Jaime F Modiano

Summary

Affiliation: AMC Cancer Research Center
Country: USA

Publications

  1. pmc Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance
    Pei yin Lin
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA, USA
    Mol Cancer 6:16. 2007
  2. ncbi Quantitative and qualitative signals determine T-cell cycle entry and progression
    J F Modiano
    Department of Pathobiology, Texas A and M University, College Station, Texas
    Cell Immunol 197:19-29. 1999
  3. ncbi CDK4 expression and activity are required for cytokine responsiveness in T cells
    J F Modiano
    Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, CO 80214, USA
    J Immunol 165:6693-702. 2000
  4. ncbi Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk
    Jaime F Modiano
    Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
    Cancer Res 65:5654-61. 2005
  5. ncbi Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells
    Ashley A Frazer-Abel
    Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2 Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA
    J Pharmacol Exp Ther 311:758-69. 2004
  6. pmc Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
  7. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
  8. ncbi Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
    Susan P Fosmire
    AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
    Lab Invest 84:562-72. 2004
  9. ncbi Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation
    Angela R Lamerato-Kozicki
    Department of Immunology and AMC Cancer Research Center, University of Colorado at Denver and Health Sciences Center Denver, CO 80214, USA
    Exp Hematol 34:870-8. 2006
  10. ncbi Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes
    J J Lucas
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA
    J Immunol 154:6275-84. 1995

