M E Stern

Summary

Affiliation: Allergan Inc
Country: USA

Publications

  1. ncbi request reprint The role of the lacrimal functional unit in the pathophysiology of dry eye
    Michael E Stern
    Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Exp Eye Res 78:409-16. 2004
  2. pmc Dry eye as a mucosal autoimmune disease
    Michael E Stern
    Biological Sciences, Inflammation Research Program, Allergan Inc, Irvine, CA 92612, USA stern
    Int Rev Immunol 32:19-41. 2013
  3. doi request reprint Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease
    Michael E Stern
    Allergan, Inc, Biological Sciences, Inflammation Research Program, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 53:2062-75. 2012
  4. pmc Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    J Inflamm (Lond) 6:31. 2009
  5. pmc Autoimmunity at the ocular surface: pathogenesis and regulation
    M E Stern
    Biological Sciences, Inflammation Research Program, Allergan, Irvine, CA, USA
    Mucosal Immunol 3:425-42. 2010
  6. ncbi request reprint The pathology of dry eye: the interaction between the ocular surface and lacrimal glands
    M E Stern
    Department of Biological Sciences, Allergan, Inc, Irvine, CA 92713 9534, USA
    Cornea 17:584-9. 1998
  7. ncbi request reprint The Th1/Th2 paradigm in ocular allergy
    Michael E Stern
    Department of Biological Sciences, Allergan, Inc, Irvine, California, USA
    Curr Opin Allergy Clin Immunol 5:446-50. 2005
  8. ncbi request reprint The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy
    J Gao
    Department of Biological Science, Allergan, Inc, Irvine, California, USA
    Cornea 17:654-63. 1998
  9. ncbi request reprint Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye
    Michael E Stern
    llergan, Inc, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 43:2609-14. 2002
  10. ncbi request reprint Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs
    A A Acheampong
    Allergan, Irvine, CA 92715, USA
    Curr Eye Res 18:91-103. 1999

