Allergan Inc

Summary

Organization: Allergan Inc
Country: USA

Top Publications

  1. ncbi Glutathione modulation and oxidative stress in human liver slices
    Alison E M Vickers
    Preclinical Safety Sciences, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Curr Drug Discov Technol 7:154-69. 2010
  2. ncbi Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa
    Abhiram S Vilupuru
    College of Optometry, University of Houston, TX 77204 2020, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1417-25. 2007
  3. ncbi Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison
    Grantley D Charles
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Appl Pharmacol 218:280-8. 2007
  4. ncbi Using translational medicine to understand clinical differences between botulinum toxin formulations
    K R Aoki
    Department of Biological Sciences, Neurotoxin Research Program, Allergan Inc, Irvine, CA 92612 1599, USA
    Eur J Neurol 13:10-9. 2006
  5. ncbi The prevention of colitis by E Prostanoid receptor 4 agonist through enhancement of epithelium survival and regeneration
    Guang Liang Jiang
    Department of Biological Sciences, Herbert Research Center, Allergan, Inc, 2525 Dupont Dr, R and D3 2B, Irvine, CA 92612, USA
    J Pharmacol Exp Ther 320:22-8. 2007
  6. ncbi Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices
    A E M Vickers
    Novartis Pharmaceuticals Corporation, One Health Plaza, E Hanover, NJ 07936, United States
    Toxicol In Vitro 20:1173-82. 2006
  7. ncbi Bimatoprost: mechanism of ocular surface hyperemia associated with topical therapy
    June Chen
    Department of Biological Sciences RD3, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Cardiovasc Drug Rev 23:231-46. 2005
  8. ncbi Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates
    Radouil Tzekov
    Biological Sciences, RD2 2C Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Doc Ophthalmol 110:111-20. 2005
  9. ncbi Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2
    Wu Yang
    Department of Pharmacokinetics and Drug Metabolism, Allergan, Inc, Irvine, CA 92623, USA
    J Lipid Res 46:2745-51. 2005
  10. ncbi Disposition and biotransformation of the acetylenic retinoid tazarotene in humans
    Mayssa Attar
    Allergan Inc, Department of Pharmacokinetics and Drug Metabolism, Irvine, California, USA
    J Pharm Sci 94:2246-55. 2005

Detail Information

Publications62

  1. ncbi Glutathione modulation and oxidative stress in human liver slices
    Alison E M Vickers
    Preclinical Safety Sciences, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Curr Drug Discov Technol 7:154-69. 2010
    ..In summary, MMI induces oxidative stress at high concentrations, which can be augmented when liver GSH levels are decreased by the co-administration of some drugs or health status...
  2. ncbi Adaptive optics scanning laser ophthalmoscopy for in vivo imaging of lamina cribrosa
    Abhiram S Vilupuru
    College of Optometry, University of Houston, TX 77204 2020, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1417-25. 2007
    ..The AOSLO provides high-quality images of the lamina cribrosa and may have potential as a tool for early identification of glaucoma...
  3. ncbi Analysis of the interaction of phytoestrogens and synthetic chemicals: an in vitro/in vivo comparison
    Grantley D Charles
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Appl Pharmacol 218:280-8. 2007
    ..However, these data suggest that extrapolation from in vitro assays to in vivo mixture effects should be approached with caution...
  4. ncbi Using translational medicine to understand clinical differences between botulinum toxin formulations
    K R Aoki
    Department of Biological Sciences, Neurotoxin Research Program, Allergan Inc, Irvine, CA 92612 1599, USA
    Eur J Neurol 13:10-9. 2006
    ....
  5. ncbi The prevention of colitis by E Prostanoid receptor 4 agonist through enhancement of epithelium survival and regeneration
    Guang Liang Jiang
    Department of Biological Sciences, Herbert Research Center, Allergan, Inc, 2525 Dupont Dr, R and D3 2B, Irvine, CA 92612, USA
    J Pharmacol Exp Ther 320:22-8. 2007
    ..AGN205203 may be unique among known EP4 agonists for its metabolic and chemical stability, and it is amenable to systemic applications for the prevention and recovery of IBD...
