Cheng Kui Qu

Summary

Affiliation: American Red Cross
Country: USA

Publications

  1. ncbi Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Oncogene 22:5995-6004. 2003
  2. ncbi A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival
    Jing Chen
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Oncogene 23:3659-69. 2004
  3. ncbi The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions
    C K Qu
    Department of Hematopoiesis, American Red Cross, Rockville, MD 20855, USA
    Cell Res 10:279-88. 2000
  4. ncbi Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
    Cheng Kui Qu
    Department of Hematopoiesis, Jerome H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Biochim Biophys Acta 1592:297-301. 2002
  5. ncbi Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 99:2351-9. 2002
  6. ncbi Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response
    Liangping Yuan
    Departments of Hematopoiesis and Experimental Pathology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:15208-16. 2003
  7. ncbi Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome
    Erica M Hanson
    Department of Immunology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:3903-11. 2003
  8. ncbi DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase
    Liangping Yuan
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:42812-20. 2003
  9. ncbi Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression
    Kevin D Bunting
    American Red Cross, Jerome H Holland Laboratory for the Biomedical Sciences, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    J Leukoc Biol 76:484-90. 2004
  10. ncbi Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
    J Immunol 174:1013-9. 2005

Collaborators

  • K D Bunting
  • R G Hawley
  • Mark S Williams
  • Raymond P Donnelly
  • Hal Broxmeyer
  • Jose Zamorano
  • Wen Mei Yu
  • Wen-Mei Yu
  • Liangping Yuan
  • Jing Chen
  • Dan Xu
  • A R M Ruhul Amin
  • Olgun Guvench
  • Yi Zhang
  • Hanako Daino
  • Hai-Feng Duan
  • Dong Wan Seo
  • Jaeyul Kwon
  • Achsah D Keegan
  • Erica M Hanson
  • Teresa S Hawley
  • Vijay S Thakur
  • Kevin M Shannon
  • Ernesto Diaz-Flores
  • Eleonora Haviernikova
  • Munna L Agarwal
  • Alexander D MacKerell
  • Brian J Druker
  • Rajib K Paul
  • Sara Rowe
  • Zhengqi Wang
  • Geqiang Li
  • William Tse
  • Zizhen Kang
  • Gen Sheng Feng
  • Hasan Mukhtar
  • Chu-Tse Wu
  • Li-Sheng Wang
  • Tere Diaz
  • Qun-Wei Zhang
  • Hong Wang
  • Young-Sik Kim
  • Beiyang Wei
  • Dong-Wan Seo
  • William G Stetler-Stevenson
  • Jeung Whan Han
  • Hongmei Li
  • Jeung-Whan Han
  • Junseo Oh
  • Young Sik Kim
  • Siying Wang
  • Jin-Soo Maeng
  • Rustom Falahati
  • Chunghee Lee
  • Min Xu
  • Harold Dickensheets
  • Zhimin Yuan
  • Christian C Haudenschild

