C A Haller

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. doi request reprint Safety issues specific to clinical development of protein therapeutics
    C A Haller
    Department of Global Regulatory Affairs and Safety, Amgen Inc, South San Francisco, California, USA
    Clin Pharmacol Ther 84:624-7. 2008
  2. pmc Dietary supplement adverse events: report of a one-year poison center surveillance project
    Christine Haller
    Amgen, Inc Department of Global Regulatory Affairs and Safety, South San Francisco, CA, USA
    J Med Toxicol 4:84-92. 2008
  3. pmc Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
    Br J Clin Pharmacol 65:833-40. 2008
  4. ncbi request reprint Enhanced stimulant and metabolic effects of combined ephedrine and caffeine
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
    Clin Pharmacol Ther 75:259-73. 2004
  5. ncbi request reprint Hemodynamic effects of ephedra-free weight-loss supplements in humans
    Christine A Haller
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA
    Am J Med 118:998-1003. 2005
  6. ncbi request reprint Short-term metabolic and hemodynamic effects of ephedra and guarana combinations
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
    Clin Pharmacol Ther 77:560-71. 2005
  7. ncbi request reprint Seizures reported in association with use of dietary supplements
    Christine A Haller
    University of California, San Francisco, San Francisco, California 94143, USA
    Clin Toxicol (Phila) 43:23-30. 2005
  8. ncbi request reprint Determination of ephedra alkaloid and caffeine concentrations in dietary supplements and biological fluids
    Peyton Jacob
    University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
    J Anal Toxicol 28:152-9. 2004
  9. ncbi request reprint Concentrations of ephedra alkaloids and caffeine in commercial dietary supplements
    Christine A Haller
    University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
    J Anal Toxicol 28:145-51. 2004
  10. ncbi request reprint Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use
    Christine A Haller
    Division of Clinical Pharmacology, San Francisco General Hospital, University of California, 94143, USA
    Clin Pharmacol Ther 71:421-32. 2002

Collaborators

Detail Information

Publications14

  1. doi request reprint Safety issues specific to clinical development of protein therapeutics
    C A Haller
    Department of Global Regulatory Affairs and Safety, Amgen Inc, South San Francisco, California, USA
    Clin Pharmacol Ther 84:624-7. 2008
  2. pmc Dietary supplement adverse events: report of a one-year poison center surveillance project
    Christine Haller
    Amgen, Inc Department of Global Regulatory Affairs and Safety, South San Francisco, CA, USA
    J Med Toxicol 4:84-92. 2008
    ..Harmful supplements may not be identified for months or years with existing adverse event monitoring mechanisms. Retrospective review of poison center statistics to capture supplement-associated toxicity also has limitations...
  3. pmc Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, San Francisco General Hospital, San Francisco, CA, USA
    Br J Clin Pharmacol 65:833-40. 2008
    ..The effect of exercise on the pharmacokinetics and pharmacodynamics of stimulant herbals is unknown...
  4. ncbi request reprint Enhanced stimulant and metabolic effects of combined ephedrine and caffeine
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
    Clin Pharmacol Ther 75:259-73. 2004
    ..We sought to determine whether ephedrine and caffeine have clinically significant pharmacologic interactions that explain these toxicities...
  5. ncbi request reprint Hemodynamic effects of ephedra-free weight-loss supplements in humans
    Christine A Haller
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, University of California, San Francisco, 94143, USA
    Am J Med 118:998-1003. 2005
    ..These supplements may have some of the health risks associated with ephedra, but studies in humans are lacking. Our aim was to characterize the pharmacokinetics and cardiovascular effects of C. aurantium dietary supplements...
  6. ncbi request reprint Short-term metabolic and hemodynamic effects of ephedra and guarana combinations
    Christine A Haller
    Department of Medicine, Division of Clinical Pharmacology, University of California, San Francisco, CA 94143, USA
    Clin Pharmacol Ther 77:560-71. 2005
    ..We sought to determine whether repeated dosing and multi-ingredient formulations contribute to the adverse effects of these supplements...
  7. ncbi request reprint Seizures reported in association with use of dietary supplements
    Christine A Haller
    University of California, San Francisco, San Francisco, California 94143, USA
    Clin Toxicol (Phila) 43:23-30. 2005
    ..Seizures in persons using dietary supplements (DS) have been reported through the Food and Drug Administration's (FDA) MedWatch system, but not formally reviewed...
  8. ncbi request reprint Determination of ephedra alkaloid and caffeine concentrations in dietary supplements and biological fluids
    Peyton Jacob
    University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
    J Anal Toxicol 28:152-9. 2004
    ..Using this method, low nanogram-per-milliliter concentrations of ephedrine, pseudoephedrine, norephedrine, norpseudoephedrine, methylephedrine, methylpseudoephedrine, and caffeine can be quantitated in a 12-min LC-MS-MS run...
  9. ncbi request reprint Concentrations of ephedra alkaloids and caffeine in commercial dietary supplements
    Christine A Haller
    University of California, San Francisco, Department of Medicine, Division of Clinical Pharmacology, San Francisco General Hospital, 1001 Potrero Avenue, Building 30, 3rd Floor, San Francisco, California 94110, USA
    J Anal Toxicol 28:145-51. 2004
    ..We conclude that product inconsistency is common among some commercially available dietary supplements that contain ephedra alkaloids and caffeine...
  10. ncbi request reprint Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use
    Christine A Haller
    Division of Clinical Pharmacology, San Francisco General Hospital, University of California, 94143, USA
    Clin Pharmacol Ther 71:421-32. 2002
    ..We assessed the pharmacokinetics and pharmacodynamics of a dietary supplement that contains these herbal stimulants...
  11. ncbi request reprint Clinical approach to adverse events and interactions related to herbal and dietary supplements
    Christine A Haller
    University of California, San Francisco, California Poison Control System, San Francisco Division, San Francisco, California 94143, USA
    Clin Toxicol (Phila) 44:605-10. 2006
  12. pmc Gamma-hydroxybutyrate and ethanol effects and interactions in humans
    Dung Thai
    Amgen Corporation, Thousand Oaks, CA, USA
    J Clin Psychopharmacol 26:524-9. 2006
    ..Gamma-hydroxybutyrate (GHB) is a common drug of abuse that can produce serious toxicity, particularly when used with other sedatives. We examined the individual and combined effects of GHB and ethanol in human volunteers...
  13. ncbi request reprint Effect of a multicomponent, ephedra-containing dietary supplement (Metabolife 356) on Holter monitoring and hemostatic parameters in healthy volunteers
    Stephanie F Gardner
    Department of Pharmacy Practice, College of Pharmacy, University of Arkansas for Medical Sciences, 4301 W Markham 522, Little Rock, AR 72205, USA
    Am J Cardiol 91:1510-3, A9. 2003
  14. ncbi request reprint An evaluation of selected herbal reference texts and comparison to published reports of adverse herbal events
    Christine A Haller
    Department of Medicine and Clinical Pharmacy, University of California, San Francisco, California, USA
    Adverse Drug React Toxicol Rev 21:143-50. 2002
    ..We systematically assessed six herbal reference texts to evaluate the information they contain on herbal toxicity...