  6. ncbi Consequences of mitochondrial injury induced by pharmaceutical fatty acid oxidation inhibitors is characterized in human and rat liver slices
    A E M Vickers
    Novartis Pharmaceuticals Corporation, One Health Plaza, E Hanover, NJ 07936, United States
    Toxicol In Vitro 20:1173-82. 2006
    ..In summary, human and rat liver slices exhibited similar effects to the inhibitors of mitochondrial beta-oxidation, and the mitochondrial injury is associated with apoptosis and inflammation in the liver slices...
  7. ncbi Bimatoprost: mechanism of ocular surface hyperemia associated with topical therapy
    June Chen
    Department of Biological Sciences RD3, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Cardiovasc Drug Rev 23:231-46. 2005
    ..These studies suggest that conjunctival hyperemia, a side effect of bimatoprost treatment, results from non-inflammatory, pharmacologically based vasodilatation...
  8. ncbi Ocular toxicity due to chloroquine and hydroxychloroquine: electrophysiological and visual function correlates
    Radouil Tzekov
    Biological Sciences, RD2 2C Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Doc Ophthalmol 110:111-20. 2005
    ..A summary and comment on the tests, with emphasis on the use of more recently developed methods, such as the multifocal electroretinography (mfERG), are presented in this review...
  9. ncbi Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2
    Wu Yang
    Department of Pharmacokinetics and Drug Metabolism, Allergan, Inc, Irvine, CA 92623, USA
    J Lipid Res 46:2745-51. 2005
    ..This endoperoxide ethanolamide intermediate has been proposed as prostamide H2...
  10. ncbi Disposition and biotransformation of the acetylenic retinoid tazarotene in humans
    Mayssa Attar
    Allergan Inc, Department of Pharmacokinetics and Drug Metabolism, Irvine, California, USA
    J Pharm Sci 94:2246-55. 2005
    ..A smaller fraction of tazarotenic acid was further metabolized to an inactive sulfoxide that was excreted in the urine...
  11. ncbi Time-course of experimental choroidal neovascularization in Dutch-Belted rabbit: clinical and histological evaluation
    Ming Ni
    Department of Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612 1599, USA
    Exp Eye Res 81:286-97. 2005
    ..Furthermore, the inhibition observed with dexamethasone points to the possibility of being able to evaluate effective means of pharmacological intervention...
  12. ncbi Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A
    K R Aoki
    Department of Biological Sciences RD 2C, Allergan, Inc, Irvine, CA 92623, USA
    Neurotoxicology 26:785-93. 2005
    ..Through this mechanism, BOTOX inhibits peripheral sensitization in these models, which leads to an indirect reduction in central sensitization...
  13. ncbi Characterization of active ion transport across primary rabbit corneal epithelial cell layers (RCrECL) cultured at an air-interface
    Joan En Chang-Lin
    Departments of Pharmaceutical Sciences, Schools of Pharmacy, Medicine, and Engineering, University of Southern California, Los Angeles, CA, USA
    Exp Eye Res 80:827-36. 2005
    ..This primary culture system may be a reliable in-vitro model for mechanistic characterization of corneal epithelial function and regulation of transport properties...
  14. ncbi Regional difference in P-glycoprotein function in rat intestine
    Aiko Iida
    Department of Drug Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Drug Metab Pharmacokinet 20:100-6. 2005
    ..In particular, the inhibition of P-gp results in an increase in absorption of the P-gp substrate limited to jejunum and ileum...
  15. ncbi Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques
    J Ni
    Department of Drug Safety Evaluation, Allergan, 2525 Dupont Dr, Irvine, CA 92612, USA
    Xenobiotica 37:205-20. 2007
    ..In conclusion, on-line H/D exchange LC-MS/MS and stable-isotope tracer techniques are useful for the characterization of brimonidine metabolites...
  16. pmc Prostamides (prostaglandin-ethanolamides) and their pharmacology
    D F Woodward
    Department of Biological Sciences, Allergan Inc, Irvine, CA 92612, USA
    Br J Pharmacol 153:410-9. 2008
    ..From the therapeutics standpoint, the prostamide F(2alpha) analogue bimatoprost is the most efficacious ocular hypotensive agent currently available for the treatment of glaucoma...
