Research Topics
| D A LeibySummaryAffiliation: American Red Cross Country: USA Publications
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Publications
Evidence of Trypanosoma cruzi infection (Chagas' disease) among patients undergoing cardiac surgeryD A Leiby
American Red Cross, Rockville, MD 20855, USA
Circulation 102:2978-82. 2000..To investigate these 2 possible outcomes, we tested a repository of blood specimens from multiply transfused cardiac surgery patients for antibodies to T cruzi...
Impact of donor deferrals for malaria on blood availability in the United StatesDavid A Leiby
Transmissible Diseases Department, American Red Cross, Rockville, Maryland 20855, USA
Transfusion 48:2222-8. 2008..This study evaluated trends in malaria deferrals and their impact on blood availability from 2000 through 2006...
Trypanosoma cruzi parasitemia in US blood donors with serologic evidence of infectionDavid A Leiby
Transmissible Diseases Dept, American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
J Infect Dis 198:609-13. 2008..This affirmation that bloodstream parasites are detectable--and potentially transmissible--decades after immigration strengthens the rationale for donor screening...
Making sense of malariaDavid A Leiby
Transmissible Diseases Department, American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA
Transfusion 47:1573-7. 2007
Babesiosis and blood transfusion: flying under the radarD A Leiby
Department of Transmissible Diseases, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
Vox Sang 90:157-65. 2006..However, recognition that the Babesia spp. are indeed an ongoing and expanding blood safety threat will probably prove instrumental in the development of viable interventions to limit transmission of these agents...
Transfusion-transmitted Babesia spp.: bull's-eye on Babesia microtiDavid A Leiby
Transmissible Diseases Department, American Red Cross Holland Laboratory, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
Clin Microbiol Rev 24:14-28. 2011..Despite current obstacles, continued discussion of TTB without proactive intervention is no longer a viable alternative...
Emerging infectious agentsD A Leiby
Transmissible Diseases Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
Dev Biol (Basel) 120:11-5. 2005..Unfortunately, for many of these agents there is an absence of viable tests or other sound interventions to prevent their transmission at this time...
Transfusion-transmitted tick-borne infections: a cornucopia of threatsDavid A Leiby
Department of Transmissible Diseases, American Red Cross Holland Laboratory, Rockville, MD 20855, USA
Transfus Med Rev 18:293-306. 2004..Given that interactions between humans and ticks are likely to increase in the future, vigilance is required as new and extant tick-borne agents pose potential threats to transfusion safety...
Threats to blood safety posed by emerging protozoan pathogensD A Leiby
Transmissible Diseases Department, Jerome H. Holland Laboratory for the Biomedical Sciences, Rockville, MD 20855, USA
Vox Sang 87:120-2. 2004
Relationship between tick bites and the seroprevalence of Babesia microti and Anaplasma phagocytophila (previously Ehrlichia sp.) in blood donorsDavid A Leiby
Transmissible Diseases Department, American Red Cross, Rockville, MD 20855, USA
Transfusion 42:1585-91. 2002..Despite an increased recognition of the threat tick-borne agents pose to blood safety, our understanding of the prevalence and transmissibility of these agents in blood donors is limited...
Trypanosoma cruzi in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmissionDavid A Leiby
Transmissible Diseases Department, American Red Cross, Jerome H Holland Laboratory, Rockville, MD 20855, USA
Transfusion 42:549-55. 2002..cruzi-endemic countries, suggests that Chagas' is a long-term public health problem. Herein, we report on a multiyear epidemiologic study of T. cruzi in Los Angeles and Miami blood donors...
Emerging infectious threats to the blood supplyRoger Y Dodd
Transmissible Diseases Department, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, Maryland 20855, USA
Annu Rev Med 55:191-207. 2004..It is certain, however, that new agents will continue to emerge as threats to blood safety and these agents are likely to require novel approaches to prevent their transmission...
Evaluation of the Mirasol pathogen [corrected] reduction technology system against Babesia microti in apheresis platelets and plasmaLaura Tonnetti
Transmissible Diseases Department, Jerome H Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
Transfusion 50:1019-27. 2010..Thus, we evaluated the ability of the Mirasol pathogen reduction technology (PRT; CaridianBCT), which uses riboflavin (RB) and ultraviolet (UV) light, to diminish the presence of B. microti in apheresis plasma and platelets (PLTs)...
Seroprevalence of Babesia microti in blood donors from Babesia-endemic areas of the northeastern United States: 2000 through 2007Stephanie T Johnson
Transmissible Diseases Department, Jerome H Holland Laboratory, and Biomedical Services, American Red Cross, Farmington, Connecticut 06032, USA
Transfusion 49:2574-82. 2009..The extent of Babesia infections among blood donors has not been well defined. To determine how common exposure to B. microti is among blood donors, a seroprevalence study was undertaken in the American Red Cross Northeast Division...
Transfusion-transmitted Babesia microti identified through hemovigilanceLaura Tonnetti
Transmissible Diseases Department, Jerome H Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
Transfusion 49:2557-63. 2009..microti increasingly poses a blood safety risk. The American Red Cross Hemovigilance Program herein describes the donor and recipient characteristics of suspected transfusion-transmitted B. microti cases reported between 2005 and 2007...
Demonstrable parasitemia among Connecticut blood donors with antibodies to Babesia microtiDavid A Leiby
Department of Transmissible Diseases, American Red Cross, Rockville, MD 20855, USA
Transfusion 45:1804-10. 2005..Although several studies have measured B. microti antibodies in blood donors, little is known about associated parasitemia and the inherent risk of transmitting the parasite by transfusion...
Risk and prevention of transfusion-transmitted babesiosis and other tick-borne diseasesRitchard G Cable
American Red Cross, Connecticut Blood Services, Farmington, and University of Connecticut Health Center, Farmington, Connecticut 06032, USA
Curr Opin Hematol 10:405-11. 2003..Although Lyme disease has not been reported from blood transfusion, newly identified tick-borne diseases such as ehrlichiosis raise additional questions about the role of the tick in transfusion-transmitted diseases...
Identification of Babesia microti-specific immunodominant epitopes and development of a peptide EIA for detection of antibodies in serumRaymond L Houghton
Department of Antigen Discovery, Corixa Corporation, Seattle, Washington 98104, USA
Transfusion 42:1488-96. 2002..To develop a test that can detect antibody responses to B. microti, peptide epitopes identified in two serocomplementary B. microti-specific antigens were used in a prototype EIA...
Immunoblot assay using recombinant antigens as a supplemental test to confirm the presence of antibodies to Trypanosoma cruziKevin Y Cheng
Emerging Pathogens and Infectious Diseases R and D, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL 60064, USA
Clin Vaccine Immunol 14:355-61. 2007..The rAg-based immunoblot assay has potential as a supplemental test for confirming the presence of antibodies to T. cruzi in blood specimens and for identifying false-positive results obtained with other assays...
Evaluation of a prototype Trypanosoma cruzi antibody assay with recombinant antigens on a fully automated chemiluminescence analyzer for blood donor screeningChi-Deu Chang
Emerging Pathogens R and D, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA
Transfusion 46:1737-44. 2006..CONCLUSION: The results obtained to date, in terms of sensitivity as well as specificity, strongly suggest that the PRISM Chagas assay should function well as a tool for screening blood for serologic evidence of T. cruzi infection...
Can ticks be vectors for hepatitis C virus?Lois Gitlin Wurzel
N Engl J Med 347:1724-5. 2002
Chlamydia pneumoniae: another agent added to the growing list of transfusion-transmitted pathogens?David A Leiby
Transfusion 43:552-5. 2003
