S L Stramer

Summary

Affiliation: American Red Cross
Country: USA

Publications

  1. ncbi request reprint Effectiveness of human T-lymphotropic virus (HTLV) recipient tracing (lookback) and the current HTLV-I and -II confirmatory algorithm, 1999 to 2004
    S L Stramer
    American Red Cross, Biomedical Services Scientific Support Office, Gaithersburg, Maryland 20877, USA
    Transfusion 46:703-7. 2006
  2. ncbi request reprint Sensitivity of HCV RNA and HIV RNA blood screening assays
    P Nico Lelie
    VQC Laboratory, Sanquin CLB Diagnostic Division, Amsterdam, The Netherlands
    Transfusion 42:527-36. 2002
  3. ncbi request reprint Strategies for testing blood donors for West Nile virus
    Susan L Stramer
    Transfusion 46:2036-7. 2006
  4. ncbi request reprint Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing
    Susan L Stramer
    American Red Cross, Gaithersburg, MD, USA
    N Engl J Med 351:760-8. 2004
  5. ncbi request reprint West Nile virus among blood donors in the United States, 2003 and 2004
    Susan L Stramer
    American Red Cross, Gaithersburg, MD 20877, USA
    N Engl J Med 353:451-9. 2005
  6. doi request reprint Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 52:1657-66. 2012
  7. doi request reprint Blood donation screening for hepatitis B virus markers in the era of nucleic acid testing: are all tests of value?
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 52:440-6. 2012
  8. ncbi request reprint Nucleic acid testing for transfusion-transmissible agents
    S L Stramer
    National Confirmatory Testing Laboratory, American Red Cross, Gaithersburg, Maryland 20877, USA
    Curr Opin Hematol 7:387-91. 2000
  9. doi request reprint Emerging infectious disease agents and their potential threat to transfusion safety
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 49:1S-29S. 2009
  10. ncbi request reprint Current risks of transfusion-transmitted agents: a review
    Susan L Stramer
    American Red Cross, 9315 Gaither Rd, Gaithersburg, MD 20877, USA
    Arch Pathol Lab Med 131:702-7. 2007

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Effectiveness of human T-lymphotropic virus (HTLV) recipient tracing (lookback) and the current HTLV-I and -II confirmatory algorithm, 1999 to 2004
    S L Stramer
    American Red Cross, Biomedical Services Scientific Support Office, Gaithersburg, Maryland 20877, USA
    Transfusion 46:703-7. 2006
    ..This study reports on the efficacy of an investigational human T-lymphotropic virus (HTLV)-I and -II lookback program in the context of differing confirmatory testing algorithms...
  2. ncbi request reprint Sensitivity of HCV RNA and HIV RNA blood screening assays
    P Nico Lelie
    VQC Laboratory, Sanquin CLB Diagnostic Division, Amsterdam, The Netherlands
    Transfusion 42:527-36. 2002
    ....
  3. ncbi request reprint Strategies for testing blood donors for West Nile virus
    Susan L Stramer
    Transfusion 46:2036-7. 2006
  4. ncbi request reprint Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testing
    Susan L Stramer
    American Red Cross, Gaithersburg, MD, USA
    N Engl J Med 351:760-8. 2004
    ....
  5. ncbi request reprint West Nile virus among blood donors in the United States, 2003 and 2004
    Susan L Stramer
    American Red Cross, Gaithersburg, MD 20877, USA
    N Engl J Med 353:451-9. 2005
    ....
  6. doi request reprint Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto Rico
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 52:1657-66. 2012
    ..In 2007, a total of 10,508 suspected dengue cases were reported in Puerto Rico. Blood donations were tested for dengue virus (DENV) RNA and recipients of RNA-positive donations traced to assess transfusion transmission...
  7. doi request reprint Blood donation screening for hepatitis B virus markers in the era of nucleic acid testing: are all tests of value?
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 52:440-6. 2012
    ..The value of all three tests was evaluated...
  8. ncbi request reprint Nucleic acid testing for transfusion-transmissible agents
    S L Stramer
    National Confirmatory Testing Laboratory, American Red Cross, Gaithersburg, Maryland 20877, USA
    Curr Opin Hematol 7:387-91. 2000
    ..Of the HCV NAT-reactive donations identified, one has not sero-converted over a 300-day period. The predominant recent risk factor identified for HCV NAT-reactive donors is intravenous drug use...