  17. ncbi Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats
    Jyotirmoy Kusari
    Department of Biological Sciences, Allergan Inc, Irvine, CA 92623 9534, USA
    Invest Ophthalmol Vis Sci 48:5152-9. 2007
    ..To test whether chronic memantine (MEM) treatment improves retinal function and prevents neurodegeneration and vascular changes in the retinas of streptozotocin (STZ)-induced diabetic rats...
  18. doi Comparison of prostaglandin E2 receptor subtype 4 agonist and sulfasalazine in mouse colitis prevention and treatment
    Guang Liang Jiang
    Research and Development, Allergan Pharmaceuticals, Inc, 2525 Dupont Dr, Irvine, California 92612
    J Pharmacol Exp Ther 335:546-52. 2010
    ....
  19. doi Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues
    Alison E M Vickers
    Drug Safety Evaluation, Allergan, 2525 Dupont Dr, Irvine, CA 92612, USA
    Toxicol Appl Pharmacol 244:354-65. 2010
    ..In summary, MMI exposure led to an oxidative stress response in blood cells, and an up-regulation of liver genes involved with oxidative stress and heme homeostasis, which was clearly separate and preceded frank hemolysis...
  20. doi Developing and executing a strategic plan
    Glenn Morley
    Allergan Medical, Inc, Irvine, California, USA
    Facial Plast Surg 26:7-11. 2010
    ..Today's needs, and yesterday's lessons, dictate that a well-documented strategic action plan be undertaken...
  21. doi Safety and tolerability of onabotulinumtoxinA in the treatment of facial lines: a meta-analysis of individual patient data from global clinical registration studies in 1678 participants
    Mitchell F Brin
    Allergan, Irvine, California, USA
    J Am Acad Dermatol 61:961-70.e1-11. 2009
    ....
  22. doi Inhibition of vitreoretinal VEGF elevation and blood-retinal barrier breakdown in streptozotocin-induced diabetic rats by brimonidine
    Jyotirmoy Kusari
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612 1599, USA
    Invest Ophthalmol Vis Sci 51:1044-51. 2010
    ....
  23. doi Bimatoprost-induced calcium signaling in human T-cells does not involve prostanoid FP or TP receptors
    June Chen
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Curr Eye Res 34:184-95. 2009
    ..The presence of both prostamide and prostanoid FP receptors in bimatoprost-sensitive preparations has made prostamide receptor classification difficult. This study investigated a novel bimatoprost-sensitive preparation...
  24. doi Characterization of hepatic mitochondrial injury induced by fatty acid oxidation inhibitors
    Alison E M Vickers
    Drug Safety Evaluation, Allergan, Inc, Irvine, California, USA
    Toxicol Pathol 37:78-88. 2009
    ..In summary, metabonomics and liver gene expression provided mechanistic information on mitochondrial dysfunction and impaired fatty acid oxidation to further define the clinical pathology and histopathology findings of hepatotoxicity...
  25. doi Tissue slices for the evaluation of metabolism-based toxicity with the example of diclofenac
    Alison E M Vickers
    Allergan, Inc, Irvine, CA 92612, USA
    Chem Biol Interact 179:9-16. 2009
    ....
  26. ncbi [First results of clinical studies on botulinum toxin A in migraine and headache]
    U Tiesler
    Pharm Allergan GmbH, Ettlingen
    Nervenarzt 79:44-6. 2008
    ..Important was also the recognition that repeat treatments with BoNT-A at dosages of up to 260 U were safe and showed no difficult side effects. Phase III clinical studies are already being conducted...
  27. doi Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity
    Cun Jian Dong
    Department of Biological Sciences, Allergan Pharmaceuticals, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 49:4515-22. 2008
    ..In this study, the authors investigated the neural mechanism that may underlie alpha2 neuroprotection of RGCs...
  28. doi Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa
    Hui Ouyang
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 98:349-61. 2009
    ..Furthermore, efflux transporters (e.g., P-gp), not metabolic enzymes (e.g., CYP 3A, esterases), restrict the permeation of peptide prodrugs across the rat intestinal mucosa...
  29. doi The science of hyaluronic acid dermal fillers
    Ahmet Tezel
    University of California Santa Barbara, Santa Barbara, California, USA
    J Cosmet Laser Ther 10:35-42. 2008
    ..This article explains the basic science of HA and describes how the physical properties of HA dermal fillers may influence clinical outcomes...