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The role of the lacrimal functional unit in the pathophysiology of dry eye
    Michael E Stern
    Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Exp Eye Res 78:409-16. 2004
    ..Factors such as neurogenic inflammation and T cell involvement in the disease pathogenesis as well as newly developed animal models of ocular surface inflammation are discussed...
  2. pmc Dry eye as a mucosal autoimmune disease
    Michael E Stern
    Biological Sciences, Inflammation Research Program, Allergan Inc, Irvine, CA 92612, USA stern
    Int Rev Immunol 32:19-41. 2013
    ..The data support the hypothesis that dry eye is a localized autoimmune disease originating from an imbalance in the protective immunoregulatory and proinflammatory pathways of the ocular surface...
  3. doi request reprint Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease
    Michael E Stern
    Allergan, Inc, Biological Sciences, Inflammation Research Program, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 53:2062-75. 2012
    ..The purpose of this study was to determine if autoantibodies play a role in the immunopathogenesis of experimental dry eye disease...
  4. pmc Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA
    J Inflamm (Lond) 6:31. 2009
    ..Soluble IL-2Ralpha (CD25) has been reported as an inflammatory marker. We evaluated the expression of CD25 and CD122 in the ocular surface epithelium and investigated the mechanism of proteolytic cleavage of CD25 from these cells...
  5. pmc Autoimmunity at the ocular surface: pathogenesis and regulation
    M E Stern
    Biological Sciences, Inflammation Research Program, Allergan, Irvine, CA, USA
    Mucosal Immunol 3:425-42. 2010
    ....
  6. ncbi request reprint The pathology of dry eye: the interaction between the ocular surface and lacrimal glands
    M E Stern
    Department of Biological Sciences, Allergan, Inc, Irvine, CA 92713 9534, USA
    Cornea 17:584-9. 1998
    ....
  7. ncbi request reprint The Th1/Th2 paradigm in ocular allergy
    Michael E Stern
    Department of Biological Sciences, Allergan, Inc, Irvine, California, USA
    Curr Opin Allergy Clin Immunol 5:446-50. 2005
    ..The objective of this article is to highlight the importance of understanding the exact mechanisms of Th1 and Th2 cells in the pathology of ocular allergy...
  8. ncbi request reprint The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy
    J Gao
    Department of Biological Science, Allergan, Inc, Irvine, California, USA
    Cornea 17:654-63. 1998
    ..The therapeutic effect of immunomodulatory agents such as cyclosporin A (CsA) in the treatment of dry eye, particularly its impact on the level of apoptosis in the target tissues, is also investigated...
  9. ncbi request reprint Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye
    Michael E Stern
    llergan, Inc, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 43:2609-14. 2002
    ..To examine the conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca (SS-KCS) and non-Sjögren's keratoconjunctivitis sicca (NS-KCS) for evidence of immune-based inflammation...
  10. ncbi request reprint Distribution of cyclosporin A in ocular tissues after topical administration to albino rabbits and beagle dogs
    A A Acheampong
    Allergan, Irvine, CA 92715, USA
    Curr Eye Res 18:91-103. 1999
    ..To determine the ocular pharmacokinetics of cyclosporin A after topical ophthalmic administration...
  11. ncbi request reprint Role of interferon-gamma in a mouse model of allergic conjunctivitis
    Michael E Stern
    Allergan, Irvine, CA, USA
    Invest Ophthalmol Vis Sci 46:3239-46. 2005
    ..To characterize the effect of repeated topical exposure to allergen in a mouse model of allergic conjunctivitis and to determine the role of interferon-gamma (IFN-gamma) in the pathogenesis of allergic conjunctivitis...
  12. doi request reprint In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation
    Karyn F Siemasko
    Allergan, Inc, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 49:5434-40. 2008
    ..To determine whether in vitro expanded CD4(+)CD25(+)Foxp3(+) regulatory T cells can suppress immune-mediated ocular surface inflammation in a mouse model of dry eye...
  13. ncbi request reprint ICAM-1 expression predisposes ocular tissues to immune-based inflammation in dry eye patients and Sjögrens syndrome-like MRL/lpr mice
    Jianping Gao
    Department of Biological Sciences, Allergan, 2525 Dupont Drive, Irvine, CA 92612, USA
    Exp Eye Res 78:823-35. 2004
    ....
  14. ncbi request reprint ICAM-1: its role in the pathophysiology of immune activation in the MRL/LPR mouse
    Jianping Gao
    Department of Biological Science, Allergan, Irvine, California, USA
    Adv Exp Med Biol 506:777-81. 2002
  15. ncbi request reprint Expression of muscarinic and adrenergic receptors in normal human conjunctival epithelium
    Amalia Enríquez de Salamanca
    Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid E 47005, Spain
    Invest Ophthalmol Vis Sci 46:504-13. 2005
    ..To study the presence of muscarinic and alpha- and beta-adrenergic receptors in a normal human conjunctival epithelial (IOBA-NHC) cell line...
  16. ncbi request reprint Future directions in therapeutic interventions for conjunctival inflammatory disorders
    Stephen C Pflugfelder
    Ocular Surface Center, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Allergy Clin Immunol 7:450-3. 2007
    ..To review recent advances in pathogenesis and treatment of conjunctival inflammatory disorders...
  17. pmc Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice
    Kyung Chul Yoon
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    J Autoimmun 30:212-21. 2008
    ..These findings indicate that desiccating environmental stress aggravates Sjögren's syndrome-like lacrimal keratoconjunctivitis in the NOD mouse which has defective immunoregulation...
  18. ncbi request reprint Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress
