Lori L Altshuler

Summary

Country: USA

Publications

  1. ncbi request reprint Subsyndromal depression is associated with functional impairment in patients with bipolar disorder
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 63:807-11. 2002
  2. doi request reprint Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute of Neuroscience and Human Behavior, UCLA, USA
    Am J Psychiatry 167:708-15. 2010
  3. pmc Gender and iron genes may modify associations between brain iron and memory in healthy aging
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Neuropsychopharmacology 36:1375-84. 2011
  4. pmc Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium
    Lara C Foland-Ross
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 211:195-201. 2013
  5. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
  6. pmc Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuroimage 59:738-44. 2012
  7. pmc Investigation of cortical thickness abnormalities in lithium-free adults with bipolar I disorder using cortical pattern matching
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, Ahmanson Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, USA
    Am J Psychiatry 168:530-9. 2011
  8. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
  9. pmc Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    J Affect Disord 147:389-96. 2013
  10. pmc fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
    Psychiatry Res 183:209-17. 2010

Detail Information

Publications95

  1. ncbi request reprint Subsyndromal depression is associated with functional impairment in patients with bipolar disorder
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Clin Psychiatry 63:807-11. 2002
    ..The purpose of this study was to assess whether a relationship exists between mild depressive symptoms and overall functioning in subjects with bipolar disorder...
  2. doi request reprint Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute of Neuroscience and Human Behavior, UCLA, USA
    Am J Psychiatry 167:708-15. 2010
    ..The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder...
  3. pmc Gender and iron genes may modify associations between brain iron and memory in healthy aging
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Neuropsychopharmacology 36:1375-84. 2011
    ..Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups...
  4. pmc Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium
    Lara C Foland-Ross
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 211:195-201. 2013
    ..Future studies, nevertheless, that further elucidate the impact of age, course of illness, and medication on amygdala structure in bipolar disorder are warranted...
  5. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  6. pmc Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neuroimage 59:738-44. 2012
    ..Future studies that assess mood-state related changes in brain activation in longitudinal bipolar samples would be of interest...
  7. pmc Investigation of cortical thickness abnormalities in lithium-free adults with bipolar I disorder using cortical pattern matching
    Lara C Foland-Ross
    Laboratory of Neuroimaging, Department of Neurology, Ahmanson Lovelace Brain Mapping Center, UCLA School of Medicine, Los Angeles, USA
    Am J Psychiatry 168:530-9. 2011
    ..The authors used MRI in conjunction with cortical pattern matching methods to assess cortical thickness abnormalities in euthymic bipolar patients who were not receiving lithium treatment...
  8. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  9. pmc Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    J Affect Disord 147:389-96. 2013
    ..Prior BP functional neuroimaging studies have not accounted for ADHD comorbidity despite its high prevalence...
  10. pmc fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
    Psychiatry Res 183:209-17. 2010
    ..The current study replicates previous research on unmedicated subjects showing no significant differences in amygdala function in depressed vs. control subjects with respect to simple tasks involving emotion observation...
  11. pmc Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Biol Psychiatry 73:127-35. 2013
    ..This study investigated frontal and limbic function and connectivity during emotion downregulation in euthymic subjects with bipolar I disorder (BPI) and healthy control subjects...
  12. pmc Mood-state effects on amygdala volume in bipolar disorder
    Lara C Foland-Ross
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    J Affect Disord 139:298-301. 2012
    ..The prefrontal cortex has recently been reported to have a lower volume in depressed versus euthymic bipolar patients. Here we examined whether similar mood state-dependent volumetric differences are detectable in the amygdala...
  13. ncbi request reprint Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism
    Eric Levander
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    J Affect Disord 101:211-7. 2007
    ..This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD)...
  14. pmc fMRI abnormalities in dorsolateral prefrontal cortex during a working memory task in manic, euthymic and depressed bipolar subjects
    Jennifer Townsend
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Psychiatry Res 182:22-9. 2010
    ..The reduction of neural activation may suggest a trait-related deficit. Subjects with bipolar disorder activated other additional frontal and temporal regions, perhaps as a compensatory mechanism, but this remains to be further explored...
  15. pmc ADHD comorbidity can matter when assessing cortical thickness abnormalities in patients with bipolar disorder
    Catherine E Hegarty
    Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California at Los Angeles UCLA, Los Angeles, CA 90095, USA
    Bipolar Disord 14:843-55. 2012
    ..We used a 2 × 2 design to evaluate the joint effects of BP and ADHD on cortical thickness and uncover the importance of ADHD comorbidity in BP subjects...
