Mike Frohn

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. doi request reprint Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity
    Mike Frohn
    Department of Medicinal Chemistry, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 22:628-33. 2012
  2. ncbi request reprint New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
    Mike Frohn
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6633-7. 2007
  3. doi request reprint Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors
    Mike Frohn
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 18:5023-6. 2008
  4. ncbi request reprint Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
    Roland W Bürli
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 16:3713-8. 2006
  5. doi request reprint Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups
    Anthony B Reed
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
    Bioorg Med Chem Lett 22:1779-83. 2012
  6. ncbi request reprint A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005

Collaborators

  • Victor J Cee
  • Paul E Harrington
  • Jennifer H Dao
  • Ning Xi
  • Celia Dominguez
  • Longbin Liu
  • Anthony B Reed
  • Michele McElvain
  • Min Wong
  • Han Xu
  • Roland W Bürli
  • Henry Morrison
  • Mike Fiorino
  • Susana Neira
  • Yang Xu
  • Andrew S Tasker
  • Andrea Itano
  • Kelvin K C Sham
  • Anu Gore
  • Scot Middleton
  • Brian A Lanman
  • Alexander J Pickrell
  • Philip Tagari
  • Kelly Regal
  • Jennifer Golden
  • Matthew H Plant
  • Kristine Muller
  • Xiaoming Zou
  • Vellarkad N Viswanadhan
  • Matthew Adlam
  • Randall Hungate

Detail Information

Publications6

  1. doi request reprint Novel 5- and 6-subtituted benzothiazoles with improved physicochemical properties: potent S1P₁ agonists with in vivo lymphocyte-depleting activity
    Mike Frohn
    Department of Medicinal Chemistry, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 22:628-33. 2012
    ....
  2. ncbi request reprint New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation
    Mike Frohn
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 17:6633-7. 2007
    ..This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro...
  3. doi request reprint Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1alpha prolyl hydroxylase-2 inhibitors
    Mike Frohn
    Department of Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 18:5023-6. 2008
    ..We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro...
  4. ncbi request reprint Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents
    Roland W Bürli
    Chemistry Research and Discovery, Amgen, Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Bioorg Med Chem Lett 16:3713-8. 2006
    ..Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration...
  5. doi request reprint Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups
    Anthony B Reed
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, United States
    Bioorg Med Chem Lett 22:1779-83. 2012
    ..A 0.3mg/kg oral dose of 8c produced a statistically significant reduction in blood lymphocyte counts 24h post-dosing in female Lewis rats...
  6. ncbi request reprint A soluble base for the copper-catalyzed imidazole N-arylations with aryl halides
    Longbin Liu
    Chemical Research and Discovery, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    J Org Chem 70:10135-8. 2005
    ..Preliminary results with aryl chlorides are also reported...