  9. doi request reprint Emerging infectious disease agents and their potential threat to transfusion safety
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 49:1S-29S. 2009
    ..There has been no comprehensive review of such infectious agents and their threat to transfusion recipient safety to date...
  10. ncbi request reprint Current risks of transfusion-transmitted agents: a review
    Susan L Stramer
    American Red Cross, 9315 Gaither Rd, Gaithersburg, MD 20877, USA
    Arch Pathol Lab Med 131:702-7. 2007
    ..In 2004, methods (primarily culturing) for detecting bacteria in platelets were also added...
  11. ncbi request reprint Viral diagnostics in the arena of blood donor screening
    S L Stramer
    American Red Cross, Gaithersburg MD 20877, USA
    Vox Sang 87:180-3. 2004
  12. ncbi request reprint Reacting to an emerging safety threat: West Nile virus in North America
    S L Stramer
    Scientific Support Office, American Red Cross Biomedical Services, Gaithersburg, MD 20887, USA
    Dev Biol (Basel) 127:43-58. 2007
    ..WNV is an example of an emergent agent in which a rapid series of interventions has been successful in controlling transmission through blood transfusion...
  13. doi request reprint Human T-lymphotropic virus antibody screening of blood donors: rates of false-positive results and evaluation of a potential donor reentry algorithm
    Susan L Stramer
    Scientific Support Office, American Red Cross Biomedical Services, Gaithersburg, Maryland 20877, USA
    Transfusion 51:692-701. 2011
    ..The licensure of the Abbott PRISM HTLV-I/HTLV-II chemiluminescent immunoassay (ChLIA) may permit the reinstatement of historically deferred donors...
  14. doi request reprint Nucleic acid testing to detect HBV infection in blood donors
    Susan L Stramer
    Scientific Support Office, American Red Cross, Gaithersburg, MD 20877, USA
    N Engl J Med 364:236-47. 2011
    ..The current use of nucleic acid testing for detection of the human immunodeficiency virus (HIV) and hepatitis C virus (HCV) RNA and HBV DNA in a single triplex assay may provide additional safety...
  15. doi request reprint Sensitivity comparison of two Food and Drug Administration-licensed, triplex nucleic acid test automated assays for hepatitis B virus DNA detection and associated projections of United States yield
    Susan L Stramer
    American Red Cross, Gaithersburg, Maryland 20877, USA
    Transfusion 51:2012-22. 2011
    ....
  16. ncbi request reprint NAT update: where are we today?
    S L Stramer
    National Testing and Reference Laboratories and Blood Services, American Red Cross, Gaithersburg, MD 20877, USA
    Dev Biol (Basel) 108:41-56. 2002
    ....
  17. ncbi request reprint US NAT yield: where are we after 2 years?
    S L Stramer
    National Testing and Reference Laboratories and Blood Services, American Red Cross, 9315 Gaither Road, Gaithersburg, MD 20877, USA
    Transfus Med 12:243-53. 2002
    ....
  18. ncbi request reprint Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population
    R Y Dodd
    Transmissible Diseases Department, American Red Cross Biomedical Services, Rockville, MD 20855, USA
    Transfusion 42:975-9. 2002
    ....
  19. ncbi request reprint Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti-HCV
    S L Orton
    American Red Cross, Gaithersburg and Rockville, Maryland, USA
    Transfusion 44:275-81. 2004
    ..Of over 26.8 million donations tested between March 3, 1999, and March 31, 2003, 810 were HCV-reactive by NAT. A subset of these donors was assessed for recent exposure risk...
  20. doi request reprint In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infection
    M Rios
    Laboratory of Molecular Virology Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
    J Infect Dis 198:1300-8. 2008
    ..All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious...
  21. ncbi request reprint Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donations
    Richard J Benjamin
    Biomedical Services, Medical Office, American Red Cross, Washington, DC 20006, USA
    Transfusion 48:295-303. 2008
    ....
