Jaime F Modiano
Affiliation: AMC Cancer Research Center
- Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistancePei yin Lin
Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA, USA
Mol Cancer 6:16. 2007..Renal cell carcinoma (RCC) is associated with frequent treatment failures (approximately 90% in metastatic cases), and these tumors frequently contain PTEN abnormalities...
- Quantitative and qualitative signals determine T-cell cycle entry and progressionJ F Modiano
Department of Pathobiology, Texas A and M University, College Station, Texas
Cell Immunol 197:19-29. 1999..The data indicate that quantitative and qualitative differences in early signaling events distinguish the acquisition of the competent state or the induction of cytokine production with a commitment to T-cell proliferation...
- CDK4 expression and activity are required for cytokine responsiveness in T cellsJ F Modiano
Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, CO 80214, USA
J Immunol 165:6693-702. 2000....
- Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable riskJaime F Modiano
Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
Cancer Res 65:5654-61. 2005..The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD...
- Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cellsAshley A Frazer-Abel
Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2 Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA
J Pharmacol Exp Ther 311:758-69. 2004..This offers insight into possible reasons that underlie the unique effects of nicotine on distinct cell types and identifies new targets that may be useful control tobacco-related diseases...
- Nicotine-mediated signals modulate cell death and survival of T lymphocytesSilvia C S Oloris
Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
Toxicol Appl Pharmacol 242:299-309. 2010..The sum of our data suggests that selective modulation of nAChRs might be useful to regulate lymphocyte activation and survival in health and disease...
- Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcomaBeth A Tamburini
Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
BMC Cancer 10:619. 2010..The hypothesis for this study was that characteristic molecular features distinguish hemangiosarcoma from non-malignant endothelial cells, and that such features are informative for the etiology of this disease...
- Canine malignant hemangiosarcoma as a model of primitive angiogenic endotheliumSusan P Fosmire
AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
Lab Invest 84:562-72. 2004..In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular...
- Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiationAngela R Lamerato-Kozicki
Department of Immunology and AMC Cancer Research Center, University of Colorado at Denver and Health Sciences Center Denver, CO 80214, USA
Exp Hematol 34:870-8. 2006..This study was designed to begin to distinguish between these possibilities, as well as to test if flow cytometry was sufficiently sensitive to detect malignant cells in blood samples from dogs with HSA...
- Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytesJ J Lucas
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA
J Immunol 154:6275-84. 1995..Thus, increased accumulation of the protein and its activity begin before IL-2/IL-2 receptor interaction, suggesting that the cdk6-cyclin D2 complex might be involved in acquisition of the competent state in human T lymphocytes...
- Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cellsJaime F Modiano
Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Clin Immunol 112:54-65. 2004..These data show that gene delivery of membrane-bound FasL can effectively recruit and eliminate autoreactive T cells...
- Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phaseJesica M McCue
Division of Allergy and Clinical Immunology, University of Colorado Health Sciences Center, 4200 E 9th Ave, B 164, Denver, CO 80262, USA
Mol Immunol 39:995-1001. 2003..These studies provide further indication of the regulatory pathways by which cigarette smoke inhibits T cell responses in the lungs of smokers...
- Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breedBeth A Tamburini
Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
PLoS ONE 4:e5549. 2009..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
- Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugsSangeeta Khare
Department of Pathobiology, Texas A and M University, College Station, TX, USA
Eur J Pharmacol 465:23-30. 2003..Moreover, detection of extracellular acidification rate changes was not restricted to a particular cell type or apoptosis pathway, making this a potentially useful tool to screen compounds for pro-apoptotic activity...
- Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and catsPeter J Fernandes
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University College Station, USA
Vet Clin Pathol 31:167-82. 2002..Advances in automated hematology instrumentation, immunophenotyping, cytogenetics, and molecular biology are significantly improving our ability to recognize and classify spontaneous myeloproliferative and lymphoproliferative disorders...
- Negative regulators in homeostasis of naïve peripheral T cellsJaime F Modiano
Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
Immunol Res 41:137-53. 2008....
- Enhancing antimelanoma immune responses through apoptosisStacie R Bianco
Center for Cancer Causation and Prevention, AMC Cancer Research Center and Donald Monk Cancer Research Foundation, Denver, Colorado 80214, USA
Cancer Gene Ther 10:726-36. 2003..The results also suggest that intratumoral administration of FasL offers a safe route for therapeutic gene delivery...
- Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibitionM G Ritt
Department of Small Animal Medicine and Surgery, Texas A and M University, College Station, TX 77843, USA
Cancer Lett 158:73-84. 2000....
- Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancerErin B Dickerson
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
J Immunother 25:36-45. 2002....
- Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionshipMatthew Breen
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27606, USA
Chromosome Res 16:145-54. 2008..These data suggest that humans and dogs share an ancestrally retained pathogenetic basis for cancer and that cytogenetic evaluation of canine tumors may provide greater insight into the biology of tumorigenesis...
- Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumorsRachael Thomas
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Genome Res 15:1831-7. 2005..Here we provide examples of the varied applications of this resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques...
- NFATc2-mediated repression of cyclin-dependent kinase 4 expressionShairaz Baksh
Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 10:1071-81. 2002..This pathway may thus regulate the expression of CDK4 at the transcriptional level and control how cells re-enter a resting, nonproliferative state...
- The dog as a cancer modelChand Khanna
Nat Biotechnol 24:1065-6. 2006