R Faggioni

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice
    R Faggioni
    Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 167:5913-20. 2001
  2. ncbi Leptin regulation of the immune response and the immunodeficiency of malnutrition
    R Faggioni
    Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, 94121, USA
    FASEB J 15:2565-71. 2001
  3. ncbi Leptin deficiency enhances sensitivity to endotoxin-induced lethality
    R Faggioni
    Metabolism Section, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Am J Physiol 276:R136-42. 1999
  4. ncbi Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18
    R Faggioni
    Metabolism Section, Department of Veteran Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 97:2367-72. 2000
  5. ncbi Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha
    R A Memon
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Biochim Biophys Acta 1484:41-50. 2000
  6. ncbi LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice
    R Faggioni
    Department of Medicine, University of California, USA
    Am J Physiol 273:R181-6. 1997

Detail Information

Publications6

  1. ncbi IL-18-binding protein protects against lipopolysaccharide- induced lethality and prevents the development of Fas/Fas ligand-mediated models of liver disease in mice
    R Faggioni
    Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 167:5913-20. 2001
    ..In conclusion, IL-18BP can be engineered and produced in recombinant form to generate an IL-18 inhibitor, IL-18BP-Fc, endowed with remarkable in vitro and in vivo properties of binding and neutralizing IL-18...
  2. ncbi Leptin regulation of the immune response and the immunodeficiency of malnutrition
    R Faggioni
    Department of Veterans Affairs Medical Center, University of California, San Francisco, San Francisco, California, 94121, USA
    FASEB J 15:2565-71. 2001
    ..Leptin regulates T cells responses, polarizing Th cells toward a Th1 phenotype. Low leptin levels occurring during starvation mediate the neuroendocrine and immune dysfunction of starvation...
  3. ncbi Leptin deficiency enhances sensitivity to endotoxin-induced lethality
    R Faggioni
    Metabolism Section, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Am J Physiol 276:R136-42. 1999
    ..These results suggest that leptin participates in the host response to inflammation by modulating the host immune and cytokine responses after LPS...
  4. ncbi Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18
    R Faggioni
    Metabolism Section, Department of Veteran Affairs Medical Center, University of California, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 97:2367-72. 2000
    ..In addition, both TNF-alpha and IL-18 appear to be essential mediators of T cell-mediated liver injury...
  5. ncbi Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role for leptin, hyperphagia, increased tissue lipid content, and TNF-alpha
    R A Memon
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Biochim Biophys Acta 1484:41-50. 2000
    ..Taken together, these results suggest that the upregulation of UCP2 mRNA levels in the liver and WAT of ob/ob mice is not due to the lack of leptin, hyperphagia, increased tissue lipid content, or over-expression of TNF-alpha...
  6. ncbi LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice
    R Faggioni
    Department of Medicine, University of California, USA
    Am J Physiol 273:R181-6. 1997
    ..No differences between db/db and ob/ob mice and their respective littermate were observed in circulating tumor necrosis factor levels after LPS. These data suggest that leptin per se is not essential for LPS-induced anorexia...