  22. doi request reprint Current value of serologic test for syphilis as a surrogate marker for blood-borne viral infections among blood donors in the United States
    Shimian Zou
    Transmissible Disease Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Transfusion 49:655-61. 2009
    ..Serologic screening for syphilis has been justified in part as a surrogate marker for infections caused by other pathogens such as human immunodeficiency virus (HIV). This study assessed the current surrogate value of the test...
  23. doi request reprint Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testing
    Shimian Zou
    Jerome H Holland Laboratory, American Red Cross Biomedical Sciences, Rockville, Maryland 20855, USA
    Transfusion 50:1495-504. 2010
    ..This study analyzes temporal trends of these two infections since NAT introduction...
  24. doi request reprint Prevalence, incidence, and residual risk of major blood-borne infections among apheresis collections to the American Red Cross Blood Services, 2004 through 2008
    Shimian Zou
    Jerome H Holland Laboratory, American Red Cross Biomedical Sciences, Rockville, Maryland 20855, USA
    Transfusion 50:1487-94. 2010
    ..The number of apheresis collections increased significantly in recent years; however, data on viral marker rates among these collections are lacking...
  25. doi request reprint West Nile fever characteristics among viremic persons identified through blood donor screening
    Shimian Zou
    American Red Cross Holland Laboratory, Rockville, Maryland, USA
    J Infect Dis 202:1354-61. 2010
    ..Female subjects and persons with higher viral loads detected in the index donation were more likely than other subjects to develop symptoms...
  26. ncbi request reprint Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United States
    Shimian Zou
    Transmissible Diseases Department, American Red Cross, Rockville, MD 20855, USA
    N Engl J Med 351:751-9. 2004
    ..We estimated the current probability of undetected viremia with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and human T-lymphotropic virus (HTLV) among tissue donors...
  27. ncbi request reprint Patterns of age- and sex-specific prevalence of major blood-borne infections in United States blood donors, 1995 to 2002: American Red Cross blood donor study
    Shimian Zou
    Transmissible Disease Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    Transfusion 44:1640-7. 2004
    ..This study analyzes the temporal trends of major blood-borne infections among blood donors...
  28. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  29. ncbi request reprint Pooled hepatitis B virus DNA testing by nucleic acid amplification: implementation or not
    Susan L Stramer
    Transfusion 45:1242-6. 2005
  30. ncbi request reprint A new strategy for estimating risks of transfusion-transmitted viral infections based on rates of detection of recently infected donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 45:254-64. 2005
    ....
  31. ncbi request reprint West Nile virus blood transfusion-related infection despite nucleic acid testing
    Alexandre Macedo de Oliveira
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Transfusion 44:1695-9. 2004
    ..A Nebraska man developed clinical encephalitis 13 days after surgery and transfusion of 26 blood components. Antibody testing confirmed WNV infection. An investigation was initiated to determine the source of this infection...
  32. ncbi request reprint Integration of nucleic acid amplification test results into hepatitis C virus supplemental serologic testing algorithms: implications for donor counseling and revision of existing algorithms
    Steven H Kleinman
    Blood Systems Research Institute, San Francisco, California, USA
    Transfusion 46:695-702. 2006
    ..The FDA has approved variance requests to use a new algorithm that eliminates the need to perform RIBA when HCV NAT results are reactive. Data are provided in support of this new algorithm...
  33. ncbi request reprint Impact of changes in viral marker screening assays
    Usha K Sharma
    Westat, Rockville, Maryland, USA
    Transfusion 43:202-14. 2003
    ..Monitoring the performance of routinely used infectious disease serologic tests is necessary to evaluate their effectiveness in identifying true-positive units and erroneously disqualifying safe blood donors...
  34. ncbi request reprint Impact of HCV 3.0 EIA relative to HCV 2.0 EIA on blood-donor screening
    Leslie H Tobler
    Blood Centers of the Pacific, Irwin Center, San Francisco, California 94118, USA
    Transfusion 43:1452-9. 2003
    ..0 EIA; the second study evaluated the differential performance of HCV 3.0 EIA in plasma donors acutely infected with HCV, identified during routine Abbott HCV 2.0 EIA and HCV NAT (using Roche Ampliscreen plate assay) donor screening...
  35. ncbi request reprint Transmission of West Nile virus through blood transfusion in the United States in 2002
    Lisa N Pealer
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 349:1236-45. 2003
    ..During the 2002 West Nile virus epidemic in the United States, patients were identified whose West Nile virus illness was temporally associated with the receipt of transfused blood and blood components...
