Affiliation: Amgen Inc
- Significant gene content variation characterizes the genomes of inbred mouse strainsGene Cutler
Lead Discovery, Amgen, South San Francisco, California 94080, USA
Genome Res 17:1743-54. 2007..Using a whole-genome association analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be associated with specific copy number changes...
- Copy number variation in the mouse genome: implications for the mouse as a model organism for human diseaseG Cutler
Lead Discovery, Amgen, South San Francisco, CA, USA
Cytogenet Genome Res 123:297-306. 2008..These genetic differences can inform us about the history of a population or species, enlighten us on gene function, and guide our selection of a model system for the study of human disease...
- Identification of transcriptional networks responding to pyrroloquinoline quinone dietary supplementation and their influence on thioredoxin expression, and the JAK/STAT and MAPK pathwaysEskouhie Tchaparian
Department of Nutrition, University of California Davis, 95616, USA
Biochem J 429:515-26. 2010..Collectively, the results provide a mechanistic basis for previous functional observations associated with PQQ deficiency or PQQ administered in pharmacological amounts...
- Multiclass cancer classification and biomarker discovery using GA-based algorithmsJane Jijun Liu
Tularik Inc, South San Francisco, CA 94080, USA
Bioinformatics 21:2691-7. 2005..With this approach, we believe that microarray-based multiclass molecular analysis can be an effective tool for cancer biomarker discovery and subsequent molecular cancer diagnosis...