Bryan D Moyer
Affiliation: Amgen Inc
Kornecook T, Yin R, Altmann S, Be X, Berry V, Ilch C, et al
. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017;362:146-160 pubmed publisher
..7 inhibitor that blocks sodium current in heterologous cells as well as DRG neurons, inhibits action potential firing in peripheral nerve fibers, and exhibits pharmacodynamic effects in translatable models of both itch and pain. ..