Detail Information

Publications21

  1. ncbi Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Oncogene 22:5995-6004. 2003
    ..Taken together, these results suggest that SHP-2 tyrosine phosphatase plays multiple roles in IL-3 signal transduction, functioning in both catalytic-dependent and -independent manners in the Jak/Stat, Erk, and PI3 kinase pathways...
  2. ncbi A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival
    Jing Chen
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Oncogene 23:3659-69. 2004
    ..Taken together, these results suggest that SHP-2 tyrosine phosphatase negatively regulates hematopoietic cell survival by dephosphorylation of STAT5...
  3. ncbi The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions
    C K Qu
    Department of Hematopoiesis, American Red Cross, Rockville, MD 20855, USA
    Cell Res 10:279-88. 2000
    ....
  4. ncbi Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response
    Cheng Kui Qu
    Department of Hematopoiesis, Jerome H Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Biochim Biophys Acta 1592:297-301. 2002
    ....
  5. ncbi Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 99:2351-9. 2002
    ..Taken together, these results suggest an important signaling role for Gab2 in regulating hematopoietic cell adhesion and migration...
  6. ncbi Role of SHP-2 tyrosine phosphatase in the DNA damage-induced cell death response
    Liangping Yuan
    Departments of Hematopoiesis and Experimental Pathology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:15208-16. 2003
    ..These results together suggest a novel nuclear function for SHP-2 phosphatase in the regulation of DNA damage-induced apoptotic responses...
  7. ncbi Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome
    Erica M Hanson
    Department of Immunology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:3903-11. 2003
    ..These results suggest that the loss of tyrosine phosphorylation of Stat6 is regulated by the action of SHP-1 and the proteasome but is not dependent on new protein synthesis...
  8. ncbi DNA damage-induced G2/M checkpoint in SV40 large T antigen-immortalized embryonic fibroblast cells requires SHP-2 tyrosine phosphatase
    Liangping Yuan
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 278:42812-20. 2003
    ..These results together provide the first evidence that SHP-2 tyrosine phosphatase enhances the DNA damage G2/M checkpoint in SV40 large T antigen immortalized murine embryonic fibroblast cells...
  9. ncbi Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression
    Kevin D Bunting
    American Red Cross, Jerome H Holland Laboratory for the Biomedical Sciences, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    J Leukoc Biol 76:484-90. 2004
    ..Therefore, the requirement for STAT6 activation during hematopoiesis is limited, and primitive hematopoietic cell types are insulated against possible effects of cytokine stimulation by Th1 cells...
  10. ncbi Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
    J Immunol 174:1013-9. 2005
    ..Together these results suggest that SHP-1 negatively regulates Th1 cell development and functions through a mechanism that is not directly related to IL-12 signaling...
  11. ncbi SHP-2 phosphatase regulates DNA damage-induced apoptosis and G2/M arrest in catalytically dependent and independent manners, respectively
    Liangping Yuan
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 280:42701-6. 2005
    ..Collectively, these studies have further defined the mechanisms by which SHP-2 phosphatase regulates DNA damage responses...
  12. ncbi SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
    Jing Chen
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Blood 109:778-85. 2007
    ..These studies identified a novel function of SHP-2 and suggest that SHP-2 might be a useful target for controlling Bcr-Abl-positive leukemias...
  13. ncbi Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
    Wen Mei Yu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Biol Chem 281:5426-34. 2006
    ....
  14. ncbi Abnormal hematopoiesis in Gab2 mutant mice
    Yi Zhang
    Department of Medicine, Division of Hematology, Case Western Reserve University School of Medicine, Cleveland, OH 44106 7284, USA
    Blood 110:116-24. 2007
    ..Therefore, we demonstrate that Gab2 adapter function is intrinsically required for hematopoietic cell response to early-acting cytokines, resulting in defective hematopoiesis in Gab2-deficient mice...
  15. ncbi SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG
    A R M Ruhul Amin
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:5419-24. 2007
    ..Our results have identified SHP-2 as a negative regulator of EGCG-induced-apoptosis and have identified a subset of p53 target genes whose expression is paradoxically not mediated by p53 but by one of its family members, p73...
  16. ncbi Shp-2 tyrosine phosphatase is required for hepatocyte growth factor-induced activation of sphingosine kinase and migration in embryonic fibroblasts
    Hai-Feng Duan
    Department of Experimental Hematology, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, P.R. China
    Cell Signal 18:2049-55. 2006
    ..Furthermore, we found that Shp-2 co-immunoprecipitated with SPK1 and c-Met in embryonic fibroblasts. These studies suggest that Shp-2 is an SPK1-interacting protein and that it plays an indispensable role in HGF-induced SPK1 activation...
  17. ncbi Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
    Dong Wan Seo
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 1500, USA
    J Biol Chem 281:3711-21. 2006
    ....
  18. ncbi Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP
    Jaeyul Kwon
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Rockville, MD 20855, USA
    EMBO J 24:2331-41. 2005
    ..The data indicate that TCR-mediated ROS generation leads to SHP-2 oxidation, which promotes T-cell adhesion through effects on an SLP-76-dependent signaling pathway to integrin activation...
  19. ncbi Protein tyrosine phosphatases in the JAK/STAT pathway
    Dan Xu
    Department of Medicine, Division of Hematology Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Front Biosci 13:4925-32. 2008
    ..Here, we review recent advances in the regulatory roles of PTPs, in particular, SHP2 phosphatase, in the JAK/STAT signaling pathway...
  20. ncbi Phosphatidylcholine-specific phospholipase C activity is necessary for the activation of STAT6
    Jose Zamorano
    Unidad de Investigacion, Hospital San Pedro de Alcantara, Caceres, Spain
    J Immunol 171:4203-9. 2003
    ..It has been reported that IL-4 signals PC-PLC activation; in this study, we provide evidence that this phospholipase plays a key role in IL-4 signaling...
  21. ncbi Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft
    Olgun Guvench
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, HSF II 629, Baltimore, MD 21201, USA
    BMC Struct Biol 7:14. 2007
    ..To better characterize the molecular process involved in N-SH2 pY-dependent binding, we have applied explicit-solvent molecular dynamics simulations to study the closed-to-open transition of the N-SH2 pY-peptide binding cleft...