Research Topics
| S L StramerSummaryAffiliation: American Red Cross Country: USA Publications
| Collaborators
|
Detail Information
Publications
Effectiveness of human T-lymphotropic virus (HTLV) recipient tracing (lookback) and the current HTLV-I and -II confirmatory algorithm, 1999 to 2004S L Stramer
American Red Cross, Biomedical Services Scientific Support Office, Gaithersburg, Maryland 20877, USA
Transfusion 46:703-7. 2006..This study reports on the efficacy of an investigational human T-lymphotropic virus (HTLV)-I and -II lookback program in the context of differing confirmatory testing algorithms...- Sensitivity of HCV RNA and HIV RNA blood screening assaysP Nico Lelie
VQC Laboratory, Sanquin-CLB Diagnostic Division, Amsterdam, The Netherlands
Transfusion 42:527-36. 2002..The FDA requirements for sensitivity of NAT blood screening assays can be met by the Gen-probe TMA, as well as by the AmpliScreen assays, particularly when combined with the NucliSens Extractor... - Strategies for testing blood donors for West Nile virusSusan L Stramer
Transfusion 46:2036-7. 2006 - Detection of HIV-1 and HCV infections among antibody-negative blood donors by nucleic acid-amplification testingSusan L Stramer
American Red Cross, Gaithersburg, MD, USA
N Engl J Med 351:760-8. 2004.... - West Nile virus among blood donors in the United States, 2003 and 2004Susan L Stramer
American Red Cross, Gaithersburg, MD 20877, USA
N Engl J Med 353:451-9. 2005.... 
Dengue viremia in blood donors identified by RNA and detection of dengue transfusion transmission during the 2007 dengue outbreak in Puerto RicoSusan L Stramer
Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
Transfusion 52:1657-66. 2012..In 2007, a total of 10,508 suspected dengue cases were reported in Puerto Rico. Blood donations were tested for dengue virus (DENV) RNA and recipients of RNA-positive donations traced to assess transfusion transmission...- Blood donation screening for hepatitis B virus markers in the era of nucleic acid testing: are all tests of value?Susan L Stramer
Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
Transfusion 52:440-6. 2012..The value of all three tests was evaluated... - Nucleic acid testing for transfusion-transmissible agentsS L Stramer
National Confirmatory Testing Laboratory, American Red Cross, Gaithersburg, Maryland 20877, USA
Curr Opin Hematol 7:387-91. 2000..Of the HCV NAT-reactive donations identified, one has not sero-converted over a 300-day period. The predominant recent risk factor identified for HCV NAT-reactive donors is intravenous drug use... - Emerging infectious disease agents and their potential threat to transfusion safetySusan L Stramer
Scientific Support Office, American Red Cross, Gaithersburg, Maryland 20877, USA
Transfusion 49:1S-29S. 2009..There has been no comprehensive review of such infectious agents and their threat to transfusion recipient safety to date... - Current risks of transfusion-transmitted agents: a reviewSusan L Stramer
American Red Cross, 9315 Gaither Rd, Gaithersburg, MD 20877, USA
Arch Pathol Lab Med 131:702-7. 2007..In 2004, methods (primarily culturing) for detecting bacteria in platelets were also added... - Viral diagnostics in the arena of blood donor screeningS L Stramer
American Red Cross, Gaithersburg MD 20877, USA
Vox Sang 87:180-3. 2004 - Reacting to an emerging safety threat: West Nile virus in North AmericaS L Stramer
Scientific Support Office, American Red Cross Biomedical Services, Gaithersburg, MD 20887, USA
Dev Biol (Basel) 127:43-58. 2007..WNV is an example of an emergent agent in which a rapid series of interventions has been successful in controlling transmission through blood transfusion... - Human T-lymphotropic virus antibody screening of blood donors: rates of false-positive results and evaluation of a potential donor reentry algorithmSusan L Stramer
Scientific Support Office, American Red Cross Biomedical Services, Gaithersburg, Maryland 20877, USA
Transfusion 51:692-701. 2011..The licensure of the Abbott PRISM HTLV-I/HTLV-II chemiluminescent immunoassay (ChLIA) may permit the reinstatement of historically deferred donors... - Nucleic acid testing to detect HBV infection in blood donorsSusan L Stramer
Scientific Support Office, American Red Cross, Gaithersburg, MD 20877, USA
N Engl J Med 364:236-47. 2011..The current use of nucleic acid testing for detection of the human immunodeficiency virus (HIV) and hepatitis C virus (HCV) RNA and HBV DNA in a single triplex assay may provide additional safety... - Sensitivity comparison of two Food and Drug Administration-licensed, triplex nucleic acid test automated assays for hepatitis B virus DNA detection and associated projections of United States yieldSusan L Stramer