  30. doi Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells
    Suofu Qin
    Retinal Disease Research, Department of Biological Sciences, Allergan, Inc, Irvine, California 92612 1599, USA
    Invest Ophthalmol Vis Sci 49:1274-81. 2008
    ..The role of AMPK in retinal pigment epithelial cell inflammatory response is addressed using AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR)...
  31. ncbi Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye
    Diane D S Tang-Liu
    Department of Pharmacokinetics and Drug Metabolism, Allergan Inc, Irvine, California 92612, USA
    Clin Pharmacokinet 44:247-61. 2005
    ..05% ciclosporin ophthalmic emulsion a promising treatment for KCS...
  32. pmc Studies using isolated uterine and other preparations show bimatoprost and prostanoid FP agonists have different activity profiles
    June Chen
    Department of Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Br J Pharmacol 144:493-501. 2005
    ..The potent contractile effects of bimatoprost in the rabbit uterus provide further pharmacological evidence for the presence of a novel receptor population that preferentially recognises bimatoprost...
  33. ncbi GABAc feedback pathway modulates the amplitude and kinetics of ERG b-wave in a mammalian retina in vivo
    Cun Jian Dong
    Department of Biological Sciences, Allergan Pharmaceuticals, RD 2C Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Vision Res 42:1081-7. 2002
    ..Our results also provide functional evidence that the feedback may be involved in temporal processing in the mammalian retina...
  34. ncbi Botulinum toxin type A and other botulinum toxin serotypes: a comparative review of biochemical and pharmacological actions
    K R Aoki
    Allergan, Inc, Irvine, CA 92715, USA
    Eur J Neurol 8:21-9. 2001
    ..As demonstrated in preclinical and clinical studies, these differences result in a unique combination of efficacy, duration of action, safety, and antigenic potential for each botulinum neurotoxin preparation...
  35. ncbi Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension
    E WoldeMussie
    Department of Biological Sciences, Allergan Inc, Irvine, California 92612 1599, USA
    Invest Ophthalmol Vis Sci 42:2849-55. 2001
    ..To examine the neuroprotective effect of the alpha(2)-adrenergic agonist brimonidine in a chronic ocular hypertension model...
  36. ncbi A comparison of simplified lansoprazole suspension administered nasogastrically and pantoprazole administered intravenously: effects on 24-h intragastric pH
    J J Täubel
    Charterhouse Clinical Research Unit, London, UK
    Aliment Pharmacol Ther 15:1807-17. 2001
    ..To compare the 24-h intragastric pH effects of simplified lansoprazole suspension, 30 mg, administered nasogastrically, with pantoprazole, 40 mg, administered intravenously...
  37. ncbi The influence of gender and the estrous cycle on learned helplessness in the rat
    J A Jenkins
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, USA
    Biol Psychol 58:147-58. 2001
    ..Male rat escape latencies were intermediate between the two female phases. These results suggest a role for gonadal hormones in the development of stress-induced behavioral depression or 'learned helplessness.'..
  38. ncbi A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice
    K R Aoki
    Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92715, USA
    Toxicon 39:1815-20. 2001
    ..8+/-1.1, respectively). Thus, the BTX preparations exhibited different safety margins in mice. These results support the hypothesis that the preparations are unique therapeutics and are not interchangeable based on a simple dose ratio...
  39. ncbi Alpha-2 adrenergic receptor agonists are neuroprotective in experimental models of glaucoma
    L A Wheeler
    Department of Biological Sciences, Allergan, Inc, Irvine, California 92612, USA
    Eur J Ophthalmol 11:S30-5. 2001
    ..Immunohistochemistry data have shown that the specific receptor targets, the alpha-2 receptors, are located in the inner retina...
  40. ncbi Exploring the potential for subtype-selective muscarinic agonists in glaucoma
    D Gil
    Department of Biological Sciences, Allergan, Inc, Irvine, CA 92612, USA
    Life Sci 68:2601-4. 2001
    ..This compound lowered IOP suggesting that muscarinic agonists targeted at muscarinic receptors other than the M3 subtype may be able to selectively lower IOP...
  41. ncbi Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey
    W Hare
    Department of Biological Sciences, Allergan, Inc, Irvine, CA 92612, USA
    Surv Ophthalmol 45:S284-9; discussion S295-6. 2001
    ....
