res Commun 305:129-35. 2003
  3. ncbi request reprint UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    Claire L Sutherland
    Department of Molecular Biology, Immunex, Seattle, WA 98101, USA
    J Immunol 168:671-9. 2002
  4. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
  5. pmc Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target
    Lara P Stepan
    Department of Oncology, Amgen Inc, Seattle, Washington 98119, USA
    J Histochem Cytochem 59:701-10. 2011
  6. ncbi request reprint A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function
    Allison P Armstrong
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:44347-56. 2002
  7. pmc Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    Claire Dunn
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    J Exp Med 197:1427-39. 2003

Collaborators

Detail Information

Publications7

  1. ncbi request reprint ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity with enhancement by IL-15
    Claire L Sutherland
    Department of Oncology, Amgen Inc, Seattle, WA, 98119, USA
    Blood 108:1313-9. 2006
    ..Together, these results demonstrate that ULBP expression can elicit a potent immune response and suggest that ULBPs, alone or in combination with IL-15, can be exploited for antitumor therapy...
  2. ncbi request reprint ULBP4 is a novel ligand for human NKG2D
    N Jan Chalupny
    Amgen, 51 University St, Seattle, WA 98101, USA
    Biochem Biophys Res Commun 305:129-35. 2003
    ..Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin...
  3. ncbi request reprint UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells
    Claire L Sutherland
    Department of Molecular Biology, Immunex, Seattle, WA 98101, USA
    J Immunol 168:671-9. 2002
    ..These results increase our understanding of the mechanisms by which NKG2D activates immune effector cells and may have implications for immune surveillance against pathogens and tumors...
  4. doi request reprint Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors
    David Meininger
    Protein Sciences, Amgen Inc, Seattle, WA 98119, USA
    Biochim Biophys Acta 1814:1947-54. 2011
    ..Docking of Amg-1 and related analogs to the known structure of IDO1 and to homology-modeled IDO2 suggests possible rationales for the different inhibition profiles of IDO1 and IDO2...
  5. pmc Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target
    Lara P Stepan
    Department of Oncology, Amgen Inc, Seattle, Washington 98119, USA
    J Histochem Cytochem 59:701-10. 2011
    ....
  6. ncbi request reprint A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function
    Allison P Armstrong
    Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
    J Biol Chem 277:44347-56. 2002
    ..These studies are the first to define the functional domains of the RANK cytoplasmic tail that control specific differentiation and activation pathways in osteoclasts...
  7. pmc Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity
    Claire Dunn
    Department of Molecular Microbiology and Immunology, Oregon Health and Sciences University, Portland, OR 97239, USA
    J Exp Med 197:1427-39. 2003
    ..The intracellular sequestration of NKG2D ligands by UL16 represents a novel HCMV immune evasion mechanism to add to the well-documented viral strategies directed against antigen presentation by classical MHC molecules...