American Red Cross, Gaithersburg, Maryland 20877, USA
Transfusion 51:2012-22. 2011.... - NAT update: where are we today?S L Stramer
National Testing and Reference Laboratories and Blood Services, American Red Cross, Gaithersburg, MD 20877, USA
Dev Biol (Basel) 108:41-56. 2002.... - US NAT yield: where are we after 2 years?S L Stramer
National Testing and Reference Laboratories and Blood Services, American Red Cross, 9315 Gaither Road, Gaithersburg, MD 20877, USA
Transfus Med 12:243-53. 2002.... - Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor populationR Y Dodd
Transmissible Diseases Department, American Red Cross Biomedical Services, Rockville, MD 20855, USA
Transfusion 42:975-9. 2002.... - Risk factors for HCV infection among blood donors confirmed to be positive for the presence of HCV RNA and not reactive for the presence of anti-HCVS L Orton
American Red Cross, Gaithersburg and Rockville, Maryland, USA
Transfusion 44:275-81. 2004..Of over 26.8 million donations tested between March 3, 1999, and March 31, 2003, 810 were HCV-reactive by NAT. A subset of these donors was assessed for recent exposure risk... - In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infectionM Rios
Laboratory of Molecular Virology Division of Emerging Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
J Infect Dis 198:1300-8. 2008..All but 1 documented WNV transmission by transfusion involved blood components negative for WNV antibodies, raising the question whether WNV antibody-positive blood components with low levels of WNV RNA are infectious... - Human immunodeficiency virus-1 infection correlates strongly with herpes simplex virus-2 (genital herpes) seropositivity in South African and United States blood donationsRichard J Benjamin
Biomedical Services, Medical Office, American Red Cross, Washington, DC 20006, USA
Transfusion 48:295-303. 2008.... - Current value of serologic test for syphilis as a surrogate marker for blood-borne viral infections among blood donors in the United StatesShimian Zou
Transmissible Disease Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
Transfusion 49:655-61. 2009..Serologic screening for syphilis has been justified in part as a surrogate marker for infections caused by other pathogens such as human immunodeficiency virus (HIV). This study assessed the current surrogate value of the test... - Prevalence, incidence, and residual risk of human immunodeficiency virus and hepatitis C virus infections among United States blood donors since the introduction of nucleic acid testingShimian Zou
Jerome H Holland Laboratory, American Red Cross Biomedical Sciences, Rockville, Maryland 20855, USA
Transfusion 50:1495-504. 2010..This study analyzes temporal trends of these two infections since NAT introduction... - Prevalence, incidence, and residual risk of major blood-borne infections among apheresis collections to the American Red Cross Blood Services, 2004 through 2008Shimian Zou
Jerome H Holland Laboratory, American Red Cross Biomedical Sciences, Rockville, Maryland 20855, USA
Transfusion 50:1487-94. 2010..The number of apheresis collections increased significantly in recent years; however, data on viral marker rates among these collections are lacking... - West Nile fever characteristics among viremic persons identified through blood donor screeningShimian Zou
American Red Cross Holland Laboratory, Rockville, Maryland, USA
J Infect Dis 202:1354-61. 2010..Female subjects and persons with higher viral loads detected in the index donation were more likely than other subjects to develop symptoms... - Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United StatesShimian Zou
Transmissible Diseases Department, American Red Cross, Rockville, MD 20855, USA
N Engl J Med 351:751-9. 2004..We estimated the current probability of undetected viremia with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and human T-lymphotropic virus (HTLV) among tissue donors... - Patterns of age- and sex-specific prevalence of major blood-borne infections in United States blood donors, 1995 to 2002: American Red Cross blood donor studyShimian Zou
Transmissible Disease Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
Transfusion 44:1640-7. 2004..This study analyzes the temporal trends of major blood-borne infections among blood donors... 
Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in manJean K Lim
Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
PLoS Pathog 5:e1000321. 2009..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...- Pooled hepatitis B virus DNA testing by nucleic acid amplification: implementation or notSusan L Stramer
Transfusion 45:1242-6. 2005 - A new strategy for estimating risks of transfusion-transmitted viral infections based on rates of detection of recently infected donorsMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 45:254-64. 2005.... - West Nile virus blood transfusion-related infection despite nucleic acid testingAlexandre Macedo de Oliveira
Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Transfusion 44:1695-9. 2004..WNV NAT assays might vary in sensitivity and pooling donations could further impact test performance. Understanding MP NAT limitations can improve strategies to maintain safety of the blood supply in the United States... - Integration of nucleic acid amplification test results into hepatitis C virus supplemental serologic testing algorithms: implications for donor counseling and revision of existing algorithmsSteven H Kleinman
Blood Systems Research Institute, San Francisco, California, USA
Transfusion 46:695-702. 2006.... - Impact of changes in viral marker screening assaysUsha K Sharma
Westat, Rockville, Maryland, USA
Transfusion 43:202-14. 2003..Before considering changes in screening tests, blood centers should be aware of, and evaluate, the potential impact on donor loss... - Impact of HCV 3.0 EIA relative to HCV 2.0 EIA on blood-donor screeningLeslie H Tobler
Blood Centers of the Pacific, Irwin Center, San Francisco, California 94118, USA
Transfusion 43:1452-9. 2003..0 EIA; the second study evaluated the differential performance of HCV 3.0 EIA in plasma donors acutely infected with HCV, identified during routine Abbott HCV 2.0 EIA and HCV NAT (using Roche Ampliscreen plate assay) donor screening... - Transmission of West Nile virus through blood transfusion in the United States in 2002Lisa N Pealer
Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 349:1236-45. 2003..During the 2002 West Nile virus epidemic in the United States, patients were identified whose West Nile virus illness was temporally associated with the receipt of transfused blood and blood components... - Viral marker rates among blood donors before and after the terrorist attacks on the United States on September 11, 2001Roger Y Dodd
Transfusion 42:1240-1. 2002 - Development and persistence of West Nile virus-specific immunoglobulin M (IgM), IgA, and IgG in viremic blood donorsHarry E Prince
Focus Diagnostics, Cypress, CA 90630, USA
J Clin Microbiol 43:4316-20. 2005..Thus, unlike some other flavivirus infections, WNV infection is not characterized by a relatively rapid disappearance of virus-specific IgA... - Dengue virus in blood donations, Puerto Rico, 2005Hamish Mohammed
Dengue Branch, Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Transfusion 48:1348-54. 2008..The high incidence of dengue in endemic countries, the high proportion of asymptomatic infection, and the median 5-day viremia, however, suggest that transfusion-associated dengue transmission may be more widespread than documented... - West Nile virus infections projected from blood donor screening data, United States, 2003Michael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Emerg Infect Dis 12:395-402. 2006..In addition to preventing transfusion-transmitted WNV infection, donor screening can serve as a tool to monitor seasonal incidence in the general population... - Emerging infectious diseases that threaten the blood supplyHarvey J Alter
Infectious Diseases Section and Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA
Semin Hematol 44:32-41. 2007..However, to approach near-zero infectious disease risk for emerging and re-emerging pathogens, new strategies such as pathogen inactivation or multi-pathogen microarray technology will need to be developed or refined... - Correlates of hepatitis C virus (HCV) RNA negativity among HCV-seropositive blood donorsMichael P Busch
Blood Systems Research Institute, San Francisco, California 94118, USA
Transfusion 46:469-75. 2006..Factors associated with resolution of viremia are not well defined. Implementation of routine nucleic acid testing (NAT) of blood donors has yielded a large data set for analysis of demographic correlates of resolved viremia... - Preventing disease transmission by deceased tissue donors by testing blood for viral nucleic acidD Michael Strong
Puget Sound Blood Center Northwest Tissue Center, 921 Terry Avenue Seattle, WA, 98104, USA
Cell Tissue Bank 6:255-62. 2005..Using these protocols, inventories from two tissue centers were tested with greater than 99% of samples producing a valid test result... - High levels of subgenomic HCV plasma RNA in immunosilent infectionsFlavien Bernardin
Blood Systems Research Institute, San Francisco, CA 94118, USA
Virology 365:446-56. 2007..The absence of immunological pressure and a high viral load may therefore promote the emergence of truncated HCV subgenomic replicons in vivo... - West Nile virus adheres to human red blood cells in whole bloodMaria Rios
Laboratory of Molecular Virology, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
Clin Infect Dis 45:181-6. 2007..Conclusions. These observations reinforce the notion that extraction of viral RNA from whole blood could improve assay sensitivity for blood donor screening and further reduce the residual risk of WNV transmission through transfusion... - Nanoparticle-Based biobarcode amplification assay (BCA) for sensitive and early detection of human immunodeficiency type 1 capsid (p24) antigenShixing Tang
Lab of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA
J Acquir Immune Defic Syndr 46:231-7. 2007.... - Distinguishing acute from chronic and resolved hepatitis C virus (HCV) infections by measurement of anti-HCV immunoglobulin G avidity indexS Klimashevskaya
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 45:3400-3. 2007..Lower AI values obtained in past resolved infections may be directly related to lower levels of immunoglobulin G anti-HCV in past resolved infections than in either new infections or chronic infections... - Utilization of follow-up specimens from viremic blood donors to assess the value of west nile virus immunoglobulin G avidity as an indicator of recent infectionHarry E Prince
Focus Diagnostics, Cypress, CA 90630, USA
Clin Diagn Lab Immunol 12:1123-6. 2005..Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection... - Transmission of HIV and hepatitis C virus from a nursing home patient to a health care workerElise M Beltrami
Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Infect Control 31:168-75. 2003..Bloodborne pathogen transmission may have been prevented in this situation by consistent, unfailing use of barrier precautions... - Chagas disease and the US blood supplyCaryn Bern
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Curr Opin Infect Dis 21:476-82. 2008..To describe new developments in blood-bank screening and management of patients with chronic Trypanosoma cruzi infection in the United States...