Vijay K Gore

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
    Vijay K Gore
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:5825-30. 2007
  2. ncbi Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists
    Vijay K Gore
    Department of Chemistry Research and Discovery, Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Bioorg Med Chem Lett 20:3573-8. 2010
  3. ncbi Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles
    Vassil I Ognyanov
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 49:3719-42. 2006
  4. ncbi Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists
    Daniel B Horne
    Departments of Chemistry Research and Discovery, Neuroscience, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, United States
    J Med Chem 57:2989-3004. 2014

Collaborators

Detail Information

Publications4

  1. ncbi Structure-activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
    Vijay K Gore
    Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:5825-30. 2007
    ..These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33...
  2. ncbi Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists
    Vijay K Gore
    Department of Chemistry Research and Discovery, Amgen Inc, Thousand Oaks, CA 91320 1799, USA
    Bioorg Med Chem Lett 20:3573-8. 2010
    ..An example from this class of BKCa agonists was shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine...
  3. ncbi Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles
    Vassil I Ognyanov
    Department of Chemistry Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Med Chem 49:3719-42. 2006
    ..Compound 46ad also reversed thermal hyperalgesia in a model of inflammatory pain, which was induced by complete Freund's adjuvant (CFA)...
  4. ncbi Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists
    Daniel B Horne
    Departments of Chemistry Research and Discovery, Neuroscience, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, United States
    J Med Chem 57:2989-3004. 2014
    ..Compound 45 demonstrated robust efficacy in both pharmacodynamic models with ED90 values <3 mg/kg. ..