  16. doi request reprint Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Psychiatry 72:1026-34. 2012
    ..We examined whether known regional differences in axon size and age at myelination influence the timing and rates of development and degeneration/repair trajectories of white matter (WM) microstructure biomarkers...
  17. pmc Regional fMRI hypoactivation and altered functional connectivity during emotion processing in nonmedicated depressed patients with bipolar II disorder
    Nathalie Vizueta
    David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Am J Psychiatry 169:831-40. 2012
    ..The authors examined neural activity in response to negative emotional faces during an emotion perception task that reliably activates emotion regulatory regions...
  18. doi request reprint Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 14:442-50. 2012
    ..While inferior frontal cortex (IFC) impairment has been reported in mania, this study explored whether this dysfunction persists in euthymia...
  19. pmc Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    Schizophr Res 132:35-41. 2011
    ..Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations...
  20. pmc Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness
    Lara C Foland-Ross
    Laboratory of Neuro Imaging, Department of Neurology, Department of Psychiatry and Biobehavioral Sciences, and Department of Psychology, University of California, Los Angeles, California 90095, USA
    J Neurosci 30:16673-8. 2010
    ..These data add support to a general role of the ventromedial PFC in regulating activity of the amygdala...
  21. pmc The impact of neurocognitive impairment on occupational recovery of clinically stable patients with bipolar disorder: a prospective study
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Bipolar Disord 13:323-33. 2011
    ..The reasons for this are not well understood. We evaluated the relationship between neurocognition and occupational function in bipolar disorder patients, following symptomatic recovery...
  22. ncbi request reprint Patterns of alcohol consumption in bipolar patients comorbid for alcohol abuse or dependence
    James W McKowen
    UCLA Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 7:377-81. 2005
    ..This report evaluates preliminary data of alcohol consumption patterns utilizing the Alcohol Timeline Followback (TLFB) method in actively drinking patients with bipolar disorder...
  23. ncbi request reprint Placental passage of antidepressant medications
    Victoria Hendrick
    Mood Disorders Research Program, UCLA Neuropsychiatric Institute and Hospital, University of California Los Angeles, 300 Medical Plaza, Suite 2345, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:993-6. 2003
    ..This study determined the placental transfer of antidepressants and their metabolites...
  24. pmc Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium
    Lara C Foland
    Laboratory of Neuroimaging, Department of Neurology, University of California, UCLA School of Medicine, Los Angeles, California, USA
    Neuroreport 19:221-4. 2008
    ..Our findings may help to explain previous inconsistencies in the bipolar literature...
  25. pmc Anterior cingulate activation relates to local cortical thickness
    Catherine E Hegarty
    Jane and Terry Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, USA
    Neuroreport 23:420-4. 2012
    ..No significant thickness-activation correlations were found in the prefrontal cortex. Correlations between cortical thickness and activation may occur only in certain brain regions...
  26. doi request reprint Subsyndromal depressive symptoms after symptomatic recovery from mania are associated with delayed functional recovery
    Michael J Gitlin
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at the University of California, Los Angeles, CA, USA
    J Clin Psychiatry 72:692-7. 2011
    ..This study examined whether the presence of subsyndromal depressive symptoms predicted functional recovery after an acute manic episode...
  27. ncbi request reprint A relationship between neurocognitive impairment and functional impairment in bipolar disorder: a pilot study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Medical Center, Los Angeles, CA, USA
    Psychiatry Res 157:289-93. 2008
    ..Poor verbal memory and executive function were associated with functional impairment, suggesting that functional disability may be restricted to a subgroup of cognitively impaired bipolar patients...
  28. pmc Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory task
    Liberty S Hamilton
    Laboratory of Neuro Imaging, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 7334, USA
    Hum Brain Mapp 30:3958-69. 2009
    ..Both patient groups showed some regional task-related hypoactivation compared to controls across the brain. Within DLPFC specifically, patients with schizophrenia exhibited more severe WM-related dysfunction than bipolar subjects...
  29. pmc Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
    ..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases...
  30. pmc A prospective, naturalistic, blinded study of early neurobehavioral outcomes for infants following prenatal antidepressant exposure
    Rita Suri
    Department of Psychiatry, UCLA Mood Disorders Research Program, 300 Medical Plaza, Ste 1544, Los Angeles, CA 90095, USA
    J Clin Psychiatry 72:1002-7. 2011
    ..This study examined the potential effects of antidepressant exposure in pregnancy on early infant neurobehavioral outcomes...
