Connie M Westhoff

Summary

Affiliation: American Red Cross
Country: USA

Publications

  1. ncbi request reprint Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter
    Connie M Westhoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 510 Stellar Chance, Philadelphia, PA 19104, USA
    J Biol Chem 277:12499-502. 2002
  2. ncbi request reprint Molecular testing for transfusion medicine
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Curr Opin Hematol 13:471-5. 2006
  3. pmc The JAL antigen (RH48) is the result of a change in RHCE that encodes Arg114Trp
    Connie M Westhoff
    Molecular Blood Group and Platelet Testing Laboratory, American Red Cross, Penn Jersey Region, Philadelphia, PA 19130, USA
    Transfusion 49:725-32. 2009
  4. ncbi request reprint Rh complexities: serology and DNA genotyping
    Connie M Westhoff
    American Red Cross, and Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19123, USA
    Transfusion 47:17S-22S. 2007
  5. ncbi request reprint Deciphering the function of the Rh family of proteins
    Connie M Westhoff
    American Red Cross and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Transfusion 45:117S-21S. 2005
  6. ncbi request reprint The Rh blood group system in review: a new face for the next decade
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Transfusion 44:1663-73. 2004
  7. pmc RHCE*ceMO is frequently in cis to RHD*DAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance
    Connie M Westhoff
    Laboratory of Immunohematology and Genomics, New York Blood Center Laboratory of Immunochemistry, New York Blood Center, New York, New York National Molecular Testing Laboratory, American Red Cross, Philadelphia, Pennsylvania
    Transfusion 53:2983-9. 2013
  8. ncbi request reprint Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG
    Don On Daniel Mak
    American Red Cross, 700 Spring Garden St, Philadelphia, PA 19123, USA
    Am J Physiol Renal Physiol 290:F297-305. 2006
  9. ncbi request reprint Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering and School of Engineering and Applied Science, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1131-6. 2004
  10. pmc RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa
    Connie M Westhoff
    Laboratory of Immunohematology and Genomics, New York Blood Center, Long Island City, New York 10065, USA
    Transfusion 53:741-6. 2013

