Mark R Fielden

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. doi request reprint Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
    Toxicol Pathol 43:581-92. 2015
  2. doi request reprint Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, South San Francisco, California 94080, USA
    Toxicol Sci 124:54-74. 2011

Detail Information

Publications2

  1. doi request reprint Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, Thousand Oaks, California, USA
    Toxicol Pathol 43:581-92. 2015
    ..These results suggest that AMG-8718 impairs phagolysosomal function in the rat RPE, which leads to photoreceptor dysfunction and ultimately loss of photoreceptors. ..
  2. doi request reprint Development and evaluation of a genomic signature for the prediction and mechanistic assessment of nongenotoxic hepatocarcinogens in the rat
    Mark R Fielden
    Comparative Biology and Safety Sciences, Amgen, South San Francisco, California 94080, USA
    Toxicol Sci 124:54-74. 2011
    ..These results support a potential early preclinical testing paradigm to catalyze broader understanding of putative NGHCs...