J H Weisburger

Summary

Affiliation: American Health Foundation
Country: USA

Publications

  1. ncbi request reprint Comments on the history and importance of aromatic and heterocyclic amines in public health
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 506:9-20. 2002
  2. ncbi request reprint Lifestyle, health and disease prevention: the underlying mechanisms
    J H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, New York, NY 10595, USA
    Eur J Cancer Prev 11:S1-7. 2002
  3. ncbi request reprint Lycopene and tomato products in health promotion
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Exp Biol Med (Maywood) 227:924-7. 2002
  4. ncbi request reprint Tea polyphenols inhibit the formation of mutagens during the cooking of meat
    John H Weisburger
    American Health Foundation, 1 Dana Road, 10595, Valhalla, NY 10595, USA
    Mutat Res 516:19-22. 2002
  5. ncbi request reprint On the occurrence of Leydig cell tumors in the F344 rat
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Cancer Lett 182:213-6. 2002
  6. ncbi request reprint Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols
    J H Weisburger
    American Health Foundation, One Dana Road, Valhalla, NY 10595, USA
    Food Chem Toxicol 40:1145-54. 2002
  7. ncbi request reprint Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595, USA
    Mutat Res 371:57-63. 1996
  8. ncbi request reprint Approaches for chronic disease prevention based on current understanding of underlying mechanisms
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595 1599, USA
    Am J Clin Nutr 71:1710S-4S; discussion 1715S-9S. 2000
  9. ncbi request reprint Green tea and the metabolism of 2-amino-3-methylimidazo
    C W Embola
    Department of Pathology, New York Medical College, Valhalla, New York, USA
    Food Chem Toxicol 39:629-33. 2001
  10. ncbi request reprint Investigation of commercial Mitolife as an antioxidant and antimutagen
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595, USA
    Nutrition 17:322-5. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Comments on the history and importance of aromatic and heterocyclic amines in public health
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 506:9-20. 2002
    ..World-wide, there have been many contributors to knowledge in this field. Adequate information may permit now to adjust lifestyle and lower the risk of human disease stemming from this entire class of aryl and HCA...
  2. ncbi request reprint Lifestyle, health and disease prevention: the underlying mechanisms
    J H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, New York, NY 10595, USA
    Eur J Cancer Prev 11:S1-7. 2002
    ..Antioxidants also extend healthy aging and may protect against Alzheimer's and Parkinson's diseases. Nutritional lifestyles can be described for most populations in the world and offer the possibility of a healthy long life...
  3. ncbi request reprint Lycopene and tomato products in health promotion
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Exp Biol Med (Maywood) 227:924-7. 2002
    ..These results lead to public health recommendations to consume more vegetables and, especially, cooked tomatoes with olive oil...
  4. ncbi request reprint Tea polyphenols inhibit the formation of mutagens during the cooking of meat
    John H Weisburger
    American Health Foundation, 1 Dana Road, 10595, Valhalla, NY 10595, USA
    Mutat Res 516:19-22. 2002
    ..This procedure is simple and effective, and utilizes inexpensive tea, a product that deserves consideration for practical use...
  5. ncbi request reprint On the occurrence of Leydig cell tumors in the F344 rat
    John H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Cancer Lett 182:213-6. 2002
    ..Etiological factors on the occurrence of this disease in animals and in humans remain to be discovered...
  6. ncbi request reprint Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols
    J H Weisburger
    American Health Foundation, One Dana Road, Valhalla, NY 10595, USA
    Food Chem Toxicol 40:1145-54. 2002
    ..The developmental aspects and growth of cancers through promotion are decreased by tea. The regular use of a widely available, tasty, inexpensive beverage, tea, has displayed valuable preventive properties in chronic human diseases...
  7. ncbi request reprint Tea polyphenols as inhibitors of mutagenicity of major classes of carcinogens
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595, USA
    Mutat Res 371:57-63. 1996
    ..No effect was found with 1-nitropyrene, and with the direct-acting (no S9) 2-chloro-4-methyl-thiobutanoic acid. Thus, with some exceptions, polyphenols considerably decreased the mutagenicity of diverse types of carcinogens...
  8. ncbi request reprint Approaches for chronic disease prevention based on current understanding of underlying mechanisms
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595 1599, USA
    Am J Clin Nutr 71:1710S-4S; discussion 1715S-9S. 2000
    ..The public must heed this information to achieve long-term health...
  9. ncbi request reprint Green tea and the metabolism of 2-amino-3-methylimidazo
    C W Embola
    Department of Pathology, New York Medical College, Valhalla, New York, USA
    Food Chem Toxicol 39:629-33. 2001
    ..Green tea, therefore, influences the manner in which the food carcinogen IQ is metabolized and excreted in urine. Formation of glucuronides, increased by green tea, represent a key means of detoxification of the heterocyclic amine, IQ...
  10. ncbi request reprint Investigation of commercial Mitolife as an antioxidant and antimutagen
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595, USA
    Nutrition 17:322-5. 2001
    ..Thus, MitoLife represents another means to decrease adverse effects associated with the oxidation of low-density lipoprotein cholesterol or of a series of carcinogens, some of which are in the human environment...
  11. ncbi request reprint Evaluation of the evidence on the role of tomato products in disease prevention
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595 1599, USA
    Proc Soc Exp Biol Med 218:140-3. 1998
    ....
  12. ncbi request reprint Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595, USA
    Mutat Res 416:125-8. 1998