    Rosa M Corrales
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Cornea 26:579-84. 2007
    ..To evaluate the effects of desiccating ocular surface stress on levels of inflammatory cytokines in the corneal epithelium, conjunctiva, and tear fluid of BALB/c and C57BL/6 mice...
  19. ncbi request reprint Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 48:2553-60. 2007
    ..To investigate the role of interferon (IFN)-gamma in the pathogenesis of conjunctival squamous metaplasia in dry eye...
  20. ncbi request reprint Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium
    Rosa M Corrales
    Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 47:3293-302. 2006
    ..To determine the effects of experimental dryness on production of matrix metalloproteinases (MMPs) and their physiological inhibitors (TIMPs) by the corneal epithelium...
  21. ncbi request reprint Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline
    Cintia S de Paiva
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Invest Ophthalmol Vis Sci 47:2847-56. 2006
    ..To evaluate the mechanism of apical corneal epithelial barrier disruption in response to experimental ocular surface desiccation and the effects of two anti-inflammatory agents (methylprednisolone and doxycycline) on this process...
  22. doi request reprint Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production
    Stephen C Pflugfelder
    Ocular Surface Center, Baylor College of Medicine, Houston, TX, USA
    Cornea 27:64-9. 2008
    ..To evaluate the effects of sequential treatment with artificial tears and cyclosporine emulsion on conjunctival goblet cell density and production of transforming growth factor (TGF)-beta2 in patients with dry eye disease...
  23. ncbi request reprint Altered expression of neurotransmitter receptors and neuromediators in vernal keratoconjunctivitis
    Laura Motterle
    Department of Neuroscience, Ophthalmology Unit, University of Padova, Padova, Italy
    Arch Ophthalmol 124:462-8. 2006
    ..There is growing evidence that autonomic innervation is involved in the pathogenesis of mucus hypersecretion, goblet cell hyperplasia, and conjunctival hyperreactivity...
  24. ncbi request reprint Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis
    Jerry Y Niederkorn
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 176:3950-7. 2006
    ....
  25. ncbi request reprint Characterization of a spontaneously immortalized cell line (IOBA-NHC) from normal human conjunctiva
    Yolanda Diebold
    University Institute of Applied Ophthalmobiology, University of Valladolid, Valladolid, Spain
    Invest Ophthalmol Vis Sci 44:4263-74. 2003
    ....
  26. ncbi request reprint A mouse model of keratoconjunctivitis sicca
    Dilek Dursun
    Ocular Surface and Tear Center, Bascom Palmer Eye Institute, Miami, Florida, USA
    Invest Ophthalmol Vis Sci 43:632-8. 2002
    ....
  27. ncbi request reprint Apoptosis of ocular surface cells in experimentally induced dry eye
    Steven Yeh
    Department of Ophthalmology, Ocular Surface Center, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Invest Ophthalmol Vis Sci 44:124-9. 2003
    ..To evaluate to effect of experimental dry eye on ocular surface apoptosis...
  28. ncbi request reprint Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca
    Bradley Strong
    Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cornea 24:80-5. 2005
    ..The purpose of this study is to determine if topical CsA treatment inhibits conjunctival epithelial apoptosis in a murine model of KCS...
  29. ncbi request reprint Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo
    Grazyna Galatowicz
    Institute of Ophthalmology, UCL, London, UK
    Clin Exp Allergy 37:1648-56. 2007
    ..Several new anti-allergic eye drops stabilize MCs and block histamine receptors, but their anti-inflammatory effects are unclear...
  30. ncbi request reprint Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye
    María J González-García
    Ocular Surface Group, Institute of Applied Ophthalmo Biology IOBA, University of Valladolid, Valladolid, Spain
    Invest Ophthalmol Vis Sci 48:4026-32. 2007
    ..Adverse environmental conditions elicit dry eye (DE)-related signs and symptoms. The purpose of this work is to determine whether these conditions can alter a normal-to-borderline ocular surface in subjects with DE symptoms...
  31. ncbi request reprint Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye
    Cintia S de Paiva
    Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, 6565 Fannin Street, NC 205, Houston, TX 77030, USA
    Exp Eye Res 83:526-35. 2006
    ..Both corticosteroid and doxycycline suppressed this molecular stress response...
  32. ncbi request reprint Immunology of the lacrimal gland and ocular tear film
    Manfred Zierhut
    Department of Ophthalmology, University of Tubingen, D 72076 Tubingen, Germany
    Trends Immunol 23:333-5. 2002
  33. ncbi request reprint Changing trends in the definition and diagnosis of dry eyes
    Murat Dogru
    Am J Ophthalmol 140:507-8. 2005
  34. ncbi request reprint Dry eye--is this a disease or a natural consequence of aging?
    Michael E Stern
    Arch Soc Esp Oftalmol 80:125-31. 2005
  35. ncbi request reprint Animal models of ocular allergy and their clinical correlations
    Margarita Calonge
    Facultad de Medicina, Instituto Universitario de Oftalmobiologia Aplicada, Ramón y Cajal 7, Valladolid E 47005, Spain
    Curr Allergy Asthma Rep 3:345-51. 2003
    ..Most recent experimental models are demonstrating that inhibiting Th2 cells and their secreted cytokines might be one important therapeutic target for inhibiting chronic allergic inflammation in the ocular surface...
  36. ncbi request reprint Alpha2-adrenergic receptors are present in normal human conjunctiva
    Yolanda Diebold
    IOBA, University of Valladolid, Valladolid, Spain
    Curr Eye Res 30:1121-9. 2005
    ..This study describes the presence of alpha2-adrenergic receptors in normal human conjunctiva...