Collaborators

Detail Information

Publications23

  1. pmc Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance
    Pei yin Lin
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, CA, USA
    Mol Cancer 6:16. 2007
    ..Renal cell carcinoma (RCC) is associated with frequent treatment failures (approximately 90% in metastatic cases), and these tumors frequently contain PTEN abnormalities...
  2. ncbi Quantitative and qualitative signals determine T-cell cycle entry and progression
    J F Modiano
    Department of Pathobiology, Texas A and M University, College Station, Texas
    Cell Immunol 197:19-29. 1999
    ..The data indicate that quantitative and qualitative differences in early signaling events distinguish the acquisition of the competent state or the induction of cytokine production with a commitment to T-cell proliferation...
  3. ncbi CDK4 expression and activity are required for cytokine responsiveness in T cells
    J F Modiano
    Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, CO 80214, USA
    J Immunol 165:6693-702. 2000
    ....
  4. ncbi Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk
    Jaime F Modiano
    Department of Immunology, AMC Cancer Center, Denver, Colorado 80214, USA
    Cancer Res 65:5654-61. 2005
    ..The data show that domestic dogs provide a unique and valuable resource to define factors that mediate risk as well as genes involved in the initiation of B-cell and T-cell LPD...
  5. ncbi Nicotine activates nuclear factor of activated T cells c2 (NFATc2) and prevents cell cycle entry in T cells
    Ashley A Frazer-Abel
    Integrated Department of Immunology, University of Colorado Health Sciences Center, AMC Cancer Center, 2 Diamond Building, 1600 Pierce Street, Denver, CO 80214, USA
    J Pharmacol Exp Ther 311:758-69. 2004
    ..This offers insight into possible reasons that underlie the unique effects of nicotine on distinct cell types and identifies new targets that may be useful control tobacco-related diseases...
  6. pmc Nicotine-mediated signals modulate cell death and survival of T lymphocytes
    Silvia C S Oloris
    Integrated Department of Immunology, School of Medicine, University of Colorado, Denver, Denver, CO, USA
    Toxicol Appl Pharmacol 242:299-309. 2010
    ..The sum of our data suggests that selective modulation of nAChRs might be useful to regulate lymphocyte activation and survival in health and disease...
  7. pmc Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado, Denver, School of Medicine, Denver, CO, USA
    BMC Cancer 10:619. 2010
    ..The hypothesis for this study was that characteristic molecular features distinguish hemangiosarcoma from non-malignant endothelial cells, and that such features are informative for the etiology of this disease...
  8. ncbi Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium
    Susan P Fosmire
    AMC Cancer Research Center and Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, 80214, USA
    Lab Invest 84:562-72. 2004
    ..In summary, these cell lines represent a unique and novel resource to improve our understanding of endothelial cell biology in general and canine HSA in particular...
  9. ncbi Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation
    Angela R Lamerato-Kozicki
    Department of Immunology and AMC Cancer Research Center, University of Colorado at Denver and Health Sciences Center Denver, CO 80214, USA
    Exp Hematol 34:870-8. 2006
    ..This study was designed to begin to distinguish between these possibilities, as well as to test if flow cytometry was sufficiently sensitive to detect malignant cells in blood samples from dogs with HSA...
  10. ncbi Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes
    J J Lucas
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA
    J Immunol 154:6275-84. 1995
    ..Thus, increased accumulation of the protein and its activity begin before IL-2/IL-2 receptor interaction, suggesting that the cdk6-cyclin D2 complex might be involved in acquisition of the competent state in human T lymphocytes...
  11. ncbi Fas ligand-dependent suppression of autoimmunity via recruitment and subsequent termination of activated T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Immunol 112:54-65. 2004
    ..These data show that gene delivery of membrane-bound FasL can effectively recruit and eliminate autoreactive T cells...
  12. ncbi Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase
    Jesica M McCue
    Division of Allergy and Clinical Immunology, University of Colorado Health Sciences Center, 4200 E 9th Ave, B 164, Denver, CO 80262, USA
    Mol Immunol 39:995-1001. 2003
    ..These studies provide further indication of the regulatory pathways by which cigarette smoke inhibits T cell responses in the lungs of smokers...
  13. pmc Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed
    Beth A Tamburini
    Integrated Department of Immunology, University of Colorado Denver, Denver, Colorado, USA
    PLoS ONE 4:e5549. 2009
    ..Our results suggest heritable factors mold gene expression phenotypes, and consequently biological behavior in sporadic, naturally occurring tumors...
  14. ncbi Early changes in metabolism of leukemic cell lines upon induction of apoptosis by cytotoxic drugs
    Sangeeta Khare
    Department of Pathobiology, Texas A and M University, College Station, TX, USA
    Eur J Pharmacol 465:23-30. 2003
    ..Moreover, detection of extracellular acidification rate changes was not restricted to a particular cell type or apoptosis pathway, making this a potentially useful tool to screen compounds for pro-apoptotic activity...
  15. ncbi Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and cats
    Peter J Fernandes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University College Station, USA
    Vet Clin Pathol 31:167-82. 2002
    ..Advances in automated hematology instrumentation, immunophenotyping, cytogenetics, and molecular biology are significantly improving our ability to recognize and classify spontaneous myeloproliferative and lymphoproliferative disorders...
  16. pmc Negative regulators in homeostasis of naïve peripheral T cells
    Jaime F Modiano
    Integrated Department of Immunology, University of Colorado Denver, Denver, CO, USA
    Immunol Res 41:137-53. 2008
    ....
  17. ncbi Enhancing antimelanoma immune responses through apoptosis
    Stacie R Bianco
    Center for Cancer Causation and Prevention, AMC Cancer Research Center and Donald Monk Cancer Research Foundation, Denver, Colorado 80214, USA
    Cancer Gene Ther 10:726-36. 2003
    ..The results also suggest that intratumoral administration of FasL offers a safe route for therapeutic gene delivery...
  18. ncbi Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition
    M G Ritt
    Department of Small Animal Medicine and Surgery, Texas A and M University, College Station, TX 77843, USA
    Cancer Lett 158:73-84. 2000
    ....
  19. ncbi Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancer
    Erin B Dickerson
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Immunother 25:36-45. 2002
    ....
  20. doi Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans--man and his best friend share more than companionship
    Matthew Breen
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27606, USA
    Chromosome Res 16:145-54. 2008
    ..These data suggest that humans and dogs share an ancestrally retained pathogenetic basis for cancer and that cytogenetic evaluation of canine tumors may provide greater insight into the biology of tumorigenesis...
  21. pmc Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Genome Res 15:1831-7. 2005
    ..Here we provide examples of the varied applications of this resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques...
  22. ncbi NFATc2-mediated repression of cyclin-dependent kinase 4 expression
    Shairaz Baksh
    Department of Pediatric Oncology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 10:1071-81. 2002
    ..This pathway may thus regulate the expression of CDK4 at the transcriptional level and control how cells re-enter a resting, nonproliferative state...
  23. ncbi The dog as a cancer model
    Chand Khanna
    Nat Biotechnol 24:1065-6. 2006