Mike Frohn

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity
    Mike Frohn
    Department of Medicinal Chemistry, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 22:628-33. 2012
  2. ncbi New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
    Mike Frohn
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6633-7. 2007
  3. ncbi Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors
    Mike Frohn
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 18:5023-6. 2008
  4. ncbi Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
    Roland W Bürli
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 16:3713-8. 2006
  5. ncbi Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups
    Anthony B Reed
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
    Bioorg Med Chem Lett 22:1779-83. 2012
  6. ncbi A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005

Collaborators

  • Victor J Cee
  • Paul E Harrington
  • Jennifer H Dao
  • Ning Xi
  • Celia Dominguez
  • Longbin Liu
  • Anthony B Reed
  • Min Wong
  • Han Xu
  • Michele McElvain
  • Roland W Bürli
  • Brian A Lanman
  • Scot Middleton
  • Alexander J Pickrell
  • Andrew S Tasker
  • Yang Xu
  • Henry Morrison
  • Kelvin K C Sham
  • Andrea Itano
  • Susana Neira
  • Anu Gore
  • Mike Fiorino
  • Philip Tagari
  • Xiaoming Zou
  • Matthew Adlam
  • Vellarkad N Viswanadhan
  • Matthew H Plant
  • Kristine Muller
  • Randall Hungate
  • Jennifer Golden
  • Kelly Regal

Detail Information

Publications6

  1. ncbi Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity
    Mike Frohn
    Department of Medicinal Chemistry, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 22:628-33. 2012
    ....
  2. ncbi New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
    Mike Frohn
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6633-7. 2007
    ..This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro...
  3. ncbi Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors
    Mike Frohn
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 18:5023-6. 2008
    ..We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro...
  4. ncbi Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
    Roland W Bürli
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 16:3713-8. 2006
    ..Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration...
  5. ncbi Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups
    Anthony B Reed
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
    Bioorg Med Chem Lett 22:1779-83. 2012
    ..A 0.3mg/kg oral dose of 8c produced a statistically significant reduction in blood lymphocyte counts 24h post-dosing in female Lewis rats...
  6. ncbi A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005
    ..Preliminary results with aryl chlorides are also reported...