Vijay K Gore

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
    Vijay K Gore
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:5825-30. 2007
  2. ncbi Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists
    Vijay K Gore
    Department of Chemistry Research and Discovery, Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Bioorg Med Chem Lett 20:3573-8. 2010
  3. ncbi Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles
    Vassil I Ognyanov
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 49:3719-42. 2006

Collaborators

Detail Information

Publications3

  1. ncbi Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
    Vijay K Gore
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:5825-30. 2007
    ..These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33...
  2. ncbi Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists
    Vijay K Gore
    Department of Chemistry Research and Discovery, Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Bioorg Med Chem Lett 20:3573-8. 2010
    ..An example from this class of BKCa agonists was shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine...
  3. ncbi Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles
    Vassil I Ognyanov
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 49:3719-42. 2006
    ..Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA)...