  42. ncbi Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel
    J Sefton
    Allergan, Inc, Irvine, and the Department of Dermatology, University of Pennsylvania College of Medicine, Philadelphia, Pennsylvania, USA
    J Am Acad Dermatol 43:656-63. 2000
    ..Tazarotene, a potent acetylenic retinoid for topical use, might be expected to benefit photodamaged skin, including improving the classical signs of fine wrinkles, mottled hyperpigmentation, and roughness...
  43. ncbi Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions
    E S Klein
    Retinoid Research, Departments of Biology and Chemistry, Allergan Pharmaceuticals, Irvine, California 92715, USA
    J Biol Chem 275:19401-8. 2000
    ..In addition, using this recruitment assay, we show that SRC-1 and the related coactivator molecule ACTR associate with the ternary complex via utilization of different helical motifs within their conserved receptor interaction domains...
  44. ncbi Synthesis and biological activity of high-affinity retinoic acid receptor antagonists
    A T Johnson
    Department of Chemistry, Allergan Inc, Irvine, CA 92623 9534, USA
    Bioorg Med Chem 7:1321-38. 1999
    ..The use of binding, transcriptional, and in vivo assays revealed that the 2,2-dimethylthiochromene analogue 59, and the 2,2-dimethylchromene derivative 85, were the most effective in blocking retinoid agonist induced activity...
  45. ncbi Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor
    S Nagpal
    Retinoid Research, Allergan Inc, Irvine, California 92713, USA
    J Biol Chem 274:22563-8. 1999
    ....
  46. ncbi Botulinum neurotoxin serotypes A and B preparations have different safety margins in preclinical models of muscle weakening efficacy and systemic safety
    K Roger Aoki
    Allergan Incorporated, 2525 Dupont Drive, Irvine, CA 92715, USA
    Toxicon 40:923-8. 2002
    ..The in vivo differences found are consistent with the different clinical profiles reported for these two products...
  47. ncbi Vascular activities of prostaglandins and selective prostanoid receptor agonists in human retinal microvessels
    Clayton S Spada
    Department of Biological Sciences, Pharmaceutical Research and Development, Allergan, Inc Irvine, CA 92612 1599, USA
    Exp Eye Res 75:155-63. 2002
    ..No significant changes in human retinal arteriolar diameters relative to baseline were observed in response to a broad panel of parent and derived compounds known to be selective for EP-, FP- and IP-prostanoid receptors...
  48. ncbi Synthesis and biological activity of retinoic acid receptor-alpha specific amides
    Richard L Beard
    Retinoid Research, Department of Chemistry, Allergan Inc, Irvine, CA 92623 9534, USA
    Bioorg Med Chem Lett 12:3145-8. 2002
    ....
  49. ncbi Corticosteroids inhibit VEGF-induced vascular leakage in a rabbit model of blood-retinal and blood-aqueous barrier breakdown
    Jeffrey L Edelman
    Department of Biological Sciences, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Exp Eye Res 80:249-58. 2005
    ..To test this hypothesis directly, the current study evaluated the effects of TAA and dexamethasone (DEX) in a newly developed rabbit model of VEGF-induced blood-retinal barrier and blood-aqueous (iris) barrier breakdown...
  50. ncbi Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues
    Yanbin Liang
    Department of Biological Science, Allergan, Inc, Irvine, CA 92612, USA
    FEBS J 272:791-9. 2005
    ..The unique expression pattern, cellular localization and functions of RGS5s suggest that RGS5s may play a critical role in the regulation of intracellular signaling pathways...
  51. ncbi Kidney slices of human and rat to characterize cisplatin-induced injury on cellular pathways and morphology
    Alison E M Vickers
    Preclinical Safety, Novartis Pharmaceuticals Corporation, One Health Plaza, E Hanover, New Jersey 07936, USA
    Toxicol Pathol 32:577-90. 2004
    ..In this study, cisplatin-induced nephrotoxicity was demonstrated morphologically in rat and human kidney slices, and the associated gene expression and functional changes characterized the cellular pathways involved...