    ..We conclude that PhIP is a good substrate found in several human foods to determine the protective effect of phytochemicals from vegetables, and beverages...
  13. ncbi request reprint Antimutagenesis and anticarcinogenesis, from the past to the future
    J H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Mutat Res 480:23-35. 2001
    ..Worldwide application of current knowledge and mechanisms to cancer prevention, the definitive means of cancer control, is likely to lower not only cancer but also heart disease risk in the current century...
  14. ncbi request reprint Tea and health: a historical perspective
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595 1599, USA
    Cancer Lett 114:315-7. 1997
    ..Most productive are multi-disciplinary approaches, considering data from epidemiology and field studies, and laboratory research in animal models for heart disease and cancers of various types, as well as through in vitro experiments...
  15. ncbi request reprint Tea, or tea and milk, inhibit mammary gland and colon carcinogenesis in rats
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595 1599, USA
    Cancer Lett 114:323-7. 1997
    ..Thus, tea decreases mammary tumor induction, and the production of foci of aberrant crypts in the colon. Milk potentiates these inhibiting effects...
  16. ncbi request reprint Prevention of cancer and other chronic diseases worldwide based on sound mechanisms
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595 USA
    Biofactors 12:73-81. 2000
    ..We review nutritional factors involved in cancer and chronic disease causation and prevention...
  17. ncbi request reprint Chemopreventive effects of cocoa polyphenols on chronic diseases
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595, USA
    Exp Biol Med (Maywood) 226:891-7. 2001
    ..These are mainly stearic triglycerides (C18:0) that are less well absorbed than other fats, and are excreted in the feces. Thus, cocoa butter is less bioavailable and has minimal effect on serum cholesterol...
  18. ncbi request reprint Effect of black tea on azoxymethane-induced colon cancer
    J H Weisburger
    Naylor Dana Institute, American Health Foundation, Valhalla, New York 10595 1599, USA
    Carcinogenesis 19:229-32. 1998
    ..These findings are accounted for by the underlying mechanism, namely the fact that tea solutions do not alter the amount of cytochrome P-4502E1 required for the metabolic activation of AOM...
  19. ncbi request reprint Tea and health: the underlying mechanisms
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595, USA
    Proc Soc Exp Biol Med 220:271-5. 1999
    ..The accumulated knowledge suggests that regular tea intake by humans might provide an approach to decrease the incidence of and mortality from major chronic diseases...
  20. ncbi request reprint Urinary excretion of N-OH-2-amino-3-methylimidazo[4,5-f]quinoline-N-glucuronide in F344 rats is enhanced by green tea
    C W Embola
    Department of Pathology, New York Medical College and American Health Foundation, Valhalla, NY 10595, USA
    Carcinogenesis 22:1095-8. 2001
    ..05) excretion of the two major glucuronides. We conclude that intake of green tea increases the excretion of N-OH-IQ-N-glucuronide, a detoxified metabolite of the proximate carcinogen N-OH-IQ...
  21. ncbi request reprint Worldwide prevention of cancer and other chronic diseases based on knowledge of mechanisms
    J H Weisburger
    American Health Foundation, Valhalla, NY 10595, USA
    Mutat Res 402:331-7. 1998
    ..Tobacco and cigarette use, particularly on a Western diet, involve a high risk of heart attacks, and cancers of the lung, pancreas, kidney, urinary bladder, and cervix, accounting for 35% of medical care expenditures...
  22. ncbi request reprint Eat to live, not live to eat
    J H Weisburger
    American Health Foundation, Valhalla, New York 10595, USA
    Nutrition 16:767-73. 2000
    ..Green and black teas are excellent sources of antioxidants of a polyphenol nature. as is cocoa and some chocolates. Nutritional lifestyles that offer the possibility of a healthy long life can be adopted by most populations in the world...
  23. ncbi request reprint Carcinogenicity and mutagenicity testing, then and now
    J H Weisburger
    American Health Foundation, 1 Dana Road, Valhalla, NY, USA
    Mutat Res 437:105-12. 1999
    ..Thus, batteries of tests are now available to detect effectively human cancer risks, and provide novel approaches to determine the underlying mechanisms, as a sound basis for cancer prevention...
  24. ncbi request reprint Induction of UDP-glucuronosyltransferase 1 (UDP-GT1) gene complex by green tea in male F344 rats
    C W Embola
    Department of Pathology, New York Medical College, 10595, Valhalla 10595, USA
    Food Chem Toxicol 40:841-4. 2002
    ..Therefore, a major mechanism of tea as a chemopreventive agent is induction of the microsomal detoxification enzyme, UDP-glucuronosyltransferase...
  25. ncbi request reprint Effect of lifetime administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice
    F Stenback
    American Health Foundation, Valhalla, NY 10595
    Mech Ageing Dev 42:129-38. 1988
    ..Also, there was no statistically significant difference between control and treated animals in the age of onset or the type of specific neoplasms. Dimethylaminoethanol did not induce any neoplasms...
  26. ncbi request reprint Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol
    O S Sohn
    American Health Foundation, Valhalla, New York 10595, USA
    Cancer Res 61:8435-40. 2001
    ..The mechanism of this effect is discussed...
  27. pmc Hazards of fast food
    John H Weisburger
    Environ Health Perspect 112:A336. 2004
  28. ncbi request reprint Contributions of Ernst L. Wynder to chronic disease control worldwide and to preventive medicine
    John H Weisburger
    American Health Foundation, Valhalla, New York, USA
    Prev Med 43:262-6. 2006
    ..Wynder--the American Health Foundation. There were outreach programs to educate people about proper lifestyles to secure disease prevention, including beginning health education in children...
  29. ncbi request reprint Dietary risk factors for gastric carcinoma
    John H Weisburger
    JAMA 291:1564; author reply 1564. 2004