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporter
    Connie M Westhoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 510 Stellar Chance, Philadelphia, PA 19104, USA
    J Biol Chem 277:12499-502. 2002
    ..14 mm) consistent with the hypothesis that the uptake of MA and ammonium involves a similar H(+)-coupled counter-transport mechanism...
  2. ncbi request reprint Molecular testing for transfusion medicine
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Curr Opin Hematol 13:471-5. 2006
    ..This review summarizes the progress made in the last decade in applying genotyping to prenatal practice and clinical transfusion medicine...
  3. pmc The JAL antigen (RH48) is the result of a change in RHCE that encodes Arg114Trp
    Connie M Westhoff
    Molecular Blood Group and Platelet Testing Laboratory, American Red Cross, Penn Jersey Region, Philadelphia, PA 19130, USA
    Transfusion 49:725-32. 2009
    ..This study was undertaken to investigate the RH gene(s) responsible for expression of JAL and to determine the structural relationship between JAL and other Rh antigens...
  4. ncbi request reprint Rh complexities: serology and DNA genotyping
    Connie M Westhoff
    American Red Cross, and Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19123, USA
    Transfusion 47:17S-22S. 2007
  5. ncbi request reprint Deciphering the function of the Rh family of proteins
    Connie M Westhoff
    American Red Cross and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Transfusion 45:117S-21S. 2005
  6. ncbi request reprint The Rh blood group system in review: a new face for the next decade
    Connie M Westhoff
    American Red Cross, Philadelphia, Pennsylvania 19130, USA
    Transfusion 44:1663-73. 2004
  7. pmc RHCE*ceMO is frequently in cis to RHD*DAU0 and encodes a hr(S) -, hr(B) -, RH:-61 phenotype in black persons: clinical significance
    Connie M Westhoff
    Laboratory of Immunohematology and Genomics, New York Blood Center Laboratory of Immunochemistry, New York Blood Center, New York, New York National Molecular Testing Laboratory, American Red Cross, Philadelphia, Pennsylvania
    Transfusion 53:2983-9. 2013
    ..We compiled serologic and DNA testing data on samples with RHCE*ceMO to determine the red blood cell (RBC) antigen expression, antibody specificity, RHD association, and the prevalence in African-American persons...
  8. ncbi request reprint Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG
    Don On Daniel Mak
    American Red Cross, 700 Spring Garden St, Philadelphia, PA 19123, USA
    Am J Physiol Renal Physiol 290:F297-305. 2006
    ....
  9. ncbi request reprint Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells
    Kris Noel Dahl
    Department of Chemical and Biomolecular Engineering and School of Engineering and Applied Science, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Blood 103:1131-6. 2004
    ..2 strongly influences CD47 levels as well as the extent of membrane skeleton attachment in the RBC, whereas protein 4.2 affects membrane skeletal attachment of RhAG, Rh, and band 3 to a lesser extent...
  10. pmc RHCE*ceTI encodes partial c and partial e and is often in cis to RHD*DIVa
    Connie M Westhoff
    Laboratory of Immunohematology and Genomics, New York Blood Center, Long Island City, New York 10065, USA
    Transfusion 53:741-6. 2013
    ..In the Rh blood group system, variant RhD and RhCE express several partial antigens. We investigated RH in samples with partial DIVa that demonstrated weak and variable reactivity with anti-C...
  11. doi request reprint High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors
    Stella T Chou
    Division of Hematology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Blood 122:1062-71. 2013
    ..Whether RH genotyping of patients and minority donors will reduce Rh alloimmunization in SCD needs to be examined. ..
  12. doi request reprint Nucleotide deletion in RHCE*cE (907delC) is responsible for a D- - haplotype in Hispanics
    Connie M Westhoff
    National Molecular Blood Group and Platelet Testing Laboratory and NRLBGS, National Reference Laboratory for Blood Group Serology, American Red Cross, Philadelphia, Pennsylvania, USA
    Transfusion 51:2142-7. 2011
    ..We investigated RH in eight samples, three presenting as D- -, whose c-E- red blood cell (RBC) typing was discordant with the RHCE genotype that predicted c+E+...
  13. pmc DIIIa and DIII Type 5 are encoded by the same allele and are associated with altered RHCE*ce alleles: clinical implications
    Connie M Westhoff
    National Molecular Blood Group and Platelet Testing Laboratory, American Red Cross, Philadelphia, Pennsylvania, USA
    Transfusion 50:1303-11. 2010
    ..We also studied additional DIIIa samples to clarify the RHD background and establish the associated RHCE...
  14. ncbi request reprint Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoprotein
    Connie M Westhoff
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennyslvania 19104, USA
    J Biol Chem 279:17443-8. 2004
    ..This report clarifies and expands previous observations of RhAG-mediated transport in yeast and supports the hypothesis that ammonium transport is coupled to the H(+) gradient and that RhAG functions as a NH(4)(+)/H(+) exchanger...
  15. ncbi request reprint A new hybrid RHCE gene (CeNR) is responsible for expression of a novel antigen
    Connie M Westhoff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania and the American Red Cross, Philadelphia, Pennsylvania, USA
    Transfusion 44:1047-51. 2004
    ..The purpose of this study was to determine the molecular basis of the Rh phenotype...
  16. ncbi request reprint Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes
    Kris Noel Dahl
    School of Engineering and Applied Science, Institute for Medicine and Engineering, and Department of Pathology and Laboratory Medicine, University of Pennsylvania, PA 19104, USA
    Blood 101:1194-9. 2003
    ..The results imply a homogeneous base distribution of CD47, restrained by cytoskeleton linkages, plus a smaller fraction of CD47, which is able to diffuse in the membrane...
  17. doi request reprint A novel JKA allele, nt561C>A, associated with silencing of Kidd expression
    Trina Horn
    National Molecular Blood Group and Platelet Antigen Testing Laboratory, American Red Cross, Philadelphia, PA, USA
    Transfusion 52:1092-6. 2012
    ..We determined the molecular basis for Jk(a-b-) in an African American family. DNA testing of samples from random African American, Caucasian, and Brazilian blacks was done to estimate the allele frequency...
  18. pmc The structure and function of the Rh antigen complex
    Connie M Westhoff
    American Red Cross and Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19123, USA
    Semin Hematol 44:42-50. 2007
    ..The Rh family of proteins now includes non-erythroid homologs present in many other tissues, and comparative genomics reveal Rh homologs in all domains of life...
  19. ncbi request reprint Ammonia secretion from fish gill depends on a set of Rh glycoproteins
    Tsutomu Nakada
    Department of Biological Sciences, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    FASEB J 21:1067-74. 2007
    ..These results suggest that pufferfish Rh glycoproteins are involved in ammonia excretion from the gill. These findings challenge the classic view that ammonia excretion in the fish gill occurs by passive diffusion...
  20. ncbi request reprint Molecular genotyping for RHD: what (not) to do?
    Connie M Westhoff
    Transfusion 47:1337-9. 2007
  21. ncbi request reprint The RHCE allele ceCF: the molecular basis of Crawford (RH43)
    Willy A Flegel
    Department of Transfusion Medicine, University Hospital, Ulm, Germany
    Transfusion 46:1334-42. 2006
    ..The Crawford antigen (RH43) was described in 1980. It occurred in African American people, as a low-prevalence Rhesus antigen, who were also VS+...
  22. ncbi request reprint Basolateral ammonium transport by the mouse inner medullary collecting duct cell (mIMCD-3)
    Mary E Handlogten
    Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 287:F628-38. 2004
    ..We conclude that mIMCD-3 cells express a basolateral electroneutral NH4+/H+ exchange activity that may be mediated by RhBG...
  23. ncbi request reprint Apical ammonia transport by the mouse inner medullary collecting duct cell (mIMCD-3)
    Mary E Handlogten
    Division of Nephrology, Hypertension and Transplantation, University of Florida College of Medicine, Gainesville, 32610 0224, USA
    Am J Physiol Renal Physiol 289:F347-58. 2005
    ....

Research Grants1

  1. DECIPHERING THE FUNCTION OF THE RH BLOOD GROUP PROTEINS
    Connie Westhoff; Fiscal Year: 2002
    ..These studies will lead, not only to an understanding of Rh function, but also to an explanation of the clinical effects that occur when this function is disrupted. ..