  31. pmc In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Schizophr Res 113:322-31. 2009
    ..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one...
  32. doi request reprint Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder
    Lori L Altshuler
    VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Bipolar Disord 12:541-9. 2010
    ..Specifically, it is not known whether differences in the density and/or volume of neurons or glial cells contribute to tissue volume changes seen on magnetic resonance images...
  33. pmc Cross-diagnostic comparison of duration mismatch negativity and P3a in bipolar disorder and schizophrenia
    Carol Jahshan
    Mental Illness Research, Education, and Clinical Center MIRECC, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Bipolar Disord 14:239-48. 2012
    ..Furthermore, MMN and P3a have not been examined between diagnostic subgroups of patients with bipolar disorder. We evaluated MMN and P3a in patients with bipolar disorder compared to patients with schizophrenia and healthy controls...
  34. doi request reprint Emotion processing and regulation in bipolar disorder: a review
    Jennifer Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7057, USA
    Bipolar Disord 14:326-39. 2012
    ..The purpose of this paper is to review the current functional magnetic resonance imaging (fMRI) literature on adult patients with BP using emotion processing or regulation paradigms...
  35. ncbi request reprint Acceleration and augmentation strategies for treating bipolar depression
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 53:691-700. 2003
    ..This review will define three types of common combination strategies--adjunctive, acceleration and augmentation--and discuss the limited literature of controlled studies reported on acceleration and augmentation approaches...
  36. pmc Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors
    Michael Gitlin
    Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Psychiatry Neurosci 29:383-6. 2004
    ..To examine the relation between baseline measurements of thyroid function and response to selective serotonin reuptake inhibitors (SSRIs) and to consider the effect of these antidepressants on thyroid hormone levels...
  37. pmc DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects
    Carinna M Torgerson
    Laboratory of Neuro Imaging LONI, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles E Young Dr S, Los Angeles, CA 90095, USA
    Brain Imaging Behav 7:129-39. 2013
    ..There were no significant differences between groups in WM tract FA for those tracts that began and ended in the brain. The significance of differences in tract length and fiber density in BD is discussed...
  38. pmc Differences in resting corticolimbic functional connectivity in bipolar I euthymia
    Salvatore Torrisi
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior Center for Cognitive Neuroscience, University of California at Los Angeles, CA 90095, USA
    Bipolar Disord 15:156-66. 2013
    ..We examined resting state functional connectivity in the brain between key emotion regulation regions in bipolar I disorder to delineate differences in coupling from healthy subjects...
  39. pmc Premenopausal hysterectomy is associated with increased brain ferritin iron
    Todd A Tishler
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 33:1950-8. 2012
    ..It is possible that brain iron can be influenced by peripheral iron levels and may thus be a modifiable risk factor for age-related degenerative diseases...
  40. pmc Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania
    Lara C Foland
    Laboratory of Neuroimaging, Department of Neurology, University of California, Los Angeles, CA, USA
    Psychiatry Res 162:27-37. 2008
    ..These findings, taken in context with previous fMRI studies of bipolar mania, suggest that reductions in inhibitory frontal activity in these patients may lead to an increased reactivity of the amygdala...
  41. doi request reprint Preliminary evidence of within-subject changes in gray matter density associated with remission of bipolar depression
    John O Brooks
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA
    Psychiatry Res 193:53-5. 2011
    ..Decreases were observed in superior and inferior frontal gyri and anterior cingulate...
  42. ncbi request reprint Unmet needs in bipolar depression
    Mark A Frye
    UCLA Bipolar Disorder Research Program, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Depress Anxiety 19:199-208. 2004
    ....
  43. ncbi request reprint Neurocognitive function in clinically stable men with bipolar I disorder or schizophrenia and normal control subjects
    Lori L Altshuler
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:560-9. 2004
    ..The degree and pattern of impairment between psychiatric groups have rarely been compared, especially when subjects are psychiatrically stable...
  44. doi request reprint Lamotrigine in psychiatric disorders
    Jennifer G Reid
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Clin Psychiatry 74:675-84. 2013
    ..The authors review the available literature on the FDA-approved and non-FDA-approved uses of lamotrigine in adults with psychiatric disorders...
