M Haniu

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
    M Haniu
    Amgen Inc, Thousand Oaks, California 91320 1799, USA
    J Biol Chem 275:21099-106. 2000
  2. ncbi Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain
    M Haniu
    Departments of Protein Structure, Protein Chemistry, and Immunology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
    J Biol Chem 273:28691-9. 1998
  3. ncbi Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor
    M Haniu
    Department of Protein Chemistry, Amgen, Inc, Thousand Oaks, California 91320, USA
    Biochemistry 35:13040-6. 1996
  4. ncbi Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking
    M Haniu
    Departments of Protein Structure, Protein Chemistry, and Immunology, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Biol Chem 272:25296-303. 1997
  5. ncbi Human neurotrophin-3: a one-step peptide mapping method and complete disulfide characterization of the recombinant protein
    J O Hui
    Protein Structure, Amgen Inc, Thousand Oaks, California 91320, USA
    J Protein Chem 15:351-8. 1996
  6. ncbi Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure
    M Haniu
    Department of Protein Structure, Amgen, Inc, Thousands Oaks, California 91320 1789, USA
    Biochemistry 35:16799-805. 1996
  7. ncbi Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region
    M Haniu
    Department of Protein Structure, Amgen, Inc, Thousand Oaks, California 91320, USA
    Arch Biochem Biophys 324:344-56. 1995
  8. ncbi Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation
    E J Bures
    Amgen, Inc, Thousand Oaks, California 91320, USA
    Biochemistry 37:12172-7. 1998
  9. ncbi Purification and identification of brain-derived neurotrophic factor from human serum
    R D Rosenfeld
    Amgen Center, Thousand Oaks, California 91320, USA
    Protein Expr Purif 6:465-71. 1995
  10. ncbi Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding
    M Haniu
    Amgen, Inc, Thousand Oaks, California 91320, USA
    Arch Biochem Biophys 322:256-64. 1995

Collaborators

Detail Information

Publications17

  1. ncbi Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties
    M Haniu
    Amgen Inc, Thousand Oaks, California 91320 1799, USA
    J Biol Chem 275:21099-106. 2000
    ..This difference may affect the substrate specificity of the enzyme. Taken together, both the presence of a transmembrane domain and the unusual disulfide bond structure lead us to conclude that BACE is an atypical pepsin family member...
  2. ncbi Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain
    M Haniu
    Departments of Protein Structure, Protein Chemistry, and Immunology, Amgen Inc, Thousand Oaks, California 91320 1789, USA
    J Biol Chem 273:28691-9. 1998
    ..On the other hand, the N-terminal WSXWS motif was not glycosylated...
  3. ncbi Disulfide structure and N-glycosylation sites of an extracellular domain of granulocyte-colony stimulating factor receptor
    M Haniu
    Department of Protein Chemistry, Amgen, Inc, Thousand Oaks, California 91320, USA
    Biochemistry 35:13040-6. 1996
    ..Glycosylation seems necessary for stabilizing the molecule against disulfide-linked oligomerization of the receptor, indicating that the free cysteine residues become reactive for oxidation and disulfide exchange upon deglycosylation...
  4. ncbi Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking
    M Haniu
    Departments of Protein Structure, Protein Chemistry, and Immunology, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Biol Chem 272:25296-303. 1997
    ..These results, obtained from a variety of experimental techniques, highlight the importance of two distinct regions of the extracellular domain of the TRKB receptor in binding BDNF...
  5. ncbi Human neurotrophin-3: a one-step peptide mapping method and complete disulfide characterization of the recombinant protein
    J O Hui
    Protein Structure, Amgen Inc, Thousand Oaks, California 91320, USA
    J Protein Chem 15:351-8. 1996
    ..This disulfide structure is homologous to the NGF family of neurotrophic factors...
  6. ncbi Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure
    M Haniu
    Department of Protein Structure, Amgen, Inc, Thousands Oaks, California 91320 1789, USA
    Biochemistry 35:16799-805. 1996
    ..Only the peptides from an N-terminal region (residues -1 to 37) were liberated by proteolytic treatment with trypsin or endoproteinase Lys-C, resulting in a stable cystine-knot protein...
  7. ncbi Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region
    M Haniu
    Department of Protein Structure, Amgen, Inc, Thousand Oaks, California 91320, USA
    Arch Biochem Biophys 324:344-56. 1995
    ..The results show that the N-terminal Met of G-CSF is located at a distance of approximately 11 A from a reactive Lys-242 of the receptor in the ligand-receptor complex...
  8. ncbi Determination of disulfide structure in agouti-related protein (AGRP) by stepwise reduction and alkylation
    E J Bures
    Amgen, Inc, Thousand Oaks, California 91320, USA
    Biochemistry 37:12172-7. 1998
    ..The chemically defined disulfide connectivity of the recombinant human AGRP was homologous to that of omega-agatoxin IVB except for an additional disulfide bond, C85-C109...
  9. ncbi Purification and identification of brain-derived neurotrophic factor from human serum
    R D Rosenfeld
    Amgen Center, Thousand Oaks, California 91320, USA
    Protein Expr Purif 6:465-71. 1995
    ..The presence of high levels of BDNF in serum suggests a role for this neurotrophin either in nerve repair at sites of injured tissue or in nonneuronal functions...
  10. ncbi Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding
    M Haniu
    Amgen, Inc, Thousand Oaks, California 91320, USA
    Arch Biochem Biophys 322:256-64. 1995
    ..Among 12 potential N-linked glycosylation sites proposed in the soluble domain of trkB, 10 sites are actually glycosylated...
  11. ncbi Formation of heterodimers from three neurotrophins, nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor
    T Arakawa
    Amgen Inc, Thousand Oaks, California 91320 1789
    J Biol Chem 269:27833-9. 1994
    ..BDNF heterodimer, and it is not stable even at 4 degrees C. These results indicate that BDNF and NT-3 have an intersubunit contact surface for dimerization resembling each other's but different from the contact surface of NGF...
  12. ncbi A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase
    B D Bennett
    Department of Neurology, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 275:37712-7. 2000
    ..Taken together, our results strongly suggest that furin, or a furin-like proprotein convertase, is responsible for cleaving the BACE propeptide domain to form the mature enzyme...
  13. ncbi The primary structure of cytochrome P-450d purified from rat liver microsomes: prediction of helical regions and domain analysis
    M Haniu
    Arch Biochem Biophys 244:323-37. 1986
    ....
  14. ncbi Complete amino acid sequence of NADPH-cytochrome P-450 reductase from porcine hepatic microsomes
    M Haniu
    Biochemistry 25:7906-11. 1986
    ..Hydropathy plot analysis reveals that two regions from residues 27-43 and from residues 523-544 exhibit a high degree of hydrophobicity, suggesting membrane binding or interaction with cytochrome P-450...
  15. ncbi Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase
    T Iyanagi
    J Biol Chem 261:15607-14. 1986
    ....
  16. ncbi Reaction of rat liver DT-diaphorase (NAD(P)H:quinone acceptor reductase) with 5'-[p-(fluorosulfonyl)benzoyl]-adenosine
    X F Liu
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Mol Pharmacol 35:818-22. 1989
    ....
  17. ncbi Amino acid sequence of subunit V of bovine heart cytochrome oxidase, the heme alpha-containing subunit
    M Tanaka
    J Biol Chem 254:3879-85. 1979
    ..0% hydrophilic residues and it is an acidic protein having a net charge of -3 at neutral pH. The molecular weight of subunit V was calculated to be 12,436 and that for the heme alpha-containing polypeptide was 13,295...