Cynthia A Afshari

Summary

Affiliation: Amgen Inc
Country: USA

Publications

  1. pmc Integrating phenotypic and expression profiles to map arsenic-response networks
    Astrid C Haugen
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Genome Biol 5:R95. 2004
  2. pmc The evolution of bioinformatics in toxicology: advancing toxicogenomics
    Cynthia A Afshari
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 120:S225-37. 2011
  3. ncbi request reprint Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity
    Hisham K Hamadeh
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Mutat Res 549:169-83. 2004
  4. doi request reprint Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors
    Hisham K Hamadeh
    Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Chem Res Toxicol 23:1025-33. 2010
  5. doi request reprint Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development
    Ryan E Morgan
    Department of Comparative Biology and Safety Sciences Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 118:485-500. 2010
  6. pmc A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity
    M Ann Mongan
    Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 5:e15595. 2010
  7. ncbi request reprint Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers
    Sushil K Thukral
    Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Pathol 33:343-55. 2005

Collaborators

  • Hisham K Hamadeh
  • Michael Trauner
  • Yudong D He
  • Guang Chen
  • Paul H Lee
  • Michael B Bass
  • Qihong Huang
  • P R Bushel
  • Ryan E Morgan
  • M Ann Mongan
  • Sushil K Thukral
  • Astrid C Haugen
  • Charles Qualls
  • Suzanne Moss
  • Robert T Dunn
  • Jeanine Bussiere
  • Christopher Dipalma
  • Steven Vonderfecht
  • Toni L Williamson
  • Nancy Everds
  • Carlo J van Staden
  • Charles W Qualls
  • Yuan Chen
  • Cheng Su
  • Michael Eschenberg
  • Ruth Lightfoot-Dunn
  • Linda Carlock
  • Marnie Higgins-Garn
  • Bharath Ramachandran
  • Leah Sullivan
  • Rong Hu
  • Laura Healy
  • Mary E Cosenza
  • Vincent D Fitzpatrick
  • Paul J Nordone
  • Eric Galambos
  • Ryan Kelley
  • Changchun Deng
  • Trey Ideker
  • J Martin Brown
  • Jennifer B Collins
  • Bennett Van Houten
  • Charles J Tucker

Detail Information

Publications7

  1. pmc Integrating phenotypic and expression profiles to map arsenic-response networks
    Astrid C Haugen
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Genome Biol 5:R95. 2004
    ..These data were then mapped to a metabolic network composed of all known biochemical reactions in yeast, as well as the yeast network of 20,985 protein-protein/protein-DNA interactions...
  2. pmc The evolution of bioinformatics in toxicology: advancing toxicogenomics
    Cynthia A Afshari
    Department of Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 120:S225-37. 2011
    ..This review will cover the evolution of the field of toxicogenomics in the context of informatics integration its current promise, and limitations...
  3. ncbi request reprint Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity
    Hisham K Hamadeh
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Mutat Res 549:169-83. 2004
    ..Finally, to help determine the correlation between gene expression changes and liver pathology, we applied traditional microarray visualization tools to the assessment of clinical chemistry and pathology parameters...
  4. doi request reprint Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors
    Hisham K Hamadeh
    Comparative Biology and Safety Sciences, and Pharmacokinetics and Drug Metabolism, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320, USA
    Chem Res Toxicol 23:1025-33. 2010
    ..Finally, we illustrate that in vivo gene expression profiles can serve as a complementary assessor of this activity and simultaneously help provide an assessment of on or off-target biological activity...
  5. doi request reprint Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development
    Ryan E Morgan
    Department of Comparative Biology and Safety Sciences Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Sci 118:485-500. 2010
    ....
  6. pmc A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity
    M Ann Mongan
    Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America
    PLoS ONE 5:e15595. 2010
    ..Comparison of concordant expression changes between PXR(+/+) and PXR(-/-) mice also suggested a PXR-independent association between CMP013 and perturbations to cellular stress, lipid metabolism, and biliary transport...
  7. ncbi request reprint Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers
    Sushil K Thukral
    Amgen Inc, Thousand Oaks, California 91320, USA
    Toxicol Pathol 33:343-55. 2005
    ..These include several transporters (Slc21a2, Slc15, Slc34a2), Kim 1, IGFbp-1, osteopontin, alpha-fibrinogen, and Gstalpha...