  45. ncbi request reprint Depression in women with polycystic ovary syndrome: clinical and biochemical correlates
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Mood Disorders Research Program, 300 Medical Plaza, Suite 1544, Los Angeles, CA 90095 7057, USA
    J Affect Disord 74:299-304. 2003
    ..We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS)...
  46. ncbi request reprint Free T4 index and clinical outcome in patients with depression
    Osama Abulseoud
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Affect Disord 100:271-7. 2007
    ..This study evaluated baseline thyroid function and its relationship to rapidity of treatment response as measured by hospital length of stay (HLOS)...
  47. doi request reprint The Pregnancy Depression Scale (PDS): a screening tool for depression in pregnancy
    Lori L Altshuler
    Mood Disorders Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, PO Box 957057, Los Angeles, CA 90095 7057, USA
    Arch Womens Ment Health 11:277-85. 2008
    ..We present a well-validated, brief scale to screen pregnant women for clinical depression. Whether this study will generalize to women who do not have a history of major depression remains to be studied...
  48. ncbi request reprint Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study
    Lori L Altshuler
    Department of Psychiatry, Los Angeles, California, USA
    Biol Psychiatry 58:763-9. 2005
    ..Specifically, we sought to evaluate activation in the lateral orbitofrontal cortex, a brain region that is normally activated during activities that require response inhibition...
  49. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  50. ncbi request reprint Weight gain in breastfed infants of mothers taking antidepressant medications
    Victoria Hendrick
    Department of Psychiatry and Behavioral Sciences, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, CA 90095, USA
    J Clin Psychiatry 64:410-2. 2003
    ..Little is known about the physical development of infants who are exposed to antidepressant medications through breast milk...
  51. ncbi request reprint Impact of axis II comorbidity on the course of bipolar illness in men: a retrospective chart review
    Joanne H Kay
    Greater Los Angeles VA Healthcare System, West Los Angeles VA Medical Center, Department of Psychiatry, Los Angeles, CA, USA
    Bipolar Disord 4:237-42. 2002
    ..The purpose of this study was to investigate whether the presence of comorbid personality disorder influences the course of bipolar illness...
  52. ncbi request reprint Atypical antipsychotics in the treatment of schizophrenia during pregnancy and the postpartum
    Deborah Yaeger
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA 90073, USA
    Am J Psychiatry 163:2064-70. 2006
  53. ncbi request reprint Treating acute mania
    Mark A Frye
    UCLA Bipolar Disorder Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, USA
    J Fam Pract . 2003
  54. ncbi request reprint Estimates of nursing infant daily dose of fluoxetine through breast milk
    Rita Suri
    UCLA Neuropsychiatric Institute and Hospital, Los Angeles, California 90095, USA
    Biol Psychiatry 52:446-51. 2002
    ..This study compared three methods of estimating the daily dose of fluoxetine to nursing infants and the relationship between these estimates and infant serum concentrations...
  55. ncbi request reprint Estrogen replacement therapy in the treatment of major depressive disorder in perimenopausal women
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, USA
    J Clin Psychiatry 63:45-8. 2002
    ..Fluctuating estrogen levels accompany the perimenopausal transition. Thus, estrogen replacement therapy (ERT) has been proposed as a potentially effective treatment for mood disorders occurring during perimenopause...
  56. ncbi request reprint Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:414-23. 2007
    ..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases...
  57. ncbi request reprint The use of SSRIs in depressive disorders specific to women
    Lori L Altshuler
    Department of Psychiatry, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, Calif, USA
    J Clin Psychiatry 63:3-8. 2002
  58. ncbi request reprint Early physical and sexual abuse associated with an adverse course of bipolar illness
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network and the Biological Psychiatry Branch, National Institute of Mental Health, Building 10, Room 3S 239, Bethesda, MD 20892 1272, USA
    Biol Psychiatry 51:288-97. 2002
    ..There is growing awareness of the association between physical and sexual abuse and subsequent development of psychopathology, but little is known, however, about their relationship to the longitudinal course of bipolar disorder...
  59. ncbi request reprint Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, Calif, USA
    J Clin Psychiatry 65:1057-63. 2004
    ..This study was conducted to evaluate comparative response rates to lithium and divalproex sodium in adolescent mania with and without this comorbidity...
  60. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  61. ncbi request reprint A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network
    Robert M Post
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:396-406. 2003
    ..This paper reviews new data on: (1) depression in bipolar illness, (2) switch rates on ADs and (3) risks of AD discontinuation that are pertinent to the ongoing discussion and recommendations...