  36. ncbi request reprint Viral marker rates among blood donors before and after the terrorist attacks on the United States on September 11, 2001
    Roger Y Dodd
    Transfusion 42:1240-1. 2002
  37. pmc Development and persistence of West Nile virus-specific immunoglobulin M (IgM), IgA, and IgG in viremic blood donors
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    J Clin Microbiol 43:4316-20. 2005
    ..Thus, unlike some other flavivirus infections, WNV infection is not characterized by a relatively rapid disappearance of virus-specific IgA...
  38. doi request reprint Dengue virus in blood donations, Puerto Rico, 2005
    Hamish Mohammed
    Dengue Branch, Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, San Juan, Puerto Rico
    Transfusion 48:1348-54. 2008
    ..The high incidence of dengue in endemic countries, the high proportion of asymptomatic infection, and the median 5-day viremia, however, suggest that transfusion-associated dengue transmission may be more widespread than documented...
  39. pmc West Nile virus infections projected from blood donor screening data, United States, 2003
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Emerg Infect Dis 12:395-402. 2006
    ..In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population...
  40. ncbi request reprint Emerging infectious diseases that threaten the blood supply
    Harvey J Alter
    Infectious Diseases Section and Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Hematol 44:32-41. 2007
    ..However, to approach near-zero infectious disease risk for emerging and re-emerging pathogens, new strategies such as pathogen inactivation or multi-pathogen microarray technology will need to be developed or refined...
  41. ncbi request reprint Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donors
    Michael P Busch
    Blood Systems Research Institute, San Francisco, California 94118, USA
    Transfusion 46:469-75. 2006
    ..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia...
  42. ncbi request reprint Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acid
    D Michael Strong
    Puget Sound Blood Center Northwest Tissue Center, 921 Terry Avenue Seattle, WA, 98104, USA
    Cell Tissue Bank 6:255-62. 2005
    ..Using these protocols, inventories from two tissue centers were tested with greater than 99% of samples producing a valid test result...
  43. pmc High levels of subgenomic HCV plasma RNA in immunosilent infections
    Flavien Bernardin
    Blood Systems Research Institute, San Francisco, CA 94118, USA
    Virology 365:446-56. 2007
    ..The absence of immunological pressure and a high viral load may therefore promote the emergence of truncated HCV subgenomic replicons in vivo...
  44. ncbi request reprint West Nile virus adheres to human red blood cells in whole blood
    Maria Rios
    Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    Clin Infect Dis 45:181-6. 2007
    ..Conclusions. These observations reinforce the notion that extraction of viral RNA from whole blood could improve assay sensitivity for blood donor screening and further reduce the residual risk of WNV transmission through transfusion...
  45. ncbi request reprint Nanoparticle-Based biobarcode amplification assay (BCA) for sensitive and early detection of human immunodeficiency type 1 capsid (p24) antigen
    Shixing Tang
    Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
    J Acquir Immune Defic Syndr 46:231-7. 2007
    ....
  46. pmc Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of anti-HCV immunoglobulin G avidity index
    S Klimashevskaya
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 45:3400-3. 2007
    ..Lower AI values obtained in past resolved infections may be directly related to lower levels of immunoglobulin G anti-HCV in past resolved infections than in either new infections or chronic infections...
  47. pmc Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infection
    Harry E Prince
    Focus Diagnostics, Cypress, CA 90630, USA
    Clin Diagn Lab Immunol 12:1123-6. 2005
    ..Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection...
  48. ncbi request reprint Transmission of HIV and hepatitis C virus from a nursing home patient to a health care worker
    Elise M Beltrami
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Infect Control 31:168-75. 2003
    ..We report a case of simultaneous HIV and hepatitis C virus (HCV) transmission from a nursing home patient to a health care worker (HCW) whose HIV and HCV infections were diagnosed during routine blood donor screening...
  49. doi request reprint Chagas disease and the US blood supply
    Caryn Bern
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Curr Opin Infect Dis 21:476-82. 2008
    ..To describe new developments in blood-bank screening and management of patients with chronic Trypanosoma cruzi infection in the United States...