Fergus R Byrne

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. ncbi Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells
    Betty S Pio
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, and the Greater Los Angeles Veterans Affairs Hospital System, Los Angeles, CA 90095 6942, USA
    Mol Imaging Biol 5:271-7. 2003
  2. ncbi CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin
    F R Byrne
    Amgen Inc, One Amgen Center Drive, Mail Stop 29 1 B, Thousand Oaks, California 91320, USA
    Gut 54:78-86. 2005
  3. ncbi rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease
    Fergus R Byrne
    Department of Pharmacology, Amgen, Thousand Oaks, California 91320, USA
    Am J Physiol Gastrointest Liver Physiol 282:G690-701. 2002
  4. ncbi An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation
    Fergus R Byrne
    Amgen Inc, Thousand Oaks, CA, USA
    Autoimmunity 42:171-82. 2009
  5. ncbi Methods of inducing inflammatory bowel disease in mice
    Joseph R Maxwell
    Amgen, Seattle, Washington, USA
    Curr Protoc Pharmacol . 2009
  6. ncbi Mouse models of inflammatory bowel disease
    Fergus R Byrne
    Amgen Inc, Department of Inflammation Research, Thousand Oaks, CA 91320, USA
    Curr Opin Drug Discov Devel 9:207-17. 2006
  7. ncbi Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation
    Gisen Kim
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:5278-88. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Noninvasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells
    Betty S Pio
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, and the Greater Los Angeles Veterans Affairs Hospital System, Los Angeles, CA 90095 6942, USA
    Mol Imaging Biol 5:271-7. 2003
    ..FDG-labeled WBC's, in conjunction with PET, can be used to provide quantitative assessment of bowel inflammation noninvasively, accurately, and rapidly...
  2. ncbi CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin
    F R Byrne
    Amgen Inc, One Amgen Center Drive, Mail Stop 29 1 B, Thousand Oaks, California 91320, USA
    Gut 54:78-86. 2005
    ..We also investigated whether osteopenia was due to malabsorption as a result of a dysregulated digestive tract or as a consequence of the inflammatory process...
  3. ncbi rHuKGF ameliorates symptoms in DSS and CD4(+)CD45RB(Hi) T cell transfer mouse models of inflammatory bowel disease
    Fergus R Byrne
    Department of Pharmacology, Amgen, Thousand Oaks, California 91320, USA
    Am J Physiol Gastrointest Liver Physiol 282:G690-701. 2002
    ..These data suggest that rHuKGF may prove useful in the clinical management of IBD and its effects are likely mediated by its ability to locally increase the levels of ITF...
  4. ncbi An antibody to IP-10 is a potent antagonist of cell migration in vitro and in vivo and does not affect disease in several animal models of inflammation
    Fergus R Byrne
    Amgen Inc, Thousand Oaks, CA, USA
    Autoimmunity 42:171-82. 2009
    ..These data suggest that the 20A9 mAb can antagonize IP-10 mediated chemotaxis in vitro and in vivo and that this is insufficient to cause a therapeutic benefit in multiple mouse models of inflammatory disease...
  5. ncbi Methods of inducing inflammatory bowel disease in mice
    Joseph R Maxwell
    Amgen, Seattle, Washington, USA
    Curr Protoc Pharmacol . 2009
    ....
  6. ncbi Mouse models of inflammatory bowel disease
    Fergus R Byrne
    Amgen Inc, Department of Inflammation Research, Thousand Oaks, CA 91320, USA
    Curr Opin Drug Discov Devel 9:207-17. 2006
    ....
  7. ncbi Spontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation
    Gisen Kim
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:5278-88. 2008
    ..This model provides an important tool for examining how B7 molecules and their effects on CTLA-4 modulate T cell function and the development of inflammatory diseases...