  62. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  63. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  64. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  65. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  66. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  67. ncbi request reprint Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:611-6. 2005
    ..These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination...
  68. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  69. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  70. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  71. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  72. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  73. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  74. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  75. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  76. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  77. ncbi request reprint Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges
    Rosanne C State
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Am J Psychiatry 159:918-25. 2002
  78. ncbi request reprint Modal subcomponents of metabolic syndrome in patients with bipolar disorder
    Jeffrey Cardenas
    Department of Psychiatry, UCLA Mood Disorders Research Program, David Geffen School of Medicine at UCLA, Los Angeles, United States
    J Affect Disord 106:91-7. 2008
    ..The metabolic syndrome is a growing global public health problem...
  79. ncbi request reprint Olanzapine versus divalproex in the treatment of acute mania
    Mauricio Tohen
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Am J Psychiatry 159:1011-7. 2002
    ..The effects of olanzapine and divalproex for the treatment of mania were compared in a large randomized clinical trial...
  80. ncbi request reprint Tiagabine in treatment refractory bipolar disorder: a clinical case series
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Bipolar Disord 4:283-9. 2002
    ..We sought to evaluate the effectiveness of tiagabine added to ongoing medication regimens in patients with bipolar disorder inadequately responsive to or intolerant of usual treatments...
  81. ncbi request reprint Reintroduction of antidepressant therapy across pregnancy in women who previously discontinued treatment. A preliminary retrospective study
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Psychother Psychosom 73:255-8. 2004
    ..Pregnancy has frequently been described as a time of emotional well-being conferring 'protection' against psychiatric disorders. However, data to support this impression are sparse...
  82. ncbi request reprint Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest
    Cameron D Quanbeck
    Department of Psychiatry, Forensic Division, University of California Davis, 2230 Stockton Boulevard, Sacramento, CA 95817, USA
    J Clin Psychiatry 65:198-203. 2004
    ....
  83. ncbi request reprint New findings from the Bipolar Collaborative Network: clinical implications for therapeutics
    Robert M Post
    Penn State College of Medicine, Hershey, PA, USA
    Curr Psychiatry Rep 8:489-97. 2006
    ..Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss...
  84. ncbi request reprint Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  85. doi request reprint Incidence of childhood-onset bipolar illness in the USA and Europe
    Robert M Post
    Department of Psychiatry, George Washington University, Washington, DC, USA
    Br J Psychiatry 192:150-1. 2008
    ..In the USA there was also twice the incidence of childhood adversity and genetic/familial risk for affective disorder. The findings deserve replication and further exploration...
  86. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  87. ncbi request reprint Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 9:531-5. 2007
    ..To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder...
  88. ncbi request reprint The poor prognosis of childhood-onset bipolar disorder
    Gabriele S Leverich
    Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Pediatr 150:485-90. 2007
    ..We examined age of onset of bipolar disorder as a potential course-of-illness modifier with the hypothesis that early onset will engender more severe illness...
  89. pmc Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
    Schizophr Res 93:13-22. 2007
    ..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia...
  90. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  91. ncbi request reprint Estrogen and response to sertraline in postmenopausal women with major depressive disorder: a pilot study
    Natalie L Rasgon
    Stanford University School of Medicine, Department of Psychiatry and Behavioral Sciences, 410 Quarry Road, Room 2368, Palo Alto, CA 94305 5723, USA
    J Psychiatr Res 41:338-43. 2007
    ..Pilot study examining the effects of estrogen therapy (ET) on antidepressant response in postmenopausal women with major depressive disorder (MDD)...
  92. ncbi request reprint Relapse of major depression during pregnancy in women who maintain or discontinue antidepressant treatment
    Lee S Cohen
    Perinatal and Reproductive Psychiatry Clinical Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    JAMA 295:499-507. 2006
    ..However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary...
  93. ncbi request reprint Longitudinal evaluation of reproductive function in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, 401 Quarry Road, Palo Alto, Ca 94305 5723 Stanford, California, United States
    J Affect Disord 89:217-25. 2005
    ..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...
  94. ncbi request reprint The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
    J Clin Psychiatry 66:870-86. 2005
    ..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
  95. ncbi request reprint High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure
    Ralph W Kupka
    Altrecht Centre for Mental Health Care and University Medical Centre Utrecht, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands
    Biol Psychiatry 51:305-11. 2002
    ..We assessed the prevalence of thyroperoxidase antibodies (TPO-Abs) and thyroid failure in outpatients with bipolar disorder compared with two control groups...