  52. ncbi Organ slice viability extended for pathway characterization: an in vitro model to investigate fibrosis
    Alison E M Vickers
    Novartis Pharmaceuticals Corporation, One Health Plaza, E Hanover, New Jersey 07936, USA
    Toxicol Sci 82:534-44. 2004
    ..The improvements in extending liver slice survival, in conjunction with its three-dimensional multi-cellular complexity, increases the application of this in vitro model for investigating pathways of injury and repair, and fibrosis...
  53. ncbi Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures
    William A Hare
    Department of Biological Sciences, Allergan Inc, Irvine, California 92612, USA
    Invest Ophthalmol Vis Sci 45:2625-39. 2004
    ..To determine, using electrophysiological measures of visual system function, whether oral daily dosing of memantine is both safe and effective to reduce the injury associated with experimental glaucoma in primates...
  54. pmc Upregulation of orphan nuclear receptor Nur77 following PGF(2alpha), Bimatoprost, and Butaprost treatments. Essential role of a protein kinase C pathway involved in EP(2) receptor activated Nur77 gene transcription
    Yanbin Liang
    Department of Biological Science, Allergan, Inc, Irvine, CA 92612, USA
    Br J Pharmacol 142:737-48. 2004
    ..5. It appears that PGF(2alpha) and Butaprost activate Nur77 transcription mechanisms through the activation of FP and EP(2) receptor-coupled signaling pathways, whereas Bimatoprost stimulates neither FP nor EP(2) receptors...
  55. ncbi The role of the lacrimal functional unit in the pathophysiology of dry eye
    Michael E Stern
    Biological Sciences, Allergan, Inc, 2525 Dupont Drive, Irvine, CA 92612, USA
    Exp Eye Res 78:409-16. 2004
    ..Factors such as neurogenic inflammation and T cell involvement in the disease pathogenesis as well as newly developed animal models of ocular surface inflammation are discussed...
  56. ncbi Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells
    Peter C Baciu
    Allergan Inc, 2525 Dupont Dr, Irvine, CA 92612, USA
    Exp Cell Res 291:167-75. 2003
    ....
  57. ncbi Pharmacokinetics of tazarotene cream 0.1% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin
    Zhiling Yu
    Department of Pharmacokinetics and Drug Metabolism, Allergan Inc, 2525 Dupont Drive, Irvine, CA 92612 1599, USA
    Clin Pharmacokinet 42:921-9. 2003
    ..1% under standard (face only) or exaggerated (15% body surface area, including the face) application conditions after a single dose and after repeat topical applications once daily to patients with acne vulgaris or photodamaged skin...
  58. ncbi Temporal modulation of scotopic visual signals by A17 amacrine cells in mammalian retina in vivo
    Cun Jian Dong
    Department of Biological Sciences, Allergan Pharmaceuticals, Irvine, California 92612, USA
    J Neurophysiol 89:2159-66. 2003
    ..Our results also suggest that in the mammalian retina the feedback may be a novel mechanism that contributes postphotoreceptorally to the termination of rod signals, especially those elicited by very dim light stimuli...
  59. pmc A randomised, double masked, multicentre clinical trial comparing bimatoprost and timolol for the treatment of glaucoma and ocular hypertension
    S M Whitcup
    Allergan, Inc, Irvine, CA, USA
    Br J Ophthalmol 87:57-62. 2003
    ..Aim: To evaluate the safety and efficacy of bimatoprost 0.03% once daily or twice daily compared with timolol 0.5% twice daily in patients with glaucoma or ocular hypertension...
  60. ncbi Physiology and pharmacology of therapeutic botulinum neurotoxins
    K Roger Aoki
    Neurotoxin Research Program, Biological Sciences, Allergan Inc, Irvine, Calif, USA
    Curr Probl Dermatol 30:107-16. 2002
  61. ncbi Immobilized metal-ion affinity chromatography of recombinant Fab protein OPG C11 in the presence of EDTA-Mg(II)
    Hui Xiang
    J Chromatogr A 978:153-64. 2002
    ..The strategy of EDTA-Mg2+ treatment may have general application potentials...
  62. ncbi The pathology of dry eye: the interaction between the ocular surface and lacrimal glands
    M E Stern
    Department of Biological Sciences, Allergan, Inc, Irvine, CA 92713 9534, USA
    Cornea 17:584-9. 1998
    ....